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公开(公告)号：NZ324691A
公开(公告)日：1999-11-29
申请号：NZ32469196
申请日：1996-12-11
Applicant: BASF AG
Inventor： AMBERG WILHELM , BARLOZZARI TERESA , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , HEGE HANS-GUENTHER , JANSSEN BERND , KLING ANDREAS , LIETZ HELMUT , RITTER KURT , ULLRICH MARTINA , WEYMANN JURGEN , ZIERKE THOMAS
Abstract: Peptides of the following formula (I): R1R2N-CHX-CO-A-B-D-E-(G)s-K in which R1, R2, A, B, D, E, G, K, X, and s have the meanings stated in the description, and the preparation thereof are described. The peptides have an antineoplastic effect.
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公开(公告)号：NZ310443A
公开(公告)日：1999-10-28
申请号：NZ31044396
申请日：1996-06-03
Applicant: BASF AG
Inventor： HAUPT ANDREAS , EMLING FRANZ , ROMERDAHL CYNTHIA A
Abstract: Novel compounds of the formulaR1R2N-CHX-CO-A-B-D-(E)s-(F)t-(G)U-KIin which R1, R2, A, B, D, E, F, G, K, X, s, t, and u have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.
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公开(公告)号：BG102479A
公开(公告)日：1999-06-30
申请号：BG10247998
申请日：1998-05-22
Applicant: BASF AG
Inventor： AMBERG WILHELM , BARLOZZARI TERESA , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , HEGE HANS-GUENTER , JANSSEN BERND , KLING ANDREAS , LIETZ HELMUT , RITTER KURT , ULLRICH MARTINA , WEYMANN JUERGEN , ZIERKE THOMAS
Abstract: The invention relates to new peptides with the formulaR1R2N-CHX-CO-A-B-D-E-(G)s-K,where R1, R2, A, B, D, E, G, K, X and s have the meanings listedin the description. The invention also relates to methods for thepreparation of the above peptides having antineoplasticproperties.9 claims
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公开(公告)号：AU9592698A
公开(公告)日：1999-04-27
申请号：AU9592698
申请日：1998-09-30
Applicant: BASF AG
Inventor： BARLOZZARI TERESA , BANERJEE SUBHASHIS , HAUPT ANDREAS
Abstract: The present invention provides compositions and methods for the treatment of rheumatoid arthritis in a subject wherein one or more compounds of Formula I as defined herein alone or in combination with one or more other antiarthritic drugs provide suppression of rheumatoid arthritis.
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公开(公告)号：CO4750840A1
公开(公告)日：1999-03-31
申请号：CO96065733
申请日：1996-12-13
Applicant: BASF AG
Inventor： AMBERG WILHELM , BARLOZZARI TERESA , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , HEGE HANS-GUENTHE , JANSSEN BERND , KLING ANDREAS
Abstract: Nuevos peptidos de la fórmula I:R1 R2 N-CHX-CO-A-B-D-E-(G)s -K Idonde R1 significa hidrógeno, metilo, o etilo; R2 significa metilo, o etilo; R1 -N-R2 forman juntos un anillo de pirrolidina; A significa un radical valilo, isoleucilo, alo-isoleucilo, 2-terc.-butilglicilo, 2-etilglicilo, norleucilo o norvalilo; B significa un radical N-metil-valilo, N-metil-norvalilo, N-metil-leucilo, N-metil-isoleucilo, N-metil-2-terc.-butilglicilo, N-metil-2-etilglicilo, o N-metilnorleucilo; D significa un radical prolilo, homoprolilo, hidroxiprolilo, o tiazolidin-4-carbonilo; E significa un radical prolilo, homoprolilo, hidroxiprolilo, tiazolidine-4-carbonilo, trans-4-fluoro-L-prolilo, cis-4-fluoro-L-prolilo, trans-4-cloro-L-prolilo o cis-4-cloro-L-prolilo; X es etilo, propilo, butilo, isopropilo, sec. butilo, terc.-butilo ciclopropilo, o ciclopentilo; G significa un radical L-2-terc-butilglicilo, D-2-terc. butilglicilo, D-valilo, D-isoleucilo, D-leucilo, D-norvalilo, 1-aminopentil-1-carbonilo, o 2,2-dimetilglicilo; s es 0 o 1:K significa-NH-C1-8 -alquilo, -NH-C3-8 - alquenilo, -NH-C3-8 -alquinilo, -NH-C6-8 - cicloalquilo, -NH-C1-4 -alqueno C3-8 -cicloalquilo,...
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Patent Agency Ranking
公开(公告)号：ZA976724B
公开(公告)日：1999-01-29
申请号：ZA976724
申请日：1997-07-29
Applicant: BASF AG
Inventor： BARLOZZARI TERESA , HAUPT ANDREAS , GRIESINGER BERND JANSSEN CHRIS , BELIK DANIEL , BORETZKY MICHAEL
Abstract: The present invention provides anti-tumor peptides of Formula I,A-B-NR3-CHD-CH(OCH3)-CH2CO-E-K(I),and the acid salts thereof. A is an amino acid residue selected from the group consisting of N-methyl-D-prolyl, N-methyl-D-homoprolyl and N,N-dimethyl-2-ethylphenylglycyl, or an amino acid residue of the formula R1R2N-CHX-CO, wherein R1 is a-methyl group or an ethyl group, R2 is a hydrogen atom, a methyl group or an ethyl group, and X is an alkyl group. B is an amino acid residue selected from the group consisting of valyl, isoleucyl, leucyl, and 2-t-butylglycyl. R3 is a hydrogen atom or a methyl group. D is a normal or branched C2-C5-alkyl group. E is an amino acid residue selected from the group consisting of prolyl, homoprolyl, 5-methylprolyl, and phenylalanyl, or E is a residue derived from an amino acid comprising a pyrrolidine group. K is an alkoxy group or an amino group. An additional embodiment of the present invention is a method for treating a malignancy in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound or compounds of Formula I in a pharmaceutically acceptable composition.
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公开(公告)号：ZA9706724B
公开(公告)日：1999-01-29
申请号：ZA9706724
申请日：1997-07-29
Applicant: BASF AG
Inventor： BARLOZZARI TERESA , HAUPT ANDREAS , GRIESINGER BERND JANSSEN CHRIS , BELIK DANIEL , BORETZKY MICHAEL
CPC classification number: C07K5/0205 , A61K38/00
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公开(公告)号：BR9611383A
公开(公告)日：1999-01-26
申请号：BR9611383
申请日：1996-10-30
Applicant: BASF AG
Inventor： RITTER KURT , BERNARD HARALD , HAUPT ANDREAS , AMBERG WILHELM , BUSCHMANN ERNST , JANSSEN BERND , MUELLER STEFAN , KLING ANDREAS , ROBINSON SIMON , ARRUDA MONIKA DE , BARLOZZARI TERESA , ZIERKE THOMAS
Abstract: Novel peptides of the formulaA-B-D-E-F-L,wherein A, B, D, E, F, and L have the meanings stated in the specification, and their preparation are disclosed. The novel compounds are suitable for controlling diseases.
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公开(公告)号：AT174035T
公开(公告)日：1998-12-15
申请号：AT95917962
申请日：1995-04-26
Applicant: BASF AG
Inventor： AMBERG WILHELM , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , JANITSCHKE LOTHAR , JANSSEN BERND , KARL ULRICH , KLING ANDREAS , MUELLER STEFAN , DE POTZOLLI BERND , RITTER KURT , THYES MARCO , ZIERKE THOMAS
Abstract: Compounds of the formulawhere R1, R2, R3 and R4 have the meaning stated in the description, and a process for preparing them are described. The compounds are suitable as starting material for synthesizing substances which are active against tumors.
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公开(公告)号：HU9801817A2
公开(公告)日：1998-11-30
申请号：HU9801817
申请日：1996-06-03
Applicant: BASF AG
Inventor： EMLING FRANZ , HAUPT ANDREAS , ROMERDAHL CYNTHIA A
Abstract: Novel compounds of the formulaR1R2N-CHX-CO-A-B-D-(E)s-(F)t-(G)U-KIin which R1, R2, A, B, D, E, F, G, K, X, s, t, and u have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.
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