公开(公告)号：EP1169625A1

公开(公告)日：2002-01-09

申请号：EP00917906.0

申请日：2000-03-15

Applicant: Cytometrics, Inc.

Inventor： COOK, Christopher, A. ,  GRONER, Warren ,  NADEAU, Richard, G.

IPC: G01J3/28 ,  G01J3/42 ,  G01N21/27

CPC classification number: G01J3/28 ,  G01J3/0213 ,  G01J3/0224 ,  G01J3/0264 ,  G01J2003/2866

Abstract: The invention comprises a system and method of calibrating a reflected spectral imaging apparatus used for analysis of living tissue. In addition to the reflected spectral imaging apparatus itself, the calibration apparatus comprises an optical filter that is placed between the light source used in the imaging apparatus and the object under analysis, and a calibration module. The filter is fabricated such that when the light is passed through the filter, an image is projected onto the focal plane where imaging is to take place within the object. The image projected by the filter comprises a plurality of areas, each having a different known optical density. For each area, the calibration module measures the intensity of the light reflected from the area and maps the light intensity measurement to the optical density known to be present at the area. This correspondence of light intensity measurements and known optical densities is then used to calibrate the reflected spectral imaging apparatus.

公开(公告)号：EP0015170B1

公开(公告)日：1983-06-22

申请号：EP80400081.8

申请日：1980-01-18

Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE Etablissement de Caractère Scientifique Technique et Industriel

Inventor： Boisde, Gilbert ,  Chevalier, Gilbert ,  Perez, Jean-Jacques

IPC: G01N21/25 ,  G01J3/42

CPC classification number: G01J3/02 ,  G01J3/0213 ,  G01J3/0218 ,  G01J3/42

公开(公告)号：EP0015170A1

公开(公告)日：1980-09-03

申请号：EP80400081.8

申请日：1980-01-18

Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE Etablissement de Caractère Scientifique Technique et Industriel

Inventor： Boisde, Gilbert ,  Chevalier, Gilbert ,  Perez, Jean-Jacques

IPC: G01N21/25 ,  G01J3/42

CPC classification number: G01J3/02 ,  G01J3/0213 ,  G01J3/0218 ,  G01J3/42

Abstract: Dispositif spectrophotométrique pour effectuer des mesures à distance sur un corps en solution contenu dans une cellule de mesure. Le dispositif comprend :

- au moins une cellule de mesure (14);
- une boucle de mesure (I) constituée par au moins deux ensembles de fibres optiques (8,17) guidant le faisceau lumineux depuis la source lumineuse jusqu'au détecteur via au moins une cellule de mesure et une boucle de référence (II) comprenant au moins une fibre optique (27) ayant une lon- . gueur et une nature telles que la boucle de référence compense sensiblement la boucle de mesure. De préférence, la cellule de mesure (14) est placée dans une enceinte de protection (10) vis-à-vis des rayonnements.

Abstract translation: 1.远程测量分光光度计，包括光源，单色仪，传感器（21），限定测量光束和参考光束的光学装置以及位于源和传感器之间的隔间（4），光 所述装置的特征在于，其还包括： - 适于接收用于分析的解决方案并且远离所述隔间（4）的至少一个测量单元（14）， - 测量回路（I ）包括在所述隔室（4）中的用于将测量光束引导出所述隔间的第一光学系统（5,6），第一光纤（8,12），其第一端（7）接收来自所述隔室的所述测量光束 第一光学系统，并且其另一端位于设置在所述单元或单元（14）的入射面的一个或多个透镜（13）处，连接一个或多个第二透镜的至少一个第二光纤（16,17） 15）设置在出口面o f将所述电池或电池（14）连接到所述隔室（4）的入口，以及在所述隔室中的第二光学系统（19,20），并且适于将由所述第二光纤发射的光束引导出所述隔室朝向所述隔室 传感器（21）和 - 参考环路（II），其包括在所述隔室（4）中的第三光学系统（24,25）以将参考光束引导出所述隔间，至少一个第三光纤（27,34） 其第一端（26）从所述第三光学系统接收所述参考光束，并且其另一端连接到所述隔室的入口;第四光学系统（36,37），其适于引导由所述第三光学系统发射的光束 光纤（27）朝向所述传感器（21），以及光学装置（29,30,40），用于在时间过程中补偿; 由分析的溶液引起的测量环路的光纤的传输特性的任何变化。

公开(公告)号：US11885677B2

公开(公告)日：2024-01-30

申请号：US17227440

申请日：2021-04-12

Applicant: Massachusetts Institute of Technology

Inventor： Derek Kita ,  Carlos Andres Rios Ocampo ,  Juejun Hu

IPC: G01J3/02 ,  G01J3/45 ,  G01J3/453 ,  G02F1/21

CPC classification number: G01J3/0256 ,  G01J3/0205 ,  G01J3/0213 ,  G01J3/45 ,  G01J3/4531 ,  G01J3/4532 ,  G02F1/212

Abstract: We disclose an on-chip photonic spectroscopy system capable of dramatically improving the signal-to-noise ratio (SNR), dynamic range, and reconstruction quality of Fourier transform spectrometers. Secondly, we disclose a system of components that makes up a complete on-chip RF spectrum analyzer with low-cost and high-performance.

公开(公告)号：US20230296511A1

公开(公告)日：2023-09-21

申请号：US18042220

申请日：2021-08-19

Applicant: Maytronics Ltd.

Inventor： Hanoch KISLEV ,  Shahar SOBOL ,  Yehonatan Evgeniy TILCHIN ,  Alexander RACHMAN

IPC: G01N21/51 ,  G01N21/31 ,  G01N21/64 ,  G01J3/42 ,  G01J3/02 ,  G01J3/28

CPC classification number: G01N21/51 ,  G01N21/31 ,  G01N21/64 ,  G01J3/42 ,  G01J3/0208 ,  G01J3/0213 ,  G01J3/0227 ,  G01J3/2803

Abstract: A liquid measuring system (LMS) comprising: a light source; a multi-region optical filter (MROF); a sample cell configured to contain a liquid sample; an optical detection subsystem (ODS) having an optical detector for measuring optical properties of light emanating from the liquid sample. The MROF may include a spectral filter region such as a bandpass or a long-pass filter type region, and natural density (ND) type filter region, for enabling simultaneous optical measuring at least of turbidity level and algae concentration in a water sample contained by the sample cell, by having light passed through the water sample and the MROF before reaching the optical detector of the ODS. Embodiments of the MROFs may be also used, for example for selective spectral attenuation of light illuminating the liquid sample to achieve reduction in distortions due to stray light.

公开(公告)号：US20180042483A1

公开(公告)日：2018-02-15

申请号：US15558162

申请日：2016-03-07

Applicant: Massachusetts Institute of Technology

Inventor： Neelkanth M. Bardhan ,  Xiangnan Dang ,  Jifa Qi ,  Angela M. Belcher

IPC: A61B5/00 ,  G01N21/64 ,  G01J3/32 ,  G01J3/44 ,  G01J3/28 ,  G01N33/22

CPC classification number: A61B5/0071 ,  A61B5/0075 ,  A61B5/0091 ,  A61B5/7232 ,  A61B2576/00 ,  A61B2576/02 ,  G01J3/0213 ,  G01J3/18 ,  G01J3/2823 ,  G01J3/32 ,  G01J3/36 ,  G01J3/4406 ,  G01N21/64 ,  G01N33/22 ,  G01N2021/6421 ,  G01N2201/12 ,  G02B21/361

Abstract: A method, and corresponding system, can include identifying a plurality of wavelength spectral band components in hyperspectral image data, the spectral band components corresponding to mutually distinct sources of image contrast. An intensity image corresponding to each respective spectral band component can be calculated, followed by combining the respective intensity images to form an inter-band image based on the respective, mutually distinct sources of image contrast for each spectral band component. Intensity images can be hyperspectral or hyperdiffuse images. Hyperdiffuse imaging can be performed for each spectral band component identified using hyperspectral measurements. Spectral position and spectral width images corresponding to each spectral band component can be calculated and used to determine depth of features inside a surface of the target. Diffuse width images can be calculated from hyperdiffuse image data and used to determine depth.

公开(公告)号：US09863877B2

公开(公告)日：2018-01-09

申请号：US14863341

申请日：2015-09-23

Applicant: Agilent Technologies, Inc.

Inventor： Charles Hoke ,  Christopher Ryan Moon ,  Andrew Ghetler ,  Yuri Beregovski ,  Richard P. Tella ,  Yang Han

IPC: G01N21/552 ,  G01N21/35 ,  G02B13/14 ,  G02B17/00 ,  G02B17/08 ,  G01N21/3563 ,  G01N21/39 ,  G01J3/02

CPC classification number: G01N21/552 ,  G01J3/0213 ,  G01J3/0229 ,  G01N21/35 ,  G01N21/3563 ,  G01N2021/399 ,  G01N2201/0633 ,  G01N2201/10 ,  G01N2201/101 ,  G02B13/14 ,  G02B17/006 ,  G02B17/0808 ,  G02B21/002 ,  G02B21/02 ,  G02B21/04 ,  G02B21/10

Abstract: A scanner and an attenuated total reflection (ATR) objective for use in such scanners are disclosed. The ATR objective includes first and second optical elements and an input port. The input port receives an input collimated light beam that is focused to a point on a planar face of the first optical element by the second optical element such that substantially all of that portion is reflected by the planar face and no portion of the input beam strikes the planar face at an angle less than the critical angle. The second optical element also generates an output collimated light beam from light reflected from the planar thce that is characterized by a central ray that is coincident with the central ray of the input collimated light beam. A light beam converter receives the first collimated light beam and generates the input collimated light beam therefrom.

公开(公告)号：US09857221B2

公开(公告)日：2018-01-02

申请号：US14813472

申请日：2015-07-30

Applicant: Seiko Epson Corporation

Inventor： Tomonori Matsushita

IPC: G01J3/00 ,  G01J3/02 ,  G01J3/26 ,  G01J3/28

CPC classification number: G01J3/0213 ,  G01J3/0256 ,  G01J3/26 ,  G01J2003/2813 ,  G01J2003/2826

Abstract: A spectral camera includes a wavelength variable interference filter, an imaging unit having a plurality of light receiving elements arranged in a two-dimensional array configuration, and a wavelength acquisition unit which acquires center wavelengths of light beams received by the light receiving elements in accordance with signal values output from the light receiving elements when reference light is received by the imaging unit. Light amounts of the reference light corresponding to different wavelength components in a certain wavelength range are uniform in a plane, and different signal values are acquired when light beams of the different wavelength components are received by the light receiving elements.

公开(公告)号：US09804092B2

公开(公告)日：2017-10-31

申请号：US14766451

申请日：2014-02-11

Applicant: British Columbia Cancer Agency Branch

Inventor： Haishan Zeng ,  Michael Short ,  Jianhua Zhao

IPC: G01N21/65 ,  G01N21/64 ,  G01J3/44 ,  A61B5/00 ,  G01J3/02

CPC classification number: G01N21/65 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B2560/0285 ,  G01J3/0213 ,  G01J3/0221 ,  G01J3/4406 ,  G01N21/64 ,  G01N21/645 ,  G01N2021/6417 ,  G01N2021/6484 ,  G01N2201/08 ,  G01N2201/0833 ,  G01N2201/084

Abstract: Examples of a spectroscopy probe for performing measurements of Raman spectra, reflectance spectra and fluorescence spectra are disclosed. The integrated spectral probe can comprise one or more light sources to provide a white light illumination to generate reflectance spectra, an excitation light to generate an UV/visible fluorescence spectra and a narrow band NIR excitation to induce Raman spectra. The multiple modalities of spectral measurements can be performed within 2 seconds or less. Examples of methods of operating the integrated spectroscopy probe disclosed.

公开(公告)号：US20170082490A1

公开(公告)日：2017-03-23

申请号：US14863225

申请日：2015-09-23

Applicant: Agilent Technologies, Inc.

Inventor： Charles Hoke ,  Christopher Ryan Moon ,  Andrew Ghetler ,  Yang Han

IPC: G01J3/28 ,  G01J3/02 ,  G01J3/10

CPC classification number: G01J3/2823 ,  G01J3/0213 ,  G01J3/0224 ,  G01J3/108 ,  G01J3/28 ,  G01J3/42

Abstract: An imaging scanner and a method for using the same are disclosed. The scanner includes a variable attenuator adapted to receive a light beam generated by a MIR laser and that generates an attenuated light beam therefrom characterized by an attenuation level. The scanner includes an optical assembly that focuses the attenuated light beam to a point on a specimen. A light detector measures an intensity of light leaving the point on the specimen, the light detector being characterized by a detector dynamic range. A controller forms a plurality of MIR images from the intensity as a function of position on the specimen, each of the plurality of MIR images being formed with a different level of attenuation of the light beam. The controller combines the plurality of MIR images to generate a combined MIR image having a dynamic range greater than the detector dynamic range.