公开(公告)号：EP3074134A2

公开(公告)日：2016-10-05

申请号：EP14865949.3

申请日：2014-11-26

Applicant: STC.UNM

Inventor： BRUECK, Steven, R.J. ,  EDWARDS, Jeremy, Scott ,  NEUMANN, Alexander ,  KUZNETSOVA, Yuliya ,  MENDOZA, Edgar, A.

IPC: B01L7/00 ,  C12M1/34 ,  C12Q1/68

Abstract: Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (>wavelength), ˜1-nm aperture “tortuous” nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.

Abstract translation: 用于长读取，无标记的光学纳米孔长链分子测序的方法和设备。 通常，本公开描述了一种新颖的测序技术，其基于纳米通道的整合以递送具有广泛间隔（>波长），〜1nm孔径“曲折”纳米孔的单个长链分子，其缓慢移位足以提供大量平行的， 使用光学技术的单基准分辨率。 使用简单的胶体纳米颗粒的新型定向自组装纳米加工方案用于在展开长链分子的纳米通道上形成纳米孔阵列。 在纳米颗粒阵列的表面，工程化等离子体/极化结构中的强定位电磁场允许使用光学技术的单碱基分辨率。

公开(公告)号：EP3039550A1

公开(公告)日：2016-07-06

申请号：EP14839346.5

申请日：2014-08-28

Applicant: STC.UNM

Inventor： PLUSQUELLIC, James ,  AARESTAD, James

IPC: G06F11/30 ,  G06F11/16

CPC classification number: H03K19/00323 ,  H03K3/84 ,  H03K19/00315 ,  H03K19/215 ,  H03K23/004 ,  H04L9/0662 ,  H04L9/0866

Abstract: A Hardware-Embedded Delay PUF (HELP) leverages entropy by monitoring path stability and measuring path delays from core logic macros. HELP incorporates techniques to deal with bias. A unique feature of HELP is that it may compare data measured from different test structures. HELP may be implemented in existing FPGA platforms. HELP may leverage both path stability and within-die variations as sources of entropy.

Abstract translation: 硬件嵌入延迟PUF（HELP）通过监视路径的稳定性和测量从核心逻辑宏路径延迟利用熵。 HELP集成了技术处理偏差。 HELP的一个独特功能是没有可能从不同的测量测试结构的数据进行比较。 HELP可以在现有FPGA平台上实现。 HELP可以利用内-变化作为熵源两个路径和稳定性。

公开(公告)号：EP3027775A1

公开(公告)日：2016-06-08

申请号：EP14832389.2

申请日：2014-08-01

Applicant: STC.UNM ,  Edwards, Jeremy, Scott

Inventor： EDWARDS, Jeremy, Scott

IPC: C12Q1/68

CPC classification number: C12Q1/6874 ,  C12Q1/6825 ,  C12Q1/6841 ,  C12Q2523/303 ,  C12Q2543/10 ,  C12Q2523/307

Abstract: This disclosure describes, in one aspect, methods for DNA sequencing and performing epigenomic analyses. Generally, the methods include immobilizing a plurality of copies of a DNA molecule on a surface, stretching at least a portion of the immobilized DNA molecules, and sequencing at least a portion of the immobilized, stretched DNA molecules.

Abstract translation: 在一个方面，本公开描述了用于DNA测序和进行表观基因组分析的方法。 通常，这些方法包括将多个DNA分子拷贝固定在表面上，拉伸至少一部分固定的DNA分子，并对至少一部分固定的，拉伸的DNA分子进行测序。

公开(公告)号：EP2906347A1

公开(公告)日：2015-08-19

申请号：EP13847996.9

申请日：2013-10-15

Applicant: STC.UNM

Inventor： SEROV, Alexey ,  ATANASSOV, Plamen, B. ,  HALEVI, Barr ,  SHORT, Paul

IPC: B01J37/08 ,  B01J23/745

CPC classification number: H01M4/9091 ,  B01J31/1805 ,  H01M4/8652 ,  H01M4/8814 ,  H01M4/8846 ,  H01M4/8885 ,  H01M4/9008 ,  H01M8/1011 ,  H01M2008/1095 ,  Y02E60/50 ,  Y02E60/523

Abstract: Novel catalytic materials and novel methods of preparing M-N—C catalytic materials utilizing a sacrificial support approach and using inexpensive active polymers as the carbon and nitrogen source and readily available metal precursors are described.

Abstract translation: 描述了新型催化材料和利用牺牲支撑方法制备M-N-C催化材料并使用廉价的活性聚合物作为碳源和氮源以及容易获得的金属前体的新方法。

公开(公告)号：EP2864762A1

公开(公告)日：2015-04-29

申请号：EP13807610.4

申请日：2013-03-15

Applicant: STC.UNM

Inventor： GRAVES, Steven, Wayde ,  AUSTIN SUTHANTHIRARA, Pearlson, Prashanth ,  SHREVE, Andrew, P. ,  LOPEZ, Gabriel, P.

IPC: G01N15/14 ,  G01N21/27 ,  C12Q1/02

CPC classification number: G01N15/1404 ,  G01N15/1459 ,  G01N2015/142

Abstract: An affordable flow cytometry system with a significantly increased analytical rate, volumetric sample delivery and usable particle size including a light beam that interrogates multiple flow streams so as to provide excitation across all of the streams, and an optical objective configured to collect light from the sample streams and image the light onto an array detector.

公开(公告)号：EP2802349A1

公开(公告)日：2014-11-19

申请号：EP13736349.5

申请日：2013-01-10

Applicant: STC.UNM

Inventor： CHACKERIAN, Bryce ,  PEABODY, David ,  TUMBAN, Ebenezer

IPC: A61K39/12 ,  C12N7/01 ,  A61P31/20

CPC classification number: A61K39/12 ,  A61K2039/5258 ,  A61K2039/58 ,  C12N2710/20034 ,  C12N2795/18142 ,  C12N2795/18143

Abstract: In one aspect, the invention provides immunogenic HPV L2-containing viral-like particles (VLPs). Related compositions (e.g. vaccines), nucleic acid constructs, and therapeutic methods are also provided. In certain aspects, the VLPs are comprised of a coat polypeptide of the bacteriophages PP7 or MS2, wherein the coat protein is modified by insertion of peptide antigens derived from HPV L2, and wherein the HPV L2 peptide is displayed on the VLP and encapsidates PP7 or MS2 mRNA. Specifically, VLPs of the invention display L2 peptides at the N- terminus of the bacteriophage coat protein. Surprisingly, these L2-displaying VLPs induce more broadly neutralizing antibody responses than when the same peptide is displayed in the AB-loop such that the immunogenic response is enhanced by a factor of at least 10. Immunogenic VLPs and related compositions of the invention induce high titer antibody responses against HPV L2 and protect against HPV challenge
in vivo.

公开(公告)号：EP2231019B1

公开(公告)日：2014-10-22

申请号：EP08860441.8

申请日：2008-12-10

Applicant: STC.UNM

Inventor： CHEN, Jingkuang

IPC: A61B5/00 ,  A61B8/12 ,  A61B8/00 ,  A61B5/02 ,  A61B8/08

CPC classification number: A61B5/0095 ,  A61B5/0086 ,  A61B5/02007 ,  A61B8/0833 ,  A61B8/12 ,  A61B8/4472 ,  A61B8/4483 ,  A61B8/483 ,  A61B2562/028 ,  Y10T29/49826

公开(公告)号：EP2637816A2

公开(公告)日：2013-09-18

申请号：EP11839022.8

申请日：2011-11-10

Applicant: STC.UNM ,  Luhrs, Claudia ,  Phillips, Jonathan ,  Soliman, Haytham

Inventor： LUHRS, Claudia ,  PHILLIPS, Jonathan ,  SOLIMAN, Haytham ,  LESEMAN, Zayd

IPC: B22F9/22 ,  B22F9/18 ,  B82B3/00 ,  B82Y40/00

CPC classification number: B22F9/26 ,  B22F1/0018 ,  B22F1/0096 ,  B22F9/22 ,  B33Y40/00 ,  B82Y40/00

Abstract: Various embodiments provide methods of forming zero valent metal particles using an aerosol- reductive/expansion synthesis (A-RES) process, in one embodiment, an aerosol stream including metal precursor compound(s) and chemical agent(s) that produces reducing gases upon thermal decomposition can be introduced into a heated inert atmosphere of a RES reactor to form zero valent metal particles corresponding to metals used for the metal precursor compound(s).

Abstract translation: 各种实施方式提供了使用气溶胶还原/膨胀合成（A-RES）方法形成零价金属颗粒的方法，在一个实施方式中，气溶胶流包括金属前体化合物和一种或多种化学试剂， 可以将热分解引入到RES反应器的加热的惰性气氛中以形成对应于用于金属前体化合物的金属的零价金属颗粒。

公开(公告)号：EP2524334A2

公开(公告)日：2012-11-21

申请号：EP11733288.2

申请日：2011-01-12

Applicant: STC.UNM

Inventor： PLUSQUELLIC, James ,  ACHARYYA, Dhura ,  HELINSKI, Ryan, L.

IPC: G06F21/02 ,  H04L9/08

Abstract: A system and method that generates a physical unclonable function ("PUF") security key for an integrated circuit ("IC") through use of equivalent resistance variations in the power distribution system ("PDS") to mitigate the vulnerability of security keys to threats including cloning, misappropriation and unauthorized use.

公开(公告)号：EP2519627A2

公开(公告)日：2012-11-07

申请号：EP10841780.9

申请日：2010-12-31

Applicant: STC.UNM

Inventor： PEABODY, David, S. ,  CHACKERIAN, Bryce

IPC: C12N7/01 ,  C12N15/33 ,  C07K14/005 ,  A61K39/12

CPC classification number: A61K39/12 ,  A61K39/07 ,  A61K2039/5256 ,  A61K2039/5258 ,  C12N7/00 ,  C12N15/1037 ,  C12N2710/20022 ,  C12N2710/20034 ,  C12N2740/16034 ,  C12N2740/16134 ,  C12N2795/16021 ,  C12N2795/16022 ,  C12N2795/16023 ,  C12N2795/16042 ,  C12N2795/18023 ,  C40B40/08

Abstract: The present invention relates to a system and method for controlling peptide display valency on virus-like particles (VLPs), especially including MS2 VLPs. In this method, large amounts of wild-type and low quantities of single-chain dimer coat proteins may be produced from a single RNA. Valency is controlled in immunogen (vaccine) production by providing a system that allows the production of large amounts of wild-type and low quantities of single-chain dimer coating proteins from a single RNA, allowing facile adjustment of display valency levels on VLPs, especially MS2 VLPS over a wide range, from few than one-on average—to as many as ninety per particle. This facilitates the production of immunogens and vaccines, including VLPs exhibiting low valency. Nucleic acid constructs useful in the expression of virus-like particles are disclosed, comprised of a coat polypeptide of MS2 modified by insertion of a heterologous peptide, wherein the heterologous peptide is displayed on the virus-like particle and encapsidates MS2 niRNA. Nucleic acid constructs are also disclosed which are useful in the expression of virus-like particles comprised of a coat polypeptide of PP7 modified by insertion of a heterologous peptide, wherein the heterologous peptide is displayed on the virus-like particle and encapsidates PP7 mRNA.