公开(公告)号：PT1570267E

公开(公告)日：2012-01-03

申请号：PT03778577

申请日：2003-12-01

Applicant: UCB PHARMA SA

Inventor： BROWN DEREK THOMAS ,  BUTLER LISA ,  CROMIE KAREN DOROTHY ,  GRIFFITHS MERYN RUTH ,  LAWSON ALASTAIR D G ,  LIGHTWOOD DANIEL JOHN

IPC: C07K16/24 ,  G01N33/52 ,  G01N33/569 ,  G01N33/58 ,  G01N33/68

公开(公告)号：AT528648T

公开(公告)日：2011-10-15

申请号：AT03778577

申请日：2003-12-01

Applicant: UCB PHARMA SA

Inventor： BROWN DEREK THOMAS ,  BUTLER LISA ,  CROMIE KAREN DOROTHY ,  GRIFFITHS MERYN RUTH ,  LAWSON ALASTAIR D G ,  LIGHTWOOD DANIEL JOHN

IPC: G01N33/52 ,  C07K16/24 ,  G01N33/569 ,  G01N33/58 ,  G01N33/68

Abstract: The present invention provides a homogeneous assay for identifying an antibody producing cell producing an antibody which binds to a selected antigen comprising: a) providing a population of antibody producing cells; b) incubating said population of antibody producing cells with a selected antigen and a labeled anti-antibody antibody, wherein said anti-antibody antibody is capable of distinguishing cells producing an antibody which binds to the selected antigen from those cells which do not; and c) identifying an antibody producing cell capable of producing an antibody which binds to the selected antigen.

公开(公告)号：HK1148776A1

公开(公告)日：2011-09-16

申请号：HK11102887

申请日：2011-03-22

Applicant: UCB PHARMA SA

Inventor： ATHWAL DILJEET SINGH ,  BROWN DEREK THOMAS ,  WEIR ANDREW NEIL CHARLES ,  POPPLEWELL ANDREW GEORGE ,  CHAPMAN ANDREW PAUL ,  KING DAVID JOHN

IPC: C12N20060101 ,  A61K39/395 ,  C12N15/09 ,  A61K47/48 ,  A61P20060101 ,  A61P19/02 ,  A61P29/00 ,  A61P37/06 ,  C07K20060101 ,  C07K16/24 ,  C07K16/46 ,  C12N1/21 ,  C12N15/13 ,  C12P21/02 ,  C12P21/08

Abstract: There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNF± There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNF±

公开(公告)号：HK1148202A1

公开(公告)日：2011-09-02

申请号：HK11102314

申请日：2011-03-08

Applicant: UCB PHARMA SA

Inventor： SCHENKEL ERIC ,  POULAIN CLAIRE ,  DODELET BERTRAND ,  FANARA DOMENICO

IPC: A61K20060101

Abstract: The present invention concerns a stable pharmaceutical solution, a process of the preparation thereof and therapeutic uses thereof.

公开(公告)号：GB201110626D0

公开(公告)日：2011-08-03

申请号：GB201110626

申请日：2011-06-22

Applicant: UCB PHARMA SA

公开(公告)号：CA2786336A1

公开(公告)日：2011-07-21

申请号：CA2786336

申请日：2011-01-13

Applicant: UCB PHARMA SA

Inventor： ELLIS MARK ,  HUMPHREYS DAVID PAUL

IPC: C07K14/245 ,  C12N15/70

Abstract: The present invention provides a recombinant gram-negative bacterial cell, characterized in that the cell: a. comprises a recombinant polynucleotide encoding DsbC; and b. has reduced Tsp protein activity compared to a wild-type cell.

公开(公告)号：CA2786335A1

公开(公告)日：2011-07-21

申请号：CA2786335

申请日：2011-01-13

Applicant: UCB PHARMA SA

Inventor： ELLIS MARK ,  HUMPHREYS DAVID PAUL

IPC: C12N15/70 ,  C07K14/245

Abstract: The present invention provides a recombinant gram-negative bacterial cell comprising a mutant spr gene encoding a spr protein having a mutation at one or more amino acids selected from D133, H145, H157, N31, R62, 170, Q73, C94, S95, V98, Q99, R100, L108, Y115, V135, L136, G140, R144 and G147 and wherein the cell has reduced Tsp protein activity compared to a wild-type cell.

公开(公告)号：ES2362698T3

公开(公告)日：2011-07-12

申请号：ES08775178

申请日：2008-07-17

Applicant: UCB PHARMA SA

Inventor： LEVEQUE JULIEN ,  BARBARIN NICOLAS ,  PALACIO MAGALI

IPC: C07C329/16 ,  C07C333/26

Abstract: Compuestos de formula (I), y sus sales, en la que: X es O o N-C(NH)NH2; M + es hidrogeno, sodio, disodio, potasio, dipotasio, amonio (NH4)+, diamonio, amonio cuaternario, calcio o magnesio.

公开(公告)号：PL208848B1

公开(公告)日：2011-06-30

申请号：PL37034402

申请日：2002-10-10

Applicant: UCB PHARMA SA

Inventor： POPPLEWELL ANDREW GEORGE ,  TICKLE SIMON PETER ,  ZINKEWICH-PEOTTI KAREN ,  MORRISON ROBERT KENDALL

IPC: C07K16/28 ,  C12N15/09 ,  A61K39/395 ,  A61K47/48 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P37/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/13 ,  C12P21/02 ,  C12P21/08

公开(公告)号：CA2780242A1

公开(公告)日：2011-05-26

申请号：CA2780242

申请日：2010-11-17

Applicant: UCB PHARMA SA

Inventor： HUMPHREYS DAVID PAUL ,  HEYWOOD SAM PHILIP ,  LAWSON ALASTAIR DAVID GRIFFITHS

IPC: C07K16/00 ,  C07K19/00

Abstract: A multivalent antibody fusion protein comprising: a heavy chain comprising, in sequence from the N-terminal, a variable domain nominally VH1, a CH1 region and a further variable domain nominally VH2, a light chain comprising, in sequence from the N-terminal, a variable domain nominally VL1, a CL domain and a variable domain nominally VL2, wherein said heavy and light chains are aligned to provide a first binding site formed by a first variable domain pair of VH1 and VL1 and a second binding site formed by a second variable domain pair of VH2 and VL2, wherein there is a disulfide bond between a variable domain pair forming a binding site, and said fusion protein is conjugated to a PEG polymer.