公开(公告)号：US20150187602A1

公开(公告)日：2015-07-02

申请号：US14583492

申请日：2014-12-26

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Sang Ouk Kim ,  Hyoung-Seok Moon

IPC: H01L21/467 ,  H01L21/027

CPC classification number: H01L21/3086 ,  B81C1/00031 ,  B81C2201/0149 ,  H01L21/02178 ,  H01L21/0337 ,  H01L21/0338 ,  H01L21/31144 ,  Y10T428/24802

Abstract: Provided is a nanoscale patterning method using self-assembly, wherein nanoscale patterns having desirable shapes such as a lamella shape, a cylinder shape, and the like, may be formed by using a self-assembly property of a block copolymer, and low segment interaction caused in a structure of 10 nm or less which is a disadvantage of the block copolymer may be prevented. In addition, even though single photolithography is used, pattern density may double as that of the existing nano patterns, and pitch and cycle of the patterns may be controlled to thereby be largely utilized for electronic apparatuses requiring high integration of circuits such as a semiconductor device, and the like.

Abstract translation: 提供了使用自组装的纳米级图案化方法，其中可以通过使用嵌段共聚物的自组装性质形成具有期望形状的诸如片状，圆柱形等的纳米级图案，并且低片段相互作用 可以防止嵌段共聚物的缺点在10nm以下的结构。 此外，即使使用单一光刻，图案密度可以是现有纳米图案的图案密度的两倍，并且可以控制图案的间距和周期，从而被大量地用于需要诸如半导体器件的电路的高集成度的电子设备 ，等等。

公开(公告)号：EP4549591A1

公开(公告)日：2025-05-07

申请号：EP23831932.1

申请日：2023-06-29

Applicant: Seoul National University R&DB Foundation ,  Institute for Basic Science

Inventor： KIM, Vic Narry ,  SEO, Jenny ,  JUNG, Soo-Jin

IPC: C12Q1/70 ,  C12Q1/6806 ,  C12N15/10

Abstract: The present disclosure relates to a method of screening a regulatory element for enhancing mRNA translation, a novel regulatory element resulting from the method, and uses thereof. Through the screening method of the present disclosure, a novel regulatory element capable of enhancing mRNA translation may be obtained. Furthermore, the novel regulatory element may increase the expression of a target protein and as such, may be applied to various fields, depending on the intended use of the target protein.

公开(公告)号：EP4534671A1

公开(公告)日：2025-04-09

申请号：EP23816336.4

申请日：2023-05-30

Applicant: Institute for Basic Science ,  Korea Advanced Institute of Science and Technology

Inventor： LEE, C. Justin ,  SA, Moonsun ,  BHALLA, Mridula Neeraj Kumar ,  KIM, Jin Kuk ,  JUNG, Eunji ,  PARK, Minsung

IPC: C12N15/113 ,  A61K31/7088 ,  A61K48/00 ,  A61P25/28

Abstract: The present invention relates to antisense oligomers against monoamine oxidase B and uses thereof, and more particularly, to antisense oligomers that modulate the expression level of a gene encoding monoamine oxidase B, specifically the mRNA of the gene, or a protein encoded thereby, and uses thereof for preventing, alleviating or treating liver disease, obesity or neurological disease.

公开(公告)号：EP4524244A1

公开(公告)日：2025-03-19

申请号：EP23803902.8

申请日：2023-05-15

Applicant: Seoul National University R&DB Foundation ,  Institute for Basic Science

Inventor： KIM, V. Narry ,  LEE, Young-Yoon ,  KIM, Haedong

IPC: C12N9/22 ,  C12N15/113

Abstract: The present invention relates to a DICER cleavage site motif that is a sequence determinant of dsRNA processing by DICER. Using the DICER cleavage site motif according to the present invention can strongly promote the processing of dsRNA by DICER, and thereby promote RNA interference. In addition, the DICER cleavage site motif according to the present invention is an integrated and conserved determinant of substrate recognition by DICER, and can be applied to any technique capable of generating siRNA through DICER processing. Thus, the present invention can greatly contribute to future studies using DICER processing, for example, studies on the biological or therapeutic use of small RNAs.

公开(公告)号：EP4245749A1

公开(公告)日：2023-09-20

申请号：EP21892368.8

申请日：2021-11-12

Applicant: Institute for Basic Science ,  Korea Institute of Science and Technology

Inventor： LEE, Chang Jun ,  CHUN, Heejung ,  WON, Woojin ,  PARK, Ki Duk ,  PARK, Jong Hyun ,  PAE, Ae Nim ,  CHOI, Ji Won ,  LEE, Elijah ,  PARK, Sun Jun ,  KIM, Hyeon Jeong ,  KIM, Yoowon ,  KIM, Byung Eun ,  KIM, Siwon

IPC: C07C211/53 ,  A61K31/136 ,  A61P25/28 ,  A23L33/10 ,  A23L29/00

Abstract: The present invention provides a novel aminoaromatic compound or a pharmaceutically acceptable salt thereof, a pharmaceutical composition that is for preventing or treating neurodegenerative diseases and comprises same as an active ingredient, and a health functional food composition for preventing or ameliorating neurodegenerative diseases.

公开(公告)号：EP4221822A1

公开(公告)日：2023-08-09

申请号：EP21876524.6

申请日：2021-09-30

Applicant: The Board Of Trustees Of The Leland Stanford Junior University ,  Institute for Basic Science

Inventor： LEE, Jin Hyung ,  SHIN, Hee-Sup

IPC: A61N1/36 ,  A61N1/40

公开(公告)号：EP4194557A1

公开(公告)日：2023-06-14

申请号：EP22208378.4

申请日：2015-08-06

Applicant: Institute for Basic Science ,  Toolgen Incorporated

Inventor： KIM, Seok Joong ,  KIM, Eun Ji

IPC: C12N15/63 ,  C12N1/21 ,  C12N9/16 ,  C12N9/22 ,  C12N15/10

Abstract: The disclosure provided herewith relates to a Campylobacter jejuni CRISPR/CAS system-derived RGEN and a use thereof.

公开(公告)号：EP4147806A1

公开(公告)日：2023-03-15

申请号：EP21799843.4

申请日：2021-05-07

Applicant: Seoul National University R & DB Foundation ,  Institute for Basic Science

Inventor： HYEON, Taeghwan ,  SUNG, Yung-Eun ,  YOO, Tae Yong ,  YOO, Ji Mun

IPC: B22F1/00 ,  B22F1/02 ,  B01J37/08 ,  B01J37/02 ,  B01J23/89 ,  B01J21/18 ,  B01J35/02 ,  B01J35/00 ,  H01M4/92

Abstract: Alloy nanoparticles, and a method for forming the alloy nanoparticles, a alloy nanocatalyst comprising the alloy nanoparticles are provided. The alloy nanoparticles are formed by a method comprising mixing a first metal complex including a first metal and a second metal complex including a second metal to form a multimetal compound and heat-treating the multimetal compound to form a alloy compound. The first metal and the second metal comprise transition metal, the first metal complex comprises a pyridine-based ligand, and a carbon shell containing N is formed on the surface of the alloy compound by the heat treatment.

公开(公告)号：EP3984558A1

公开(公告)日：2022-04-20

申请号：EP20813525.1

申请日：2020-06-01

Applicant: Seoul National University R & DB Foundation ,  Institute for Basic Science

Inventor： KIM, V. Narry ,  YEO, Jinah ,  KIM, Dongwan ,  LEE, Young-Suk ,  JUNG, Soo-Jin

IPC: A61K48/00 ,  A61K31/713 ,  A61K31/7105 ,  A61P31/20 ,  A61P31/22 ,  C12Q1/70 ,  C12N15/113

Abstract: The present invention relates to a technology for preventing or treating virus infection and infectious disease by inducing a mixed tailing regarding an RNA virus

公开(公告)号：EP3561059A1

公开(公告)日：2019-10-30

申请号：EP17885347.9

申请日：2017-12-22

Applicant: Institute for Basic Science

Inventor： KIM, Jin-Soo ,  KIM, Kyoung Mi ,  RYU, Seuk Min

IPC: C12N15/10 ,  C12N15/85 ,  C12N15/877 ,  C12N9/16 ,  C12N9/78 ,  C12N9/02 ,  C07K14/47

Abstract: Provided are a base editing composition comprising deaminase and target-specific nuclease, a base editing method using the base editing composition, and a method for producing a genetically modified animal. The base editing composition has a base editing activity in mammalian embryos.