公开(公告)号：EP0304151B1

公开(公告)日：1993-12-15

申请号：EP88306087.3

申请日：1988-07-04

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Musacchio, John ,  Premoli, Pietro ,  Manzoni, Angelo ,  Bergkuist, Carolyn

IPC: G01N33/84

CPC classification number: G01N33/84

公开(公告)号：EP0321032B1

公开(公告)日：1993-09-01

申请号：EP88202827.7

申请日：1988-12-09

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Calzi, Claudio ,  Zaccai, Gianfranco

IPC: A61B5/14

CPC classification number: A61B5/154 ,  A61B5/15003 ,  A61B5/150351 ,  A61B5/150389 ,  A61B5/150496 ,  A61B5/150732

公开(公告)号：EP0528472A3

公开(公告)日：1993-07-21

申请号：EP92202344.5

申请日：1992-07-29

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Antocci, Joseph D. ,  Darling, Richard H. ,  Lawrence, Maxwell E., Jr. ,  Luongo, Joseph A.

IPC: G01N21/07 ,  G01N35/00

CPC classification number: G01N21/07 ,  Y10T436/111666 ,  Y10T436/113332 ,  Y10T436/25375

Abstract: A multicuvette rotor (10) which reduces unacceptable tendencies of reagent or a sample material to spontaneously move or "wick" from one chamber compartment (40) to the other (42), resulting in premature conmingling of reactants, and of sample or reagent material to flow out of one or more of the radially outer loading ports (18) during acceleration of the rotor for transfer of the sample or reagent material from inner chambers (40) to corresponding outer chambers (42). Cover member disc (14) has planar lower surface (50) on which is formed a radially extending guide channel (56) adjacent each outer loading port (18); and an array of perimeter energy director ridges (60), each of which extends about the perimeter of an individual cuvette (30).

公开(公告)号：EP0420296A1

公开(公告)日：1991-04-03

申请号：EP90120207.7

申请日：1985-10-07

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Webster, Milo E., c/o Instrumentation Lab. Inc.

IPC: G01N35/08 ,  G01N33/48

CPC classification number: G01N35/08

Abstract: A liquid handling system useful in apparatus for analyzing biological liquid specimens or the like includes a plurality of sample metering chambers (22, 24, 26, 28), a distribution manifold (150) connected between a sample inlet port (16) and the sample metering chambers, and a corresponding plurality of auxiliary liquid metering chambers (30, 32, 34) connected to corresponding auxiliary liquid reservoirs (50, 54, 66). Liquids are flowed from the sample inlet port through the distribution manifold to the sample metering chambers and from auxiliary liquid reservoirs to the auxiliary liquid metering chambers under the influence of reduced pressures which are selectively connected to the flow network through an integrated valve array and reduced pressure manifolds.

Abstract translation: 用于分析生物液体样本等的装置中的液体处理系统包括多个样品计量室（22,24,26,28），分配歧管（150），连接在样品入口（16）和样品 计量室以及连接到相应的辅助液体储存器（50,54,66）的相应的多个辅助液体计量室（30,32,34）。 在减压的影响下，液体从样品入口通过分配歧管流到样品计量室，并从辅助液体储存器流到辅助液体计量室，这些压力通过集成的阀阵列选择性地连接到流动网络，减压 歧管。

公开(公告)号：EP0350116A3

公开(公告)日：1990-07-04

申请号：EP89201743.5

申请日：1989-06-29

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Calzi, Claudio

IPC: G01N27/28

CPC classification number: G01N27/403

Abstract: An electrochemical cell for measuring the activity of one or more ionic species such as pNa, pK, pCa, pNH₄, pCl etc. consisting of two sensors selective to the actual ionic species, one of which is used as the reference electrode and the other as the measurement electrode. The two sensors are chosen preferably identical. The electrode used as the reference electrode is brought into contact with a solution of known ionic activity and an ionic strength which is greater, equal to or substantially greater than that of the unknown solution to be measured. The measurment electrode is brought into contact with the unknown solution to be measured, while a third electrode is used purely for instrumental reasons and does not participate in the measurement.

公开(公告)号：EP0341793A2

公开(公告)日：1989-11-15

申请号：EP89201165.1

申请日：1989-05-08

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Manzoni, Angelo ,  Belluati, Mario

IPC: G01N27/416

CPC classification number: G01N33/492 ,  G01N33/84

Abstract: The invention relates to the formulation of combined-composition electrolyte and pH buffers for use as standardization solutions in analyzers for clinical chemistry which simultaneously use more than one ion-selective electrode plus more than one standard solution.
Each ion is present in the standard solution in stoichiometric quantity such as to compensate the effect due to the incomplete dissociation of the salt used, and to obtain an activity coefficient and liquid junction potential such as to reduce the error generated by the use of standardization solutions which do not take account of these quantities.
Buffer solutions are described having a pH within the range of 6-8 and an electrolyte composition (Na⁺, K⁺, Ca⁺ and Cl⁻) which reflect the composition of the biological liquid to be analyzed, namely whole blood, plasma or serum, in equilibrium with different partial pressures of oxygen and CO₂.

Abstract translation: 本发明涉及组合电解质和pH缓冲剂的配制，用作临床化学分析仪中的标准化溶液，其同时使用多于一种的离子选择性电极加上多于一种的标准溶液。 每个离子以化学计量的量存在于标准溶液中，以补偿由于所使用的盐的不完全解离而产生的影响，并且获得活性系数和液体接合电位，以减少使用标准化溶液产生的误差 这些都不考虑这些数量。 描述了pH在6-8范围内的缓冲溶液和反映待分析的生物液体的组成的电解质组合物（Na +，K +，Ca +和Cl - ） ，即全血，血浆或血清，与氧气和二氧化碳的不同分压平衡。

公开(公告)号：EP0299659A2

公开(公告)日：1989-01-18

申请号：EP88306086.5

申请日：1988-07-04

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Geiselman, Theodore S.

IPC: G01N35/08 ,  G01N35/06 ,  G01N1/00

CPC classification number: G01N35/085 ,  G01N35/10 ,  G01N2035/00326

Abstract: An analysis system includes analysis station structure, sample station structure spaced from the analysis station structure along a straight line path, support shaft structure disposed along an axis parallel to the straight line path, and a transport carriage with probe structure mounted on the carriage. The transport carriage is mounted on the support shaft structure for movement along that shaft and is keyed thereto for pivoting movement in response to rotation of the shaft. A first drive includes a drive motor and cable structure coupled between the carriage and the drive motor for moving the transport carriage along the shaft to selectively position the probe structure at the sample and analysis stations, and a second drive rotates the shaft for inserting the probe into and withdrawing the probe from chamber structure at the sample and analysis stations. Metering means coupled to the probe flows liquid into and discharges liquid from the probe.

Abstract translation: 分析系统包括分析站结构，沿着直线路径与分析站结构隔开的采样站结构，沿着平行于直线路径的轴线设置的支撑轴结构，以及安装在滑架上的探针结构的运输托架。 运输托架安装在支撑轴结构上，用于沿着该轴移动，并且被连接到其上以响应于轴的旋转而枢转运动。 第一驱动器包括驱动马达和电缆结构，其联接在托架和驱动马达之间，用于沿着轴移动运输托架以选择性地将探针结构定位在样本和分析台处，并且第二驱动器使轴旋转以插入探针 从样品和分析台的室结构进入和取出探针。 耦合到探针的计量装置将液体流入并从探针排出液体。

公开(公告)号：EP0184242A2

公开(公告)日：1986-06-11

申请号：EP85201845.6

申请日：1985-11-12

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Calzi, Claudio ,  Preda, Luigi

IPC: G01N21/51 ,  G01N33/86 ,  G01N33/48 ,  G01N21/07 ,  G01N21/82

CPC classification number: G01N21/82 ,  G01N21/07 ,  G01N21/51 ,  G01N33/4905 ,  Y10S436/909 ,  Y10T436/111666 ,  Y10T436/25375

Abstract: An instrument for measuring coagulation parameters is provided in which plasma and at least one reagent are mixed by spinning in a cuvette with transparent windows and in which measurement is then made of scatter by the mixture of the energy of a light beam sent into the mixture.
Upon spin, the plasma components and reagent are displaced into the chamber,thus determining the initiation of the presence of the mixture in which the clot forms, and a photodetecting unit senses the change in the energy of the scattered light, caused by clot formation.

公开(公告)号：EP0153783A2

公开(公告)日：1985-09-04

申请号：EP85200206.2

申请日：1985-02-19

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Premoli, Pietro ,  Manzoni, Angelo ,  Calzi, Claudio

IPC: G01N33/487 ,  G01N27/28

CPC classification number: G01N33/84 ,  H02K19/34 ,  H02K21/48 ,  Y10T436/10 ,  Y10T436/106664

Abstract: Description of a method for the potentiometric determination of the total calcium (II) content in biological fluids (serum, plasma and urine) based on dilution of the sample.
The results obtained, when compared to the usual methods in current use, show the validity of the proposed method; furthermore, the pH of the buffer solution used for diluting the sample guarantees optimum operating conditions as well as long working life of the potentiometric sensing elements and maximum reliability when compared to other methods employing acidification of the sample.

Abstract translation: 描述根据样品的稀释度电位测定生物液体（血清，血浆和尿液）中总钙（II）含量的方法。 ...得到的结果与当前使用的通常方法相比较，显示了所提出方法的有效性; 此外，与使用样品酸化的其他方法相比，用于稀释样品的缓冲溶液的pH保证最佳操作条件以及电位传感元件的长使用寿命和最大可靠性。

公开(公告)号：EP2259071A3

公开(公告)日：2011-03-09

申请号：EP10180205.6

申请日：1999-04-20

Applicant: Instrumentation Laboratory S.p.A.

Inventor： Nebuloni, Luigi ,  Lattuada, Elena

IPC: G01N35/02 ,  G01N21/07 ,  G01N35/04

CPC classification number: G01N35/04 ,  G01N21/07 ,  G01N21/13 ,  G01N21/253 ,  G01N35/00029 ,  G01N35/0099 ,  G01N35/025 ,  G01N2035/0462 ,  Y10T436/111666

Abstract: The present invention relates to photometric analysis apparatus of the type which uses disk-shaped rotors, in which the rotors are loaded automatically.
In particular, the present invention relates to photometric analysis apparatus of the type which uses disk-shaped rotors, wherein it has a device for loading the rotors (3) onto analysis apparatus (5) automatically, the device comprising a hopper (2) for supplying the rotors, the hopper (2) comprising asymmetric means for locating the rotors (3) positively in the hopper.