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21.发明申请公开(公告)号：US20010005591A1
公开(公告)日：2001-06-28
申请号：US09780653
申请日：2001-02-09
Applicant: Osiris Therapeutics, Inc.
Inventor： Pankaj Qasba , Mark A. Thiede
IPC: A61K048/00 , C12N005/00 , C12N005/02
CPC classification number: C12N5/0644 , A61K2035/124 , C12N2501/125 , C12N2501/145 , C12N2501/22 , C12N2501/23 , C12N2501/26 , C12N2502/1358 , C12N2510/00
Abstract: The present invention is directed to hematopoietic progenitor cells isolated from a tissue specimen, such as marrow cells or peripheral blood, and to the method of co-culturing isolated hematopoietic progenitor cells with human mesenchymal stem cells to induce megakaryocyte differentiation and platelet production. In addition, hematopoietic stem cells can be genetically engineered to carry genes of interest particularly for the expression of physiologically active proteins. In the presence of mesenchymal stem cells, the transduced cells carry the new genetic material and express gene products that can be used to modulate blood disorders.
Abstract translation: 本发明涉及从诸如骨髓细胞或外周血的组织标本分离的造血祖细胞，以及与人间充质干细胞共培养分离的造血祖细胞以诱导巨核细胞分化和血小板产生的方法。 此外，造血干细胞可以被遗传工程化以携带感兴趣的基因，特别是用于表达生理活性蛋白质。 在间充质干细胞的存在下，转导的细胞携带新的遗传物质并表达可用于调节血液病症的基因产物。
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公开(公告)号：US20240189361A1
公开(公告)日：2024-06-13
申请号：US18584293
申请日：2024-02-22
Applicant: OSIRIS THERAPEUTICS, INC.
Inventor： Samson TOM , Alla DANILKOVITCH , Dana YOO , Timothy JANSEN , Jin-Qiang KUANG , Jennifer Michelle MARCONI
CPC classification number: A61K35/28 , A01N1/0221 , A61K35/50 , A61K38/1825 , A61K38/1841 , A61K38/39 , A61K38/57 , C12N5/0605 , C12N2500/02 , C12N2501/115 , C12N2502/025
Abstract: Provided herein is a placental product comprising an immunocompatible amniotic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
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公开(公告)号：US20240165166A1
公开(公告)日：2024-05-23
申请号：US18043064
申请日：2021-09-30
Applicant: OSIRIS THERAPEUTICS, INC.
Inventor： Chaoyang LI , Vimal JACOB , Min Sung PARK , Sandeep DHALL , Malathi SATHYAMOORTHY
Abstract: Disclosed are methods and compositions useful for regenerative medicine for the therapeutic regeneration and repair of cells, tissues, or organs. The present disclosure relates to methods of priming viable placental tissue, primed viable placental tissue, and products thereof. Various priming techniques are disclosed including exposure viable placental tissue to hypoxia, UV light, bioactive materials, or combinations thereof.
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公开(公告)号：US20230381241A1
公开(公告)日：2023-11-30
申请号：US18094148
申请日：2023-01-06
Applicant: OSIRIS THERAPEUTICS, INC.
Inventor： Samson TOM , Alla DANILKOVITCH , Dana YOO , Timothy JANSEN , Jin-Qiang KUANG , Jennifer Michelle MARCONI
CPC classification number: A61K35/28 , A01N1/0221 , A61K35/50 , A61K38/1825 , A61K38/1841 , A61K38/39 , A61K38/57 , C12N5/0605 , C12N2500/02 , C12N2502/025 , C12N2501/115
Abstract: Provided herein is a placental product comprising an immunocompatible chorionic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
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公开(公告)号：US20230113145A1
公开(公告)日：2023-04-13
申请号：US17969461
申请日：2022-10-19
Applicant: OSIRIS THERAPEUTICS, INC.
Inventor： Samson Tom , Alla Danilkovitch , Dana Yoo , Timothy Jansen , Jin-Qiang Kuang , Jennifer Michelle Marconi
Abstract: Provided herein is a placental product comprising an immunocompatible chorionic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
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Patent Agency Ranking
公开(公告)号：US20220331485A1
公开(公告)日：2022-10-20
申请号：US17854688
申请日：2022-06-30
Applicant: OSIRIS THERAPEUTICS, INC.
Inventor： Dana Sue Yoo , Jin-Qiang Kuang , Jaime Paden , Scott A. Maxson , Alla Danilkovitch , Erasmo Lopez , Samson Tom
Abstract: A cryopreserved cartilage product is disclosed. The cryopreserved cartilage product can include a partially digested cryopreserved natural cartilage collagen matrix isolated from a subject. The collagen matrix can include viable cells embedded within the collagen matrix that are native to the collagen matrix and that were embedded in the collagen matrix when the collagen matrix was isolated from the subject, at least 70% of the embedded cells native to the collagen matrix can be viable in the cryopreserved cartilage product, and the partially digested collagen matrix can retain interaction between the collagen matrix and the native cells.
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公开(公告)号：US11413373B2
公开(公告)日：2022-08-16
申请号：US14498394
申请日：2014-09-26
Applicant: Osiris Therapeutics, Inc.
Inventor： Dana Sue Yoo , Jin-Qiang Kuang , Jaime Paden , Scott A. Maxson , Alla Danilkovitch , Erasmo Lopez , Samson Tom
Abstract: This invention provides disrupted cartilage products, methods of manufacturing disrupted cartilage products, and methods of treating a subject comprising administering a cartilage product. The cartilage products are manufactured by a method comprising disrupting a collagen matrix, e.g. to produce a flexible cartilage product. Optionally, the cartilage products comprise viable chondrocytes, bioactive factors such as chondrogenic factors, and a collagen type II matrix. Optionally, the cartilage products are non-immunogenic.
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公开(公告)号：US20220016180A1
公开(公告)日：2022-01-20
申请号：US17400864
申请日：2021-08-12
Applicant: OSIRIS THERAPEUTICS, INC.
Inventor： Alla DANILKOVITCH , Yi DUAN-ARNOLD , Matthew MOORMAN , Anne LERCH , Jin-Qiang KUANG
Abstract: Disclosed are compositions comprising umbilical tissue, wherein the umbilical tissue comprises one or more engineered channels. Also disclosed are compositions comprising a previously cryopreserved umbilical tissue, wherein after cryopreservation and subsequent thawing the umbilical tissue comprises: a) viable cells native to the umbilical tissue; b) tissue integrity of native umbilical tissue; c) one or more growth factors that are native to the umbilical tissue; and d) depleted amounts of one or more types of functional immunogenic cells. Disclosed are methods of producing compositions comprising umbilical tissue, wherein the umbilical tissue comprises one or more engineered channels. Also disclosed are methods of treating damaged tissue comprising administering to the site of the damaged tissue compositions comprising umbilical tissue, wherein the umbilical tissue comprises one or more engineered channels.
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公开(公告)号：US20210369784A1
公开(公告)日：2021-12-02
申请号：US17401758
申请日：2021-08-13
Applicant: OSIRIS THERAPEUTICS, INC.
Inventor： Samson TOM , Alla DANILKOVITCH , Dana YOO , Timothy JANSEN , Jin-Qiang KUANG , Jennifer Michelle MARCONI
Abstract: Provided herein is a placental product comprising an immunocompatible amniotic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
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公开(公告)号：US20200000853A1
公开(公告)日：2020-01-02
申请号：US16296463
申请日：2019-03-08
Applicant: Osiris Therapeutics, Inc.
Inventor： Samson Tom , Alla Danilkovitch , Dana Yoo , Timothy Jansen , Jin-Qiang Kuang , Jennifer Michelle Marconi
Abstract: Provided herein is a placental product comprising an immunocompatible chorionic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
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