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22.发明授权
公开(公告)号：KR101258086B1
公开(公告)日：2013-04-25
申请号：KR1020110077924
申请日：2011-08-04
Applicant: 한국과학기술연구원
CPC classification number: B29C47/004 , B29C47/0004 , B29C47/0009 , B29C47/0057 , B29C47/782 , B29C47/92 , B29C2947/92514 , B29C2947/9258 , B29C2947/92704 , B29K2067/043 , B29K2067/046 , B29K2867/043 , B29K2867/046 , B29K2995/0056 , B29K2995/006 , C08G63/08
Abstract: 본 발명은 생분해성 고분자 소재의 제조방법, 생분해성 고분자 소재 및 조직 고정용 제품에 관한 것으로, 본 발명에 의한 생분해성 고분자 소재의 제조방법은 중량평균분자량이 100,000 이상인 중합체를 이용하여 폴리락티드 입체이성질 복합체를 제조하는 복합체 제조단계, 상기 복합체를 압축성형하는 성형단계, 상기 압축성형된 복합체를 냉각하는 냉각단계, 그리고 상기 냉각된 복합체를 고상압출하는 압출단계를 포함한다. 상기 제조방법에 의하여 제조된 생분해성 고분자 소재는 고강도가 필요한 뼈나 척추 등의 고정용으로 적용할 수 있는 뼈 조직 고정용 제품으로 적용할 수 있어서 체내에서 부식의 염려가 없으면서도, 뼈 및 조직의 치유 후에도 별도의 제거수술이 필요 없고, 응력차폐(stress shielding) 현상도 막을 수 있는 생분해성 고분자 소재를 적용할 수 있다.
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23.发明公开
公开(公告)号：KR1020130015748A
公开(公告)日：2013-02-14
申请号：KR1020110077924
申请日：2011-08-04
Applicant: 한국과학기술연구원
CPC classification number: B29C47/004 , B29C47/0004 , B29C47/0009 , B29C47/0057 , B29C47/782 , B29C47/92 , B29C2947/92514 , B29C2947/9258 , B29C2947/92704 , B29K2067/043 , B29K2067/046 , B29K2867/043 , B29K2867/046 , B29K2995/0056 , B29K2995/006 , C08G63/08
Abstract: PURPOSE: A method for manufacturing a biodegradable polymer material is provided to reduce molecular weight and to enhance strength of the biodegradable polymer material. CONSTITUTION: A method for manufacturing a biodegradable polymer material comprises: a step of preparing a polylactide stereocomplex using polymers; a step of molding the stereocomplex by pressing; a step of cooling the molded stereocomplex; a step of extruding the stereocomplex. The polymer has a type D polymer or a type L polymer. A monomer forming the polymer includes cyclic ester monomer with chiral carbon.
Abstract translation: 目的：提供一种用于制造可生物降解的聚合物材料的方法，以降低分子量并提高可生物降解的聚合物材料的强度。 构成：生物可降解聚合物材料的制造方法包括：使用聚合物制备聚丙交酯立体络合物的步骤; 通过压制成型立体复合物的步骤; 冷却模制的立体络合物的步骤; 挤出立体络合物的步骤。 该聚合物具有D型聚合物或L型聚合物。 形成聚合物的单体包括具有手性碳的环状酯单体。
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公开(公告)号：KR1020070006551A
公开(公告)日：2007-01-11
申请号：KR1020060034400
申请日：2006-04-17
Applicant: 한국과학기술연구원
Abstract: A method of preparing porous polymer is provided to improve a cell seeding efficiency by a uniform size of a gap and excellent interconnectedness between gaps, and to prepare simply porous polymer scaffold appropriate for a tissue engineering by an excellent mechanical strength. The method comprises the steps of: manufacturing polymer solution by melting biocompatible polymers in organic solvents; forming polymer gel from non-solvent solutions by spinning the polymer solution obtained in the pre-step to non-solvent stirred by a rotating shaft; forming porous polymer scaffold by making the polymer gel formed in the pre-step wound on the rotating shaft; and removing the organic solvents by drying the porous polymer scaffold obtained in the pre-step.
Abstract translation: 提供一种制备多孔聚合物的方法，以通过间隙的均匀尺寸和间隙之间的优异相互连接来改善细胞接种效率，并且通过优异的机械强度制备适于组织工程的简单多孔聚合物支架。 该方法包括以下步骤：通过在有机溶剂中熔融生物相容性聚合物制备聚合物溶液; 通过将在前步骤中获得的聚合物溶液旋转到通过旋转轴搅拌的非溶剂，从非溶剂溶液形成聚合物凝胶; 通过使前述步骤中形成的聚合物凝胶在旋转轴上形成多孔聚合物支架; 并通过干燥在前步骤中获得的多孔聚合物支架来除去有机溶剂。
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公开(公告)号：KR100590137B1
公开(公告)日：2006-06-15
申请号：KR1020030002289
申请日：2003-01-14
Applicant: 한국과학기술연구원
IPC: C07C309/21
Abstract: 본 발명은 술폰산화 폴리에틸렌옥시드(PEO, poly(ethylene oxide))를 함유하는 비닐 단량체와 그 중합체 및 그들의 제조 방법에 관한 것이다.
본 발명의 단량체로 이루어진 중합체 및 표면 그라프트 개질체는 항혈전성이 우수하므로 혈액과 접촉되는 의료용 소재로 응용할 수 있다.
술폰산화 PEO 함유 비닐 단량체, 항혈전성 중합체, 의료용 재료-
Patent Agency Ranking
公开(公告)号：KR100517097B1
公开(公告)日：2005-09-27
申请号：KR1020020084892
申请日：2002-12-27
Applicant: 한국과학기술연구원
IPC: A61L31/04
Abstract: 본 발명은 뛰어난 유연성 및 적당한 가수분해성을 가진 생분해성 고분자 및 이 중합체로부터 형성된 다공성 지지체에 관한 것이다. 더욱 상세히 말하자면, 본 발명은 생분해성 재료인 락타이드와 ε-카프로락톤을 이용하여 중량 평균 분자량이 10,000 이상인 락타이드/ε-카프로락톤의 생분해성 공중합체를 제조하고, 이를 이용하여 상처피복재, 세포 배양용 지지체 재료로 사용 가능한 다공성 지지체 제조에 관한 것이다.
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27.发明公开
公开(公告)号：KR1020040058572A
公开(公告)日：2004-07-05
申请号：KR1020020084892
申请日：2002-12-27
Applicant: 한국과학기술연구원
IPC: A61L31/04
Abstract: PURPOSE: Provided is a porous support obtained from biodegradable lactide/epsilon-caprolactone copolymer, which has excellent mechanical properties including flexibility and elasticity suitable to be used in tissue engineering. CONSTITUTION: The porous support obtained from biodegradable lactide/ epsilon-caprolactone copolymer has repeating units represented by formula 1 and a weight average molecular weight of 10,000 or more, wherein the mole ratio of lactide to epsilon-caprolactone is 2:8 to 8:2: wherein each of x and y is an integer of 1 or more, and n is an integer of 18 or more. Particularly, the porous support has a pore size of 1 to 800 micrometers and a porosity of 50-99%.
Abstract translation: 目的：提供由生物可降解丙交酯/ε-己内酯共聚物获得的多孔载体，其具有优异的机械性能，包括适合用于组织工程的柔性和弹性。 构成：由生物可降解丙交酯/ε-己内酯共聚物获得的多孔载体具有由式1表示的重复单元，重均分子量为10,000以上，其中丙交酯与ε-己内酯的摩尔比为2：8〜8：2 ：其中x和y各自为1以上的整数，n为18以上的整数。 特别地，多孔载体的孔径为1至800微米，孔隙率为50-99％。
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公开(公告)号：KR100408458B1
公开(公告)日：2003-12-06
申请号：KR1020000082684
申请日：2000-12-27
Applicant: 한국과학기술연구원
IPC: A61L27/56
Abstract: Disclosed is a biocompatible medical material and porous scaffold for use in tissue engineering, made from a biodegradable glycolide/epsilon-caprolactone copolymer having a repeat unit of wherein x and y are integers greater than or equal to 18, the copolymer has an average molecular weight of about 10,000 daltons or more, and the molar ratio of glycolide: epsilon-caprolactone in the copolymer is about 4.0:6.0 to 6.0:4.0.
Abstract translation: 公开了一种用于组织工程的生物相容性医用材料和多孔支架，由具有重复单元的可生物降解的乙交酯/ε-己内酯共聚物制成，其中x和y是大于或等于18的整数，所述共聚物的平均分子量 约10,000道尔顿或更多，共聚物中乙交酯：ε-己内酯的摩尔比为约4.0:6.0至6.0:4.0。
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公开(公告)号：KR1020030032420A
公开(公告)日：2003-04-26
申请号：KR1020010064182
申请日：2001-10-18
Applicant: 한국과학기술연구원
IPC: A61L27/58
Abstract: PURPOSE: A porous substrate of a biodegradable polymer for regenerating an impaired ocular tissue is provided to cure the impaired ocular tissue by installing in the impaired ocular tissue region. CONSTITUTION: The porous substrate of the biodegradable polymer for regenerating the impaired ocular tissue is prepared with the biodegradable polymer selected from the group consisting of polyglycolic acid, polylactic acid, polycaprolactone, polydioxanone, polytrimethylene carbonate and copolymer thereof, and has the pore size of 10 to 800 micrometers, and the porosity of 50 to 99%. The ocular region is selected from the group consisting of cornea, conjunctiva and sclera.
Abstract translation: 目的：提供用于再生受损的眼组织的生物可降解聚合物的多孔底物，以通过安装在受损的眼组织区域中来治愈受损的眼组织。 构成：用于再生受损眼睛组织的可生物降解聚合物的多孔基材由选自聚乙醇酸，聚乳酸，聚己内酯，聚二恶烷酮，聚三亚甲基碳酸酯及其共聚物的生物降解性聚合物制备，孔径为10 至800微米，孔隙率为50至99％。 眼部区域选自角膜，结膜和巩膜。
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公开(公告)号：KR100367041B1
公开(公告)日：2003-01-15
申请号：KR1019990043181
申请日：1999-10-07
Applicant: 한국과학기술연구원
IPC: C08F120/06
Abstract: PURPOSE: A poly-methyl methacrylate having hydrophilic surface and a use thereof as ophthalmic material are provided, which maintains an optical property of PMMA and which reduces adhesion growth of cell and protein. CONSTITUTION: A preparation method of poly-methyl methacrylate having hydrophilic surface is formed by bonding poly-ethylene oxide derivative of formula: NH2-R1-O-(CH2CH2O)n-X containing amino group at the end in the presence of catalyst at the surface of poly-methyl methacrylate chemically. In formula, R1 is (CH2CH2)2-3, n is 15-300, X is hydrogen, CH3, (CH2CH2)2-3-NH2 or (CH2CH2)2-3-NH-(CH2)3-SO3H. The molecular weight of poly-ethylene oxide is 200-10,000. The catalyst is tri-ethylamine.
Abstract translation: 目的：提供一种具有亲水性表面的聚甲基丙烯酸甲酯及其作为眼科材料的用途，其保持了PMMA的光学性能并且减少了细胞和蛋白质的粘附生长。 构成：具有亲水表面的聚甲基丙烯酸甲酯的制备方法是通过在催化剂存在下在表面上结合含有氨基的式：NH2-R1-O-（CH2CH2O）nX的聚环氧乙烷衍生物而形成的 聚甲基丙烯酸甲酯化学。 在通式中，R1是（CH2CH2）2-3，n是15-300，X是氢，CH3，（CH2CH2）2-3-NH2或（CH2CH2）2-3-NH-（CH2）3-SO3H。 聚环氧乙烷的分子量为200-10,000。 催化剂是三乙胺。
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