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公开(公告)号：KR1020150046781A
公开(公告)日：2015-04-30
申请号：KR1020150052561
申请日：2015-04-14
Applicant: 한국식품연구원
Abstract: 본발명은청국장에탄올용해(ethanol-soluble) 추출물을유효성분으로포함하는전신면역및 장관면역보강제에관한것으로, 본발명의청국장에탄올용해(ethanol-soluble) 추출물을포함하는면역보강제는안전성이확보된식품소재를사용함으로써독성및 부작용이없으며, 저렴한생산비용과사용의편이성을제공할수 있다. 또한, 본발명의면역보강제는면역원과경구투여시 경구감염성병원성미생물은물론비경구감염성병원성미생물이나바이러스, 암항원, 일반항원등에대하여도 Th1 및 Th2 반응을유도하며효과적인특이항체 (혈중 IgG 및소장 IgA)를생산할수 있다.
Abstract translation: 本发明涉及一种全身或肠内免疫佐剂，其包含可溶于乙醇的Cheonggukjang（韩国快速发酵豆酱）提取物作为活性成分。 本发明的免疫佐剂既没有毒性也没有副作用，因为使用安全保证的食物，可以降低生产成本并提供易于使用。 此外，免疫佐剂以及免疫原的口服给药可通过诱导Th1和Th2对肠外感染性致病微生物以及口腔感染性致病微生物的应答产生有效的特异性抗体（血液中的IgG和小肠中的IgA） 或病毒，癌抗原，常见抗原等
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22.发明公开옥촉서예, 유향 또는 상지의 추출물을 포함하는 Ｔｈ2-매개 면역 질환의 예방, 개선 또는 치료용 조성물 无效옥촉서예，유향또는상지의추물물을함하하는는Th Th Th，，，，，，，，，，，，，，，물물물물물물물물물물물
公开(公告)号：KR1020140111230A
公开(公告)日：2014-09-18
申请号：KR1020140089808
申请日：2014-07-16
Applicant: 한국식품연구원
IPC: A61K36/324 , A61P37/08 , A61P37/00
Abstract: The prevention relates to a composition for the prevention, alleviation or treatment of a Th2-mediated immune disease, the composition including, as an active ingredient, an extract of at least one natural substance selected from the group consisting of Zea mays, Boswellia carterii and Morus alba. According to the present invention, the extract of a natural substance has inhibitory effects against the generation of IL-4 and the degranulation of mast cells, and thus can prevent, alleviate or treat a Th2-mediated immune disease.
Abstract translation: 所述预防涉及用于预防，减轻或治疗Th2介导的免疫疾病的组合物，所述组合物包含作为活性成分的至少一种选自玉米，卡氏乳香和乳香 桑属阿尔巴。 根据本发明，天然物质提取物具有抑制IL-4产生和肥大细胞脱粒的作用，因此可以预防，缓解或治疗Th2介导的免疫疾病。
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23.发明公开
公开(公告)号：KR1020140073721A
公开(公告)日：2014-06-17
申请号：KR1020120141324
申请日：2012-12-06
Applicant: 한국식품연구원
CPC classification number: A61K36/39 , A23L33/105 , A23V2002/00 , A23V2200/324 , A61K8/97 , A61Q19/00
Abstract: The present invention relates to a composition for prevention, alleviation or treatment of Th2-mediated immune diseases comprising a Pharbitis nil Chois extract as an active ingredient. According to the present invention, the Pharbitis nil Chois extract has inhibitory activities against the generation of IL-4 and the degranulation of mast cells and thus can prevent, alleviate or treat the Th2-mediated immune diseases.
Abstract translation: 本发明涉及一种用于预防，缓解或治疗Th2介导的免疫疾病的组合物，其包含作为活性成分的无希冀提取物。 根据本发明，枸杞子提取物具有抑制IL-4产生和肥大细胞脱粒的作用，从而可以预防，减轻或治疗Th2介导的免疫疾病。
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24.发明公开바실러스 아리아바타이(Bacillus aryabhattai) 또는 바실러스 아리아바타이(Bacillus aryabhattai)에 의한 콩 발효물을 유효성분으로 포함하는 항알레르기성 조성물 有权含有BACILLUS ARYABHATTAI的抗过敏组合物或使用物种的发芽大豆的物质
公开(公告)号：KR1020140053677A
公开(公告)日：2014-05-08
申请号：KR1020120119898
申请日：2012-10-26
Applicant: 한국식품연구원
Abstract: The present invention relates to an anti-allergic composition which comprises Bacillus aryabhattai or a fermented soybean substance using Bacillus aryabhattai as an active ingredient. The Bacillus aryabhattai or the fermented soybean substance using Bacillus aryabhattai of the present invention is excellent for promoting Th1 cellular response and inhibiting Th2 cellular response, thereby can adjust balance of Th1/Th2 immune response.
Abstract translation: 本发明涉及一种抗过敏组合物，其包含芽孢杆菌属（Bacillus aryabhattai）或使用芽孢杆菌属（Bacillus aryabhattai）作为活性成分的发酵大豆物质。 使用本发明的芽孢杆菌的芽孢杆菌或发酵大豆物质对于促进Th1细胞应答和抑制Th2细胞应答是极好的，从而可以调节Th1 / Th2免疫应答的平衡。
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25.发明公开바실러스 메틸로트로피쿠스(Bacillus methylotrophicus) 또는 바실러스 메틸로트로피쿠스(Bacillus methylotrophicus)에 의한 콩 발효물을 유효성분으로 포함하는 항알레르기성 조성물 有权含有BACILLUS METHYLOTROPHICUS的抗过敏组合物或使用物种的发芽大豆的物质
公开(公告)号：KR1020140053673A
公开(公告)日：2014-05-08
申请号：KR1020120119894
申请日：2012-10-26
Applicant: 한국식품연구원
Abstract: The present invention relates to an anti-allergic composition which comprises Bacillus methylotrophicus or a fermented soybean substance using Bacillus methylotrophicus as an active ingredient. The Bacillus methylotrophicus or the fermented soybean substance using Bacillus methylotrophicus of the present invention is excellent for promoting Th1 cellular response and inhibiting Th2 cellular response, thereby can adjust balance of Th1/Th2 cytokine.
Abstract translation: 本发明涉及一种抗过敏组合物，其包含甲硝酸芽孢杆菌或使用甲氨喋呤作为活性成分的发酵大豆物质。 使用本发明的甲氨喋呤的芽孢杆菌甲基营养生物或发酵大豆物质对于促进Th1细胞应答和抑制Th2细胞应答是极好的，从而可以调节Th1 / Th2细胞因子的平衡。
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Patent Agency Ranking
公开(公告)号：KR101392184B1
公开(公告)日：2014-05-08
申请号：KR1020120117607
申请日：2012-10-23
Applicant: 한국식품연구원
Abstract: 본발명은은행외과피의혐오취를저감시키는방법및 이를이용한고추장발효식품에관한것으로, 은행외과피를고추장을혼합하여은행외과피고추장을제조하고, 상기은행외과피고추장을발효시키는단계를포함하는은행외과피혐오취를저감시키는방법및 이를이용한고추장발효식품을제공한다.
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公开(公告)号：KR101879826B1
公开(公告)日：2018-07-18
申请号：KR1020170134209
申请日：2017-10-16
Applicant: 한국식품연구원
IPC: A61K36/12 , A61K36/185 , A61K36/896 , A23L33/105
Abstract: 본발명은넉줄고사리() 추출물, 시로미() 추출물, 수선화() 추출물, 네가래() 추출물, 협죽도() 추출물, 솜양지꽃() 추출물및 풀고사리() 추출물로구성된군으로부터선택되는하나이상의추출물을유효성분으로포함하는 Th1-매개면역질환또는 Th2-매개면역질환의예방, 개선또는치료용조성물에관한것이다. 본발명에따르면, 상기추출물은 IL-4 생성억제, 알레르겐의장상피세포통과억제, 비만세포의탈과립억제및 Treg 세포로의분화유도활성을가짐으로 Th1-매개면역질환또는 Th2-매개면역질환을예방, 개선또는치료할수 있다.
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公开(公告)号：KR101838177B1
公开(公告)日：2018-03-13
申请号：KR1020150174585
申请日：2015-12-09
Applicant: 한국식품연구원
Abstract: 본발명은효소가처리된후추추출물을유효성분으로포함하는, Th2-매개면역질환의예방또는치료용조성물에관한것이다. 본발명자들은 OVA로면역시켜알레르기를유발시킨마우스의비장세포에효소처리후추추출물을처리한결과효소를처리하지않은후추추출물에비하여 IL-4 생성억제활성이현저히증진됨을확인함으로써효소처리후추추출물의 Th2-매개면역반응의억제활성을확인하였는바, 본발명에따른조성물은 Th2-매개면역질환의예방, 개선, 또는치료를위한치료제, 건강기능성식품, 및화장품등의개발에유용하게이용될수 있을것으로기대된다.
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