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22.发明授权작약 종자 추출물, 이의 분획물 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 퇴행성 뇌질환 예방 또는 치료용 약학적 조성물 有权药物组合物，其包含提取物芍药，其馏分或其分离的化合物作为活性成分
公开(公告)号：KR101338172B1
公开(公告)日：2013-12-09
申请号：KR1020100079356
申请日：2010-08-17
Applicant: 한국화학연구원
IPC: A61K36/65 , A61K31/343 , A61P25/28 , A61P25/00
Abstract: 본 발명에 따른 작약 종자의 추출물, 이의 분획물 또는 이로부터 분리한 화합물은 BACE-1 활성을 저해시켜 알츠하이머형 치매, 파킨슨 병, 진행성 핵상마비 등 퇴행성 뇌질환의 예방 또는 치료에 유용하게 사용될 수 있다.
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23.发明公开작약 종자 추출물, 이의 분획물 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 퇴행성 뇌질환 예방 또는 치료용 약학적 조성물 有权包含提取物的活性成分的药物组合物，其分离物或其分离的化合物作为活性成分
公开(公告)号：KR1020130083428A
公开(公告)日：2013-07-22
申请号：KR1020130081165
申请日：2013-07-10
Applicant: 한국화학연구원
IPC: A61K31/343 , A61K31/045 , A61K31/05 , A61K36/65
Abstract: PURPOSE: A Paeonia lactiflora seed extract, a fraction thereof, or a compound isolated therefrom, and a pharmaceutical composition containing the same are provided to suppress the activation of beta-secretase (BECE-1) and to prevent or treat neurodegenerative diseases. CONSTITUTION: A pharmaceutical composition for preventing or treating neurodegenerative diseases contains one or more kinds of compounds selected among compounds of chemical formulas 1-8, as active ingredients. A method for preparing the compounds of chemical formulas 1-8 comprises the steps of: adding water, C1-C4 alcohols, or a mixture thereof to Paeonia lactiflora seeds and obtaining a Paeonia lactiflora seed extract; fractioning the extract with water, dichloromethane, and ethyl acetate and obtaining a fraction; and isolating compounds by performing silicagel column chromatography of the fraction and purifying the compounds.
Abstract translation: 目的：提供芍药芍药提取物，其一部分或从其分离的化合物和含有它们的药物组合物以抑制β-分泌酶（BECE-1）的活化并预防或治疗神经变性疾病。 构成：用于预防或治疗神经变性疾病的药物组合物含有选自化学式1-8化合物的一种或多种化合物作为活性成分。 制备化学式1-8的化合物的方法包括以下步骤：将水，C 1 -C 4醇或其混合物加入到芍药芍药种子中并获得芍药提取物; 用水，二氯甲烷和乙酸乙酯分级提取物，得到一部分; 并通过对级分进行硅胶柱色谱法分离化合物并纯化化合物。
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24.发明授权
公开(公告)号：KR101209889B1
公开(公告)日：2012-12-10
申请号：KR1020100045593
申请日：2010-05-14
IPC: A61K36/232 , A61K31/37 , A61P3/04 , A61P3/00
Abstract: 본발명은당귀의주성분인데쿠르신으로부터합성된유도체인데쿠시놀벤조에이트(Decursinol benzoate)를이용한비만예방용또는비만치료용조성물에관한것으로써, 보다상세하게는상기데쿠시놀벤조네이트는 AMPK(5' adenosine monophosphate-activated protein kinase)활성능을가짐으로써지방산합성을억제하는것을특징으로갖거나, PPAR-GAMMA(Peroxisome proliferator-activated receptor gamma)의발현및 전사활성을억제하는것을특징으로가질수 있다.
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公开(公告)号：KR101048748B1
公开(公告)日：2011-07-14
申请号：KR1020080106418
申请日：2008-10-29
Applicant: 한국화학연구원
IPC: C07D311/10
Abstract: 본 발명은 하기 화학식 1로 표시되는 신규 갈바닉산 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 다약제내성 억제용 약학적 조성물에 관한 것으로, 본 발명에 따른 갈바닉산 유도체는 다약제내성의 주요 원인인 P-당단백질의 과발현에 대한 억제활성 및 항암제와의 병용투여시 항암활성의 증가를 나타내어 항암제에 대한 다약제내성 극복제제, 치료제 또는 조절제로 이용될 수 있으며, 항암제의 효과를 증진시켜 암환자의 생존률을 높일 수 있고, 병용 투여하는 항암제의 용량을 줄여 정상세포에 대한 부작용을 감소시킬 수 있으므로 항암치료에 유용하게 사용될 수 있다.
[화학식 1]
(상기 화학식 1에서, R
1 및 R
2 는 본 명세서에 정의된 바와 같다)
갈바닉산, 유도체, 다약제내성, 억제, 암-
Patent Agency Ranking
公开(公告)号：KR1020110061976A
公开(公告)日：2011-06-10
申请号：KR1020090118532
申请日：2009-12-02
Applicant: 한국화학연구원
IPC: A61K36/346 , A61P9/10
Abstract: PURPOSE: A pharmaceutical composition containing Platycodon grandiflorum membrane-separated extract is provided to reduce lipid peroxide concentrate and to prevent or treat myocardial infarcton. CONSTITUTION: A pharmaceutical composition for preventing or treating myocardial infarction contains Platycodon grandiflorum membrane-separated extract as an active ingredient. A method for preparing the extract comprises: a step of adding water, organic solvent, or mixture solvent thereof to Platycodon grandiflorum; and a step of isolating membrane. The organic solvent is alcohol of C1-C4, acetic acid ethyl, methylene chloride or chloroform.
Abstract translation: 目的：提供含有桔梗大蒜膜分离提取物的药物组合物，以减少脂质过氧化物浓缩物并预防或治疗心肌梗死。 构成：用于预防或治疗心肌梗死的药物组合物含有桔梗膜分离提取物作为活性成分。 制备提取物的方法包括：将水，有机溶剂或其混合溶剂加入到大蒜中的步骤; 和隔离膜的步骤。 有机溶剂是C1-C4，乙酸乙酯，二氯甲烷或氯仿的醇。
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公开(公告)号：KR1020100009151A
公开(公告)日：2010-01-27
申请号：KR1020080069892
申请日：2008-07-18
IPC: A61K36/78 , A61K36/539 , A61P19/10
CPC classification number: A61K36/539 , A61K36/78 , A61K2300/00
Abstract: PURPOSE: A composition containing mixture extract of Saururus chinensis and Scutellaria baicalensis is provided to suppress osteoclast differentiation, enhance bone density and bone content, and prevent or treat osteoporosis. CONSTITUTION: A pharmaceutical composition for preventing or treating osteoporosis contains mixture extract of Saururus chinensis and Scutellaria baicalensis as an active ingredient. The weight ratio of the Saururus chinensis and Scutellaria baicalensis is 1:10-10:1. A food composition for preventing and relieving osteoporosis contains mixture extract of Saururus chinensis and Scutellaria baicalensis as an active ingredient. A method for producing the mixture extract comprises: a step of washing Saururus chinensis and Scutellaria baicalensis with water and drying; a step of extracting the Saururus chinensis and Scutellaria baicalensis with solvent; a step of cooling the extract at room temperature and filtering; a step of decompress-concentrating and freeze-drying; and a step of mixing the extract of Saururus chinensis and Scutellaria baicalensis.
Abstract translation: 目的：提供含有Saururus chinensis和黄芩的混合物提取物的组合物，以抑制破骨细胞分化，增强骨密度和骨含量，并预防或治疗骨质疏松症。 构成：用于预防或治疗骨质疏松症的药物组合物含有中华黄牛和黄芩的混合物提取物作为活性成分。 中华黄牛和黄芩的重量比为1:10-10:1。 用于预防和缓解骨质疏松症的食物组合物含有中华黄芪和黄芩的混合物提取物作为活性成分。 制备混合物提取物的方法包括：用水洗涤中华黄芩和黄芩的步骤; 用溶剂萃取中华黄龙和黄芩的一步; 在室温下冷却提取物并过滤的步骤; 减压浓缩和冷冻干燥步骤; 并将中国黄芪和黄芩提取物混合在一起。
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公开(公告)号：KR1020090064823A
公开(公告)日：2009-06-22
申请号：KR1020070132164
申请日：2007-12-17
IPC: A61K36/185 , A61P9/08 , A61P9/12
Abstract: A composition for relaxing blood vessel which contains an Ulmus macrocarpa extract prevent and treat various cardiovascular diseases by inducing the relaxation of vascular smooth muscle. A pharmaceutical composition for relaxing blood vessel contains an Ulmus macrocarpa extract as an active ingredient. The composition is effective in preventing and treating hypertension, coronary artery disease, cerebrovascular disease, peripheral vascular disease, main artery disease, kidney dysfunction, cardiac insufficiency or vision disorder An organic solvent for extracting the Ulmus macrocarpa is selected from ethanol, ethanol solution, methanol, methanol solution, butanol, dichloromethane, ethyl acetate, hexane and their mixture. A health food having the effect of blood vessel relaxation contains Ulmus macrocarpa extract.
Abstract translation: 用于放松血管的组合物含有榆木提取物通过诱导血管平滑肌的松弛来预防和治疗各种心血管疾病。 用于放松血管的药物组合物含有榆木大pa提取物作为活性成分。 该组合物有效预防和治疗高血压，冠状动脉疾病，脑血管疾病，外周血管疾病，主动脉疾病，肾功能不全，心功能不全或视力障碍。用于提取榆树的有机溶剂选自乙醇，乙醇溶液，甲醇 ，甲醇溶液，丁醇，二氯甲烷，乙酸乙酯，己烷及其混合物。 具有血管松弛作用的保健食品包含榆树提取物。
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29.发明授权포도나무 수피로부터 분리된 ＢＡＣＥ-1 저해 효과를 갖는활성물질을 포함하는 퇴행성 뇌질환의 예방 또는 치료용조성물 有权用于预防或治疗包含活性成分的神经病变组合物，其从VITIS VINIFERA的标准分离，其对BACE-1具有抑制作用
公开(公告)号：KR100860540B1
公开(公告)日：2008-09-26
申请号：KR1020070095884
申请日：2007-09-20
Applicant: 한국화학연구원
IPC: A61K31/343 , A61K31/05 , A61P25/28
Abstract: 본 발명은 비티신(vitisin) B, 입실론-비니페린 (ε-viniferin), 암펠롭신 (ampelopsin) A 및 이들의 혼합물로 이루어진 군으로부터 선택된 화합물 또는 이를 포함하는 포도나무 (
Vitis vinifera ) 수피 (樹皮) 추출물을 유효성분으로 포함하는 조성물에 관한 것으로, 본 발명의 조성물은 각종 치매의 원인 물질로 널리 알려진 베타-아밀로이드 (beta-amyloid)의 형성을 매개하는 BACE-1 (beta-site APP-cleaving enzyme 1)을 효과적으로 저해하므로 알쯔하이머병, 파킨슨병, 루게릭병, 헌팅턴병 및 니만-픽병과 같은 다양한 퇴행성 뇌질환의 예방 및 치료에 유용하게 사용될 수 있다.-
公开(公告)号：KR1020080064238A
公开(公告)日：2008-07-09
申请号：KR1020070000902
申请日：2007-01-04
CPC classification number: A61K36/78 , A23L2/38 , A23L33/105 , A23V2002/00 , A61K31/065 , A61K31/36 , A23V2200/326 , A23V2250/21
Abstract: A composition comprising a root extract of Saururus chinensis or a compound isolated from the extract is provided to show excellent blood pressure lowering effect through vascular relaxation, thereby being usefully used as a pharmaceutical composition or a health food composition for preventing and treating various cardiovascular diseases caused by hypertension and complications of the hypertension. A pharmaceutical composition for vascular relaxation comprises a compound selected from the group consisting of machilin D, saucerneol D and a mixture thereof or a root extract of Saururus chinensis comprising the same compound as an effective ingredient, wherein the extract is prepared by using an organic solvent selected from the group consisting of ethanol, an aqueous solution of the ethanol, methanol, an aqueous solution of the methanol, butanol. dichloromethane, ethylacetate, hexane and a mixture thereof.
Abstract translation: 提供了包含中华鲟的根提取物或从提取物中分离的化合物的组合物，以通过血管松弛显示优异的降血压效果，从而有效地用作预防和治疗引起的各种心血管疾病的药物组合物或保健食品组合物 通过高血压和并发症的高血压。 用于血管松弛的药物组合物包含选自机体D，香草醇D及其混合物的化合物或包含与有效成分相同的化合物的中华黄瓜的根提取物，其中所述提取物通过使用有机溶剂 选自乙醇，乙醇水溶液，甲醇，甲醇水溶液，丁醇组成的组。 二氯甲烷，乙酸乙酯，己烷及其混合物。
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