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公开(公告)号：KR1020130063714A
公开(公告)日：2013-06-17
申请号：KR1020110130230
申请日：2011-12-07
Abstract: PURPOSE: DHNQ(5,8-dihydroxy-1,4-naphthoquinone) is provided to suppress KAPAS(7-keto-8-aminopelargonic acid synthase) which is related to a biotin biosynthesis pathway of microbes and plants, and to significantly remove Sicyos angulatus L. with safety to human body. CONSTITUTION: An herbicidal composition for preventing Sicyos angulatus L. contains DHNQ of chemical formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient. DHNQ is derived from black walnut and suppresses KAPAS activity. A method for controlling Sicyos angulatus L. comprises a step of treating Sicyos angulatus L., a seed thereof, or a habitat thereof with the herbicidal composition.
Abstract translation: 目的：提供DHNQ（5,8-二羟基-1,4-萘醌）以抑制与微生物和植物的生物素生物合成途径相关的KAPAS（7-酮-8-氨基壬酸合成酶），并显着除去Sicyos angulatus L.具有安全的人体。 构成：用于防治水atus atus的除草组合物含有化学式1的DHNQ或其药学上可接受的盐作为活性成分。 DHNQ来自黑胡桃，抑制KAPAS活性。 用于控制ang鱼的方法包括用除草组合物处理芸苔的种子或其栖息地的步骤。
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公开(公告)号：KR101251589B1
公开(公告)日：2013-04-08
申请号：KR1020120108010
申请日：2012-09-27
Applicant: 한국화학연구원
Abstract: 본 발명은 도라지 또는 도라지 추출물로부터의 순도 및 유효 사포닌 함량이 증가된 조사포닌 조성물의 제조방법에 관한 것으로, 더욱 구체적으로 상기 제조방법은 도라지로부터 착즙공정 또는 증류수, C
1 내지 C
3 의 저급알코올, 에틸아세테이트, 핵산, 디클로로메탄 또는 이들의 혼합용매를 이용하여 도라지 추출물을 수득하는 단계(단계 1); 상기 단계 1에서 수득한 추출물을 증류수에 용해시킨 후 역상겔이 충진된 컬럼에 가하여 사포닌 성분을 흡착시키는 흡착공정 및 흡착된 사포닌을 에탄올 또는 메탄올 수용액으로 용출시키는 용출공정을 포함하는 사포닌을 수득하는 단계(단계 2); 및 상기 단계 2에서 수득한 사포닌을 유기용매를 사용하여 정제하는 단계(단계 3)를 포함한다. 본 발명은 도라지 추출물을 부탄올로 추출하는 종래의 조사포닌 제조방법에 비하여 순도가 높을 뿐만 아니라 유효 사포닌 함량이 증가된 조사포닌 조성물을 얻을 수 있으므로 도라지 또는 도라지 추출물로부터 사포닌 추출시 유용하게 활용될 수 있다.-
23.发明公开노랑꽃창포 종자로부터 분리된 레스베라트롤 유도체 화합물을 포함하는 항암제 조성물 有权用于治疗包含从IRIS PSEUDACORUS的种子分离的RESVERATROL衍生物的癌症的药物组合物
公开(公告)号：KR1020120119693A
公开(公告)日：2012-10-31
申请号：KR1020110037820
申请日：2011-04-22
Applicant: 한국화학연구원 , 국민대학교산학협력단
IPC: A61K31/343 , A61K36/882 , A61P35/00
Abstract: PURPOSE: An anticancer drug composition which includes resveratrol derivative compound separated from iris tectorum seeds is provided to be used as therapeutic agent for various malign tumors. CONSTITUTION: An anticancer drug composition contains irisferin A, irisferin B, irisferin C, a pharmaceutically acceptable salt, isomer or a mixture thereof, or iris pseudacorus seed extract including the same as an active ingredient. The iris pseudacorus seed extract is obtained by extracting the iris pseudacorus seed with methanol, methanol aqueous solution, ethanol, ethanol water solution, butanol, dichloromethane, ethyl acetate or a mixture thereof. The cancer is lung cancer, ovarian cancer, melanoma, central nervous system cancer or colon carcinoma. A health supplement having the anti-cancer cell growth obstruction efficacy is irisferin A, irisferin B, irisferin C, a pharmaceutically acceptable salt, isomer or a mixture thereof, or iris pseudacorus seed extract including the same.
Abstract translation: 目的：提供一种抗癌药物组合物，其中包括从虹膜花粉种子分离的白藜芦醇衍生物，用作各种恶性肿瘤的治疗剂。 构成：抗癌药物组合物含有虹膜蛋白A，虹膜蛋白B，虹膜蛋白C，其药学上可接受的盐，异构体或其混合物，或包含其作为活性成分的虹膜假科种子提取物。 通过用甲醇，甲醇水溶液，乙醇，乙醇水溶液，丁醇，二氯甲烷，乙酸乙酯或其混合物提取虹膜假科种获得虹膜假科种子提取物。 癌症是肺癌，卵巢癌，黑素瘤，中枢神经系统癌或结肠癌。 具有抗癌细胞生长阻塞功效的健康补充剂是虹膜蛋白A，虹膜蛋白B，虹膜蛋白C，其药学上可接受的盐，异构体或其混合物，或包含其的虹膜假科种子提取物。
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24.发明公开
公开(公告)号：KR1020110125940A
公开(公告)日：2011-11-22
申请号：KR1020100045593
申请日：2010-05-14
IPC: A61K36/232 , A61K31/37 , A61P3/04 , A61P3/00
CPC classification number: A61K36/232 , A61K31/216 , A61K31/235 , A61K31/366 , Y10S514/909
Abstract: PURPOSE: A composition containing derivatives synthesized from decursin for preventing or treating obesity is provided to suppress fatty acid synthesis. CONSTITUTION: A composition for preventing or treating obesity contains decursinol benzoate which is synthedized from decursin. The decursinol benzoate suppresses fatty acid synthesis by AMPK(5' adenosine monophosphate-activated protein kinase) activity. A method for synthesizing decursinol benzoate comprises: a step of performing enfleurage of dried Angelicae gigantis Radix in methanol at room temperature for seven days and filtering; a step of suspending the methanol extract in distilled water and isolating dichloromethane; and a step of freeze-drying and performing silicagel column chromatography to prepare six fraction.
Abstract translation: 目的：提供含有由前代素合成的用于预防或治疗肥胖症的衍生物的组合物以抑制脂肪酸合成。 构成：用于预防或治疗肥胖症的组合物含有由前胡素合成的去甲基苯甲酸酯。 苯酚去甲酚抑制AMPK（5'腺苷单磷酸激活蛋白激酶）活性的脂肪酸合成。 合成前酚醇苯甲酸酯的方法包括：在室温下在甲醇中进行七天的过滤干燥的当归香草， 将甲醇提取物悬浮在蒸馏水中并分离二氯甲烷的步骤; 和冷冻干燥并进行硅胶柱色谱以制备6份。
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公开(公告)号：KR101077913B1
公开(公告)日：2011-10-31
申请号：KR1020090011087
申请日：2009-02-11
Applicant: 한국화학연구원 , 동아대학교 산학협력단
IPC: C12N9/16 , C07K14/195 , C12N15/09 , A01H1/00
Abstract: 본발명은토양메타게놈유래신규에스터라제(esterase) 유전자및 이로부터암호화되는에스터라제단백질에관한것으로, 보다상세하게는토양미생물의총 유전체인메타게놈으로부터분리한신규에스터라제가우수한에스터라제활성을나타내고, 온도, pH 및유기용매에대한효소활성안정성을나타내며, 짧은사슬(short chain) 지방산을가지는지질및 3-하이드록시팔미트산메틸에스테르(3-OH palmitic acid methyl ester; 3-OH PAME)를분해하여식물병원성균에대한바이오필름저해활성을나타냄으로써식물세균병저항성작물또는식물세균병제어제개발에유용하게사용될수 있다.
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Patent Agency Ranking
公开(公告)号：KR1020100091749A
公开(公告)日：2010-08-19
申请号：KR1020090011087
申请日：2009-02-11
Applicant: 한국화학연구원 , 동아대학교 산학협력단
IPC: C12N9/16 , C07K14/195 , C12N15/09 , A01H1/00
Abstract: PURPOSE: A soil metagenome-derived novel esterase gene is provided to ensure enzyme activity stability and to use in developing an agent which controls plant bacterial diseases. CONSTITUTION: A polypeptide having esterase activity comprises: a polypeptide encoded by polynucleotide of sequence number 1; a polypeptide encoded by a polynucleotide which is hybridized with the polynucleotide of sequence number 1; and a polypeptide with an amino acid sequence of sequence number 2. A method for preparing a recombinant esterase comprises: a step of preparing a recombinant expression vector containing the polynueotide; a step of preparing a transformant by introducing a recombinant expression vector to host cells; and a step of culturing the transformant to induce recombinant protein expression.
Abstract translation: 目的：提供一种土壤巨蛋白衍生新型酯酶基因，以确保酶活性的稳定性，并用于开发控制植物细菌性疾病的药剂。 构成：具有酯酶活性的多肽包括：由序列号1的多核苷酸编码的多肽; 由与序列号1的多核苷酸杂交的多核苷酸编码的多肽; 和具有序列号2的氨基酸序列的多肽。制备重组酯酶的方法包括：制备含有多核苷酸的重组表达载体的步骤; 通过将重组表达载体引入宿主细胞来制备转化体的步骤; 以及培养转化体诱导重组蛋白表达的步骤。
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27.发明公开상엽 추출물, 이의 분획물 또는 이로부터 분리된 화합물을 유효성분으로 함유하는 식욕 억제, 우울증의 예방 및 개선, 또는 불안증의 예방 및 개선용 식품 조성물 失效含有作为活性成分的以MCH受体拮抗活性为基础的MORI FOLIUM，其分离物或其化合物或其化合物用于预防或改善代谢或饮食障碍的饮食组合物
公开(公告)号：KR1020100024793A
公开(公告)日：2010-03-08
申请号：KR1020080083509
申请日：2008-08-26
CPC classification number: A23L33/105 , A23V2002/00 , A23V2200/322 , A23V2200/332 , A23V2250/21
Abstract: PURPOSE: A food composition for preventing and improving of a metabolic disorder and an eating disorder based on MCH receptor antagonistic activity is provided to improve and prevent coronary artery diseases, hyperlipidemia, degenerative arthritis, melancholia, anxiety, and mental anxiety etc. CONSTITUTION: A food composition contains mulberry leaf extract extracted with a solvent including water, an organic solvent, or a mixture of water and the organic solvent as a beneficial component. The organic solvent is alcohol of C1-C4, dichloromethane or ethyl acetate. The alcohol of C1-C4 is methanol or ethanol. The mulberry leaf materials is produced by separating the mulberry leaf extract with dichloromethane.
Abstract translation: 目的：提供一种用于预防和改善基于MCH受体拮抗活性的代谢紊乱和进食障碍的食物组合物，用于改善和预防冠状动脉疾病，高脂血症，退行性关节炎，忧郁症，焦虑和精神焦虑等。构成：A 食品组合物含有用溶剂，包括水，有机溶剂或水和有机溶剂的混合物萃取的桑叶提取物作为有益成分。 有机溶剂是C1-C4的醇，二氯甲烷或乙酸乙酯。 C1-C4的醇是甲醇或乙醇。 通过将桑叶提取物与二氯甲烷分离来生产桑叶。
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28.发明公开[10]-진저다이온 또는 1-데하이드로-[10]-진저다이온을 포함하는 항 염증용 조성물 有权用于抗炎，组织改善的组合物，来自手术或布鲁斯的加速恢复，或治疗或预防心脏疾病，包括分离的ZINGIBER OFFICINALE或活性化合物的提取物
公开(公告)号：KR1020090104373A
公开(公告)日：2009-10-06
申请号：KR1020080029772
申请日：2008-03-31
Applicant: 한국화학연구원
IPC: A61K31/12 , A61K36/9068
CPC classification number: A61K31/12 , A23L2/52 , A23L29/035 , A61K36/9068 , Y10S514/886
Abstract: PURPOSE: A composition for treating or preventing heart diseases or for anti-inflammation, topical edema reduction, treatment or prevention of heart diseases is provided to enhance uptake function of macrophage and remove waste from the body. CONSTITUTION: A pharmaceutical composition for preventing or treating heart diseases or for anti-inflammation, topical edema reduction, or recovery promotion from surgery or contusion contains [10]-gingerdione of the chemical formula 1, 1-dehydro-[10]-gingerdione of the chemical formula 2 or their composite.
Abstract translation: 目的：提供用于治疗或预防心脏病或抗炎，局部水肿减轻，治疗或预防心脏病的组合物，以增强巨噬细胞的摄取功能，并从体内清除废物。 构成：用于预防或治疗心脏病或用于抗炎，局部水肿减轻或从手术或挫伤中恢复促进的药物组合物含有化学式1，1-dehydro- [10] - 二烯酮的[10] 化学式2或其复合物。
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公开(公告)号：KR100891762B1
公开(公告)日：2009-04-07
申请号：KR1020070000902
申请日：2007-01-04
CPC classification number: A61K36/78 , A23L2/38 , A23L33/105 , A23V2002/00 , A61K31/065 , A61K31/36 , A23V2200/326 , A23V2250/21
Abstract: 본 발명은 마칠린 디 (machilin D), 사우스네올 디 (saucerneol D) 및 이들의 혼합물로 구성된 군으로부터 선택된 화합물 또는 이를 포함하는 삼백초 (
Saururus chinenesis ) 뿌리 추출물을 유효성분으로 함유하는 혈관 이완용 조성물에 관한 것으로서, 본 발명에 따른 조성물은 혈관 평활근 이완작용을 통해 우수한 혈압 강하효과를 나타내므로, 고혈압 및 고혈압의 합병증으로 인한 각종 심혈관계 질환의 예방 및 치료를 위한 약학 조성물 또는 건강 식품 조성물로 유용하게 사용될 수 있다.-
公开(公告)号：KR1020070068689A
公开(公告)日：2007-07-02
申请号：KR1020050130601
申请日：2005-12-27
Abstract: A composition for immunosuppression comprising the extract of Saururus chinensis or active compounds isolated therefrom is provided to inhibit abnormal proliferation of B cell and T cell, so that the composition is useful for prevention and treatment of diseases caused by hypersensitive immune responses. The composition for immunosuppression comprises the extract of Saururus chinensis or an active compound isolated from the Saururus chinensis extract selected from (-)-saucerneol, saucerneol C, manassantin A, manassantin B and a mixture thereof as effective ingredient, wherein the Saururus chinensis extract is prepared by using an organic solvent selected from methanol, methanol solution, ethanol, ethanol solution, butanol, dichloromethane, ethylacetate and a mixture thereof. The composition is a pharmaceutical or health food composition. The pharmaceutical composition prevents or treats diseases caused by hypersensitive immune responses including organ transplant rejection, autoimmune disease including lupous erythematosus and rheumatoid arthritis, and allergy disease including rhinitis, asthma and atopic dermatitis, and the health food composition is formulated as drink.
Abstract translation: 提供了包含中华黄牛提取物或从其分离的活性化合物的免疫抑制组合物以抑制B细胞和T细胞的异常增殖，使得该组合物可用于预防和治疗由过敏免疫应答引起的疾病。 用于免疫抑制的组合物包含中华黄牛提取物或从中选出的（ - ） - 沙美拉诺，沙门氏菌素C，马那敏蛋白A，他曼那丁B及其混合物中选择的中华黄瓜提取物作为有效成分分离的活性化合物，其中中华黄瓜提取物为 通过使用选自甲醇，甲醇溶液，乙醇，乙醇溶液，丁醇，二氯甲烷，乙酸乙酯及其混合物的有机溶剂制备。 该组合物是药物或保健食品组合物。 药物组合物预防或治疗由过敏免疫应答引起的疾病，包括器官移植排斥反应，自身免疫性疾病，包括红斑狼疮和类风湿性关节炎，以及过敏疾病，包括鼻炎，哮喘和特应性皮炎，健康食品组合物配制成饮料。
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