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    COMPOSITIONS AND METHODS FOR CRYSTALLIZING ANTIBODY FRAGMENTS
    21.
    发明专利
    COMPOSITIONS AND METHODS FOR CRYSTALLIZING ANTIBODY FRAGMENTS 未知

    公开(公告)号：CA2713342A1

    公开(公告)日：2009-08-13

    申请号：CA2713342

    申请日：2009-01-29

    Applicant: ABBOTT LAB

    Inventor： ARGIRIADI MARIA A ,  BORHANI DAVID W ,  XIANG TAO ,  WU CHENGBIN ,  GHAYUR TARIQ

    IPC: A61K39/395

    Abstract: The invention provides methods of crystallizing antibodies and fragments thereof as well as crystals produced thereby. More particularly, the invention provides methods of crystallizing human and non-human Fab fragments of antibodies, either alone or as co-crystals with their target ligand. For example, a crystal comprising a murine Fab fragment of the antibody 125-2H or a human Fab fragment of the antibody ABT-325, which bind to IL-18, are provided as well as a co-crystal of a murine Fab fragment bound to IL-18. ABT-325 and 125-2H differ significantly in combining site character and architecture, thus explaining their ability to bind IL-18 simultaneously at distinct epitopes.

    CRYSTALLINE ANTI-HUMAN IL-12 ANTIBODIES
    22.
    发明专利
    CRYSTALLINE ANTI-HUMAN IL-12 ANTIBODIES 未知

    公开(公告)号：NZ580379A

    公开(公告)日：2012-10-26

    申请号：NZ58037908

    申请日：2008-03-27

    Applicant: ABBOTT LAB

    Inventor： BORHANI DAVID W ,  FRAUNHOFER WOLFGANG ,  KRAUSE HANS-JUERGEN ,  KOENIGSDORFER ANETTE ,  WINTER GERHARD ,  GOTTSCHALK STEFAN

    IPC: C12P21/08 ,  C07K16/00

    Abstract: Disclosed is a batch crystallization method for crystallizing an anti-human IL-12 antibody, the method comprising the steps of: (a) providing an aqueous crystallization mixture having an aqueous solution of the antibody in admixture with at least one polyalkylene glycol having an average molecular weight in the range of about 400 to about 10,000 as a crystallization agent wherein the antibody concentration is in the range of about 0.5 to about 280 mg/ml; and (b) incubating the aqueous crystallization mixture at a pH of about pH 4 to about 6.5 and at a temperature of about 4o C to about 37o C until crystals of the antibody having a length of about 2-500 ìm are formed. Also disclosed is a crystal of an anti-human IL-12 antibody obtained by a batch crystallization method. Further disclosed is the use of the anti-human IL-12 antibody crystal in the manufacture of a medicament for the treatment of an IL-12 related disorder

    COMPOSITIONS AND METHODS FOR CRYSTALLIZING ANTIBODIES
    23.
    发明专利
    COMPOSITIONS AND METHODS FOR CRYSTALLIZING ANTIBODIES 未知

    公开(公告)号：SG183709A1

    公开(公告)日：2012-09-27

    申请号：SG2012059085

    申请日：2008-08-08

    Applicant: ABBOTT LAB

    Inventor： FRAUNHOFER WOLFGANG ,  BORHANI DAVID W ,  WINTER GERHARD ,  GOTTSCHALK STEFAN

    Abstract: Compositions and Methods for Crystallizing Antibodies5AbstractThe present invention relates to a batch crystallization method for crystallizing anti 10 human TNFalpha (hTNFalpha) antibody and antibody fragments which allows the production of said antibody on an industrial scale; a method of controlling the size of antibody crystals, for example, crystals of anti-hTNFalpha antibody fragments, compositions containing said crystals as well as methods of use of said crystals and compositions.15Figure 1

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