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公开(公告)号：WO2007028051A3
公开(公告)日：2007-11-01
申请号：PCT/US2006034275
申请日：2006-09-01
Applicant: ABBOTT LAB , BRIENLINGER ERIC C , CALDERWOOD DAVID J , FRANK KRISTINE E , BETSCHMANN PATRICK , HIRST GAVIN C , MORYTKO MICHAEL J , DIXON RICHARD W
Inventor： BREINLINGER ERIC C , CALDERWOOD DAVID J , FRANK KRISTINE E , BETSCHMANN PATRICK , HIRST GAVIN C , MORYTKO MICHAEL J , DIXON RICHARD W
IPC: A01N43/50
CPC classification number: C07D487/04
Abstract: The present invention is directed to novel imidazopyrazine and imidazopyrimidine compounds of formula (I), wherein the variables are as defined herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.
Abstract translation: 本发明涉及式（I）的新咪唑并吡嗪和咪唑并嘧啶化合物，其中变量如本文所定义。 式（I）化合物可用作激酶抑制剂，因此可用于治疗某些病症和疾病，特别是炎性病症和疾病以及增殖性病症和病症，例如癌症。
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公开(公告)号：WO2007117465A3
公开(公告)日：2008-08-28
申请号：PCT/US2007008307
申请日：2007-04-02
Applicant: ABBOTT LAB , ERICSSON ANNA M , BURCHAT ANDREW , FRANK KRISTINE E , CALDERWOOD DAVID J , ABBOTT LILY K , ARGIRIADI MARIA A , BORHANI DAVID W , CUSACK KEVIN P , DIXON RICHARD W , GORDON THOMAS D , MULLEN KELLY D , TALANIAN ROBERT V , WU XIAOYUN , ZHANG XIAOLEI , WANG LU X , LI BIQIN , BARBERIS CLAUDE E , WISHART NEIL
Inventor： ERICSSON ANNA M , BURCHAT ANDREW , FRANK KRISTINE E , CALDERWOOD DAVID J , ABBOTT LILY K , ARGIRIADI MARIA A , BORHANI DAVID W , CUSACK KEVIN P , DIXON RICHARD W , GORDON THOMAS D , MULLEN KELLY D , TALANIAN ROBERT V , WU XIAOYUN , ZHANG XIAOLEI , WANG LU X , LI BIQIN , BARBERIS CLAUDE E , WISHART NEIL
IPC: A61K31/5377
CPC classification number: C07D487/04 , C07D403/12 , C07D403/14 , C07D409/04 , C07D409/14
Abstract: Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.
Abstract translation: 式（I）的新型化合物或其药学上可接受的盐，前体药物和式（I）的生物活性代谢物，其中取代基如本文所定义，其可用作治疗剂。
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公开(公告)号：WO2008063287A3
公开(公告)日：2008-08-07
申请号：PCT/US2007021497
申请日：2007-10-05
Applicant: ABBOTT LAB , BORHANI DAVID W , CALDERWOOD DAVID J , FRANK KRISTINE E , DAVIS HEATHER M , JOSEPHSOHN NATHAN S , SKINNER BARBARA S
Inventor： BORHANI DAVID W , CALDERWOOD DAVID J , FRANK KRISTINE E , DAVIS HEATHER M , JOSEPHSOHN NATHAN S , SKINNER BARBARA S
IPC: A61K31/41 , C07D257/04
CPC classification number: C07D498/04 , C07D513/04 , C07D519/00
Abstract: The present invention is directed to novel compounds of formula (I) wherein the variables are as defined herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.
Abstract translation: 本发明涉及新的式（I）化合物，其中变量如本文所定义。 式（I）化合物可用作激酶抑制剂，因此可用于治疗某些病症和疾病，特别是炎性病症和疾病以及增殖性疾病和病症，例如癌症。
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公开(公告)号：EP2068869A4
公开(公告)日：2011-05-25
申请号：EP07870771
申请日：2007-10-05
Applicant: ABBOTT LAB
Inventor： BORHANI DAVID W , CALDERWOOD DAVID J , FRANK KRISTINE E , DAVIS HEATHER M , JOSEPHSOHN NATHAN S , SKINNER BARBARA S
IPC: A61K31/41 , C07D257/04
CPC classification number: C07D498/04 , C07D513/04 , C07D519/00
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公开(公告)号：EP2139329A4
公开(公告)日：2010-04-21
申请号：EP08742312
申请日：2008-03-27
Applicant: ABBOTT LAB
Inventor： CALDERWOOD DAVID J , FRANK KRISTINE E , BETSCHMANN PATRICK , BREINLINGER ERIC C , DIXON RICHARD W
IPC: C07D487/04 , A61K31/519 , A61P35/00
CPC classification number: C07D487/04
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Patent Agency Ranking
公开(公告)号：EP2299821A4
公开(公告)日：2012-02-08
申请号：EP09763424
申请日：2009-06-09
Applicant: ABBOTT LAB
Inventor： WISHART NEIL , ARGIRIADI MARIA A , CALDERWOOD DAVID J , ERICSSON ANNA M , FIAMENGO BRYAN A , FRANK KRISTINE E , FRIEDMAN MICHAEL , GEORGE DAWN M , GOEDKEN ERIC R , JOSEPHSOHN NATHAN S , LI BIQIN C , MORYTKO MICHAEL J , STEWART KENT D , VOSS JEFFREY W , WALLACE GRIER A , WANG LU , WOLLER KEVIN R
IPC: A01N43/42 , C07D487/14 , C07D498/14 , C07D513/14
CPC classification number: C07D487/14 , C07D498/14 , C07D513/14
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公开(公告)号：EP1928237A4
公开(公告)日：2011-03-09
申请号：EP06824879
申请日：2006-09-01
Applicant: ABBOTT LAB
Inventor： BREINLINGER ERIC C , CALDERWOOD DAVID J , FRANK KRISTINE E , BETSCHMANN PATRICK , HIRST GAVIN C , MORYTKO MICHAEL J , DIXON RICHARD W
IPC: A01N43/50
CPC classification number: C07D487/04
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公开(公告)号：EP2506716A4
公开(公告)日：2013-05-29
申请号：EP10835061
申请日：2010-12-01
Applicant: ABBOTT LAB
Inventor： WISHART NEIL , ARGIRIADI MARIA A , CALDERWOOD DAVID J , ERICSSON ANNA M , FIAMENGO BRYAN A , FRANK KRISTINE E , FRIEDMAN MICHAEL , GEORGE DAWN M , GOEDKEN ERIC R , JOSEPHSOHN NATHAN S , LI BIQIN C , MORYTKO MICHAEL J , STEWART KENT D , VOSS JEFFREY W , WALLACE GRIER A , WANG LU , WOLLER KEVIN R
IPC: C07D487/14 , A61K31/437 , A61K31/4985 , A61P19/00 , C07D471/14 , C07D498/14 , C07D513/14
CPC classification number: C07D487/14 , A61K31/437 , A61K31/4985 , A61K45/06 , C07D471/14 , C07D498/14 , C07D513/14
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公开(公告)号：EP2001480A4
公开(公告)日：2011-06-15
申请号：EP07754773
申请日：2007-04-02
Applicant: ABBOTT LAB
Inventor： ERICSSON ANNA M , BURCHAT ANDREW , FRANK KRISTINE E , CALDERWOOD DAVID J , ABBOTT LILY K , ARGIRIADI MARIA A , BORHANI DAVID W , CUSACK KEVIN P , DIXON RICHARD W , GORDON THOMAS D , MULLEN KELLY D , TALANIAN ROBERT V , WU XIAOYUN , ZHANG XIAOLEI , WANG LU X , LI BIQIN , BARBERIS CLAUDE E , WISHART NEIL
IPC: A61K31/196 , A61P35/00 , C07D403/12
CPC classification number: C07D487/04 , C07D403/12 , C07D403/14 , C07D409/04 , C07D409/14
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公开(公告)号：PE20140407A1
公开(公告)日：2014-04-25
申请号：PE2013001090
申请日：2009-06-09
Applicant: ABBOTT LAB
Inventor： WISHART NEIL , ARGIRIADI MARIA A , CALDERWOOD DAVID J , ERICSSON ANNA M , FIAMENGO BRYAN A , FRANK KRISTINE E , FRIEDMAN MICHAEL , GEORGE DAWN M , GOEDKEN ERIC R , JOSEPHSOHN NATHAN S , LI BIQIN C , MORYTKO MICHAEL J , STEWART KENT D , VOSS JEFFREY W , WALLACE GRIER A , WANG LU , WOLLER KEVIN R
IPC: C07D487/14 , A61K31/4985 , A61P35/00 , C07D498/14 , C07D513/14
Abstract: REFERIDA A UN COMPUESTO TRICICLICO DE FORMULA (I), DONDE T ES CR6, N, O, NR6, S; U ES N, CR4; X ES CR3, NR3; Y ES N O C; R1, R2 Y R5 SON H, HALOGENO, NO2, CN, ENTRE OTROS; R3 ES H, CICLOALQUILO C5-C12, ARILO C6-C10, ENTRE OTROS; R4 Y R6 SON H, HALOGENO, CICLOALQUILO C5-C12, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 3-((3R,4R)-3-(6H-IMIDAZO[1,5-a]PIRROLO[2,3-e]PIRAZIN-1-IL)-4-METILPIPERIDIN-1-IL)-3-OXOPROPANONITRILO, 7-(5-METOXI-1-METIL-1H-INDOL-3-IL)-1-METIL-6H-IMIDAZO[1,5-a]PIRROLO[2,3-e]PIRAZINA, 1-CICLOHEXIL-6H-IMIDAZO[1,5-a]PIRROLO[2,3-e]PIRAZINA, ENTRE OTROS. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES INMUNOLOGICAS Y ONCOLOGICAS
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