公开(公告)号：WO2007117465A3

公开(公告)日：2008-08-28

申请号：PCT/US2007008307

申请日：2007-04-02

Applicant: ABBOTT LAB ,  ERICSSON ANNA M ,  BURCHAT ANDREW ,  FRANK KRISTINE E ,  CALDERWOOD DAVID J ,  ABBOTT LILY K ,  ARGIRIADI MARIA A ,  BORHANI DAVID W ,  CUSACK KEVIN P ,  DIXON RICHARD W ,  GORDON THOMAS D ,  MULLEN KELLY D ,  TALANIAN ROBERT V ,  WU XIAOYUN ,  ZHANG XIAOLEI ,  WANG LU X ,  LI BIQIN ,  BARBERIS CLAUDE E ,  WISHART NEIL

Inventor： ERICSSON ANNA M ,  BURCHAT ANDREW ,  FRANK KRISTINE E ,  CALDERWOOD DAVID J ,  ABBOTT LILY K ,  ARGIRIADI MARIA A ,  BORHANI DAVID W ,  CUSACK KEVIN P ,  DIXON RICHARD W ,  GORDON THOMAS D ,  MULLEN KELLY D ,  TALANIAN ROBERT V ,  WU XIAOYUN ,  ZHANG XIAOLEI ,  WANG LU X ,  LI BIQIN ,  BARBERIS CLAUDE E ,  WISHART NEIL

IPC: A61K31/5377

CPC classification number: C07D487/04 ,  C07D403/12 ,  C07D403/14 ,  C07D409/04 ,  C07D409/14

Abstract: Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.

Abstract translation: 式（I）的新型化合物或其药学上可接受的盐，前体药物和式（I）的生物活性代谢物，其中取代基如本文所定义，其可用作治疗剂。

公开(公告)号：WO2012149280A3

公开(公告)日：2014-05-08

申请号：PCT/US2012035401

申请日：2012-04-27

Applicant: ABBOTT LAB ,  FRANK KRISTINE E ,  BURCHAT ANDREW ,  COX PHILIP ,  IHLE DAVID C ,  MULLEN KELLY D ,  SOMAL GAGANDEEP ,  VASUDEVAN ANIL ,  WANG LU ,  WILSON NOEL S

Inventor： FRANK KRISTINE E ,  BURCHAT ANDREW ,  COX PHILIP ,  IHLE DAVID C ,  MULLEN KELLY D ,  SOMAL GAGANDEEP ,  VASUDEVAN ANIL ,  WANG LU ,  WILSON NOEL S

IPC: A01N43/54 ,  C07D401/04 ,  C07D471/04

CPC classification number: C07D487/14

Abstract: The invention provides compounds of Formula (I), pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

Abstract translation: 本发明提供式（I）的化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。

公开(公告)号：WO2008063287A3

公开(公告)日：2008-08-07

申请号：PCT/US2007021497

申请日：2007-10-05

Applicant: ABBOTT LAB ,  BORHANI DAVID W ,  CALDERWOOD DAVID J ,  FRANK KRISTINE E ,  DAVIS HEATHER M ,  JOSEPHSOHN NATHAN S ,  SKINNER BARBARA S

Inventor： BORHANI DAVID W ,  CALDERWOOD DAVID J ,  FRANK KRISTINE E ,  DAVIS HEATHER M ,  JOSEPHSOHN NATHAN S ,  SKINNER BARBARA S

IPC: A61K31/41 ,  C07D257/04

CPC classification number: C07D498/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present invention is directed to novel compounds of formula (I) wherein the variables are as defined herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.

Abstract translation: 本发明涉及新的式（I）化合物，其中变量如本文所定义。 式（I）化合物可用作激酶抑制剂，因此可用于治疗某些病症和疾病，特别是炎性病症和疾病以及增殖性疾病和病症，例如癌症。

公开(公告)号：WO2011156698A3

公开(公告)日：2012-02-09

申请号：PCT/US2011039958

申请日：2011-06-10

Applicant: ABBOTT LAB ,  WOLLER KEVIN R ,  CURTIN MICHAEL L ,  FRANK KRISTINE E ,  JOSEPHSOHN NATHAN S ,  LI BIQIN C ,  WISHART NEIL

Inventor： WOLLER KEVIN R ,  CURTIN MICHAEL L ,  FRANK KRISTINE E ,  JOSEPHSOHN NATHAN S ,  LI BIQIN C ,  WISHART NEIL

IPC: A01N43/38 ,  A61K31/40

CPC classification number: C07D487/04

Abstract: The present disclosure is directed to novel compounds of Formula (I), pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are as defined herein. The compounds of Formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, Crohn's disease, psoriasis and asthma.

Abstract translation: 本公开涉及新的式（I）化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量如本文所定义。 式（I）的化合物可用作激酶抑制剂，因此可用于治疗某些病症和疾病，特别是炎性病症和疾病以及增殖性疾病和病症，例如类风湿性关节炎，系统性红斑狼疮，多发性硬化症，克罗恩病 疾病，牛皮癣和哮喘。

公开(公告)号：WO2007028051A3

公开(公告)日：2007-11-01

申请号：PCT/US2006034275

申请日：2006-09-01

Applicant: ABBOTT LAB ,  BRIENLINGER ERIC C ,  CALDERWOOD DAVID J ,  FRANK KRISTINE E ,  BETSCHMANN PATRICK ,  HIRST GAVIN C ,  MORYTKO MICHAEL J ,  DIXON RICHARD W

Inventor： BREINLINGER ERIC C ,  CALDERWOOD DAVID J ,  FRANK KRISTINE E ,  BETSCHMANN PATRICK ,  HIRST GAVIN C ,  MORYTKO MICHAEL J ,  DIXON RICHARD W

IPC: A01N43/50

CPC classification number: C07D487/04

Abstract: The present invention is directed to novel imidazopyrazine and imidazopyrimidine compounds of formula (I), wherein the variables are as defined herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.

Abstract translation: 本发明涉及式（I）的新咪唑并吡嗪和咪唑并嘧啶化合物，其中变量如本文所定义。 式（I）化合物可用作激酶抑制剂，因此可用于治疗某些病症和疾病，特别是炎性病症和疾病以及增殖性病症和病症，例如癌症。

公开(公告)号：EP2068869A4

公开(公告)日：2011-05-25

申请号：EP07870771

申请日：2007-10-05

Applicant: ABBOTT LAB

Inventor： BORHANI DAVID W ,  CALDERWOOD DAVID J ,  FRANK KRISTINE E ,  DAVIS HEATHER M ,  JOSEPHSOHN NATHAN S ,  SKINNER BARBARA S

IPC: A61K31/41 ,  C07D257/04

CPC classification number: C07D498/04 ,  C07D513/04 ,  C07D519/00

公开(公告)号：EP2139329A4

公开(公告)日：2010-04-21

申请号：EP08742312

申请日：2008-03-27

Applicant: ABBOTT LAB

Inventor： CALDERWOOD DAVID J ,  FRANK KRISTINE E ,  BETSCHMANN PATRICK ,  BREINLINGER ERIC C ,  DIXON RICHARD W

IPC: C07D487/04 ,  A61K31/519 ,  A61P35/00

CPC classification number: C07D487/04

公开(公告)号：EP2299821A4

公开(公告)日：2012-02-08

申请号：EP09763424

申请日：2009-06-09

Applicant: ABBOTT LAB

Inventor： WISHART NEIL ,  ARGIRIADI MARIA A ,  CALDERWOOD DAVID J ,  ERICSSON ANNA M ,  FIAMENGO BRYAN A ,  FRANK KRISTINE E ,  FRIEDMAN MICHAEL ,  GEORGE DAWN M ,  GOEDKEN ERIC R ,  JOSEPHSOHN NATHAN S ,  LI BIQIN C ,  MORYTKO MICHAEL J ,  STEWART KENT D ,  VOSS JEFFREY W ,  WALLACE GRIER A ,  WANG LU ,  WOLLER KEVIN R

IPC: A01N43/42 ,  C07D487/14 ,  C07D498/14 ,  C07D513/14

CPC classification number: C07D487/14 ,  C07D498/14 ,  C07D513/14

公开(公告)号：EP1928237A4

公开(公告)日：2011-03-09

申请号：EP06824879

申请日：2006-09-01

Applicant: ABBOTT LAB

Inventor： BREINLINGER ERIC C ,  CALDERWOOD DAVID J ,  FRANK KRISTINE E ,  BETSCHMANN PATRICK ,  HIRST GAVIN C ,  MORYTKO MICHAEL J ,  DIXON RICHARD W

IPC: A01N43/50

CPC classification number: C07D487/04

公开(公告)号：EP2506716A4

公开(公告)日：2013-05-29

申请号：EP10835061

申请日：2010-12-01

Applicant: ABBOTT LAB

Inventor： WISHART NEIL ,  ARGIRIADI MARIA A ,  CALDERWOOD DAVID J ,  ERICSSON ANNA M ,  FIAMENGO BRYAN A ,  FRANK KRISTINE E ,  FRIEDMAN MICHAEL ,  GEORGE DAWN M ,  GOEDKEN ERIC R ,  JOSEPHSOHN NATHAN S ,  LI BIQIN C ,  MORYTKO MICHAEL J ,  STEWART KENT D ,  VOSS JEFFREY W ,  WALLACE GRIER A ,  WANG LU ,  WOLLER KEVIN R

IPC: C07D487/14 ,  A61K31/437 ,  A61K31/4985 ,  A61P19/00 ,  C07D471/14 ,  C07D498/14 ,  C07D513/14

CPC classification number: C07D487/14 ,  A61K31/437 ,  A61K31/4985 ,  A61K45/06 ,  C07D471/14 ,  C07D498/14 ,  C07D513/14