公开(公告)号：WO2009011850A2

公开(公告)日：2009-01-22

申请号：PCT/US2008008645

申请日：2008-07-15

Applicant: ABBOTT LAB ,  BREINLINGER ERIC C ,  CUSACK KEVIN P ,  HOBSON ADRIAN D ,  LI BIN ,  GORDON THOMAS D ,  STOFFEL ROBERT H ,  WALLACE GRIER A ,  GRONSGAARD PINTIPA ,  WANG LU

Inventor： BREINLINGER ERIC C ,  CUSACK KEVIN P ,  HOBSON ADRIAN D ,  LI BIN ,  GORDON THOMAS D ,  STOFFEL ROBERT H ,  WALLACE GRIER A ,  GRONSGAARD PINTIPA ,  WANG LU

IPC: C07D249/10 ,  A61K31/415 ,  A61K31/4196 ,  A61K31/42 ,  A61P35/00 ,  C07D231/14 ,  C07D261/14 ,  C07D403/12

CPC classification number: C07D249/10 ,  C07D231/14 ,  C07D249/06 ,  C07D261/14 ,  C07D261/18 ,  C07D273/02 ,  C07D333/36 ,  C07D333/38 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: Disclosed herein are novel compounds of Formula (I), wherein the variables are defined as herein. The compounds of Formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases as well as proliferative disorders such as cancer.

Abstract translation: 本文公开了式（I）的新化合物，其中变量如本文所定义。 式（I）的化合物可用作激酶抑制剂，因此可用于治疗某些病症和疾病，特别是炎性疾病和疾病以及增殖性疾病如癌症。

公开(公告)号：WO2007117465A3

公开(公告)日：2008-08-28

申请号：PCT/US2007008307

申请日：2007-04-02

Applicant: ABBOTT LAB ,  ERICSSON ANNA M ,  BURCHAT ANDREW ,  FRANK KRISTINE E ,  CALDERWOOD DAVID J ,  ABBOTT LILY K ,  ARGIRIADI MARIA A ,  BORHANI DAVID W ,  CUSACK KEVIN P ,  DIXON RICHARD W ,  GORDON THOMAS D ,  MULLEN KELLY D ,  TALANIAN ROBERT V ,  WU XIAOYUN ,  ZHANG XIAOLEI ,  WANG LU X ,  LI BIQIN ,  BARBERIS CLAUDE E ,  WISHART NEIL

Inventor： ERICSSON ANNA M ,  BURCHAT ANDREW ,  FRANK KRISTINE E ,  CALDERWOOD DAVID J ,  ABBOTT LILY K ,  ARGIRIADI MARIA A ,  BORHANI DAVID W ,  CUSACK KEVIN P ,  DIXON RICHARD W ,  GORDON THOMAS D ,  MULLEN KELLY D ,  TALANIAN ROBERT V ,  WU XIAOYUN ,  ZHANG XIAOLEI ,  WANG LU X ,  LI BIQIN ,  BARBERIS CLAUDE E ,  WISHART NEIL

IPC: A61K31/5377

CPC classification number: C07D487/04 ,  C07D403/12 ,  C07D403/14 ,  C07D409/04 ,  C07D409/14

Abstract: Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.

Abstract translation: 式（I）的新型化合物或其药学上可接受的盐，前体药物和式（I）的生物活性代谢物，其中取代基如本文所定义，其可用作治疗剂。

公开(公告)号：EP2001480A4

公开(公告)日：2011-06-15

申请号：EP07754773

申请日：2007-04-02

Applicant: ABBOTT LAB

Inventor： ERICSSON ANNA M ,  BURCHAT ANDREW ,  FRANK KRISTINE E ,  CALDERWOOD DAVID J ,  ABBOTT LILY K ,  ARGIRIADI MARIA A ,  BORHANI DAVID W ,  CUSACK KEVIN P ,  DIXON RICHARD W ,  GORDON THOMAS D ,  MULLEN KELLY D ,  TALANIAN ROBERT V ,  WU XIAOYUN ,  ZHANG XIAOLEI ,  WANG LU X ,  LI BIQIN ,  BARBERIS CLAUDE E ,  WISHART NEIL

IPC: A61K31/196 ,  A61P35/00 ,  C07D403/12

CPC classification number: C07D487/04 ,  C07D403/12 ,  C07D403/14 ,  C07D409/04 ,  C07D409/14

公开(公告)号：EP2509424A4

公开(公告)日：2013-09-04

申请号：EP10836346

申请日：2010-08-24

Applicant: ABBOTT LAB

Inventor： CUSACK KEVIN P ,  BREINLINGER ERIC C ,  FIX-STENZEL SHANNON R ,  STOFFEL ROBERT H ,  WOLLER KEVIN R

IPC: A01N43/82 ,  A61K31/41 ,  C07D413/12 ,  C07D471/04 ,  C07D487/04

CPC classification number: C07D413/04 ,  C07D271/06 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

公开(公告)号：EP2120575A4

公开(公告)日：2011-04-27

申请号：EP07863237

申请日：2007-12-21

Applicant: ABBOTT LAB

Inventor： WALLACE GRIER A ,  BREINLINGER ERIC C ,  CUSACK KEVIN P ,  FIX-STENZEL SHANNON R ,  GORDON THOMAS D ,  HOBSON ADRIAN D ,  HAYES MARTIN E ,  ANSELL GRAHAM K ,  GRONGSAARD PINTIPA

IPC: A01N43/50 ,  A61K31/415 ,  A61P25/28 ,  C07C215/38 ,  C07C215/42 ,  C07C217/74 ,  C07C229/14 ,  C07C229/48 ,  C07D205/04 ,  C07D207/12 ,  C07D207/14 ,  C07D213/30 ,  C07D263/32 ,  C07D263/52 ,  C07D271/06 ,  C07D307/22 ,  C07D307/24 ,  C07D333/16 ,  C07D413/04 ,  C07F9/30 ,  C07F9/38 ,  C07F9/40 ,  C07F9/653 ,  C07F9/655 ,  C07F9/6553

CPC classification number: C07D413/04 ,  C07C215/38 ,  C07C215/42 ,  C07C217/52 ,  C07C217/74 ,  C07C229/14 ,  C07C229/48 ,  C07C2601/02 ,  C07C2601/08 ,  C07D205/04 ,  C07D207/12 ,  C07D207/14 ,  C07D213/30 ,  C07D263/32 ,  C07D263/52 ,  C07D271/06 ,  C07D307/22 ,  C07D307/24 ,  C07D333/16 ,  C07D491/107 ,  C07F9/091 ,  C07F9/301 ,  C07F9/3808 ,  C07F9/3826 ,  C07F9/4006 ,  C07F9/653 ,  C07F9/65515 ,  C07F9/655345

公开(公告)号：EP2109364A4

公开(公告)日：2010-04-14

申请号：EP07867755

申请日：2007-12-14

Applicant: ABBOTT LAB

Inventor： HOBSON ADRIAN D ,  FIX-STENZEL SHANNON ,  CUSACK KEVIN P ,  BREINLINGER ERIC C ,  ANSELL GRAHAM K ,  STOFFEL ROBERT H ,  WOLLER KEVIN R ,  GRONGSAARD PINTIPA

IPC: A01N43/82 ,  A61K31/41

CPC classification number: C07D271/07 ,  C07D271/06 ,  C07D413/04 ,  C07D413/06 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04

公开(公告)号：BRPI0720043A2

公开(公告)日：2014-01-07

申请号：BRPI0720043

申请日：2007-12-14

Applicant: ABBOTT LAB

Inventor： HOBSON ADRIAN D ,  FIX-STENZEL SHANNON ,  CUSACK KEVIN P ,  BREINLINGER ERIC C ,  ANSELL GRAHAM K ,  STOFFEL ROBERT H ,  WOLLER KEVIN R ,  GRONSAARD PINTIPA

IPC: A01N43/82 ,  A61K31/41

Abstract: Novel oxadiazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions as agonists or antagonists of the S1P family of G protein-coupled receptors for treating diseases associated with modulation of S1P family receptor activity, in particular by affording a beneficial immunosuppressive effect are disclosed.

公开(公告)号：UY33957A

公开(公告)日：2012-10-31

申请号：UY33957

申请日：2012-03-15

Applicant: ABBOTT LAB

Inventor： ERICSSON ANNA M ,  MICHAEL FRIEDMAN ,  MORYTKO MICHAEL J ,  CUSACK KEVIN P ,  GORDON THOMAS D ,  IHLE DAVID C ,  HAYES MARTIN E ,  BREINLINGER ERIC C ,  BIN LI ,  LEI WANG ,  MARTINEZ GLORIA Y ,  ANDREW BURCHAT ,  HOBSON ADRIAN D ,  MULLEN KELLY D

IPC: A61K31/047 ,  A61K31/122 ,  A61K31/357 ,  A61K31/416 ,  A61K31/44 ,  A61P43/00 ,  C07C39/23 ,  C07C49/513 ,  C07C49/747 ,  C07C49/755 ,  C07D213/75 ,  C07D223/18 ,  C07D231/54 ,  C07D317/72 ,  C07D401/12 ,  C07D491/10

Abstract: Un compuesto de fórmula I, sales, prodrogas, metabolitos biológicamente activos, estereoisómeros e isómeros farmacéuticamente aceptables del mismo, en donde las variables se definieron en la presente. Los compuestos de la invención son de utilidad para el tratamiento de condiciones inmunológicas y oncológicas.

公开(公告)号：MX2009006751A

公开(公告)日：2009-06-30

申请号：MX2009006751

申请日：2007-12-21

Applicant: ABBOTT LAB

Inventor： FIX-STENZEL SHANNON R ,  GORDON THOMAS D ,  WALLACE GRIER A ,  GRONGSAARD PINTIPA ,  CUSACK KEVIN P ,  HOBSON ADRIAN D ,  BREINLINGER ERIC C ,  ANSELL GRAHAM K ,  HAYES MARTIN E

IPC: A01N43/50 ,  A61K31/415

Abstract: La presente invención se dirige a agentes novedosos, potentes y selectivos, los cuales son agonistas o antagonistas del uno omás de los receptores individuales de la familia del receptor S1P. Los compuestos de la presente invención son útiles como terapéuticos para tratar condiciones médicas asociadas con agonismo o antagonismo de los receptores individuales de la familia del receptor S1P.

公开(公告)号：SG177221A1

公开(公告)日：2012-01-30

申请号：SG2011094539

申请日：2007-12-14

Applicant: ABBOTT LAB

Inventor： HOBSON ADRIAN D ,  FIX-STENZEL SHANNON ,  CUSACK KEVIN P ,  BREINLINGER ERIC C ,  ANSELL GRAHAM K ,  STOFFEL ROBERT H ,  WOLLER KEVIN R ,  GRONGSAARD PINTIPA

Abstract: Novel oxadiazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions as agonists or antagonists of the SIP family of G protein-coupled receptors for treating diseases associated with modulation of SIP family receptor activity, in particular by affording a beneficial immunosuppressive effect are disclosed.