公开(公告)号：PE15612008A1

公开(公告)日：2008-10-30

申请号：PE0000512008

申请日：2008-01-02

Applicant: ABBOTT LAB

Inventor： WALLACE GRIER A ,  CUSACK KEVIN P ,  GORDON THOMAS D ,  BREINLINGER ERIC C ,  FIX-STENZEL SHANNON R ,  HOBSON ADRIAN D ,  ANSELL GRAHAM K ,  HAYES MARTIN E ,  GRONGSAARD PINTIPA

IPC: C07D205/00 ,  C07D207/00 ,  C07D211/00 ,  C07D229/00 ,  C07D231/00 ,  C07D237/00

CPC classification number: C07D413/04 ,  C07C215/38 ,  C07C215/42 ,  C07C217/52 ,  C07C217/74 ,  C07C229/14 ,  C07C229/48 ,  C07C2601/02 ,  C07C2601/08 ,  C07D205/04 ,  C07D207/12 ,  C07D207/14 ,  C07D213/30 ,  C07D263/32 ,  C07D263/52 ,  C07D271/06 ,  C07D307/22 ,  C07D307/24 ,  C07D333/16 ,  C07D491/107 ,  C07F9/091 ,  C07F9/301 ,  C07F9/3808 ,  C07F9/3826 ,  C07F9/4006 ,  C07F9/653 ,  C07F9/65515 ,  C07F9/655345

Abstract: REFERIDA A UN DERIVADO DE FENILO DE FORMULA (I), DONDE D ES H, N(R5)2, OR6; X ES CH, C(CH3), N; A ES H, OH, CH2OH, C(O)-OCH3, ENTRE OTROS; Y ES CH2. O, S, NR3; R1 Y R2 SON H, CF3, HALOGENO, ALQUILO C1-C20, ENTRE OTROS; m ES 1 O 2; u ES 0, 1 O 2. SON COMPUESTOS PREFERIDOS: [(1R,3S)-1-AMINO-3-(4-OCT-1-INIL-FENIL)CICLOPENTIL]METANOL, [(1R,3S)-1-AMINO-3-(4-OCTIL-FENIL)CICLOPENTIL]METANOL, {(1R,3S)-1-AMINO-3-[4-(3-FENOXI-PROPIL)FENIL]CICLOPENTIL}METANOL, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON AGONISTAS Y ANTAGONISTAS DE LOS RECEPTORES DE ESFINGOSINA-1-FOSFATO (S1P) Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL, ARTRITIS, LUPUS ERITEMATOSO SISTEMICO, ASMA, ENTRE OTROS

公开(公告)号：AU2007338700A1

公开(公告)日：2008-07-03

申请号：AU2007338700

申请日：2007-12-21

Applicant: ABBOTT LAB

Inventor： BREINLINGER ERIC C ,  GRONGSAARD PINTIPA ,  ANSELL GRAHAM K ,  HAYES MARTIN E ,  FIX-STENZEL SHANNON R ,  WALLACE GRIER A ,  HOBSON ADRIAN D ,  CUSACK KEVIN P ,  GORDON THOMAS D

IPC: A01N43/50 ,  A61K31/415

Abstract: The present invention is directed to novel, potent, and selective agents, which are agonists or antagonists of the one or more of the individual receptors of the S1P receptor family. The compounds of the invention are useful as therapeutics for treating medical conditions associated with agonism or antagonism of the individual receptors of the S1P receptor family.

公开(公告)号：AU2007334436A1

公开(公告)日：2008-06-26

申请号：AU2007334436

申请日：2007-12-14

Applicant: ABBOTT LAB

Inventor： FIX-STENZEL SHANNON ,  WOLLER KEVIN R ,  BREINLINGER ERIC C ,  GRONGSAARD PINTIPA ,  CUSACK KEVIN P ,  HOBSON ADRIAN D ,  STOFFEL ROBERT H ,  ANSELL GRAHAM K

IPC: A01N43/82 ,  A61K31/41

Abstract: Novel oxadiazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions as agonists or antagonists of the S1P family of G protein-coupled receptors for treating diseases associated with modulation of S1P family receptor activity, in particular by affording a beneficial immunosuppressive effect are disclosed.