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    4''-DEOXY-4''-OXOERYTHROMYCIN B DERIVATIVES
    21.
    发明专利
    4''-DEOXY-4''-OXOERYTHROMYCIN B DERIVATIVES 未知

    公开(公告)号：ZA743085B

    公开(公告)日：1975-05-28

    申请号：ZA743085

    申请日：1974-05-14

    Applicant: ABBOTT LAB

    Inventor： JONES P ,  PAUVLIK J ,  TADANIER J ,  MARTIN J ,  MCALPINE J

    IPC: C07H17/08 ,  C07C

    Abstract: 1463850 4 11 -Dioxy-4-oxo-erythromycin B derivatives ABBOTT LABORATORIES 19 June 1974 [21 June 1973] 27249/74 Heading C2C Novel compounds I and II in which R 5 is CH(R 7 )-SR 8 (where R 7 is hydrogen or C 1-6 alkyl and R 8 is C 1-6 alkyl) and R 6 is hydrogen or C 2-6 alkanoyl provided that when R 6 is hydrogen then R 5 is also hydrogen are prepared by reacting erythromycin B with a di-C 1-6 alkyl-sulphoxide and C 2-6 alkanoic acid anhydride to form a compound I (R 5 = CH(R 7 )-SR 8 and R 6 = C 2-6 alkanoyl) which is hydrolysed with an alkali metal bicarbonate to form a compound I (R 5 =CH(R 7 )-SR 8 and R 6 = hydrogen) which in the presence of HgO/ HgCl 2 forms a compound II which is hydrolysed by dil. HCl to compound I (R 5 = R 6 = hydrogen). Compound I (R 5 =R 6 =hydrogen) is also prepared by treating compound II with chloramine T.

    24.
    发明专利
    未知

    公开(公告)号：BR6912055D0

    公开(公告)日：1973-05-10

    申请号：BR21205569

    申请日：1969-09-02

    Applicant: ABBOTT LAB

    Inventor： JONES P ,  WIEGAND R ,  CHUN A

    IPC: C07H17/08 ,  C07D9/00

    Abstract: 1,258,352. Erythromycin salts. ABBOTT LABORATORIES. 3 Sept., 1969 [4 Sept., 1968], No. 43710/69. Heading C2A. Novel erythromycin aliphatic sulphate salts having the general formula wherein Ery represents the erythronolide and cladinose moieties of erythromycin A or B and n is zero or an integer from 1 to 4, are prepared by adding to a solution of erythromycin A or B in a suitable solvent (e.g. aqueous acetone) a molar equivalent of an alkali metal salt of an aliphatic sulphate, of formula CH 3 (CH 2 ) (10 +2n) .CH 2 OSO 2 (O-Alkali metal) wherein n is as above, together with an excess of an acid or acid salt over that required to react with the alkali metal from said alkali metal salt. The acid or acid salt (e.g. acetic acid, HC1, sodium dihydrogen phosphate or sodium hydrogen sulphate) is preferably added in sufficient quantity to bring the pH to 5.5 to 6.5. The mixture is preferably warmed to aid the reaction, and the product is precipitated by adding water to the reaction mixture. Pharmaceutical compositions having antibiotic activity comprise an erythromycin aliphatic sulphate salt of Formula I as defined above together with a pharmaceutically acceptable carrier. They are preferably in forms for oral administration, e.g. tablets, chewable tablets or reconstitutable powders or granules.

    25.
    发明专利
    未知

    公开(公告)号：BR6800021D0

    公开(公告)日：1973-02-22

    申请号：BR20002168

    申请日：1968-06-20

    Applicant: ABBOTT LAB

    Inventor： JONES P

    IPC: C07H17/08

    26.
    发明专利
    未知

    公开(公告)号：SE346993B

    公开(公告)日：1972-07-24

    申请号：SE507367

    申请日：1967-04-12

    Applicant: ABBOTT LAB

    Inventor： JONES P

    IPC: C07H17/08

    Abstract: 1,125,544. Erythromycin derivatives. ABBOTT LABORATORIES. 5 April, 1967 [13 April, 1966], No. 15717/67. Heading C2A. The invention relates to 3 1 -desdimethylamino- #3 1 ,4 1 -erythromycins A and B of formula wherein R is hydrogen (B compound) or hydroxy (A compound). The compounds are prepared by heating erythromycin A-N-oxide or erythromycin B-N-oxide under vacuum to a temperature of 150-190‹ C. The compounds are active against schistomiasia infections. A suspension in aqueous tragacanth solution of one of the above compounds may be used for treating schistomiasis in animals.

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