公开(公告)号：BE885399A

公开(公告)日：1981-03-25

申请号：BE202232

申请日：1980-09-25

Applicant: ABBOTT LAB

Inventor： MARTIN J ,  TADANIER J ,  HALLAS R

IPC: A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/7036 ,  A61K31/7042 ,  A61P31/04 ,  C07H15/224 ,  C07H17/00 ,  C07D ,  A61K

公开(公告)号：PH10395A

公开(公告)日：1977-03-04

申请号：PH15865

申请日：1974-05-27

Applicant: ABBOTT LAB

Inventor： JONES P ,  MARTIN J ,  TADANIER J ,  MCALPINE J ,  PAULIK J

IPC: C07H17/08 ,  C07G11/00

Abstract: 1463850 4 11 -Dioxy-4-oxo-erythromycin B derivatives ABBOTT LABORATORIES 19 June 1974 [21 June 1973] 27249/74 Heading C2C Novel compounds I and II in which R 5 is CH(R 7 )-SR 8 (where R 7 is hydrogen or C 1-6 alkyl and R 8 is C 1-6 alkyl) and R 6 is hydrogen or C 2-6 alkanoyl provided that when R 6 is hydrogen then R 5 is also hydrogen are prepared by reacting erythromycin B with a di-C 1-6 alkyl-sulphoxide and C 2-6 alkanoic acid anhydride to form a compound I (R 5 = CH(R 7 )-SR 8 and R 6 = C 2-6 alkanoyl) which is hydrolysed with an alkali metal bicarbonate to form a compound I (R 5 =CH(R 7 )-SR 8 and R 6 = hydrogen) which in the presence of HgO/ HgCl 2 forms a compound II which is hydrolysed by dil. HCl to compound I (R 5 = R 6 = hydrogen). Compound I (R 5 =R 6 =hydrogen) is also prepared by treating compound II with chloramine T.

公开(公告)号：PH14238A

公开(公告)日：1981-04-09

申请号：PH21929

申请日：1978-12-12

Applicant: ABBOTT LAB

Inventor： MARTIN J ,  TADANIER J

IPC: A01N43/14 ,  C07H15/224 ,  C07G3/00 ,  A61K31/00 ,  C07G11/00

公开(公告)号：BE885402A

公开(公告)日：1981-03-25

申请号：BE202235

申请日：1980-09-25

Applicant: ABBOTT LAB

Inventor： NADZAN A ,  TADANIER J ,  MARTIN J ,  JOHNSON P

IPC: C07H15/224 ,  C07D ,  A61K

公开(公告)号：ZA7705652B

公开(公告)日：1979-04-25

申请号：ZA7705652

申请日：1977-09-21

Applicant: ABBOTT LAB

Inventor： TADANIER J ,  MORI Y ,  SATO M ,  MARTIN J ,  KURATH P

IPC: C07D309/14 ,  A61K31/35 ,  A61K31/351 ,  A61K31/415 ,  A61P31/04 ,  C07D405/12 ,  C07H15/224 ,  A61K ,  C07C

CPC classification number: C07H15/224

公开(公告)号：ZA7402272B

公开(公告)日：1975-03-26

申请号：ZA7402272

申请日：1974-04-09

Applicant: ABBOTT LAB

Inventor： TADANIER J ,  HALLAS R ,  MARTIN J

IPC: A61K31/335 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  C07C

CPC classification number: C07H17/08

公开(公告)号：ZA7403085B

公开(公告)日：1975-05-28

申请号：ZA7403085

申请日：1974-05-14

Applicant: ABBOTT LAB

Inventor： JONES P ,  PAUVLIK J ,  TADANIER J ,  MARTIN J ,  MCALPINE J

IPC: C07H17/08 ,  C07C

CPC classification number: C07H17/08