公开(公告)号：WO1997030750A1

公开(公告)日：1997-08-28

申请号：PCT/US1997002418

申请日：1997-02-18

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  WANG, Jianjun ,  BOUSKA, Annette, G. ,  DRAYER, Lonnie, R.

IPC: A61M37/00

CPC classification number: A61B8/4281 ,  A61M37/0092 ,  G10K11/18

Abstract: A method for conducting an ultrasound procedure on an object having a target surface. The method includes the step of providing an ultrasound probe having an acoustical wave emitting end portion. A pad for transmitting acoustical waves between the ultrasound probe and a target surface of an object also is provided. The pad includes a first layer having a first porous portion which defines first layer pores therethrough. The first layer pores have a first layer pore dimension. The pad further includes a second layer having a first porous portion which defines second layer pores therethrough. The second layer pores have a second layer pore dimension. The second layer is attached to the first layer so as to define a space therebetween. The first porous portion of the first layer overlies the first porous portion of the layer. An ultrasound couplant is disposed in the space defined between the first layer and the second layer. The ultrasound couplant has a molecule size which is less than or substantially equal to the first layer pore dimension, and which is less than or substantially equal to the second layer pore dimension. The method further includes the steps of placing the first porous portion of the second layer in contact with a target surface and placing the acoustical wave emitting end portion of the ultrasound probe in contact with the first porous portion of the first layer. The ultrasound probe is then activated.

Abstract translation: 一种用于在具有目标表面的物体上进行超声程序的方法。 该方法包括提供具有声波发射端部的超声波探头的步骤。 还提供了用于在超声波探头和物体的目标表面之间传输声波的垫。 垫包括具有第一多孔部分的第一层，其限定穿过其中的第一层孔。 第一层孔具有第一层孔尺寸。 垫还包括具有第一多孔部分的第二层，第一多孔部分限定穿过其中的第二层孔。 第二层孔具有第二层孔尺寸。 第二层连接到第一层以便在它们之间限定一个空间。 第一层的第一多孔部分覆盖在该层的第一多孔部分上。 超声耦合剂设置在第一层和第二层之间限定的空间中。 超声耦合剂具有小于或基本上等于第一层孔尺寸的分子尺寸，其小于或基本上等于第二层孔尺寸。 该方法还包括以下步骤：将第二层的第一多孔部分与目标表面接触，并将超声波探头的声波发射端部与第一层的第一多孔部分接触。 然后激活超声波探头。

公开(公告)号：WO1997030045A1

公开(公告)日：1997-08-21

申请号：PCT/US1997001936

申请日：1997-02-12

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  WINN, Martin ,  BOYD, Steven, A. ,  HUTCHINS, Charles, W. ,  JAE, Hwan-Soo ,  TASKER, Andrew, S. ,  VON GELDERN, Thomas, W. ,  KESTER, Jeffrey, A. ,  SORENSEN, Bryan, K. ,  SZCZEPANKIEWICZ, Bruce, G. ,  HENRY, Kenneth, J., Jr. ,  LIU, Gang ,  WITTENBERGER, Steven, J. ,  KING, Steven, A.

IPC: C07D405/04

CPC classification number: C07D401/04 ,  C07D207/16 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  Y02P20/55

Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.

Abstract translation: 公开了式（I）化合物或其药学上可接受的盐，以及其制备方法和中间体，以及拮抗内皮素的方法。

公开(公告)号：WO1997029090A1

公开(公告)日：1997-08-14

申请号：PCT/US1997001953

申请日：1997-02-06

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  KOLASA, Teodozyj ,  GUNN, David, E. ,  BROOKS, Clint, D., W.

IPC: C07D215/14

CPC classification number: C07D215/18 ,  C07D215/14 ,  C07D241/42 ,  C07D277/64

Abstract: Compounds having structure (I), where m is an integer of from one to nine; n is an integer of from one to four; W is selected from unsubstituted quinolyl, benzothiazolyl, or quinoxalyl, or quinolyl, benzothiazolyl, or quinoxalyl substituted with one, two or three substituents selected from the group consisting of halogen, C1-6 alkyl, and C1-6 alkoxy; X is absent or is selected from the group consisting of (a) C1-6 alkylene; (b) C1-6 alkenylene; and (c) C1-6 alkynylene; Y is one to four substituents independently selected from halogen, C1-6 alkyl, and C1-6 alkoxy; Z is selected from the group consisting of (a) COB; (b) C(R )2-O-N=A-COB; and (c) C(R )=N-O-A-COB where A is C1-6 alkylene, and B is selected from the group consisting of (a) -OH; (b) -O M where M is a pharmaceutically acceptable cation; (c) -OR where R is hydrogen or alkyl of one to six carbon atoms; (d) -NR R where R is as previously defined and R is selected from the group consisting of hydrogen, alkyl of one to six carbon atoms, hydroxy, and alkoxy of from one to six carbon atoms, or R and R , together with the atom to which they are attached, form a ring of five to eight members containing one optional heteratom selected from N, O and S; and (e) -O-D where D is a metabolically cleavable group, are inhibitors of leukotriene biosynthesis.

Abstract translation: 具有结构（I）的化合物，其中m是1至9的整数; n是1到4的整数; W选自未取代的喹啉基，苯并噻唑基或喹喔啉基，或喹啉基，苯并噻唑基或喹喔啉基，其被一个，两个或三个选自卤素，C 1-6烷基和C 1-6烷氧基的取代基取代; X不存在或选自（a）C 1-6亚烷基; （b）C 1-6亚烯基; 和（c）C1-6亚炔基; Y是一至四个独立地选自卤素，C 1-6烷基和C 1-6烷氧基的取代基; Z选自（a）COB; （b）C（R 2）2 -O-N = A-COB; 和（c）C（R 2）= N-O-A-COB，其中A是C 1-6亚烷基，B选自（a）-OH; （b）-O - M +，其中M是药学上可接受的阳离子; （c）-OR 6其中R 6为氢或1至6个碳原子的烷基; （d）-NR 6 R 7，其中R 6如前所定义，R 7选自氢，1至6个碳原子的烷基，羟基和1位的烷氧基 至6个碳原子，或R 6和R 7与它们所连接的原子一起形成含有一个任选的选自N，O和S的杂原子的五至八个成员的环; 和（e）-O-D，其中D是代谢可裂解基团，是白三烯生物合成的抑制剂。

公开(公告)号：WO1997028376A1

公开(公告)日：1997-08-07

申请号：PCT/US1997001329

申请日：1997-01-30

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  PAN, Jeffrey, Y. ,  MAGREGANY, Mehran

IPC: F15C05/00

CPC classification number: F16K99/0001 ,  F15C5/00 ,  F16K31/02 ,  F16K99/0015 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/008 ,  Y10T137/0318

Abstract: An actuator and a method of controlling the actuator are disclosed. In one embodiment, the actuator is a valve (18) comprising a first port (26) and a second port (28) fluidly connected with the first port such that fluid communicates between the first port and the second port. A flexible member (22) is operatively connected with the first port and the second port. The flexible member is movable between a first position permitting fluid communication between the first port and the second port and a second position reducing fluid communication between the first port and the second port. A first controller (36) is operatively connected with the flexible member for moving the flexible member between the first position and the second position. A second controller (44A) is operatively connected with the flexible member for retaining the flexible member in the second position.

Abstract translation: 公开了一种致动器和控制致动器的方法。 在一个实施例中，致动器是阀（18），其包括与第一端口流体连接的第一端口（26）和第二端口（28），使得流体在第一端口和第二端口之间连通。 柔性构件（22）可操作地与第一端口和第二端口连接。 柔性构件可在允许第一端口和第二端口之间流体连通的第一位置和第二位置之间移动，从而减少第一端口和第二端口之间的流体连通。 第一控制器（36）可操作地与柔性构件连接，用于在第一位置和第二位置之间移动柔性构件。 第二控制器（44A）可操作地与柔性构件连接，用于将柔性构件保持在第二位置。

公开(公告)号：WO1997027486A1

公开(公告)日：1997-07-31

申请号：PCT/US1997001074

申请日：1997-01-17

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  HACKETT, John, R., Jr. ,  HOFF, Jane, A. ,  OSTROW, David, H. ,  GOLDEN, Alan, M.

IPC: G01N33/96

CPC classification number: G01N33/6857 ,  G01N33/6854 ,  G01N33/96

Abstract: The present invention relates to the use of a reagent that binds specifically to a predetermined ligand, contains one or more antibody constant region epitopes, and is uniform in specificity and affinity. The reagent can be produced continually, in the manufacture of calibrators (standards) and/or controls for diagnostic kits designed to qualitatively or quantitatively measure antibodies specific for a desired ligand. For example, the present invention encompasses recombinant mouse-human chimeric antibodies which may be used as calibrators (standards) and/or positive controls in assays and kits which measure human antibodies. Any species may be used in creating the chimeric antibodies, and the presence of any corresponding species of antibody may be detected.

Abstract translation: 本发明涉及特异性结合预定配体的试剂的使用，含有一个或多个抗体恒定区表位，并且具有特异性和亲和性。 试剂可以连续生产，用于制造用于定性或定量测量所需配体特异性抗体的诊断试剂盒（标准）和/或对照。 例如，本发明包括重组小鼠 - 人嵌合抗体，其可用作测定人抗体的测定和试剂盒中的校准物（标准品）和/或阳性对照。 可以使用任何物种来产生嵌合抗体，并且可以检测任何相应种类的抗体的存在。

公开(公告)号：WO1997027274A1

公开(公告)日：1997-07-31

申请号：PCT/US1997001441

申请日：1997-01-24

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  MAZER, Terrence, Bruce ,  MILLER, Robert, A. ,  BARNICKI, Scott, D. ,  SUMNER, Charles, Edwan, Jr.

IPC: C11C01/02

CPC classification number: C11C3/02 ,  C11C1/025 ,  C11C1/10 ,  C11C3/003

Abstract: This invention relates to a process for the isolation of fatty acids and fatty acid esters from complex naturally occurring mixtures which contain sterols, triglycerides and phospholipids. A preferred embodiment of the invention comprises (a) extracting lipids from egg yolk solids with methanol; (b) separating lipids including sterols from insoluble egg yolk components; (c) submitting the methanolic solution of lipids to alkaline hydrolysis and subsequent neutralization to convert lipids to free fatty acids together with sterols; (d) separating the said sterols and acids from an aqueous phase formed in the hydrolysis reaction; (e) heating said free fatty acids and sterols to convert the sterols to fatty acid sterol esters; (f) subjecting the mixture to distillation to separate the sterol esters from the free fatty acids; and (g) subjecting the said acids to esterification in the presence of glycerol to produce triglycerides of said fatty acids wherein the resulting triglycerides contain reduced quantities of sterols and phosphorus. An enteral nutritional formula containing the triglycerides produced in the above process is also disclosed.

Abstract translation: 本发明涉及从含有甾醇，甘油三酯和磷脂的复杂天然存在的混合物中分离脂肪酸和脂肪酸酯的方法。 本发明的优选实施方案包括（a）用甲醇从蛋黄固体中提取脂质; （b）分离包括固醇的脂质不溶于蛋黄成分; （c）将脂质的甲醇溶液提取到碱性水解并随后中和，将脂质与甾醇一起转化为游离脂肪酸; （d）从所述水解反应中形成的水​​相中分离所述甾醇和酸; （e）加热所述游离脂肪酸和甾醇以将甾醇转化为脂肪酸甾醇酯; （f）使混合物进行蒸馏以将固醇酯与游离脂肪酸分离; 和（g）在甘油存在下使所述酸进行酯化以产生所述脂肪酸的甘油三酸酯，其中所得甘油三酸酯含有降低量的甾醇和磷。 还公开了含有在上述方法中生产的甘油三酯的肠内营养配方。

公开(公告)号：WO1997023162A1

公开(公告)日：1997-07-03

申请号：PCT/US1996019315

申请日：1996-12-05

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  HUGHES, Timothy, J.

IPC: A61B05/029

CPC classification number: A61B5/028 ,  A61B5/7257 ,  G01K7/25

Abstract: A method and apparatus for correcting thermal drift in cardiac output measurements based upon a temperature signal indicative of the change in temperature of blood leaving the heart is disclosed. In a first preferred embodiment of a cardiac output monitoring system (10), the catheter (14) is provided with an electrical resistance heater (22). An electrical current having a sinusoidal waveform with a period of from 30 to 60 seconds is applied to the heater, causing power to be dissipated into the blood within a patient's heart (12). A temperature sensor (24) disposed near a distal end of the catheter produces a signal indicative of the temperature of blood leaving the heart. The temperature signal and the signal corresponding to the electrical power dissipated in the heater (an input signal) are filtered at a frequency omega n corresponding to the frequency of the applied electrical current, i.e., the frequency of the input signal. An output signal indicative of the temperature of the blood leaving the heart corrected for the effects of thermal drift is then calculated. The blood temperature output signal is first split into two equal overlapping time periods. The two signals are then filtered separately to produce two partially independent output signals in the frequency domain. These two frequency domain output signals are then combined into a single corrected frequency domain output signal with the effects of thermal drift removed. The amplitude of the input power, the amplitude of the temperature signal corrected for thermal drift, and their phase difference are then used in calculating cardiac output.

Abstract translation: 公开了一种基于指示离开心脏的血液温度变化的温度信号来校正心输出量测量中的热漂移的方法和装置。 在心输出量监测系统（10）的第一优选实施例中，导管（14）设置有电阻加热器（22）。 将具有30至60秒周期的正弦波形的电流施加到加热器，使得电力消散到患者心脏（12）内的血液中。 设置在导管的远端附近的温度传感器（24）产生指示离开心脏的血液的温度的信号。 对应于在加热器（输入信号）中消耗的电功率的温度信号和信号以与所施加的电流的频率即输入信号的频率相对应的频率ωn被滤波。 然后计算表示为热漂移的影响而校正的离开心脏的血液的温度的输出信号。 首先将血液温度输出信号分为两个等重叠时间段。 然后分别对两个信号进行滤波，以在频域中产生两个部分独立的输出信号。 然后将这两个频域输出信号组合成单个校正的频域输出信号，并消除热漂移的影响。 输入功率的振幅，热漂移校正的温度信号的振幅及其相位差用于计算心输出量。

公开(公告)号：WO1997022291A1

公开(公告)日：1997-06-26

申请号：PCT/US1996018870

申请日：1996-11-26

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  HENNING, Timothy, P. ,  SHAIN, Eric, B. ,  KHALIL, Gamal ,  ELSTROM, Tuan, A.

IPC: A61B05/00

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/6848

Abstract: The present invention relates to a device (10) for the sampling of blood or other body fluids which includes means (16) for the direct measurement of the analyte of interest within the fluid. Also disclosed is a "closed-loop" device and method wherein the analyte is measured and the required amount of drug is determined and injected, without removal of the device from the patient's body.

Abstract translation: 本发明涉及一种用于对血液或其他体液进行取样的装置（10），其包括用于直接测量流体内感兴趣分析物的装置（16）。 还公开了一种“闭环”装置和方法，其中测量分析物，并且确定和注射所需量的药物，而不从装置从患者身体移除。

公开(公告)号：WO1997022252A1

公开(公告)日：1997-06-26

申请号：PCT/US1996020596

申请日：1996-12-20

Applicant: BASF CORPORATION ,  ABBOTT LABORATORIES

Inventor： BASF CORPORATION ,  ABBOTT LABORATORIES

IPC: A01N43/40

CPC classification number: A01N43/40 ,  A01N25/04 ,  A01N37/36 ,  A01N37/44 ,  A01N2300/00 ,  A01N43/653 ,  A01N43/54 ,  A01N37/42 ,  A01N37/30 ,  A01N33/12

Abstract: Provided are compositions and methods of improving a plant growth factor. The compositions and methods contain combinations of aminoethoxyvinylglycine and mepiquat chloride. The compositions provide an improvement in a plant growth factor, such as an increase in yield in cotton plant.

Abstract translation: 提供改善植物生长因子的组合物和方法。 组合物和方法含有氨基乙氧基乙烯基甘氨酸和氯化丙基氯的组合。 组合物提供了植物生长因子的改善，例如棉花植物的产量增加。

公开(公告)号：WO1997021994A1

公开(公告)日：1997-06-19

申请号：PCT/US1996020466

申请日：1996-12-13

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  YOUNG RAN, Kim ,  YEE, Michael, W. ,  MEHTA, Suresh, N. ,  SAGALA, Josefino, C.

IPC: G01N15/14

CPC classification number: G01N15/1456

Abstract: Simultaneous and quantitative, flow cytometric analysis method of determining nucleated red blood cells (NRBC), white blood cells (WBC), damaged WBC and a WBC differential (WBC/Diff) utilizing a triple trigger AND/OR logic.

Abstract translation: 同时和定量的流式细胞分析方法，使用三重触发AND / OR逻辑确定有核红细胞（NRBC），白细胞（WBC），损伤的WBC和WBC差异（WBC / Diff）。