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21.发明授权TRICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS 失效三环取代六氢苯并[E]异吲哚ALPHA-1肾上腺素能受体拮抗剂
公开(公告)号：EP0808318B1
公开(公告)日：2000-06-28
申请号：EP96903340.6
申请日：1996-01-11
Applicant: Abbott Laboratories
Inventor： MEYER, Michael, D. , ALTENBACH, Robert, J. , BASHA, Fatima, Z. , CARROLL, William, A. , DRIZIN, Irene , KERWIN, James, F., Jr. , LEBOLD, Suzanne, A. , LEE, Edmund, L. , ELMORE, Steven, W. , SIPPY, Kevin, B. , TIETJE, Karin, R. , WENDT, Michael, D. , YAMAMOTO, Diane, M.
IPC: C07D495/04 , C07D491/048 , C07D487/04 , C07D403/06 , C07D491/147 , C07D495/14 , C07D487/16 , C07D471/14 , A61K31/395
CPC classification number: C07D403/06 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/04 , C07D491/14 , C07D495/04 , C07D495/14
Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an α-1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are α-1 antagonist compositions and a method for antagonizing α-1 receptors and treating BPH.
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公开(公告)号：EP1124828B1
公开(公告)日：2008-01-02
申请号：EP99960168.5
申请日：1999-10-28
Applicant: ABBOTT LABORATORIES
Inventor： CARROLL, William, A. , AGRIOS, Konstantinos, A. , ALTENBACH, Robert, J. , DRIZIN, Irene , KORT, Michael, E.
IPC: C07D471/04 , C07D471/14 , C07D495/14 , C07D491/04 , C07D491/14 , C07D495/04 , A61K31/44 , A61K31/47 , A61P9/12 , A61P11/06 , A61P13/10 , A61P15/00 , A61P21/00 , A61P25/08 , A61P29/00
CPC classification number: C07D471/04 , C07C45/00 , C07C45/298 , C07C45/41 , C07C45/63 , C07C205/44 , C07D471/14 , C07D491/14 , C07D495/14 , C07C47/565 , C07C47/55
Abstract: The present invention provides novel compounds of formula (I) which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.
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公开(公告)号：EP1278747B1
公开(公告)日：2006-08-23
申请号：EP01935065.1
申请日：2001-05-03
Applicant: ABBOTT LABORATORIES
Inventor： CARROLL, William, A. , AGRIOS, Konstantinos A. , ALTENBACH, Robert, J. , DRIZIN, Irene , KORT, Michael, J.
IPC: C07D471/14 , C07D491/14 , C07D495/14 , C07D471/04 , A61K31/4745 , A61P13/10 , A61P15/00
CPC classification number: C07D471/04 , C07C45/00 , C07C45/298 , C07C45/41 , C07C45/63 , C07C205/44 , C07D471/14 , C07D491/14 , C07D495/14 , C07C47/565 , C07C47/55
Abstract: The present invention provides novel compounds of formula (I), which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.
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24.发明授权TRICYCLIC DIHYDROPYRAZOLONE AND TRICYCLIC DIHYDROISOXAZOLONE POTASSIUM CHANNEL OPENERS 有权三环dihydropyrazolones和三环DIHYDROISOAXAZOLONE钾通道开放
公开(公告)号：EP1259510B1
公开(公告)日：2004-06-02
申请号：EP01918338.3
申请日：2001-03-02
Applicant: ABBOTT LABORATORIES
Inventor： DRIZIN, Irene , ALTENBACH, Robert, J. , CARROLL, William, A.
IPC: C07D471/04 , C07D495/14 , C07D491/04 , C07D491/14 , C07D498/14 , C07D498/04 , A61K31/4353 , A61P13/00 , A61P9/00
CPC classification number: C07D471/04 , C07C45/298 , C07C45/41 , C07C45/63 , C07C205/44 , C07D491/14 , C07D495/14 , C07C47/55
Abstract: Compounds of formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
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公开(公告)号：EP1242422A1
公开(公告)日：2002-09-25
申请号：EP00980801.5
申请日：2000-11-17
Applicant: ABBOTT LABORATORIES
Inventor： HOLLADAY, Mark, W. , CARROLL, William, A. , DRIZIN, Irene , YI, Lin , ZHANG, Henry, Q.
IPC: C07D487/04 , C07D495/14 , C07D491/14 , A61K31/505 , A61P9/12
CPC classification number: C07D487/04 , C07D491/14 , C07D495/14
Abstract: Compounds of formula (I), are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
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Patent Agency Ranking26.发明公开BENZOPYRANOPYRROLE AND BENZOPYRANOPYRIDINE ALPHA-1 ADRENERGIC COMPOUNDS 失效苯并吡喃吡咯和苯并吡喃吡啶ALPHA-1 ADRENERGIC化合物
公开(公告)号：EP0942911A1
公开(公告)日：1999-09-22
申请号：EP97951555.0
申请日：1997-12-04
Applicant: Abbott Laboratories
Inventor： MEYER, Michael, D. , ALTENBACH, Robert, J. , BASHA, Fatima , CARROLL, William, A. , DRIZIN, Irene , KERWIN, James, F. , WENDT, Michael, D. , HAIGHT, Anthony, R. , ZHANG, Weijiang
CPC classification number: C07D491/04
Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are α-1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are α-1 antagonist compositions and a method for antagonizing α-1 adrenoreceptors and treating BPH.
Abstract translation: 本发明涉及式（I）化合物及其药学上可接受的盐，其中W为双环杂环系统。 这些化合物是α-1肾上腺素能拮抗剂，可用于治疗BPH; 还公开了α-1拮抗剂组合物和用于拮抗α-1肾上腺素受体并治疗BPH的方法。
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27.发明公开TRICYCLIC SUBSTITUTED HEXAHYDROBENZ E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS 失效三环取代六氢苯并（E）异吲哚α-1肾上腺素能拮抗剂
公开(公告)号：EP0808318A1
公开(公告)日：1997-11-26
申请号：EP96903340.0
申请日：1996-01-11
Applicant: Abbott Laboratories
Inventor： MEYER, Michael, D. , ALTENBACH, Robert, J. , BASHA, Fatima, Z. , CARROLL, William, A. , DRIZIN, Irene , KERWIN, James, F., Jr. , LEBOLD, Suzanne, A. , LEE, Edmund, L. , ELMORE, Steven, W. , SIPPY, Kevin, B. , TIETJE, Karin, R. , WENDT, Michael, D. , YAMAMOTO, Diane, M.
CPC classification number: C07D403/06 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/04 , C07D491/14 , C07D495/04 , C07D495/14
Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an α-1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are α-1 antagonist compositions and a method for antagonizing α-1 receptors and treating BPH.
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28.发明授权FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR 有权CONDENSED AZABICYCLISCHEVERBINDUNGEN作为香草素受体1的抑制剂（VR1）
公开(公告)号：EP1478363B1
公开(公告)日：2009-01-14
申请号：EP03716014.0
申请日：2003-02-11
Applicant: ABBOTT LABORATORIES
Inventor： LEE, Chih-Hung , BAYBURT, Erol, K. , DIDOMENICO, Stanley Jr. , DRIZIN, Irene , GOMTSYAN, Arthur, R. , KOENIG, John R. , PERNER, Richard, J. , SCHMIDT, Robert G. , TURNER, Sean C. , WHITE, Tammie, K. , ZHENG, Guo, Zhu
IPC: A61K31/502 , C07D217/02 , C07D237/28 , C07D217/22 , C07D209/08 , C07D231/56 , A61K31/472 , A61K31/416 , A61K31/404
CPC classification number: C07D249/08 , A61K31/404 , A61K31/416 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D209/08 , C07D217/02 , C07D217/22 , C07D217/24 , C07D217/26 , C07D231/12 , C07D231/56 , C07D233/56 , C07D237/28 , C07D401/12 , C07D405/12
Abstract: Compounds of formula (I), are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.
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公开(公告)号：EP1040097B1
公开(公告)日：2004-04-14
申请号：EP98963249.2
申请日：1998-12-16
Applicant: Abbott Laboratories
Inventor： CARROLL, William, A. , HOLLADAY, Mark, W. , SULLIVAN, James, P. , DRIZIN, Irene , ZHANG, Henry, Q.
IPC: C07D211/84 , C07D215/36 , C07D495/04 , C07D495/14 , A61K31/44 , A61K31/47 , A61K31/38
CPC classification number: C07D221/04 , C07C45/298 , C07D215/36 , C07D495/04 , C07D495/14 , C07C47/55
Abstract: Compounds having the formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
Abstract translation: 具有式（I）的化合物可用于治疗由钾通道开放剂预防或改善的疾病。 还公开了钾通道开放组合物和在哺乳动物中打开钾通道的方法。
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公开(公告)号：EP1278747A1
公开(公告)日：2003-01-29
申请号：EP01935065.1
申请日：2001-05-03
Applicant: Abbott Laboratories
Inventor： CARROLL, William, A. , AGRIOS, Konstantinos A. , ALTENBACH, Robert, J. , DRIZIN, Irene , KORT, Michael, J.
IPC: C07D471/14 , C07D491/14 , C07D495/14 , C07D471/04 , A61K31/4745 , A61P13/10 , A61P15/00
CPC classification number: C07D471/04 , C07C45/00 , C07C45/298 , C07C45/41 , C07C45/63 , C07C205/44 , C07D471/14 , C07D491/14 , C07D495/14 , C07C47/565 , C07C47/55
Abstract: The present invention provides novel compounds of formula (I), which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.
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