公开(公告)号：CA2276110A1

公开(公告)日：1998-07-09

申请号：CA2276110

申请日：1997-12-29

Applicant: BASF AG

Inventor： ALTMANN-JOEHL REGULA ,  SEULBERGER HARALD ,  ALTHOEFER HENNING ,  PHILIPPSEN PETER

IPC: C12N15/09 ,  C07K14/37 ,  C12N1/15 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10 ,  C12N9/88 ,  C12N15/00 ,  C12N15/31 ,  C12N15/60 ,  C12P25/00 ,  C12Q1/18 ,  C12Q1/68 ,  C12R1/645 ,  C12R1/865 ,  C12N5/10 ,  C12N1/14 ,  C12N1/19 ,  C12N1/20

Abstract: A gene is disclosed which contains the nucleotide sequence represented by SE ID NO:1 and which extends from nucleotide 671 to nucleotide 6295, or a nucleotide sequence derived therefrom by substitution, insertion or deletion of up to 30 %, 20 %, 10 % or 5 % of its nucleotides, the lower percentages being preferable, and whose genetic product exhibits the enzymatic activity of an adenylate cyclase. Also disclosed is its use.

公开(公告)号：DE60314258T2

公开(公告)日：2008-02-07

申请号：DE60314258

申请日：2003-08-23

Applicant: BASF AG

Inventor： FREUND ANNETTE ,  ROEHL FRANZ ,  ALTHOEFER HENNING ,  KAROS MARVIN ,  KAESLER BRUNO ,  LACOUR THIERRY

IPC: C12Q1/34 ,  A01N43/90 ,  A01N61/00 ,  C12N9/78 ,  C12N15/04 ,  C12N15/52 ,  C12Q1/32

Abstract: The present invention relates to methods for determining GTP Cyclohydrolase I or II activity in a sample.

公开(公告)号：CA2457807A1

公开(公告)日：2003-03-06

申请号：CA2457807

申请日：2002-08-23

Applicant: BASF AG

Inventor： REVUELTA DOVAL JOSE L ,  KAROS MARVIN ,  KROEGER BURKHARD ,  ALTHOEFER HENNING

IPC: C12N15/09 ,  C07K16/40 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N15/31 ,  C12P25/00 ,  C12Q1/68 ,  C12N15/52 ,  C12Q1/25 ,  C12N15/81

Abstract: The invention relates to novel polynucleotides of Ashbya gossypii; oligonucleotides hybridizing therewith; expression cassettes and vectors containing said polynucleotides; microorganisms transformed therewith; polypetides coded by said polynucleotides; and the use of the novel polypeptides and polynucleotides as targets in the modulation of metabolism reactions and especially in order to improve vitamin B2 production in microorganisms of the genus Ashbya.

公开(公告)号：DE10046083A1

公开(公告)日：2002-03-28

申请号：DE10046083

申请日：2000-09-15

Applicant: BASF AG

Inventor： ALTHOEFER HENNING ,  REVUELTA DOVAL JOSE L ,  SANTOS MARIA

IPC: C07K14/37 ,  C12N1/15 ,  C12P13/04

Abstract: The invention relates to novel nucleic acid molecules and polypeptides encoded thereby, which may be used for identification or classification of Ashbya gossypii or related types of micro-organisms.

公开(公告)号：DE60314258D1

公开(公告)日：2007-07-19

申请号：DE60314258

申请日：2003-08-23

Applicant: BASF AG

Inventor： FREUND ANNETTE ,  ROEHL FRANZ ,  ALTHOEFER HENNING ,  KAROS MARVIN ,  KAESLER BRUNO ,  LACOUR THIERRY

IPC: C12Q1/34 ,  A01N43/90 ,  A01N61/00 ,  C12N9/78 ,  C12N15/04 ,  C12N15/52 ,  C12Q1/32

Abstract: The present invention relates to methods for determining GTP Cyclohydrolase I or II activity in a sample.

公开(公告)号：AT364095T

公开(公告)日：2007-06-15

申请号：AT03750433

申请日：2003-08-23

Applicant: BASF AG

Inventor： FREUND ANNETTE ,  ROEHL FRANZ ,  ALTHOEFER HENNING ,  KAROS MARVIN ,  KAESLER BRUNO ,  LACOUR THIERRY

IPC: C12Q1/34 ,  A01N43/90 ,  A01N61/00 ,  C12N9/78 ,  C12N15/04 ,  C12N15/52 ,  C12Q1/32

Abstract: The present invention relates to methods for determining GTP Cyclohydrolase I or II activity in a sample.

公开(公告)号：DE10315760A1

公开(公告)日：2004-10-21

申请号：DE10315760

申请日：2003-04-07

Applicant: BASF AG

Inventor： ALTHOEFER HENNING ,  KESELER MARIA

IPC: C12N9/04 ,  C12N15/53 ,  C12P7/04 ,  C12P13/00 ,  C12P17/00 ,  C12P41/00 ,  C12P7/02

Abstract: The present invention relates to proteins having an enzymatic activity of reducing substituted alkanones such as 3-methylamino-1-(2-thienyl)-propan-1-one. The invention furthermore relates to nucleic acids coding for said proteins, nucleic acid constructs, vectors, genetically modified microorganisms and to methods for preparing substituted (S)-alkanols, such as, for example, (S)-3-methylamino-1-(2-thienyl)-(S)-propanol.

公开(公告)号：DE10209363A1

公开(公告)日：2003-09-11

申请号：DE10209363

申请日：2002-03-02

Applicant: BASF AG

Inventor： ALTHOEFER HENNING

IPC: A01H5/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/52 ,  C12N15/80 ,  C12P25/00 ,  C12R1/15 ,  C12R1/645 ,  C12R1/865 ,  C12N15/00 ,  C12N15/63

Abstract: The invention relates to transcription terminators, to an organism containing at least one of these transcription terminators, and to a method for producing riboflavin. According to the invention, an organism is grown, which is capable of producing riboflavin and has at least one of these transcription terminators, whereby the respective transcription terminator is operatively linked to at least one rib gene.

公开(公告)号：CA2456828A1

公开(公告)日：2003-03-06

申请号：CA2456828

申请日：2002-08-21

Applicant: BASF AG

Inventor： REVUELTA DOVAL JOSE L ,  KAROS MARVIN ,  KROEGER BURKHARD ,  ALTHOEFER HENNING

IPC: C12N15/09 ,  A61K31/7052 ,  A61K38/00 ,  A61P43/00 ,  C07K14/37 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P19/32 ,  C12Q1/02 ,  C12N15/31 ,  C07H21/00 ,  C12P25/00 ,  C12N15/11 ,  C12P17/12 ,  C07K14/39 ,  C12N15/63

Abstract: The invention relates to novel polynucleotides from Ashbya gossypii; oligonucleotides hybridised therewith; expression cassettes and vectors, containing said polynucleotide; microorganism transformed therewith; polypeptides coded by said polynucleotides and the use of the novel polypeptides and polynucleotides as targets for modulation of the cell wall or cytoskeletion construction and in particular for improving the production of vitamin B2 in microorganisms of the species Ashbya.

公开(公告)号：DE10133372A1

公开(公告)日：2003-01-23

申请号：DE10133372

申请日：2001-07-10

Applicant: BASF AG

Inventor： KAROS MARVIN ,  ALTHOEFER HENNING ,  KROEGER BURKHARD ,  REVUELTA DOVAL JOSE L

IPC: C07K14/37 ,  C07K14/47 ,  C12N1/15 ,  C07H21/00 ,  C12N15/52 ,  C12N15/80

Abstract: Polynucleotide (I) that encodes a protein (II) of the stress response and isolatable from Ashbya gossypii. Independent claims are also included for the following: (1) Oligonucleotides (ON) that hybridize to (I), particularly under stringent conditions; (2) Polynucleotides (Ia) that hybridize to ON, particularly under stringent conditions, and encode a gene product from the genus Ashbya or its functional equivalent; (3) Polypeptides (IIa) encoded by (I), or its fragments, or (Ib), or having an amino acid (aa) sequence that includes at least 10 consecutive aa from any of 10 sequences reproduced, or their functional equivalents; (4) Expression cassettes (EC) containing (I), ON or (Ia) linked to regulatory sequences; (5) Recombinant vector containing at least one EC; (6) Prokaryotic or eukaryotic host transformed with at least one vector of (5), or in which at least one gene encoding (IIa) is modulated, or in which the biological activity of (IIa) is altered; (7) Method for identifying effector targets for modulating microbial production of Vitamin B2 or its precursors or derivatives; (8) Method for modulation microbial production of Vitamin B2 or its precursors or derivatives by treatment with an effector that interacts with (IIa) or nucleic acid encoding it; (9) Effectors (X) for (IIa) or nucleic acid encoding it; and (10) Microbial production of Vitamin B2 or its precursors or derivatives using a host cell of (6).