公开(公告)号：DE3026537A1

公开(公告)日：1982-02-11

申请号：DE3026537

申请日：1980-07-12

Applicant: BASF AG

Inventor： HAGEN HELMUT DIPL ING DR ,  MARKERT JUERGEN DIPL CHEM DR ,  ZIEGLER HANS DIPL CHEM DR

IPC: C07D339/04 ,  C07D495/04 ,  A01N43/90 ,  C07D409/12 ,  C07D495/08

公开(公告)号：DE2944222A1

公开(公告)日：1981-05-14

申请号：DE2944222

申请日：1979-11-02

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER DIPL CHE ,  FRANKE ALBRECHT DIPL CHEM DR ,  HAGEN HELMUT DIPL ING DR ,  LENKE DIETER PROF DR ,  GRIES JOSEF DR MED

IPC: C07D275/04 ,  A61K31/425

Abstract: Novel amino-derivs. of 1,2-benzisothiazole are of formula (I). n is 2 or 3; R1 and R2 are H or opt. branched 1-5C alkyl; R3 is Ph, opt. mono-, di- or tri-substd. by halogen, alkyl, alkoxy, alkylthio, haloalkyl or haloalkoxy (these 2 gps. contg. 1-3 halogen), hydroxyalkyl or alkoxyalkyl (all alkyl gps. contg. 1-5C), 2-6C alkenyl, alkinyl or alkinyloxy, 3-8 ring C cycloalkoxy, methylene dioxy, amino, 1-5C alkylamino or di(1-5C)alkylamino. R3 may also be indanyl or tetrabydropaphthyl). The physiologically acceptable acid addn.-salts of (I) are also new. (I) are pharmaceuticals and can be used in heart and circulatory disorders. As a result of their beta-sympatholytic action, (I) are esp. suitable for the treatment of coronary heart disease, hypertonia and disturbances of cardiac rhythm. Suitable unit doese for humans are 1-100 (sp. 3-50) mg. (I) are strong beta-sympatholytics of low toxicity and have a therapeutic breadth 3-12 times greater than that of the known beta-sympatholitic propandol.

公开(公告)号：DE2919630A1

公开(公告)日：1980-11-27

申请号：DE2919630

申请日：1979-05-16

Applicant: BASF AG

Inventor： MERGER FRANZ DIPL CHEM DR ,  HUTMACHER HANS-MARTIN DIPL CHE ,  HAGEN HELMUT DIPL ING DR

IPC: C07C255/34 ,  C07C121/30 ,  C07C120/00 ,  C07C121/70

公开(公告)号：DE2826011A1

公开(公告)日：1980-01-03

申请号：DE2826011

申请日：1978-06-14

Applicant: BASF AG

Inventor： HAGEN HELMUT DIPL ING DR ,  KANTLEHNER WILLI PROF DIPL CHE ,  SPEH PETER DIPL CHEM DR

IPC: C07D295/023 ,  C07C87/20 ,  C07C85/22 ,  C07D403/06

公开(公告)号：DE2734926A1

公开(公告)日：1979-02-22

申请号：DE2734926

申请日：1977-08-03

Applicant: BASF AG

Inventor： HAGEN HELMUT DIPL ING DR ,  NAARMANN HERBERT DIPL CHEM DR ,  PENZIEN KLAUS DIPL CHEM DR

IPC: C08L25/00 ,  C08J9/00 ,  C08K5/16 ,  C08K5/17 ,  C08K5/34 ,  C08K5/3492 ,  C08L7/00 ,  C08L21/00 ,  C08L23/00 ,  C08L25/04 ,  C08L33/00 ,  C08L33/02 ,  C08L51/00 ,  C08L51/02 ,  C08L101/00 ,  C08K5/02 ,  C08J9/12 ,  C08J9/14

Abstract: A flameproof thermoplastic molding material based on a styrene polymer and containing from 0.05 to 5 percent by weight of an organic bromine compound as the flameproofing agent, with or without a blowing agent, wherein the bromine compound contains a heterocyclic ring, comprising the group IN ITS MOLECULE, AND IS HEAT-STABLE UP TO AT LEAST 150 DEG C. The preferred bromine compound has the formula The molding materials may be used for the manufacture of self-extinguishing moldings, eg. foam moldings.

公开(公告)号：DE2734866A1

公开(公告)日：1979-02-22

申请号：DE2734866

申请日：1977-08-03

Applicant: BASF AG

Inventor： HAGEN HELMUT DIPL ING DR ,  KOHLER ROLF-DIETER DIPL CHEM D ,  MARKERT JUERGEN DIPL CHEM DR

IPC: C07D275/04

Abstract: Novel 1,2-benzisothiazoles and a process for the manufacture of 1,2-benzisothiazoles by reacting o-haloaryl ketones with ammonia and elementary sulfur. The compounds are starting materials for the manufacture of dyes, crop protection agents and drugs.

公开(公告)号：CH603627A5

公开(公告)日：1978-08-31

申请号：CH785474

申请日：1974-06-07

Applicant: BASF AG

Inventor： HAGEN HELMUT DIPL ING DR ,  FLEIG HELMUT DR

IPC: C07D417/06 ,  A23K1/16 ,  A61D7/00 ,  A61K31/41 ,  A61K31/44 ,  C07D213/83 ,  C07D285/12 ,  C07D307/71 ,  C07D307/74 ,  C07D417/14

公开(公告)号：DE2704794A1

公开(公告)日：1978-08-17

申请号：DE2704794

申请日：1977-02-05

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER DIPL CHE ,  HAGEN HELMUT DIPL ING DR ,  OHNSORGE ULRICH DIPL CHEM DR ,  FRANKE ALBRECHT DIPL CHEM DR ,  LENKE DIETER PROF DR ,  GRIES JOSEF DR MED ,  LEHMANN HANS DIETER DR MED

IPC: A61K31/428 ,  C07D275/04 ,  A61K31/425

Abstract: New aminopropanol derivatives of 4-hydroxy-1,2-benzisothiazole and their addition salts with acids, their preparation, and pharmaceutical formulations which contain the said compounds and may be used for the treatment and prophylaxis of cardiac and circulatory disorders.

公开(公告)号：DE2704179A1

公开(公告)日：1978-08-10

申请号：DE2704179

申请日：1977-02-02

Applicant: BASF AG

Inventor： FLEIG HELMUT DIPL CHEM DR ,  HAGEN HELMUT DIPL ING DR ,  NAARMANN HERBERT DIPL CHEM DR

IPC: C07D285/12

Abstract: (I) is made by brominating 2,5-dimethyl-1,3,4-thiadiazole in the presence of an organic acid. (I) is useful as a flame retardant additive in styrene polymers; as an adhesion promoter; as an intermediate in the prodn. of dyes; and as a phosphorescent marking agent for plastics. The process gives high yields of (I), largely free from dark coloured highly brominated by-prods. which have a deleterious effect on the flame retardant properties of the compsn.

公开(公告)号：DE2507187A1

公开(公告)日：1976-09-02

申请号：DE2507187

申请日：1975-02-20

Applicant: BASF AG

Inventor： HAGEN HELMUT DIPL ING DR ,  HANSEN GUENTHER DIPL CHEM DR ,  NIESS ROLF DIPL CHEM DR

IPC: C09B29/08 ,  C09B39/00

Abstract: Monoazo dyes of formula: (in which R1 is H, alkyl, opt. substd. phenyl of alkoxycarbonyl; R2 is H, alkyl, Cl, Br, NO2, CN, acyloxy or acylamino; R3 is H, alkyl, opt. substd. phenyl of OH; R4 is alkanoyl, aroyl, alkoxycarbonyl, CN, NO2, nitrophenyl or a hetero-aromatic gp.; R5 is H, Cl, CH3, acetylamino, or propionylamino; R6 is H, CH3, methoxy or ethoxy; R7 is 1-4C alkyl, 2-3C hydroxyalkyl, 3-7C alkoxyalkyl, 4-7C alkanoylalkyl, cyanethyl, 1-4C alkoxycarbonyl ethyl, chlorethyl, acetoacetoxy ethyl, gamma-acetyl aminopropyl, benzyl, phenylethyl, phenyl, methoxy- or ethoxy-phenyl, or cyclohexyl; R8 is H, 1-4C alkyl, 2-3C hydroxyalkyl or 4-7C alkanoyl oxy-alkyl), are useful as dispersion dyes for colouring synthetic fibres, e.g. cellulose esters, polyamides or esp. polyesters, in yellow-orange to blue shades, with good fastness.