中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

31 records (took 0.021 seconds)

    23.
    发明专利
    未知

    公开(公告)号：AT359992T

    公开(公告)日：2007-05-15

    申请号：AT01130515

    申请日：2001-12-21

    Applicant: BASF AG

    Inventor： PFEFFINGER JOACHIM ,  HUELLMANN MICHAEL DR ,  HOEHN ARTHUR DR ,  FUNKE FRANK DR ,  OHLBACH FRANK DR ,  GERLACH TILL DR

    IPC: C07B61/00 ,  C07C209/48 ,  C07C211/05 ,  C07C211/11 ,  C07C211/14

    Abstract: Secondary amines of the formula (II)whereX is a C1-20-alkyl, C2-20-alkenyl or C3-8-cycloalkyl group which may be unsubstituted or substituted by C1-20-alkyl, C3-8-cycloalkyl, C4-20-alkylcycloalkyl, C4-20-cycoalkylalkyl, C2-20-alkoxyalkyl, C6-14-aryl, C7-20-alkylaryl, C7-20-aralkyl, C1-20-alkoxy, hydroxy, C1-20-hydroxyalkyl, amino, C1-20-alkylamino, C2-20-dialkylamino, C2-12-alkenylamino, C3-8-cycloalkylamino, arylamino, diarylamino, aryl-C1-8-alkylamino, halogen, mercapto, C2-20-alkenyloxy, C3-8-cycloalkoxy, aryloxy and/or C2-8-alkoxycarbonyl,are prepared by reacting nitriles of the formula (III)with hydrogen at from 20 to 250° C. and pressures of from 60 to 350 bar in the presence of an Rh-containing catalyst comprising from 0.1 to 5% by weight, based on the total weight of the catalyst, of Rh on a support to give mixtures of primary amines of the formula (I)and secondary amines of the formula (II)and returning at least part of the primary amines separated from the mixtures obtained to the reaction.

    24.
    发明专利
    未知

    公开(公告)号：ES2133447T3

    公开(公告)日：1999-09-16

    申请号：ES94111340

    申请日：1994-07-21

    Applicant: BASF AG

    Inventor： HUELLMANN MICHAEL DR ,  BECKER RAINER DR ,  SCHARF EMIL DR

    IPC: B01J23/74 ,  B01J23/88 ,  C07B61/00 ,  C07D295/08 ,  C07D295/088

    Abstract: N-(2-Hydroxyethyl)piperazine of the formula I is prepared by reaction of triethanolamine of the formula II with ammonia in the presence of hydrogen at temperatures from 100 to 500 DEG C and pressures from 10 to 500 bar on heterogeneous catalysts, employing heterogeneous catalysts having an active mass containing 20 to 85% by weight of ZrO2 and/or Al2O3, 1 to 30% by weight of oxygen-containing compounds of copper, calculated as CuO, 1 to 60% by weight of oxygen-containing compounds of cobalt calculated as CoO and/or oxygen-containing compounds of nickel, calculated as NiO and/or oxygen-containing compounds of molybdenum, calculated as MoO3.

    25.
    发明专利
    未知

    公开(公告)号：DE59407416D1

    公开(公告)日：1999-01-21

    申请号：DE59407416

    申请日：1994-01-08

    Applicant: BASF AG

    Inventor： FRANZ LOTHAR DR ,  HUELLMANN MICHAEL DR

    IPC: C07B61/00 ,  C07D207/26 ,  C07D207/267

    Abstract: Process for the preparation of N-alkenylpyrrolidones of the general formula I in which R denotes hydrogen or C1- to C20-alkyl by reacting N-alkylpyrrolidones of the general formula II in which R has the abovementioned meanings and X and Y represent OH, C1- to C20-alkoxy or C2- to C20-alkoxycarbonyl, with the proviso that one of the two radicals X and Y denotes hydrogen, at temperatures from 200 to 600@C and pressures from 0.1 to 5 bar, the process being carried out in the presence of acidic heterogeneous catalysts, with the exception of oxides of the metals of sub-groups II, III, IV and VI of the Periodic Table of the Elements.

    26.
    发明专利
    未知

    公开(公告)号：DE4325023A1

    公开(公告)日：1995-02-02

    申请号：DE4325023

    申请日：1993-07-26

    Applicant: BASF AG

    Inventor： BECKER RAINER DR ,  HUELLMANN MICHAEL DR ,  PALM CHRISTOF DR ,  FRANZISCHKA WOLFGANG DR

    IPC: C08G65/06 ,  C08G65/02 ,  C08G65/10 ,  C08G65/20 ,  C08G65/26

    Abstract: A process for the preparation of polytetrahydrofuran or C2- to C10-alkylene oxide-tetrahydrofuran copolymers having a mean molecular weight of from 250 to 20000 daltons by cationic polymerisation of tetrahydrofuran or tetrahydrofuran and C2- to C10-alkylene oxides in the presence of a promoter, in which process the catalyst used is a mixture of one or more C2- to C6-di- or tricarboxylic acids with boric acid.

    28.
    发明专利
    未知

    公开(公告)号：ES2052295T3

    公开(公告)日：1994-07-01

    申请号：ES91103536

    申请日：1991-03-08

    Applicant: BASF AG

    Inventor： HUELLMANN MICHAEL DR ,  MAYR HERBERT PROF DR ,  BECKER RAINER DR

    IPC: C07B61/00 ,  C07C2/00 ,  B01J31/26 ,  C07C2/72 ,  C07C13/48

    Abstract: A process for preparing 1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene of the formula I (I) comprises reacting p-cymene of the formula II (II) with a hexene of the formula IIIa, IIIb and/or IIIc (IIIa) (IIIb) (IIIc) in the presence of a catalytic amount of aluminum halide and a catalytic amount of a triphenylmethyl compound of the formula IV (IV) wherein R1, R2 and R3 are each, independently of one another, hydrogen, C1-C4-alkyl, nitro or halogen and X is hydrogen or halogen.

    Racemic alpha- and gamma-lipoic acid prepn. - from cyclohexanone and vinyl alkyl ether in good yield by economical multi-stage process
    29.
    发明专利
    Racemic alpha- and gamma-lipoic acid prepn. - from cyclohexanone and vinyl alkyl ether in good yield by economical multi-stage process 未知

    公开(公告)号：DE4229914A1

    公开(公告)日：1994-03-10

    申请号：DE4229914

    申请日：1992-09-08

    Applicant: BASF AG

    Inventor： BALKENHOHL FRIEDHELM DR ,  PAUST JOACHIM DR ,  HUELLMANN MICHAEL DR

    IPC: C07C69/708 ,  C07C319/08 ,  C07C323/52 ,  C07D313/04 ,  C07D339/04

    Abstract: Prepn. of racemic gamma-liponic acid of formula (Ia) and racemic alpha-liponic acid of formula (Ib) comprises: (a) reacting cyclohexanone of formula (II) with a vinyl alkyl ether of formula (III) in the presence of a radical initiator; (b) converting the resulting 2-alkoxyethyl-cyclohexanone of formula (IV) by Baeyer-Villiger oxidn. using an organic peracid or salt or an inorganic peroxo cpd. into an 8-alkoxy-6-hydroxy-octanoic acid lactone of formula (V) or a mixt. of this lactone with the parent acid, of formula (VI) and (c) converting the prod. with thiourea in the presence of HBr or Hl into (Ia) and isolated this: and, where (Ib) is required, (d) oxidising the crude (Ia) with air in the presence of a ferric catalyst; (e) continuously distilling the crude (IB) obtd. in a film evaporator under 0.02-0.2 mbar press. at 60-200 deg.C; and (f) isolating (Ib) by crystallisation R1 = 1-3C alkyl. Pref. step a) is carried out using di-tert-butyl peroxide as the radical initiator. Sodium metaperborate or permaleic acid (prepd. in situ.) is used as the reagent in step B). Ferric chloride is the catalyst used in step d). Step e) is carried out under 0.05-0.1 bar pressure and at 130-160 deg.C (Ib) is crystallised from diisopropyl ether or hexane/ethyl acetate in step f). USE/ADVANTAGE - (Ib) is useful in treating liver disease, neuropathies, esp. diabetic polyneuropathy, HIV-1 and HTLV IIIB. Use of (Ia) is described in DE4035456. Compared with the processes described in DE3512911, the method is simpler and uses cheaper starting materials and milder conditions. Overall yield is 35%, compared with 10% using cyclohexanone and 2-ethoxyethyl bromide and 19% using cyclohexanone according to JACS 79 (1957), pp 3503-3505 or US2993056. In an example, a) Cyclohexanone (II) (2940 g) is treated at reflux with a soln. of di-tert.butyl peroxide (87.6 g) in ethyl vinyl ether (III) (216 g). Refluxing, cooling, removal of volatiles and distillation of the residue gives 2-(2-ethoxyethyl)-cyclohexanone (IV) (350 g; 69% yield); b.pt. 60-65 deg.C/0.5mbar. b) (IV) (680 g) was added while stirring and maintaining gentle boiling to a suspension of m-chloroperbenzoic acid (1506 g) in CH2Cl2 (2 l). The mixt. is stirred at 40 deg.C, cooled, treated with satd. Na2CO3 soln. (3 l) and the sepd. organic phase is washed (Na2CO3), dried (MgSO4) and concentrated to give lactone (V) (640 g; 86% yield).

Patent Agency Ranking