公开(公告)号：CA1187878A

公开(公告)日：1985-05-28

申请号：CA394179

申请日：1982-01-14

Applicant: BASF AG

Inventor： THIEME PETER C ,  STEINER GERD ,  ROHR WOLFGANG ,  LENKE DIETER ,  GRIES JOSEF ,  WEIFENBACH HARALD ,  TESCHENDORF HANS-JUERGEN ,  HOFMANN HANS P ,  KREISKOTT HORST

IPC: C07D249/08 ,  A61K31/41 ,  A61K31/415 ,  A61K31/495 ,  A61K31/496 ,  A61P9/02 ,  A61P11/00 ,  A61P25/20 ,  C07D231/12 ,  C07D233/60 ,  C07D233/61 ,  C07D271/10 ,  C07D295/06 ,  C07D295/067 ,  C07D295/096 ,  C07D521/00 ,  C07D295/04 ,  C07D403/12

Abstract: Novel phenylpiperazinylpropane and -butane derivatives of hetarylphenols and hetarylanilines of the formula where R1 is hydrogen or alkyl of 1 to 4 carbon atoms, R2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms or alkoxy where alkyl is of 1 to 3 carbon atoms, the phenyl ring can be monosubstituted or disubstituted by R2, X is oxygen or an NH group, and the heterocyclic structure Het. is 1,3,4oxadiazolyl, triazolyl, imidazolyl or pyrazolyl, and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and exhibit predominantly sedative, neuroleptic and hypotensive properties.

公开(公告)号：DK585984D0

公开(公告)日：1984-12-07

申请号：DK585984

申请日：1984-12-07

Applicant: BASF AG

Inventor： RASCHACK MANFRED ,  KREISKOTT HORST ,  SEITZ WERNER

IPC: C07B57/00 ,  A61K20060101 ,  A61K31/275 ,  A61P9/00 ,  C07B31/00 ,  C07C20060101 ,  C07C67/00 ,  C07C253/00 ,  C07C255/32 ,  C07C255/42 ,  C07C255/58 ,  C07D20060101 ,  C07D

Abstract: 1,7-diphenyl-3-methylaza-7-cyano-8-methylnonane and its antipodes and salts are used for the treatment of diseases.

公开(公告)号：CA1170258A

公开(公告)日：1984-07-03

申请号：CA387495

申请日：1981-10-07

Applicant: BASF AG

Inventor： STEINER GERD ,  TESCHENDORF HANS-JUERGEN ,  KREISKOTT HORST ,  HOFMANN HANS P

IPC: A61K31/55 ,  A61P25/00 ,  A61P25/08 ,  A61P25/20 ,  C07D223/00 ,  C07D333/00 ,  C07D495/14

Abstract: of the disclosure: 5-substituted 9-cyanomethyl-ene-dithieno¢3,4-b:4',3'-e!-azepines, processes for thelr preparation, and therapeutic agents which contain these compounds and can be used as sedatives, hypnotlc drugs, tranquilizers, neuroleptic drugs or anti-Parkinson drugs.

公开(公告)号：FI63403C

公开(公告)日：1983-06-10

申请号：FI781872

申请日：1978-06-12

Applicant: BASF AG

Inventor： BINNIG FRITZ ,  FRIEDRICH LUDWIG ,  HOFMANN HANS PETER ,  KREISKOTT HORST ,  MUELLER CLAUS ,  RASCHACK MANFRED

IPC: A61K31/435 ,  A61K31/445 ,  A61P9/06 ,  C07D221/00 ,  C07D471/08

Abstract: Bispidine derivatives of the formula where R1 is H or C6H5, R2 is H, Cl or CF3, R3 is H, F or Cl and X is 0 or 1, and drugs which contain these compounds. The compounds are prepared by condensing N-monobenzylbispidine with appropriately substituted phenylethyl halides or by a Mannich reaction of N-benzylpiperid-4-one with appropriately substituted phenylalkylamines, followed by reduction. They exhibit mainly anti-arrhythmic action.

公开(公告)号：ZA82293B

公开(公告)日：1982-12-29

申请号：ZA82293

申请日：1982-01-18

Applicant: BASF AG

Inventor： THIEME PETER C ,  STEINER GERD ,  ROHR WOLFGANG ,  LENKE DIETER ,  GRIES JOSEF ,  WEIFENBACH HARALD ,  TESCHENDORF HANS JUERGEN ,  HOFMANN HANS PETER ,  KREISKOTT HORST

IPC: C07D249/08 ,  A61K31/41 ,  A61K31/415 ,  A61K31/495 ,  A61K31/496 ,  A61P9/02 ,  A61P11/00 ,  A61P25/20 ,  C07D231/12 ,  C07D233/60 ,  C07D233/61 ,  C07D271/10 ,  C07D295/06 ,  C07D295/067 ,  C07D295/096 ,  C07D521/00 ,  A61K ,  C07C ,  C07D

Abstract: Novel phenylpiperazinylpropane and -butane derivatives of hetarylphenols and hetarylanilines of the formula where R1 is hydrogen or alkyl of 1 to 4 carbon atoms, R2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms or alkoxy where alkyl is of 1 to 3 carbon atoms, the phenyl ring can be monosubstituted or disubstituted by R2, X is oxygen or an NH group, and the heterocyclic structure Het. is 1,3,4-oxadiazolyl, triazolyl, imidazolyl or pyrazolyl, and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and exhibit predominantly sedative, neuroleptic and hypotensive properties.

公开(公告)号：ZA8200293B

公开(公告)日：1982-12-29

申请号：ZA8200293

申请日：1982-01-18

Applicant: BASF AG

Inventor： THIEME PETER C ,  STEINER GERD ,  ROHR WOLFGANG ,  LENKE DIETER ,  GRIES JOSEF ,  WEIFENBACH HARALD ,  TESCHENDORF HANS JUERGEN ,  HOFMANN HANS PETER ,  KREISKOTT HORST

IPC: C07D249/08 ,  A61K31/495 ,  A61K31/496 ,  A61P9/02 ,  A61P11/00 ,  A61P25/20 ,  C07D231/12 ,  C07D233/60 ,  C07D233/61 ,  C07D271/10 ,  C07D295/06 ,  C07D295/067 ,  C07D295/096 ,  C07D521/00 ,  A61K ,  C07C ,  C07D

CPC classification number: C07D271/10 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D295/067 ,  C07D295/096

公开(公告)号：ZA814688B

公开(公告)日：1982-08-25

申请号：ZA814688

申请日：1981-07-10

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  LENKE DIETER ,  GRIES JOSEF ,  WEIFENBACH HARALD ,  HOFMANN HANS PETER ,  KREISKOTT HORST

IPC: C07D295/08 ,  A61K31/495 ,  A61P9/12 ,  A61P25/20 ,  C07C45/70 ,  C07D295/092 ,  C07D303/22 ,  A61K ,  C07C

公开(公告)号：NO810761L

公开(公告)日：1981-09-09

申请号：NO810761

申请日：1981-03-05

Applicant: BASF AG

Inventor： STEINER GERD ,  HOFMAN HANS PETER ,  KREISKOTT HORST ,  TESCHENDORF HANS-JUERGEN ,  LENKE DIETER

IPC: A61K31/275 ,  C07D295/14 ,  A61K31/395 ,  A61K31/50 ,  A61K31/55 ,  A61P25/20 ,  C07C67/00 ,  C07C253/00 ,  C07C255/37 ,  C07C255/42 ,  C07D243/08 ,  C07D295/08 ,  C07D295/155 ,  C07D

Abstract: 10-Substituted 5-cyanomethylene-dibenzo[a,d]-cycloheptenes, their pure cis- and trans-isomers, their N-oxides and their pharmaceutically tolerated addition salts with acids, processes for their preparation, therapeutic agents containing these compounds and their use as drugs, especially as sedatives, hypnotics or tranquilizers.

公开(公告)号：DD150602A5

公开(公告)日：1981-09-09

申请号：DD22101680

申请日：1980-05-09

Applicant: BASF AG

Inventor： STEINER GERG ,  FRANKE ALBRECHT ,  LENKE DIETER ,  TESCHENDORF HANS-JUERGEN ,  WORSTMANN WOLFGANG ,  KREISKOTT HORST

IPC: A61K31/55 ,  A61P25/18 ,  C07D223/20 ,  C07D401/06 ,  C07D403/04

Abstract: 6-Substituted 11-alkylene-morphanthridines, also referred to as 11-alkylene-dibenzo[b,e]-azepines, their pure cis- and trans-isomers, processes for their preparation, and therapeutic agents containing these compounds, which may be used as drugs, in particular neuroleptics, sedatives, hypnotics, analgesics, antidepressants or agents for treating Parkinson's syndrome.

公开(公告)号：NO801387L

公开(公告)日：1980-11-11

申请号：NO801387

申请日：1980-05-09

Applicant: BASF AG

Inventor： STEINER GERD ,  FRANKE ALBRECHT ,  LENKE DIETER ,  TESCHENDORF HANS-JUERGEN ,  WORSTMANN WOLFGANG ,  KREISKOTT HORST

IPC: A61K31/55 ,  A61P25/18 ,  C07D223/20 ,  C07D401/06 ,  C07D403/04 ,  C07D

Abstract: 6-Substituted 11-alkylene-morphanthridines, also referred to as 11-alkylene-dibenzo[b,e]-azepines, their pure cis- and trans-isomers, processes for their preparation, and therapeutic agents containing these compounds, which may be used as drugs, in particular neuroleptics, sedatives, hypnotics, analgesics, antidepressants or agents for treating Parkinson's syndrome.