公开(公告)号：HUT75554A

公开(公告)日：1997-05-28

申请号：HU9601298

申请日：1994-11-10

Applicant: BASF AG

Inventor： HILLEN HEINZ ,  JACOB ELARD ,  KROEGER BURKHARD ,  MEYER THOMAS ,  OTTER RAINER ,  SCHMIDT MARTIN ,  SEULBERGER HARALD ,  SUBKOWSKI THOMAS

IPC: G01N33/573 ,  A01K67/027 ,  A61K31/70 ,  A61K35/12 ,  A61K38/00 ,  A61K38/43 ,  A61K38/48 ,  A61K39/395 ,  A61K48/00 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  C07H21/04 ,  C07K14/47 ,  C07K16/40 ,  C12N5/00 ,  C12N5/10 ,  C12N9/64 ,  C12N15/09 ,  C12N15/113 ,  C12N15/57 ,  C12R1/91 ,  C12N15/11

Abstract: PCT No. PCT/EP94/03706 Sec. 371 Date May 16, 1996 Sec. 102(e) Date May 16, 1996 PCT Filed Nov. 10, 1994 PCT Pub. No. WO95/14095 PCT Pub. Date May 26, 1995The invention relates to endothelin-converting enzymes containing the polypeptide sequence described in SEQ. ID. NO. 30 or SEQ. ID. NO. 36 or functional fragments thereof, genes which code for such enzymes, and processes for producing the said enzymes and the use thereof.

公开(公告)号：NZ275817A

公开(公告)日：1997-02-24

申请号：NZ27581794

申请日：1994-11-10

Applicant: BASF AG

Inventor： KROGER BURKHARD ,  SEULBERGER HARALD ,  MEYER THOMAS ,  SCHMIDT MARTIN ,  JACOB ELARD ,  OTTER RAINER ,  SUBKOWSKI THOMAS ,  HILLEN HEINZ

IPC: G01N33/573 ,  A01K67/027 ,  A61K31/70 ,  A61K35/12 ,  A61K38/00 ,  A61K38/43 ,  A61K38/48 ,  A61K39/395 ,  A61K48/00 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  C07H21/04 ,  C07K14/47 ,  C07K16/40 ,  C12N5/00 ,  C12N5/10 ,  C12N9/64 ,  C12N15/09 ,  C12N15/113 ,  C12N15/57 ,  C12R1/91 ,  C12N9/14 ,  C12N15/55 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/37

Abstract: PCT No. PCT/EP94/03706 Sec. 371 Date May 16, 1996 Sec. 102(e) Date May 16, 1996 PCT Filed Nov. 10, 1994 PCT Pub. No. WO95/14095 PCT Pub. Date May 26, 1995The invention relates to endothelin-converting enzymes containing the polypeptide sequence described in SEQ. ID. NO. 30 or SEQ. ID. NO. 36 or functional fragments thereof, genes which code for such enzymes, and processes for producing the said enzymes and the use thereof.

公开(公告)号：PL314480A1

公开(公告)日：1996-09-16

申请号：PL31448094

申请日：1994-11-10

Applicant: BASF AG

Inventor： KROEGER BURKHARD ,  SEULBERGER HARALD ,  MEYER THOMAS ,  SCHMIDT MARTIN ,  JACOB ELARD ,  OTTER RAINER ,  SUBKOWSKI THOMAS ,  HILLEN HEINZ

IPC: G01N33/573 ,  A01K67/027 ,  A61K31/70 ,  A61K35/12 ,  A61K38/00 ,  A61K38/43 ,  A61K38/48 ,  A61K39/395 ,  A61K48/00 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  C07H21/04 ,  C07K14/47 ,  C07K16/40 ,  C12N5/00 ,  C12N5/10 ,  C12N9/64 ,  C12N15/09 ,  C12N15/113 ,  C12N15/57 ,  C12R1/91

Abstract: PCT No. PCT/EP94/03706 Sec. 371 Date May 16, 1996 Sec. 102(e) Date May 16, 1996 PCT Filed Nov. 10, 1994 PCT Pub. No. WO95/14095 PCT Pub. Date May 26, 1995The invention relates to endothelin-converting enzymes containing the polypeptide sequence described in SEQ. ID. NO. 30 or SEQ. ID. NO. 36 or functional fragments thereof, genes which code for such enzymes, and processes for producing the said enzymes and the use thereof.

公开(公告)号：CA2176507A1

公开(公告)日：1995-05-26

申请号：CA2176507

申请日：1994-11-10

Applicant: BASF AG

Inventor： KROEGER BURKHARD ,  SEULBERGER HARALD ,  MEYER THOMAS ,  SCHMIDT MARTIN ,  JACOB ELARD ,  OTTER RAINER ,  SUBKOWSKI THOMAS ,  HILLEN HEINZ

IPC: G01N33/573 ,  A01K67/027 ,  A61K31/70 ,  A61K35/12 ,  A61K38/00 ,  A61K38/43 ,  A61K38/48 ,  A61K39/395 ,  A61K48/00 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  C07H21/04 ,  C07K14/47 ,  C07K16/40 ,  C12N5/00 ,  C12N5/10 ,  C12N9/64 ,  C12N15/09 ,  C12N15/113 ,  C12N15/57 ,  C12R1/91 ,  C12Q1/37

Abstract: The invention relates to endothelin-converting enzymes containing the polypeptide sequence described in SEQ. ID. NO. 30 or SEQ. ID. NO. 36 or functional fragments thereof, genes which code for such enzymes, and processes for producing the said enzymes and the use thereof.

公开(公告)号：PL295719A1

公开(公告)日：1994-03-07

申请号：PL29571992

申请日：1992-08-24

Applicant: BASF AG

Inventor： KIRSTGEN REINHARD ,  NEUBAUER HANS-JUERGEN ,  OTTER RAINER ,  KUENAST CHRISTOPH ,  KARDORFF UWE ,  HARRIES VOLKER

IPC: A01N43/707 ,  C07D249/10

公开(公告)号：NO333555B1

公开(公告)日：2013-07-08

申请号：NO20016148

申请日：2001-12-17

Applicant: BASF AG

Inventor： OTTER RAINER ,  MAAS-BRUNNER MELANIE ,  THIL LUCIEN ,  BREITSCHEIDEL BORIS

IPC: C08K5/12 ,  C07C61/08 ,  C07C61/09

Abstract: The invention relates to the use of a cyclohexane polycarboxylic acid or of one of its derivatives, or of a mixture of one or more of said acids as plasticizers in the production of plastics which are rated toxicologically favourable. In animal experiments, using rodents, to which a daily oral dose of 1000 mg/kg body weight of the corresponding cyclohexane polycarboxylic acid, or a derivative thereof, or a mixture of two or more of said acids is administered by oesophageal tube over a period of at least 14 days, said dose, in comparison to untreated control animals, leads neither to a significant increase in the weight of the liver after treatment, nor to a doubling of the specific cyanide-insensitive palmitoyl-CoA oxidase activity, measured in the liver homogenisate.

公开(公告)号：DE50012023D1

公开(公告)日：2006-03-30

申请号：DE50012023

申请日：2000-06-16

Applicant: BASF AG

Inventor： BRUNNER MELANIE ,  THIL LUCIEN ,  BREITSCHEIDEL BORIS ,  OTTER RAINER

IPC: C08K5/12 ,  C07C61/08 ,  C07C61/09 ,  C08K5/092

Abstract: The invention relates to the use of a cyclohexane polycarboxylic acid or of one of its derivatives, or of a mixture of one or more of said acids as plasticizers in the production of plastics which are rated toxicologically favourable. In animal experiments, using rodents, to which a daily oral dose of 1000 mg/kg body weight of the corresponding cyclohexane polycarboxylic acid, or a derivative thereof, or a mixture of two or more of said acids is administered by oesophageal tube over a period of at least 14 days, said dose, in comparison to untreated control animals, leads neither to a significant increase in the weight of the liver after treatment, nor to a doubling of the specific cyanide-insensitive palmitoyl-CoA oxidase activity, measured in the liver homogenisate.

公开(公告)号：PL352273A1

公开(公告)日：2003-08-11

申请号：PL35227300

申请日：2000-06-16

Applicant: BASF AG

Inventor： MAAS-BRUNNER MELANIE ,  THIL LUCIEN ,  BREITSCHEIDEL BORIS ,  OTTER RAINER

IPC: C07C61/08 ,  C07C61/09 ,  C08K5/12

Abstract: The invention relates to the use of a cyclohexane polycarboxylic acid or of one of its derivatives, or of a mixture of one or more of said acids as plasticizers in the production of plastics which are rated toxicologically favourable. In animal experiments, using rodents, to which a daily oral dose of 1000 mg/kg body weight of the corresponding cyclohexane polycarboxylic acid, or a derivative thereof, or a mixture of two or more of said acids is administered by oesophageal tube over a period of at least 14 days, said dose, in comparison to untreated control animals, leads neither to a significant increase in the weight of the liver after treatment, nor to a doubling of the specific cyanide-insensitive palmitoyl-CoA oxidase activity, measured in the liver homogenisate.

公开(公告)号：NO20016148D0

公开(公告)日：2001-12-17

申请号：NO20016148

申请日：2001-12-17

Applicant: BASF AG

Inventor： MAAS-BRUNNER MELANIE ,  THIL LUCIEN ,  BREITSCHEIDEL BORIS ,  OTTER RAINER

IPC: C07C61/08 ,  C07C61/09 ,  C08K5/12 ,  C08K

Abstract: The invention relates to the use of a cyclohexane polycarboxylic acid or of one of its derivatives, or of a mixture of one or more of said acids as plasticizers in the production of plastics which are rated toxicologically favourable. In animal experiments, using rodents, to which a daily oral dose of 1000 mg/kg body weight of the corresponding cyclohexane polycarboxylic acid, or a derivative thereof, or a mixture of two or more of said acids is administered by oesophageal tube over a period of at least 14 days, said dose, in comparison to untreated control animals, leads neither to a significant increase in the weight of the liver after treatment, nor to a doubling of the specific cyanide-insensitive palmitoyl-CoA oxidase activity, measured in the liver homogenisate.

公开(公告)号：DE19927977A1

公开(公告)日：2000-12-21

申请号：DE19927977

申请日：1999-06-18

Applicant: BASF AG

Inventor： BRUNNER MELANIE ,  THIL LUCIEN ,  BREITSCHEIDEL BORIS ,  OTTER RAINER

IPC: C07C61/08 ,  C07C61/09 ,  C08K5/12 ,  C08K5/10 ,  C07C69/75

Abstract: Cyclohexane-polycarboxylic acids or their derivatives which do not cause a significant increase in liver weight or a doubling of specific enzyme activity in liver homogenates when tested in rodents at oral dosage levels of 1000 mg/kg per day for at least 14 days, are used as plasticizers for toxicologically acceptable plastics. Cyclohexane-polycarboxylic acids or their derivatives (or mixtures of these) which do not cause a significant increase in liver weight or a doubling of the specific activity of cyanide-insensitive palmitoyl-CoA oxidase in liver homogenates after administration to rodents by stomach tube at a daily dosage of 1000 mg/kg body weight for at least 14 days are used as plasticizers for the production of toxicologically acceptable plastics.