公开(公告)号：CO4600682A1

公开(公告)日：1998-05-08

申请号：CO97006960

申请日：1997-02-11

Applicant: BASF AG

Inventor： RADITSCH MARTIN ,  BOLLSCHWEILE CLAUS ,  HANS WOLGANG ,  RUBSAMEN KLAUS ,  FRIEDRICH THOMAS ,  SCHWEDEN JURGEN ,  SCHMIDT MARTIN

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/36 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91

Abstract: LA PRESENTE INVENCION SE REFIERE A NUEVAS TROMBIN MUTEINAS SU PREPARACION Y UTILIZACION COMO ANTIDOTO PARA LOS INHIBIDORES DE LA TROMBINA.

公开(公告)号：AU1768497A

公开(公告)日：1997-08-28

申请号：AU1768497

申请日：1997-02-11

Applicant: BASF AG

Inventor： RADITSCH MARTIN ,  FRIEDRICH THOMAS ,  BOLLSCHWEILER CLAUS ,  SCHMIDT MARTIN ,  HOFFKEN HANS WOLFGANG ,  SCHWEDEN JURGEN ,  RUBSAMEN KLAUS

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91 ,  A61K38/48

Abstract: PCT No. PCT/EP97/00612 Sec. 371 Date Aug. 4, 1998 Sec. 102(e) Date Aug. 4, 1998 PCT Filed Feb. 11, 1997 PCT Pub. No. WO97/29198 PCT Pub. Date Aug. 14, 1997The invention concerns thrombin muteins which have the following differences in their sequences as compared with natural thrombin: (a) the exchange of a Gly after Ala, the Gly being in the sequence environment Tyr-Gly-Phe and having position 558 in natural human thrombin (SEQ ID No. 14); (b) at least one exchange or deletion of the following radicals: (b1) His, located in the sequence environment Ala-His-Cys and having position 363 in natural human thrombin (SEQ ID No. 14); (b2) Asp, located in the sequence environment Arg-Asp-Ile and having position 419 in natural human thrombin (SEQ ID No. 14); (b3) Ser, located in the sequence environment Asp-Ser-Gly and having position 525 in natural human thrombin (SEQ ID No. 14). The invention further concerns the use of these muteins as antidotes.

公开(公告)号：BR9408195A

公开(公告)日：1997-08-26

申请号：BR9408195

申请日：1994-11-25

Applicant: BASF AG

Inventor： SCHWEDEN JURGEN ,  ECKES PETER ,  HORNBERGER WILFRIED ,  SUBKOWSKI THOMAS

IPC: A61K38/00 ,  A61K47/48 ,  A61P7/02

Abstract: PCT No. PCT/EP94/03901 Sec. 371 Date May 31, 1996 Sec. 102(e) Date May 31, 1996 PCT Filed Nov. 25, 1994 PCT Pub. No. WO95/15183 PCT Pub. Date Jun. 8, 1995The invention relates to novel hirudin conjugates formed from a hirudin and one or more lipophilic compounds, where the lipophilic compound has an octanol/water partition coefficient of more than 1.8 and is chemically linked to the hirudin, to the preparation thereof and to the use thereof.

公开(公告)号：NO962261D0

公开(公告)日：1996-05-31

申请号：NO962261

申请日：1996-05-31

Applicant: BASF AG

Inventor： SCHWEDEN JURGEN ,  ECKES PETER ,  HORNBERGER WILFRIED ,  SUBKOWSKI THOMAS

IPC: A61K38/00 ,  A61K47/48 ,  A61P7/02

Abstract: PCT No. PCT/EP94/03901 Sec. 371 Date May 31, 1996 Sec. 102(e) Date May 31, 1996 PCT Filed Nov. 25, 1994 PCT Pub. No. WO95/15183 PCT Pub. Date Jun. 8, 1995The invention relates to novel hirudin conjugates formed from a hirudin and one or more lipophilic compounds, where the lipophilic compound has an octanol/water partition coefficient of more than 1.8 and is chemically linked to the hirudin, to the preparation thereof and to the use thereof.

公开(公告)号：PL354402A1

公开(公告)日：2004-01-12

申请号：PL35440200

申请日：2000-06-07

Applicant: BASF AG

Inventor： RADEMACHER WILHELM ,  KRAMER KLAUS ,  SCHWEDEN JURGEN

IPC: A01G7/00 ,  A01N37/42 ,  A61K8/96 ,  A61K8/97 ,  A61K36/00 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P35/00 ,  A61P39/06 ,  A61P43/00

Abstract: The invention relates to a method of increasing the flavonoid content of plants by treating the plants with the growth-regulating acylcyclohexadiones according to formula (I).

公开(公告)号：BG105246A

公开(公告)日：2001-10-31

申请号：BG10524601

申请日：2001-02-13

Applicant: BASF AG

Inventor： RADEMACHER WILHELM ,  KRAMER KLAUS ,  SCHWEDEN JURGEN ,  HERBERS KARIN

IPC: A01H5/00 ,  A23K1/14 ,  A23L1/30 ,  A61K8/96 ,  A61K8/97 ,  A61K36/00 ,  A61K36/18 ,  A61K36/23 ,  A61K36/48 ,  A61K36/73 ,  A61K36/75 ,  A61K36/81 ,  A61K36/896 ,  A61K36/899 ,  A61P1/14 ,  A61P3/06 ,  A61P29/00 ,  A61P35/00 ,  A61P39/06 ,  A61P43/00 ,  A61Q19/00 ,  C12N5/10 ,  C12N9/02 ,  C12N15/09 ,  C12N15/29 ,  C12N15/53 ,  C12N15/82 ,  C10M169/04 ,  H01B3/20

Abstract: The invention relates to a method for increasing flavonoid content in plants. Said method is characterized that a plant is produced using molecular genetic methods in which the activity of enzyme flavanon-3-hydroxylase is reduced. 5 claims, 3 figures

公开(公告)号：AU5970400A

公开(公告)日：2001-01-09

申请号：AU5970400

申请日：2000-06-07

Applicant: BASF AG

Inventor： RADEMACHER WILHELM ,  KRAMER KLAUS ,  SCHWEDEN JURGEN ,  HERBERS KARIN

IPC: A01H5/00 ,  A23K1/14 ,  A23L1/30 ,  A61K8/96 ,  A61K8/97 ,  A61K36/00 ,  A61K36/18 ,  A61K36/23 ,  A61K36/48 ,  A61K36/73 ,  A61K36/75 ,  A61K36/81 ,  A61K36/896 ,  A61K36/899 ,  A61P1/14 ,  A61P3/06 ,  A61P29/00 ,  A61P35/00 ,  A61P39/06 ,  A61P43/00 ,  A61Q19/00 ,  C12N5/10 ,  C12N9/02 ,  C12N15/09 ,  C12N15/29 ,  C12N15/53 ,  C12N15/82 ,  A23L1/00 ,  A61K31/35

Abstract: The invention relates to a method for increasing flavonoid content in plants. Said method is characterized that a plant is produced using molecular genetic methods in which the activity of enzyme flavanon-3-hydroxylase is reduced.

公开(公告)号：CA2371896A1

公开(公告)日：2000-12-28

申请号：CA2371896

申请日：2000-06-07

Applicant: BASF AG

Inventor： RADEMACHER WILHELM ,  SCHWEDEN JURGEN ,  KRAMER KLAUS

IPC: A01G7/00 ,  A01N37/42 ,  A61K8/96 ,  A61K8/97 ,  A61K36/00 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P35/00 ,  A61P39/06 ,  A61P43/00

Abstract: The invention relates to a method of increasing the flavonoid content of plants by treating the plants with the growth-regulating acylcyclohexadiones according to formula (I).

公开(公告)号：SG49156A1

公开(公告)日：1998-05-18

申请号：SG1996006978

申请日：1994-11-25

Applicant: BASF AG

Inventor： ECKES PETER ,  HORNBERGER WILFRIED ,  SCHWEDEN JURGEN ,  SUBKOWSKI THOMAS

IPC: A61K38/00 ,  A61K47/48 ,  A61P7/02

Abstract: PCT No. PCT/EP94/03901 Sec. 371 Date May 31, 1996 Sec. 102(e) Date May 31, 1996 PCT Filed Nov. 25, 1994 PCT Pub. No. WO95/15183 PCT Pub. Date Jun. 8, 1995The invention relates to novel hirudin conjugates formed from a hirudin and one or more lipophilic compounds, where the lipophilic compound has an octanol/water partition coefficient of more than 1.8 and is chemically linked to the hirudin, to the preparation thereof and to the use thereof.

公开(公告)号：NZ276410A

公开(公告)日：1997-03-24

申请号：NZ27641094

申请日：1994-11-25

Applicant: BASF AG

Inventor： SCHWEDEN JURGEN ,  ECKES PETER ,  HORNBERGER WILFRIED ,  SUBKOWSKI THOMAS

IPC: A61K38/00 ,  A61K47/48 ,  A61P7/02 ,  A61K38/58 ,  C07K14/815

Abstract: PCT No. PCT/EP94/03901 Sec. 371 Date May 31, 1996 Sec. 102(e) Date May 31, 1996 PCT Filed Nov. 25, 1994 PCT Pub. No. WO95/15183 PCT Pub. Date Jun. 8, 1995The invention relates to novel hirudin conjugates formed from a hirudin and one or more lipophilic compounds, where the lipophilic compound has an octanol/water partition coefficient of more than 1.8 and is chemically linked to the hirudin, to the preparation thereof and to the use thereof.