公开(公告)号：WO9805360A3

公开(公告)日：1998-05-07

申请号：PCT/EP9703899

申请日：1997-07-21

Applicant: BASF AG ,  KOLTER KARL ,  SUBKOWSKI THOMAS ,  RADITSCH MARTIN ,  SCHEHLMANN VOLKER

Inventor： KOLTER KARL ,  SUBKOWSKI THOMAS ,  RADITSCH MARTIN ,  SCHEHLMANN VOLKER

IPC: A61K9/02 ,  A61K9/06 ,  A61K9/10 ,  A61K9/107 ,  A61K9/14 ,  A61K9/16 ,  A61K9/20 ,  A61K9/28 ,  A61K31/78 ,  A61K33/24 ,  A61K45/06 ,  A61K47/32

CPC classification number: A61K47/32 ,  A61K9/2027 ,  A61K9/2846 ,  A61K31/78 ,  A61K33/24 ,  A61K45/06 ,  A61K2300/00

Abstract: (Meth)acrylic acid copolymers used to increase the permeability of mucous membranes contain as comonomers (meth)acrylic acid esters and/or other radically polymerisable monomers, the molar ratio between (meth)acrylic acid and comonomer varying between 99:1 and 1:99.

公开(公告)号：HU9900574A2

公开(公告)日：1999-06-28

申请号：HU9900574

申请日：1997-02-11

Applicant: BASF AG

Inventor： BOLLSCHWEILER CLAUS ,  FRIEDRICH THOMAS ,  HOEFFKEN HANS WOLFGANG ,  RADITSCH MARTIN ,  RUEBSAMEN KLAUS ,  SCHMIDT MARTIN ,  SCHWEDEN JUERGEN

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91 ,  A61K38/48

Abstract: PCT No. PCT/EP97/00612 Sec. 371 Date Aug. 4, 1998 Sec. 102(e) Date Aug. 4, 1998 PCT Filed Feb. 11, 1997 PCT Pub. No. WO97/29198 PCT Pub. Date Aug. 14, 1997The invention concerns thrombin muteins which have the following differences in their sequences as compared with natural thrombin: (a) the exchange of a Gly after Ala, the Gly being in the sequence environment Tyr-Gly-Phe and having position 558 in natural human thrombin (SEQ ID No. 14); (b) at least one exchange or deletion of the following radicals: (b1) His, located in the sequence environment Ala-His-Cys and having position 363 in natural human thrombin (SEQ ID No. 14); (b2) Asp, located in the sequence environment Arg-Asp-Ile and having position 419 in natural human thrombin (SEQ ID No. 14); (b3) Ser, located in the sequence environment Asp-Ser-Gly and having position 525 in natural human thrombin (SEQ ID No. 14). The invention further concerns the use of these muteins as antidotes.

公开(公告)号：NO983677A

公开(公告)日：1998-08-11

申请号：NO983677

申请日：1998-08-11

Applicant: BASF AG

Inventor： RADITSCH MARTIN ,  FRIEDRICH THOMAS ,  BOLLSCHWEILER CLAUS ,  SCHMIDT MARTIN ,  H FFKEN HANS WOLFGANG ,  SCHWEDEN J RGEN ,  R BSAMEN KLAUS

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91 ,  A61K38/48

CPC classification number: C12N9/6429 ,  A61K38/00 ,  C12Y304/21005

公开(公告)号：ES2221060T3

公开(公告)日：2004-12-16

申请号：ES97934501

申请日：1997-07-21

Applicant: BASF AG

Inventor： KOLTER KARL ,  SUBKOWSKI THOMAS ,  RADITSCH MARTIN ,  SCHEHLMANN VOLKER

IPC: A61K9/02 ,  A61K9/06 ,  A61K9/10 ,  A61K9/107 ,  A61K9/14 ,  A61K9/16 ,  A61K9/20 ,  A61K9/28 ,  A61K31/78 ,  A61K33/24 ,  A61K45/06 ,  A61K47/32

Abstract: UTILIZACION DE COPOLIMEROS DEL ACIDO (MET)ACRILICO PARA ELEVAR LA PERMEABILIDAD DE LA MUCOSA, CONTENIENDO COMO COMONOMEROS ESTERES DEL ACIDO (MET)ACRILICO Y/O OTROS MONOMEROS POLIMERIZABLES DE MANERA RADICAL, Y VARIANDO LA RELACION MOLAR ACIDO (MET)ACRILICO : COMONOMERO DE 99 : 1 HASTA 1 : 99.

公开(公告)号：BR9707280A

公开(公告)日：1999-07-20

申请号：BR9707280

申请日：1997-02-11

Applicant: BASF AG

Inventor： RADITSCH MARTIN ,  FRIEDRICH THOMAS ,  BOLLSCHWEILER CLAUS ,  SCHMIDT MARTIN ,  HOFFKEN HANS WOLFGANG ,  SCHWEDEN JURGEN ,  RUBSAMEN KLAUS

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91 ,  A61K38/48

Abstract: PCT No. PCT/EP97/00612 Sec. 371 Date Aug. 4, 1998 Sec. 102(e) Date Aug. 4, 1998 PCT Filed Feb. 11, 1997 PCT Pub. No. WO97/29198 PCT Pub. Date Aug. 14, 1997The invention concerns thrombin muteins which have the following differences in their sequences as compared with natural thrombin: (a) the exchange of a Gly after Ala, the Gly being in the sequence environment Tyr-Gly-Phe and having position 558 in natural human thrombin (SEQ ID No. 14); (b) at least one exchange or deletion of the following radicals: (b1) His, located in the sequence environment Ala-His-Cys and having position 363 in natural human thrombin (SEQ ID No. 14); (b2) Asp, located in the sequence environment Arg-Asp-Ile and having position 419 in natural human thrombin (SEQ ID No. 14); (b3) Ser, located in the sequence environment Asp-Ser-Gly and having position 525 in natural human thrombin (SEQ ID No. 14). The invention further concerns the use of these muteins as antidotes.

公开(公告)号：ZA9701107B

公开(公告)日：1998-08-11

申请号：ZA9701107

申请日：1997-02-11

Applicant: BASF AG

Inventor： RADITSCH MARTIN ,  FRIEDRICH THOMAS ,  BOLLSCHWEILER CLAUS ,  SCHMIDT MARTIN ,  HOEFFKEN HANS WOLFGANG ,  SCHWEDEN JUERGEN ,  RUEBSAMEN KLAUS

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91 ,  C07K ,  A61K ,  C07H

CPC classification number: C12N9/6429 ,  A61K38/00 ,  C12Y304/21005

公开(公告)号：NO983677L

公开(公告)日：1998-08-11

申请号：NO983677

申请日：1998-08-11

Applicant: BASF AG

Inventor： RADITSCH MARTIN ,  FRIEDRICH THOMAS ,  BOLLSCHWEILER CLAUS ,  SCHMIDT MARTIN ,  H FFKEN HANS WOLFGANG ,  SCHWEDEN J RGEN ,  R BSAMEN KLAUS

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91 ,  A61K38/48

Abstract: PCT No. PCT/EP97/00612 Sec. 371 Date Aug. 4, 1998 Sec. 102(e) Date Aug. 4, 1998 PCT Filed Feb. 11, 1997 PCT Pub. No. WO97/29198 PCT Pub. Date Aug. 14, 1997The invention concerns thrombin muteins which have the following differences in their sequences as compared with natural thrombin: (a) the exchange of a Gly after Ala, the Gly being in the sequence environment Tyr-Gly-Phe and having position 558 in natural human thrombin (SEQ ID No. 14); (b) at least one exchange or deletion of the following radicals: (b1) His, located in the sequence environment Ala-His-Cys and having position 363 in natural human thrombin (SEQ ID No. 14); (b2) Asp, located in the sequence environment Arg-Asp-Ile and having position 419 in natural human thrombin (SEQ ID No. 14); (b3) Ser, located in the sequence environment Asp-Ser-Gly and having position 525 in natural human thrombin (SEQ ID No. 14). The invention further concerns the use of these muteins as antidotes.

公开(公告)号：AU3769197A

公开(公告)日：1998-02-25

申请号：AU3769197

申请日：1997-07-21

Applicant: BASF AG

Inventor： KOLTER KARL ,  SUBKOWSKI THOMAS ,  RADITSCH MARTIN ,  SCHEHLMANN VOLKER

IPC: A61K9/02 ,  A61K9/06 ,  A61K9/10 ,  A61K9/107 ,  A61K9/14 ,  A61K9/16 ,  A61K9/20 ,  A61K9/28 ,  A61K31/78 ,  A61K33/24 ,  A61K45/06 ,  A61K47/32

Abstract: (Meth)acrylic acid copolymers are used to increase mucosal permeability, comonomers present being (meth)acrylic esters and/or other monomers capable of free-radical polymerization, and the (meth)acrylic acid:comonomer molar ratio varying from 99:1 to 1:99.

公开(公告)号：CA2245546A1

公开(公告)日：1997-08-14

申请号：CA2245546

申请日：1997-02-11

Applicant: BASF AG

Inventor： H FFKEN HANS WOLFGANG ,  SCHWEDEN JUERGEN ,  RADITSCH MARTIN ,  FRIEDRICH THOMAS ,  RUEBSAMEN KLAUS ,  SCHMIDT MARTIN ,  BOLLSCHWEILER CLAUS

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91 ,  A61K38/48

Abstract: The invention concerns thrombin muteins which have the following differences in their sequences as compared with natural thrombin: (a) the exchange of a Gly after Ala, the Gly being in the sequence environment Tyr-Gly-Phe and having position 558 in natural human thrombin (SEQ ID No. 14); (b) at least one exchange or deletion of the following radicals: (b1) His, located in the sequence environment Ala-His-Cys and having position 363 in natural human thrombin (SEQ ID No. 14); (b2) Asp, located in the sequence environment ArgAsp-Ile and having position 419 in natural human thrombin (SEQ ID No. 14); (b3) Ser, located in the sequence environment Asp-Ser-Gly and having position 525 in natural human thrombin (SEQ ID No. 14). The invention further concerns the use of these muteins as antidotes.

公开(公告)号：BR9710889A

公开(公告)日：1999-08-17

申请号：BR9710889

申请日：1997-07-21

Applicant: BASF AG

Inventor： KOLTER KARL ,  SUBKOWSKI THOMAS ,  RADITSCH MARTIN ,  SCHEHLMANN VOLKER

IPC: A61K9/02 ,  A61K9/06 ,  A61K9/10 ,  A61K9/107 ,  A61K9/14 ,  A61K9/16 ,  A61K9/20 ,  A61K9/28 ,  A61K31/78 ,  A61K33/24 ,  A61K45/06 ,  A61K47/32

Abstract: (Meth)acrylic acid copolymers are used to increase mucosal permeability, comonomers present being (meth)acrylic esters and/or other monomers capable of free-radical polymerization, and the (meth)acrylic acid:comonomer molar ratio varying from 99:1 to 1:99.