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公开(公告)号：BG63500B1
公开(公告)日：2002-03-29
申请号：BG10111397
申请日：1997-01-06
Applicant: BASF AG
Inventor： HELLENDAHL BEATE , LANSKY ANNEGRET , MUNSCHAUER RAINER , BIALOJAN SIEGFRIED , UNGER LILIANE , TESCHENDORF HANS-JUERGEN , WICKE KARSTEN , DRESCHER KARLA
IPC: C07D249/08 , A61K31/41 , A61K31/435 , A61K31/4427 , A61K31/445 , A61K31/505 , A61K31/53 , A61P1/08 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , C07D249/12 , C07D249/14 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
Abstract: The invention relates to triazole compounds with the formula where R1 & R2 mean hydrogen or different substituents, A is a two-valent group, B is residue with formula a, b or c and Ar in a given case means substituted phenyl, pyridyl, pyrimidyl or triazinyl. The compounds have higher affinity to dopamine-D3-receptors and can be used for the treatment of diseases which react to dopamine-D3-ligands. 13 claims
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公开(公告)号：ZA200101976B
公开(公告)日：2002-03-11
申请号：ZA200101976
申请日：2001-03-09
Applicant: BASF AG
Inventor： STEINER GERD , HOEGER THOMAS , UNGER LILIANE , TESCHENDORF HANS-JUERGEN , JUCHELKA FRIEDER
IPC: A61K31/425 , A61K31/428 , A61P25/00 , C07D417/06 , C07D , A61K
Abstract: Compounds of the formula I:in which R1, R2, R3 and R4 have the meanings stated in the description, are described.The novel compounds are suitable for controlling diseases.
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公开(公告)号：SK9682001A3
公开(公告)日：2002-03-05
申请号：SK9682001
申请日：1999-12-22
Applicant: BASF AG
Inventor： STEINER GERD , SCHELLHAAS KURT , LUBISCH WILFRIED , HOLZENKAMP UTA , STARCK DOROTHEA , SZABO LASZLO , EMLING FRANZ , GARCIA-LADONA FRANCISCO JAVIER , HOFMANN HANS-PETER , UNGER LILIANE
IPC: C07D275/06 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/502 , A61K31/517 , A61K31/519 , A61K31/522 , A61K31/55 , A61K31/551 , A61P9/10 , A61P25/28 , C07D401/12 , C07D417/12 , C07D471/04 , A61K31/428
Abstract: The invention relates to the utilisation of compounds of formula (I) wherein the substituents have the meanings given in the description. The invention also relates to the salts thereof comprising pharmacologically compatible acids for producing medicaments for the prophylaxis and therapy of cerebral ischaemia and strokes.
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公开(公告)号：NZ504289A
公开(公告)日：2002-03-01
申请号：NZ50428998
申请日：1998-11-04
Applicant: BASF AG
Inventor： UNGER LILIANE , RASCHACK MANFRED , AMBERG WILHELM , JANSEN ROLF , HILLEN HEINZ , HERGENRODER STEFAN
IPC: C07D249/12 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/433 , A61P9/04 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/08 , A61P13/12 , A61P35/00 , A61P43/00 , C07D231/20 , C07D233/70 , C07D261/12 , C07D263/38 , C07D271/06 , C07D271/10 , C07D273/01 , C07D275/02 , C07D275/03 , C07D277/20 , C07D277/32 , C07D277/34 , C07D277/60 , C07D277/68 , C07D285/00 , C07D285/08 , C07D285/12 , C07D291/04 , C07D413/12 , C07D417/12 , A61P9/00
Abstract: Carboxylic acid derivatives of formula I, and their preparation and use as endothelin receptor antagonists.
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公开(公告)号：HU0100054A2
公开(公告)日：2002-02-28
申请号：HU0100054
申请日：1998-10-16
Applicant: BASF AG
Inventor： AMBERG WILHELM , HERGENROEDER STEFAN , JANSEN ROLF , RASCHACK MANFRED , UNGER LILIANE
IPC: A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61P9/02 , A61P9/10 , A61P9/12 , A61P13/08 , A61P13/12 , A61P35/00 , A61P43/00 , C07D239/34 , C07D239/36 , C07D239/52 , C07D239/60 , C07D239/70 , C07D401/12 , C07D403/12 , C07D491/048
Abstract: The invention relates to carboxylic acid derivatives of formula (I), wherein the substituents have the meaning as commented in the description. It also relates to the production and use of same as endothelin receptor antagonists.
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Patent Agency Ranking
公开(公告)号：HRP950115B1
公开(公告)日：2001-12-31
申请号：HRP950115
申请日：1995-03-09
Applicant: BASF AG
Inventor： BAUMANN ERNST , VOGELBACHER UWE JOSEF , RHEINHEIMER JOACHIM , KLINGE DAGMAR , RIECHERS HARTMUT , KROEGER BURGHARD , BIALOJAN SIEGFRIED , BOLLSCHWEILER CLAUS , WERNET WOLFGANG , UNGER LILIANE , RASCHACK MANFRED
IPC: C07D251/26 , A61K31/00 , A61K31/505 , A61K31/506 , A61K31/53 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , A61P39/02 , C07D239/26 , C07D239/34 , C07D239/38 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: PCT No. PCT/EP95/01099 Sec. 371 Date Sep. 30, 1996 Sec. 102(e) Date Sep. 30, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/26716 PCT Pub. Date Oct. 12, 1995A method of inhibiting endothelin receptors by administering to a patient a compound of the formula I I
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公开(公告)号：GR3036606T3
公开(公告)日：2001-12-31
申请号：GR20010401467
申请日：2001-09-12
Applicant: BASF AG
Inventor： BAUMANN ERNST , VOGELBACHER UWE JOSEF , RHEINHEIMER JOACHIM , KLINGE DAGMAR , RIECHERS HARTMUT , KROEGER BURKHARD , BIALOJAN SIEGFRIED , BOLLSCHWEILER CLAUS , WERNET WOLFGANG , UNGER LILIANE , RASCHACK MANFRED
IPC: C07D251/26 , A61K31/00 , A61K31/505 , A61K31/506 , A61K31/53 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , A61P39/02 , C07D239/26 , C07D239/34 , C07D239/38 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: PCT No. PCT/EP95/01099 Sec. 371 Date Sep. 30, 1996 Sec. 102(e) Date Sep. 30, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/26716 PCT Pub. Date Oct. 12, 1995A method of inhibiting endothelin receptors by administering to a patient a compound of the formula I I
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公开(公告)号：ID30022A
公开(公告)日：2001-11-01
申请号：ID20011717
申请日：1999-12-22
Applicant: BASF AG
Inventor： STEINER GERD , SCHELLHAAS KURT , LUBISCH WILFRIED , HOLZENKAMP UTA , STARCK DOROTHEA , SZABO LASZLO , EMLING FRANZ , LADONA FRANSISCO JAVIER GARCIA , HOFMANN HANS PETER , UNGER LILIANE
IPC: C07D495/04 , A61K31/505 , A61K31/519 , A61P9/10 , C07D495/14
Abstract: Use of pyrimidine derivatives of the formula Iwhere the substituents are as defined in the description, and of their physiologically tolerated salts for producing medicaments for the prophylaxis and treatment of cerebral ischemia and strokes.
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29.发明专利
公开(公告)号：AU740351B2
公开(公告)日：2001-11-01
申请号：AU5659498
申请日：1997-12-04
Applicant: BASF AG
Inventor： AMBERG WILHELM , JANSEN ROLF , KLING ANDREAS , KLINGE DAGMAR , RIECHERS HARTMUT , HERGENRODER STEFAN , RASCHACK MANFRED , UNGER LILIANE
IPC: C07D253/06 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/53 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/08 , C07D237/14 , C07D237/16 , C07D241/18 , C07D253/07 , C07D253/075 , C07D253/10 , C07D403/12 , C07D491/04 , C07D253/08 , C07D241/20 , C07D237/18 , C07D237/20 , C07D237/22
Abstract: The present invention relates to carboxylic acid derivatives of the formula Iwhere the substituents have the meanings explained in the description, and to preparation and use as endothelin receptor antagonists.
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公开(公告)号：DK0752854T3
公开(公告)日：2001-10-08
申请号：DK95914301
申请日：1995-03-23
Applicant: BASF AG
Inventor： BAUMANN ERNST , RHEINHEIMER JOACHIM , VOGELBACHER UWE JOSEF , BOLLSCHWEILER CLAUS , UNGER LILIANE , KLINGE DAGMAR , RASCHACK MANFRED , WERNET WOLFGANG , RIECHERS HARTMUT , KROEGER BURKHARD , BIALOJAN SIEGFRIED
IPC: C07D251/26 , A61K31/00 , A61K31/505 , A61K31/506 , A61K31/53 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , A61P39/02 , C07D239/26 , C07D239/34 , C07D239/38 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: PCT No. PCT/EP95/01099 Sec. 371 Date Sep. 30, 1996 Sec. 102(e) Date Sep. 30, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/26716 PCT Pub. Date Oct. 12, 1995A method of inhibiting endothelin receptors by administering to a patient a compound of the formula I I
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