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21.发明专利
公开(公告)号：CA2365557A1
公开(公告)日：2000-10-26
申请号：CA2365557
申请日：2000-04-12
Applicant: BAXTER INT
Inventor： BILSTAD ARNOLD C , BUCHANAN BRADLEY H , MARTTILA ALAN W , WOODWORTH ARCHIE
IPC: A61L2/24 , A61L2/00 , A61L2/08 , A61L2/10 , A61L2/14 , A61L2/20 , A61M39/18 , B29C65/00 , B29C65/02 , B29C65/04 , B29C65/10 , B29C65/48 , B67C7/00 , B65B55/02
Abstract: The connection, assembly, or fill of two or more pre-sterilized components having at least one terminal end each for attachment to another component, a nd an apparatus for performing such a connection, while maintaining the sterili ty of the components is disclosed. The resulting connection is made permanent b y bonding the contacting components together using either a solvent bonding technique, a radio frequency sealer, a heat sealer, or any other suitable process. The connection is preferably made within an active sterile field. Using a low-voltage electron beam instrument, such as the MIN-EBTM, a suitab le sterile field sphere can be created. The terminal ends of the multiple components remain withing the sterile field sphere until the possibility of contamination within the sealed components is significantly reduced to industry acceptable standards.
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公开(公告)号：CA1270467A
公开(公告)日：1990-06-19
申请号：CA536719
申请日：1987-05-08
Applicant: BAXTER INT
Inventor： PATTILLO MARTHA C , BACEHOWSKI DAVID V , BILSTAD ARNOLD C , CULLIS HERBERT M , DENNEHEY T MICHAEL , YANG JAMES W , BROWN WILLIAM C
Abstract: SYSTEM FOR METERING NUTRIENT MEDIA TO CELL CULTURE CONTAINERS AND METHOD A system for metering nutrient media to cell culture containers includes a media flow conduit which defines at one end means for substantially aseptic communication with the source of the media. In a preferred embodiment, sterile connectors may be used from essentially sterile conditions. A branch conduit extends from the flow conduit at a location spaced from the ends. The branch conduit communicates with means for receiving a predetermined-volume aliquot of media through the media flow conduit from said one end. The flow conduit also defines a portion downstream from the branch conduit, which communicates with at least one cell culture container, each container being a flexible bag. At least part of the flexible bag is made of a material capable of providing at least 2 times the oxygen diffusion and at least 2 times the carbon dioxide diffusion between the bag interior and exterior, compared with an identically-sized, scaled bag having polyethylene walls 0.013 inch thick.
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Patent Agency Ranking
公开(公告)号：DE3475872D1
公开(公告)日：1989-02-09
申请号：DE3475872
申请日：1984-05-24
Applicant: BAXTER INT
Inventor： BILSTAD ARNOLD C , BROWN RICHARD I , KRUGER ROBERT J
Abstract: A single needle batch-type blood fractionation system for separating plasma from whole blood includes a disposable flow system having a single-lumen phlebotomy needle and associated donor conduit, a flow-through plasma separation filter, and an in-process fluid reservoir. During an initial draw cycle whole blood is pumped through the filter to the in-process reservoir by a peristaltic-type inlet pump operating at a predetermined draw rate. When a predetermined volume of filtered plasma-deficient blood has been collected in the reservoir, as sensed by the weight of the reservoir the system reverts to a return cycle wherein a portion of the plasma deficient blood in the reservoir is pumped back to the donor conduit by a peristaltic-type return pump operating at a predetermined return rate higher than the draw rate of the inlet pump. Depending on the relative operating speeds of the inlet and return pumps, an operator-controlfable portion of the plasma-deficient blood from the in-process reservoir is returned to the donor through the phlebotomy needle, and the remaining portion is recirculated through the filter. The partial recirculation of plasma-deficient blood through the filter during the return mode reduces the processing time of the system, provides for improved accommodation of whole blood of unusually high or low hematocrit, and enables the use of a smaller and less expensive filter.
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公开(公告)号：BR0210919A
公开(公告)日：2006-10-24
申请号：BR0210919
申请日：2002-06-12
Applicant: BAXTER INT
Inventor： WILLIAMSON MARK E , ARIAGNO SCOTT R , MARTTILA ALAN W , BILSTAD ARNOLD C , DIPERNA PAUL M , PRISCO MICHAEL R , PENNINGTON DAVID W , YARDIMCI ATIF M , SMITH SIDNEY T , PERRY MARK C , BELLOTTI MARC
IPC: F16K7/12 , A47G21/18 , A61J1/05 , A61J1/10 , A61J15/00 , A61M11/06 , A61M15/00 , A61M39/00 , A61M39/22 , F16K7/17 , F16K15/02 , F16K15/03 , F16K15/14 , B65D47/20 , A61M39/24
Abstract: A vacuum demand valve for delivering a flowable material is disclosed. The valve has a housing having a proximal end, a distal end, an intermediate segment therebetween defining a passageway wherein the flowable substance can flow from the proximal end to the distal end. The housing can be a tubing. A valve member is located along the intermediate segment. The valve member has a closed condition wherein the flow of the flowable material from the proximal end to the distal end is stopped and an open condition wherein the flow of the flowable material from the proximal end to the distal end is unstopped. The valve member is biased in the closed condition and is responsive to a partial vacuum provided by the user through the passageway for placing the valve member in the open condition.
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公开(公告)号：CA1268154A
公开(公告)日：1990-04-24
申请号：CA498642
申请日：1985-12-24
Applicant: BAXTER INT
Inventor： ANTHONY JACK , BILSTAD ARNOLD C , LEBLONG WAYNE T , KRUGER ROBERT J
Abstract: A storage system (10) is provided that includes an interior envelope (12) and an exterior envelope (14). Tissue or other material to be stored may be placed in interior envelope (12), sealed and placed in exterior envelope (14). Exterior envelope (14) is sealable in a first sealed position that allows gas sterilization of the interior of exterior envelope (14) and the contents contained therein. After sterilization, exterior envelope (14) is sealed in a gas impermeable position. Each of interior and exterior envelopes (12, 14) have one side which is transparent. A grid (22) may be provided on the transparent side of interior envelope (12) for sizing tissue contained therein.
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公开(公告)号：CA1261217A
公开(公告)日：1989-09-26
申请号：CA455157
申请日：1984-05-25
Applicant: BAXTER INT
Inventor： BILSTAD ARNOLD C , BROWN RICHARD I , KRUGER ROBERT J
Abstract: SINGLE NEEDLE BLOOD FRACTIONATION SYSTEM HAVING ADJUSTABLE RECIRCULATION THROUGH FILTER A single needle batch-type blood fractionation system for separating plasma from whole blood includes a disposable flow system having a single-lumen phlebotomy needle and associated donor conduit, a flow-through plasma separation filter, and an in-process fluid reservoir. During an initial draw cycle whole blood is pumped through the filter to the in-process reservoir by a peristaltictype inlet pump operating at a predetermined draw rate. When a predetermined volume of filtered plasma-deficient blood has been collected in the reservoir, as sensed by the weight of the reservoir the system reverts to a return cycle wherein a portion of the plasma deficient blood in the reservoir is pumped back to the donor conduit by a peristaltic-type return pump operating at a predetermined return rate higher than the draw rate of the inlet pump. Depending on the relative operating speeds of the inlet and return pumps, an operator-controllable portion of the plasma-deficient blood from the in-process reservoir is returned to the donor through the phlebotomy needle, and the remaining portion is recirculated through the filter. The partial recirculation of plasma-deficient blood through the filter during the return mode reduces the processing time of the system, provides for improved accommodation of whole blood of unusually high or low hematocrit, and enables the use of a smaller and less expensive filter.
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公开(公告)号：AU1449888A
公开(公告)日：1988-07-07
申请号：AU1449888
申请日：1988-04-11
Applicant: BAXTER INT
Inventor： BILSTAD ARNOLD C , BROWN RICHARD I , KRUGER ROBERT J
IPC: A61M1/00 , A61M1/10 , A61M1/14 , A61M1/30 , A61M1/34 , B01D61/20 , B01D61/28 , F04B43/06 , F04B23/06 , F04B21/02
Abstract: A disposable prepackaged fluid processing module (20) for deriving plasma from whole blood includes an integral housing (22) wherein anticoagulant (ACD), saline and collection containers (43,44, and 30), tubing segments (27,28,31,56,60), a membrane filter element (141), and other components (63) required in the procedure are contained. Fluid communication between the containers, tubing segments and filter element is provided by a fluid circuit formed by a panel (36) of the housing (22), and an overlying fluid-impermeable flexible sheet member (71). The fluid circuit includes pump and valve elements (130-137) which operate in response to pressures applied to the sheet member. Upon installation of the system in a related actuator apparatus (21), pneumatic actuator ports (100-107) apply pressures to the pump and valve elements to circulate fluid through the fluid circuit.
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