公开(公告)号：AU9165191A

公开(公告)日：1992-07-22

申请号：AU9165191

申请日：1991-12-20

Applicant: BAXTER INT

Inventor： BISCHOF DANIEL F ,  WOLF LUDWIG JR ,  FOLEY JOHN T ,  BRATTEN WILLIAM R

IPC: A61M1/36 ,  A61L2/00 ,  A61L2/08 ,  A61M1/34 ,  B01J19/12 ,  A61M37/00

Abstract: A system and method for treating a fluid carrying a biological contaminant to which a photoactive material has been bound include a treatment device that defines a flow passage with a gap. The system and method operate to establish a flow of fluid from the inlet end of the gap to the outlet end of the gap. The system and method expose the fluid, as it transits the gap, to a source of radiation that activates the photoactive material bound to the contaminant. The system and method also mix the fluid as it flows within the gap.

公开(公告)号：CA2075640A1

公开(公告)日：1992-06-21

申请号：CA2075640

申请日：1991-12-20

Applicant: BAXTER INT ,  QUADRA LOGIC TECHNOLOGIES

Inventor： WOLF LUDWIG JR ,  FOLEY JOHN T ,  BRATTEN WILLIAM R ,  KUNZ GARY ,  STONEFIELD MICHAEL

IPC: A61L2/00 ,  A61L2/08 ,  A61L2/10 ,  A61M1/36 ,  B01J19/12

Abstract: A system (10) and method for treating a fluid carrying a contaminant to which a photoactive material has been bound include a treatment device (12) that defines a flow passage (36) with a dap (28). The system and method operate to establish a flow of fluid from the inlet (38) end of the gap (28) to the outlet end (40) of the, gap (28). The system and method also channel he flow of fluid in the gap (28) in succession through one or more paths. The system and method esta- blished at least two discrete sources of ra- diation (30), in the flow path (36) at spaced, apart locations along the direc- lion of fluid flow. At least one of the ra- diation sources (30) comprises a photodi- ode. The system and method further in- clude a control far operating each dis- crete source of radiation at a selected wavelength within the prescribed range to activate the photoactive material bound to the contaminant. Upon activa- tion, the material eradicates the contami- nant. The system and method provide ex- tracorporeal treatment of fluids like blood to quickly and effectively eradicate infection agents at relatively high flow rates.

公开(公告)号：CA2296364C

公开(公告)日：2008-05-06

申请号：CA2296364

申请日：1998-06-22

Applicant: BAXTER INT

Inventor： BROWN RICHARD I ,  FOLEY JOHN T ,  SAHLIN MARK ,  MIN KYUNGYOON

IPC: A61M1/36 ,  G01N33/49 ,  A61B5/145 ,  A61K35/14 ,  A61M1/02 ,  A61P7/00 ,  B01D17/02 ,  B01D17/12 ,  B01D21/24 ,  B01D21/26 ,  B04B5/04 ,  B04B13/00 ,  G01N21/35

Abstract: A blood processing chamber (22) separates blood into constituents including a plasma constituent that includes a platelet volume. An optical monitor (98) detects the optical density of the plasma constituen t and generates a first output indicative of the optical density. A processing element (100) integrates the first output relative to the volum e of plasma constituent and generates an integrated output. The integrated output correlates to the platelet volume. A second processing element (72) generates a third output based, at least in part, upon the integrated output, which encompasses parameters for storing the platelet volume.

公开(公告)号：CA2124806C

公开(公告)日：2004-02-10

申请号：CA2124806

申请日：1993-03-23

Applicant: BAXTER INT

Inventor： BROWN RICHARD I ,  FOLEY JOHN T

IPC: A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  B01D21/26 ,  B04B5/00 ,  B04B5/04 ,  G01D5/347 ,  B04B5/12 ,  G01D5/34

Abstract: System transmit a control signal between a rotating element and a stationary element of a blood separation centrifuge (78). An interface control system (234) mounts the element that views the interface on a rotating element of the centrifuge. The interface control system (234) includes a light source (236) and a light detector (244) on a viewing head (238) and a data link (278) for transmitting light intensity signals from the viewing head (238) to an interface control circuit (270) on the stationary frame of the centrifuge (78). The data link (278) includes an intensity control circuit (252) which adjusts the input to the light source (236) and a second light source (254).

公开(公告)号：BR0014802A

公开(公告)日：2003-11-11

申请号：BR0014802

申请日：2000-10-12

Applicant: BAXTER INT

Inventor： PIERCE JENNIFER A ,  PATNO TIMOTHY J ,  STINAFF RUSSELL D ,  NAYAK ABINASH ,  FOLEY JOHN T ,  WEBER MARK ,  DUNCAN TAMMY ,  BLICKHAN BRYAN J

IPC: G01N33/48 ,  A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  A61M37/00 ,  B01D33/15 ,  C02F1/68

公开(公告)号：CA2437094A1

公开(公告)日：2002-08-29

申请号：CA2437094

申请日：2002-02-12

Applicant: BAXTER INT

Inventor： CAIRONE ROBERT ,  FOLEY JOHN T ,  PIERCE JENNIFER A ,  PATNO TIMOTHY J

IPC: G01N33/48 ,  A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  A61M37/00

Abstract: Blood processing systems and methods convey blood drawn from a donor through a blood processing circuit to separate the blood into at least one targeted blood component for collection. The systems and methods derive an estimated effect of the procedure upon the donor. The estimated effect can be expresse d in terms of a net blood fluid volume loss, or as a hematodcrit of the donor after completion of the desired blood collection procedure. The systems and methods present the estimated effect to an operator for viewing, reading, or offloading.

公开(公告)号：CA2386482A1

公开(公告)日：2001-04-26

申请号：CA2386482

申请日：2000-10-12

Applicant: BAXTER INT

Inventor： FOLEY JOHN T ,  PATNO TIMOTHY J ,  BROWN RICHARD I

IPC: G01N33/49 ,  A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  B01D17/02 ,  B01D21/24 ,  B01D21/26 ,  B04B5/04 ,  B04B13/00 ,  G01N21/59 ,  B01D17/12

Abstract: Blood processing systems and methods separate blood into constituents including a plasma constituent that includes a platelet volume. The systems and methods detect the optical density of the plasma constituent and generat e a first output indicative of the optical density. A processing element integrates the first output relative to the volume of plasma constituent and generates an integrated output. The integrated output correlates to the platelet volume. A second processing element (324) generates an output based , at least in part, upon the integrated output, which depicts a value indicati ng a blood volume that needs to be processed to obtain a desired platelet volum e.

公开(公告)号：DE3855891T2

公开(公告)日：1997-11-20

申请号：DE3855891

申请日：1988-01-29

Applicant: BAXTER INT

Inventor： BROWN RICHARD I ,  SMITH SIDNEY ,  CERNY DAVID E ,  FOLEY JOHN T

IPC: A61K35/14 ,  A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  B01D17/02 ,  B01D21/24 ,  B01D21/26 ,  B04B5/00 ,  B04B5/04 ,  B04B7/08 ,  B04B11/04 ,  B04B13/00 ,  G01D5/347

Abstract: A method of separating a selected component, such as platelets, using a centrifuge, comprises separating the fluid into components in three regions (104,106,198) and conveying fluid into the centrifuge while discharging components from the outer two regions through respective ports (50c,50b). Also during such discharge, the selected component is accumulated in the intermediate region 9108) and, after a predetermined volume of one of the other components has been discharged, discharging the third component through one of the ports (50b).

公开(公告)号：DE3855891D1

公开(公告)日：1997-05-28

申请号：DE3855891

申请日：1988-01-29

Applicant: BAXTER INT

Inventor： BROWN RICHARD I ,  SMITH SIDNEY ,  CERNY DAVID E ,  FOLEY JOHN T

IPC: A61K35/14 ,  A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  B01D17/02 ,  B01D21/24 ,  B01D21/26 ,  B04B5/00 ,  B04B5/04 ,  B04B7/08 ,  B04B11/04 ,  B04B13/00 ,  G01D5/347

Abstract: A method of separating a selected component, such as platelets, using a centrifuge, comprises separating the fluid into components in three regions (104,106,198) and conveying fluid into the centrifuge while discharging components from the outer two regions through respective ports (50c,50b). Also during such discharge, the selected component is accumulated in the intermediate region 9108) and, after a predetermined volume of one of the other components has been discharged, discharging the third component through one of the ports (50b).

公开(公告)号：CA2154761A1

公开(公告)日：1995-06-22

申请号：CA2154761

申请日：1994-12-09

Applicant: BAXTER INT

Inventor： FOLEY JOHN T ,  CHAPMAN JOHN ,  WOLF LUDWIG JR

IPC: G01N33/48 ,  A01N1/02 ,  A61K35/14 ,  A61K38/00 ,  A61L2/00 ,  A61M1/02 ,  A61M1/36 ,  B01D15/08 ,  B01D61/00 ,  C12N7/04 ,  A61L2/08 ,  A61L2/18

Abstract: A method for treating a body fluid to at least substantially inactivate viral contaminants that may be present therein comprising the steps of: providing a body fluid; adding to the body fluid a viral inactivating agent to create a resultant product; and passing the resultant product through a column including material having an affinity for the viral inactivating agent.