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21.发明专利
公开(公告)号：AU3300901A
公开(公告)日：2001-08-07
申请号：AU3300901
申请日：2001-01-26
Applicant: BAXTER INT
Inventor： WOO LECON , BOGGS DANIEL R , STERNBERG SHMUEL , SANDFORD CRAIG , KHARE ATUL , BREILLATT JULIAN
Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous flow arrangement while exhibiting radiation dose uniformity and narrow residence time distribution of the fluid within the device. The device (10) comprises a radiation permeable cylindrical tube (12) having a concentric cylindrical rotor (14) disposed therein, thereby providing a thin gap (16) therebetween. A top plate (18) having a fluid outlet (26) and a bottom plate (20) having a fluid inlet (24) seal the cylindrical tube (12). The inlet (24) and outlet (26) are both in fluid communication with the thin gap (16). A rotor shaft (36) is diposed axially through the cylindrical rotor (14) and is connected to a motor (30). A pump provides fluid flow through the device (10). A radiation source provides sterilizing radiation to the fluid through the cylindrical tube (12). As the fluid flows, the motor (30) drives the rotor (14) to impart Taylor vortices to the fluid flow, which exchanges the fluid closer to the cylindrical tube (12) with the fluid closer to the rotor (14).
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公开(公告)号：CA2538839C
公开(公告)日：2014-02-18
申请号：CA2538839
申请日：2004-09-08
Applicant: BAXTER INT
Inventor： REITZ DOUGLAS W , ARIAGNO SCOTT , SHETH MIHIR , YARDIMCI ATIF , CLARKE ROBERT A , PENNINGTON DAVID W , PRISCO MICHAEL R , CHIM EDWIN , PAULEY ROBIN , SANDFORD CRAIG , SITES ARCH
Abstract: Flow-through systems for processing biological fluid are disclosed. The flow-through systems include a removal device in the flow path for removing unwanted compounds and agents. The removal device includes a removal media contained within a housing made of two separate portions sealed together. The housing is maintained in a substantially vertical disposition, thereby ensuring substantially uniform and complete exposure of the fluid to the media.
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23.发明专利
公开(公告)号：ES2340250T3
公开(公告)日：2010-06-01
申请号：ES01905092
申请日：2001-01-26
Applicant: BAXTER INT
Inventor： WOO LECON , BOGGS DANIEL R , STERNBERG SHMUEL , SANDFORD CRAIG , KHARE ATUL , BREILLATT JULIAN
Abstract: Dispositivo (110) para inactivar agentes patógenos en fluidos, que comprende: un recipiente (112) permeable a la radiación que comunica con un fluido de una corriente de fluido; una mezcladora (126, 128) dispuesta dentro del recipiente y que forma un intersticio entre la mezcladora (126, 128) y el recipiente (112), una fuente de radiación dispuesta a una distancia fija del recipiente, irradiando la fuente de radiación el fluido que se desplaza a través del recipiente, caracterizado porque la mezcladora comprende una superficie en cascada (128) y, a causa de su geometría, produce una turbulencia dentro del flujo de fluido que se desplaza a través del intersticio; y la fuente de radiación se selecciona entre el grupo consistente en radiación ultravioleta, gamma y por haz electrónico.
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公开(公告)号：DE60141509D1
公开(公告)日：2010-04-22
申请号：DE60141509
申请日：2001-01-26
Applicant: BAXTER INT
Inventor： WOO LECON , BOGGS DANIEL R , STERNBERG SHMUEL , SANDFORD CRAIG , KHARE ATUL , BREILLATT JULIAN
Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous thin fluid flow arrangement that exhibits radiation dose uniformity for fluids having high optical densities. Radiation dose uniformity is achieved in part through a "carrying" mechanism that moves or carries the fluid, thereby eliminating a channel flow velocity profile where flow volumes near the channel walls run the risk of overexposure to the radiation due to very large residence times within the channel. The device comprises a relatively flat belt chamber (22) connected to a fluid flow through an inlet (24) and an outlet (26) on the belt chamber (22). The belt chamber (22) has a top surface (28) and a bottom surface (30). A radiation permeable plate (32) is disposed adjacent the top surface (28) of the belt chamber (22) and is in contact with the belt chamber (22). A radiation source (42) is provided adjacent to the plate (32) adjacent to a side opposite the belt chamber (22). A belt (34) having a plurality of flexible vanes (36) is disposed adjacent the bottom surface (30) of the belt chamber (22) such that the vanes (36) make contact with the belt chamber (22). The belt is driven by a roller mechanism (38) in the direction of the fluid flow. As the fluid flows through the belt chamber (22), the flexible vanes (36) provide a squeegee-like mechanism to move the fluid through the belt chamber (22) in discrete packets (40) defined by a pair of vanes (36). As the packets of fluid move through the belt chamber, they are exposed to sterilizing radiation passing through the plate (32).
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公开(公告)号：AT450568T
公开(公告)日：2009-12-15
申请号：AT04794048
申请日：2004-10-04
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： SHANG SHERWIN , WOO LECON , YANG TAHUA , LING MICHAEL T K , SANDFORD CRAIG
Abstract: A monolayer film of a polymer blend of a first component selected from the group consisting of an ethylene containing polymer, the first component present in an amount by weight of the film from about 60% to about 1%, the first component having a first melting point temperature determined by DSC, a second component selected from the group consisting of propylene containing polymers and methyl pentene containing polymers, the second component being present in an amount by weight of the film from about 99% to about 40%, the second component having a second melting point temperature determined by DSC; and the film being capable of withstanding steam sterilization at a temperature from about 100° C. to about 130 ° C.
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Patent Agency Ranking
公开(公告)号：AU2004283213B2
公开(公告)日：2008-12-11
申请号：AU2004283213
申请日：2004-10-04
Applicant: BAXTER HEALTHCARE SA , BAXTER INT
Inventor： WOO LECON , LING MICHAEL T K , SANDFORD CRAIG , YANG TAHUA , SHANG SHERWIN
Abstract: A monolayer film of a polymer blend of a first component selected from the group consisting of an ethylene containing polymer, the first component present in an amount by weight of the film from about 60% to about 1%, the first component having a first melting point temperature determined by DSC, a second component selected from the group consisting of propylene containing polymers and methyl pentene containing polymers, the second component being present in an amount by weight of the film from about 99% to about 40%, the second component having a second melting point temperature determined by DSC; and the film being capable of withstanding steam sterilization at a temperature from about 100° C. to about 130 ° C.
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27.发明专利
公开(公告)号：CA2398247C
公开(公告)日：2008-12-02
申请号：CA2398247
申请日：2001-01-26
Applicant: BAXTER INT
Inventor： STERNBERG SHMUEL , SANDFORD CRAIG , BOGGS DANIEL R , WOO LECON , BREILLATT JULIAN , KHARE ATUL
Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous thin fluid flow arrangement that exhibits radiation dose uniformity for fluids having high optical densities. Radiation dose uniformity is achieved in part through a "carrying" mechanism that moves or carries the fluid, thereby eliminating a channel flow velocity profile where flow volumes near the channel walls run the risk of overexposure to th e radiation due to very large residence times within the channel. The device comprises a relatively flat belt chamber (22) connected to a fluid flow through an inlet (24) and an outlet (26) on the belt chamber (22). The belt chamber (22) has a top surface (28) and a bottom surface (30). A radiation permeable plate (32) is disposed adjacent the top surface (28) of the belt chamber (22) and is in contact with the belt chamber (22). A radiation source (42) is provided adjacent to the plate (32) adjacent to a side opposite the belt chamber (22). A belt (34) having a plurality of flexible vanes (36) is disposed adjacent the bottom surface (30) of the belt chamber (22) such that the vanes (36) make contact with the belt chamber (22). The belt is driven by a roller mechanism (38) in the direction of the fluid flow. As the fluid flows throughthe belt chamber (22), the flexible vanes (36) provide a squeegee-like mechanism to move the fluid through the belt chamber (22) in discrete packets (40) defined by a pair of vanes (36). As the packets of fluid move through the belt chamber, they are exposed to sterilizing radiation passing through the plate (32).
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公开(公告)号：MX2007009289A
公开(公告)日：2008-01-28
申请号：MX2007009289
申请日：2006-01-31
Applicant: BAXTER INT
Inventor： SANDFORD CRAIG , BRUNDLE ALAN , LURVEY KENT , WERT TROY , BOJAN PETER , DARVASI JOHN , TOMICKI PETER , MCGRAGHAN THOMAS
Abstract: Se describen un sistema y metodo para suministrar automaticamente un insuflado a un paciente. El sistema incluye un juego de infusion y un dispositivo de infusion. Un componente de senalizacion dispuesto en el componente del juego de infusion identifica un protocolo de administracion para el juego de infusion. Un dispositivo de deteccion, conectado operativamente con el dispositivo de infusion detecta el componente de senalizacion e identifica el protocolo de administracion. El dispositivo de infusion entonces se configura para operar de conformidad con el protocolo de administracion.
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公开(公告)号：BRPI0414270A
公开(公告)日：2006-11-07
申请号：BRPI0414270
申请日：2004-09-08
Applicant: BAXTER INT
Inventor： REITZ DOUGLAS W , ARIAGNO SCOTT , SHETH MIHIR , YARDIMCI ATIF , CLARKE ROBERT A , PENNINGTON DAVID W , PRISCO MICHAEL R , CHIM EDWIN , PAULEY ROBIN , SANDFORD CRAIG , SITES ARCH
Abstract: Flow-through systems for processing biological fluid are disclosed. The flow-through systems include a removal device in the flow path for removing unwanted compounds and agents. The removal device includes a removal media contained within a housing made of two separate portions sealed together. The housing is maintained in a substantially vertical disposition, thereby ensuring substantially uniform and complete exposure of the fluid to the media.
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30.发明专利
公开(公告)号：MXPA06004100A
公开(公告)日：2006-06-27
申请号：MXPA06004100
申请日：2004-10-04
Applicant: BAXTER INT
Inventor： SANDFORD CRAIG
Abstract: Una pelicula de capa unica de una mezcla de polimero de un primer componente seleccionado del grupo que consiste de un polimero que contiene etileno, el primer componente presente en una cantidad en peso de la pelicula de aproximadamente 60% a aproximadamente 1%, el primer componente teniendo una primera temperatura de punto de fusion determinada por DSC, un segundo componente seleccionado del grupo que consiste de polimeros que contienen propileno y polimeros que contienen metil penteno, el segundo componente presentandose en una cantidad en peso de la pelicula de aproximadamente 99% a aproximadamente 40%, el segundo componente teniendo una segunda temperatura de punto de fusion determinada por DSC; y la pelicula siendo capaz de soportar la esterilizacion de vapor a una temperatura de aproximadamente 100 degree C a aproximadamente 30 degree C.
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