公开(公告)号：CA1159469A

公开(公告)日：1983-12-27

申请号：CA381423

申请日：1981-07-09

Applicant: DEGUSSA

Inventor： SCHWARZE WERNER ,  KLEEMANN AXEL ,  LEUCHTENBERGER WOLFGANG

IPC: B01J23/00 ,  C07B61/00 ,  C07C51/00 ,  C07C61/15 ,  C07C67/00 ,  C07C69/74

Abstract: 1-methyl-2-chlorocyclopropane carboxylic acid and its lower alkyl esters are produced by selective hydrogenating dechlorination of the corresponding 1-methyl-2,2-dichlorocyclo-propane compounds. The novel compounds can be used as intermediate products for the production of pesticides and drugs.

公开(公告)号：DK146687B

公开(公告)日：1983-12-05

申请号：DK201679

申请日：1979-05-16

Applicant: DEGUSSA

Inventor： ENGEL JUERGEN ,  KLEEMANN AXEL ,  POSSELT KLAUS ,  STROMAN FRITZ ,  THIEMER KLAUS

IPC: A61K31/135 ,  A61K20060101 ,  A61K31/13 ,  A61K31/137 ,  A61K31/43 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P29/00 ,  C07C20060101 ,  C07C67/00 ,  C07C213/00 ,  C07C213/02 ,  C07C213/08 ,  C07C215/30 ,  C07C215/60 ,  C07C221/00 ,  C07C225/06 ,  C07C225/10 ,  C07C225/14 ,  C07C91/16 ,  C07C91/34 ,  C07C97/10

Abstract: There are prepared compounds of the formula: wherein X is the group >C=O or >CH(OH), Y is the group R2 is hydrogen or C1 to C6 alkyl, R3 is hydrogen or a hydroxy group and R1 is the adamantyl group or a saturated or single unsaturated C3 to C16 cycloalkyl group where the C3 to C16 cycloalkyl group can be substituted by a C1-C4 alkyl group or a halogen atom and their salts. The compounds are useful in dilating the peripheral blood vessels and in lowering blood pressure.

公开(公告)号：NO149209B

公开(公告)日：1983-11-28

申请号：NO781159

申请日：1978-04-03

Applicant: DEGUSSA

Inventor： KLEEMANN AXEL ,  JAKOVLEV VLADIMIR ,  THIEMER KLAUS ,  ENGEL JUERGEN

IPC: C07D295/08 ,  A61K31/495 ,  A61K31/496 ,  A61P25/18 ,  A61P25/20 ,  C07D213/74 ,  C07D213/80 ,  C07D295/033 ,  C07D295/088 ,  C07D295/092 ,  C07D295/135 ,  C07D303/24 ,  C07D307/68 ,  C07D333/38 ,  C07D295/10 ,  C07D401/04 ,  C07D401/12

公开(公告)号：CH638795A5

公开(公告)日：1983-10-14

申请号：CH354378

申请日：1978-04-03

Applicant: DEGUSSA

Inventor： KLEEMANN AXEL ,  JAKOVLEV VLADIMIR ,  THIEMER KLAUS ,  ENGEL JUERGEN

IPC: C07D295/08 ,  A61K31/495 ,  A61K31/496 ,  A61P25/18 ,  A61P25/20 ,  C07D213/74 ,  C07D213/80 ,  C07D295/033 ,  C07D295/088 ,  C07D295/092 ,  C07D295/135 ,  C07D303/24 ,  C07D307/68 ,  C07D333/38 ,  C07D401/04

公开(公告)号：CA1147341A

公开(公告)日：1983-05-31

申请号：CA371425

申请日：1981-02-20

Applicant: DEGUSSA

Inventor： KLEEMANN AXEL ,  SCHALKE PETER

IPC: C07C67/00 ,  C07C253/00 ,  C07C253/04 ,  C07C253/34 ,  C07C255/32 ,  C07C255/33 ,  C07C255/35 ,  C07C255/36 ,  C07C255/53 ,  C07D333/10 ,  C07D333/24 ,  C07C121/66

Abstract: The production of aromatic or heteroaromatic nitriles from their reactiongases, which are formed in the reaction of cyanogen chloride with aromatic or heteroaromatic methylene or methyl compounds, is carried out by partial condensation of the reaction gases at decreasing temperature stages so that the nitriles are not subjected, for a lengthy period, to a contact with the simultaneously formed hydrogen chloride.

公开(公告)号：FI831933A0

公开(公告)日：1983-05-30

申请号：FI831933

申请日：1983-05-30

Applicant: DEGUSSA

Inventor： DRAUZ KARLHEINZ ,  KLEEMANN AXEL ,  WIRTHWEIN ROLF

IPC: C01B15/017 ,  C01B

公开(公告)号：HU180716B

公开(公告)日：1983-04-29

申请号：HUDE001009

申请日：1979-09-05

Applicant: DEGUSSA

Inventor： KLINGER KARL-HEINZ ,  KLEEMANN AXEL ,  STROMAN FRITZ ,  THIEMER KLAUS

IPC: A61K31/403 ,  A61K31/405 ,  A61K31/155 ,  A61P25/02 ,  A61P27/02 ,  C07C67/00 ,  C07C239/00 ,  C07C279/04 ,  C07C279/12 ,  C07D209/08 ,  C07D209/43 ,  C07D209/86 ,  C07D209/88 ,  C07C129/12 ,  C07D209/32

Abstract: Compounds corresponding to the formula I are disclosed, wherein Alk represents a C2-C5-alkylene groups optionally substituted by a hydroxy group and Ar represent an optionally substituted phenyl, naphthyl, tetrahydronaphthyl, indanyl or indenyl radical or a monocyclic or condensed bicyclic or tricyclic heterocyclic radical which is optionally substituted, the heterocyclic radical consisting of individual rings having 5 or 6 members and optionally containing from 1 to 4 hetero atoms, and the acid addition salts thereof. A process for producing these compounds is also disclosed. These substituted aminoalkyl guanidines block the beta -receptors of the adrenergic nerve system, and also reduce blood pressure.

公开(公告)号：CA1132139A

公开(公告)日：1982-09-21

申请号：CA356440

申请日：1980-07-17

Applicant: DEGUSSA

Inventor： KLEEMANN AXEL ,  NUBERT INGOMAR ,  STROMAN FRITZ ,  THIEMER KLAUS

IPC: C07D333/12

Abstract: The present invention provides compounds corresponding to the general formula: (II) in which Alk represents a straight-chain or branched chain C1 C5 alkylene group and X represents chlorine, bromine or iodine. These compounds are intermediates in the preparation of pharmaceuticals.

公开(公告)号：NO146634B

公开(公告)日：1982-08-02

申请号：NO792874

申请日：1979-09-05

Applicant: DEGUSSA

Inventor： KLINGER KARL-HEINZ ,  KLEEMANN AXEL ,  STROMAN FRITZ ,  THIEMER KLAUS

IPC: A61K31/403 ,  A61K31/155 ,  A61K31/405 ,  A61P25/02 ,  A61P27/02 ,  C07C67/00 ,  C07C239/00 ,  C07C279/04 ,  C07C279/12 ,  C07D209/08 ,  C07D209/43 ,  C07D209/86 ,  C07D209/88 ,  C07C129/12

Abstract: Compounds corresponding to the formula I are disclosed, wherein Alk represents a C2-C5-alkylene groups optionally substituted by a hydroxy group and Ar represent an optionally substituted phenyl, naphthyl, tetrahydronaphthyl, indanyl or indenyl radical or a monocyclic or condensed bicyclic or tricyclic heterocyclic radical which is optionally substituted, the heterocyclic radical consisting of individual rings having 5 or 6 members and optionally containing from 1 to 4 hetero atoms, and the acid addition salts thereof. A process for producing these compounds is also disclosed. These substituted aminoalkyl guanidines block the beta -receptors of the adrenergic nerve system, and also reduce blood pressure.

公开(公告)号：AU522618B2

公开(公告)日：1982-06-17

申请号：AU3239178

申请日：1978-01-12

Applicant: DEGUSSA

Inventor： KLEEMANN AXEL ,  KIEL REINHOLD ,  NUBERT INGOMAR

IPC: C07D333/14 ,  A61K31/382 ,  C07D333/16 ,  C07D333/20

Abstract: [1,1-dithien-(3)-yl-1-hydroxy-(3)-propyl]-[1-phenyl-1-hydroxy-(2)-prop yl]-amine is prepared by condensing thien-(3)-yl lithium with a beta -halogen propionic acid alkyl ester of the formula (II) where R is a lower alkyl group and Hal is chlorine, bromine or iodine, in an inert medium at a temperature below -50 DEG C. to form a compound of the formula (III) which is then reacted with 2-amino-1-hydroxy-1-phenylpropane in an inert medium in the presence of a basic compound. The product cn be converted to [1,1-dithien-(3)-yl-(1)-propen-(3)-yl]-[1-phenyl-(2)-propyl]-amine by dehydration.