公开(公告)号：NZ511414A

公开(公告)日：2003-11-28

申请号：NZ51141499

申请日：1999-10-25

Applicant: DELSYS PHARMACEUTICAL CORP

Inventor： CHRAI SUGGY S ,  MCGINN JOSEPH THOMAS ,  SINGH BAWA

IPC: A61J7/00 ,  A61K9/00 ,  A61M15/00 ,  A61M15/02 ,  A61J3/00 ,  B05D1/06 ,  B05D1/04

Abstract: A method of depositing dielectric elongated pharmaceutical active medicament dry powder particles on a substrate comprising: Providing a plurality of dielectric elongated pharmaceutical active medicament dry particles each having a longitudinal axis; and Electrostatically depositing the particles on a surface of the substrate with the longitudinal axes aligned substantially normal to the substrate surface, the particles being attracted to the substrate by an electric field so as to minimize agglomeration of the particles and to minimize adherence of the particles to the substrate.

公开(公告)号：HU0104759A2

公开(公告)日：2002-03-28

申请号：HU0104759

申请日：1999-10-25

Applicant: DELSYS PHARMACEUTICAL CORP

Inventor： CHRAI SUGGY S ,  MCGINN JOSEPH THOMAS ,  SINGH BAWA

IPC: A61J7/00 ,  A61J3/00 ,  A61K9/00 ,  A61M15/00 ,  A61M15/02 ,  B05D1/06

Abstract: A dry powder, for example, a medicament for an inhaler, comprises elongated particles with an aspect ratio sufficient to cause the particles to be bound to a preferably metal or non-metallic sheet material substrate at the particle tips by electrostatic deposition and for aligning a plurality of particles with their major axes aligned normal to the substrate and oriented tip-to-tip. Particles deposited form a low density, high relative void deposition to minimize attractive forces between the particles. This minimizes agglomeration and bonding forces to the substrate facilitating the release of a powdered medicament in an inhaler. Medicament dosages in a substrate pocket are covered by a sealing layer. An embodiment of a drug dosage inhaler substrate and inhaler is disclosed.

公开(公告)号：AU1322800A

公开(公告)日：2000-05-29

申请号：AU1322800

申请日：1999-10-25

Applicant: DELSYS PHARMACEUTICAL CORP

Inventor： CHRAI SUGGY S ,  MCGINN JOSEPH THOMAS ,  SINGH BAWA

IPC: A61J3/00 ,  A61J7/00 ,  A61K9/00 ,  A61M15/00 ,  A61M15/02 ,  B05D1/06 ,  B05D1/04

Abstract: A dry powder, for example, a medicament for an inhaler, comprises elongated particles with an aspect ratio sufficient to cause the particles to be bound to a preferably metal or non-metallic sheet material substrate at the particle tips by electrostatic deposition and for aligning a plurality of particles with their major axes aligned normal to the substrate and oriented tip-to-tip. Particles deposited form a low density, high relative void deposition to minimize attractive forces between the particles. This minimizes agglomeration and bonding forces to the substrate facilitating the release of a powdered medicament in an inhaler. Medicament dosages in a substrate pocket are covered by a sealing layer. An embodiment of a drug dosage inhaler substrate and inhaler is disclosed.

公开(公告)号：AU4675599A

公开(公告)日：1999-12-30

申请号：AU4675599

申请日：1999-06-08

Applicant: DELSYS PHARMACEUTICAL CORP

Inventor： CHEN JEN-CHI ,  CHRAI SUGGY S ,  DESAI NITIN VITHALBHAI ,  HAMMER LAWRENCE HARRISON ,  KELLER DAVID ,  KUMAR NALIN ,  LAL PRINCE ,  LEVINE AARON WILLIAM ,  MURARI RAMASWAMY ,  O'MARA KERRY DENNIS ,  POLINIAK EUGENE SAMUEL ,  RIVENBURG HOWARD CHRISTOPHER ,  ROACH WILLIAM RONALD ,  ROSATI DOMINIC STEPHEN ,  SINGH BAWA ,  SOUTHGATE PETER DAVID ,  SUN HOI CHEONG ,  ZANZUCCHI PETER JOHN

IPC: A61K9/14 ,  A61J1/03 ,  A61J3/00 ,  A61K9/16 ,  A61K9/51 ,  A61K9/70 ,  B05B5/025 ,  B05B5/08 ,  B05B5/16 ,  B65B1/04 ,  B65B1/30 ,  B65B11/50

Abstract: The present invention provides a product (1) that includes a pharmaceutical unit dosage or diagnostic form (6) that includes at least one active ingredient that is present in an amount that advantageously does not vary by more than about five percent from a predetermined target amount. In one embodiment, the unit form comprises a substrate (8), a deposit (14) that is disposed on the substrate and a cover layer (9) that overlies the deposit and is joined to the substrate by a bond that encircles that deposit, thereby encapsulating it between the substrate and cover substrates. The deposit comprises a powder, at least some of which includes the at least one active ingredient. The unit form is created via a dry powder deposition apparatus that electrostatically deposits the powder on the substrate utilizing an electrostatic chuck and charged powder delivery apparatus.

公开(公告)号：CA2333107A1

公开(公告)日：1999-12-16

申请号：CA2333107

申请日：1999-06-08

Applicant: DELSYS PHARMACEUTICAL CORP

Inventor： POLINIAK EUGENE SAMUEL ,  SINGH BAWA ,  RIVENBURG HOWARD CHRISTOPHER ,  SOUTHGATE PETER DAVID ,  SUN HOI CHEONG ,  ZANZUCCHI PETER JOHN ,  KUMAR NALIN ,  CHRAI SUGGY S ,  ROACH WILLIAM RONALD ,  DESAI NITIN VITHALBHAI ,  HAMMER LAWRENCE HARRISON ,  KELLER DAVID ,  CHEN JEN-CHI ,  O'MARA KERRY DENNIS ,  MURARI RAMASWAMY ,  LAL PRINCE ,  ROSATI DOMINIC STEPHEN ,  LEVINE AARON WILLIAM

IPC: A61K9/14 ,  A61J1/03 ,  A61J3/00 ,  A61K9/16 ,  A61K9/51 ,  A61K9/70 ,  B05B5/025 ,  B05B5/08 ,  B05B5/16 ,  B65B1/04 ,  B65B1/30 ,  B65B11/50

Abstract: The present invention provides a product (1) that includes a pharmaceutical unit dosage or diagnostic form (6) that includes at least one active ingredient that is present in an amount that advantageously does not vary by more than about five percent from a predetermined target amount. In one embodiment, the unit form comprises a substrate (8), a deposit (14) that is disposed on the substrate and a cover layer (9) that overlies the deposit an d is joined to the substrate by a bond that encircles that deposit, thereby encapsulating it between the substrate and cover substrates. The deposit comprises a powder, at least some of which includes the at least one active ingredient. The unit form is created via a dry powder deposition apparatus that electrostatically deposits the powder on the substrate utilizing an electrostatic chuck and charged powder delivery apparatus.

公开(公告)号：NZ508402A

公开(公告)日：2003-08-29

申请号：NZ50840299

申请日：1999-06-08

Applicant: DELSYS PHARMACEUTICAL CORP

Inventor： ROSATI DOMINIC STEPHEN ,  SINGH BAWA ,  SOUTHGATE PETER DAVID ,  SUN HOI CHEONG ,  ZANZUCCHI PETER JOHN ,  ROACH WILLIAM RONALD ,  CHEN JEN-CHI ,  CHRAI SUGGY S ,  DESAI NITIN VITHALBHAI ,  HAMMER LAWRENCE HARRISON ,  KELLER DAVID ,  KUMAR NALIN ,  LAL PRINCE ,  LEVINE AARON WILLIAM ,  MURARI RAMASWAMY ,  O'MARA KERRY DENNIS ,  POLINIAK EUGENE SAMUEL ,  RIVENBURG HOWARD CHRISTOPHER

IPC: A61K9/14 ,  A61J1/03 ,  A61J3/00 ,  A61K9/16 ,  A61K9/51 ,  A61K9/70 ,  B05B5/025 ,  B05B5/08 ,  B05B5/16 ,  B65B1/04 ,  B65B1/30 ,  B65B11/50 ,  A61J3/02

Abstract: A dry powder deposition apparatus for depositing powder on a substrate comprises a deposition means for electrostatically depositing the powder at discrete locations on the substrate and an optical measurement device for nondestructively measuring the amount of powder deposited on the substrate. The powder comprises a pharmaceutically- or biologically active ingredient on a substrate and wherein. The deposition means comprises an electrostatic chuck wherein the electrostatic chuck has at least one collection zone. The collection zone is operable in conjunction with a bias source to generate a powder-attracting electrostatic field and the substrate is detachably engaged to the electrostatic chuck and overlies the collection zone.

公开(公告)号：HU0204188A2

公开(公告)日：2003-03-28

申请号：HU0204188

申请日：2000-09-11

Applicant: DELSYS PHARMACEUTICAL CORP

Inventor： RIVENBURG HOWARD CHRISTOPHER ,  SINGH BAWA ,  SUN HOI CHEONG

IPC: H02N13/00 ,  H02N1/00

Abstract: Provided is a method of moving a charged particle from a first position at which it is retained by a first electrode to a second position at which it is retained by a second electrode, the method comprising: applying a potential to the second electrode to attract the particle; and applying a potential to a guide electrode offset from the particle at the first position, wherein the applied potential is effective to reduce the attraction of the particle to the first position sufficiently to allow the potential applied at the second electrode to be effective to move the particle from the first position to the second position.

公开(公告)号：AU749087B2

公开(公告)日：2002-06-20

申请号：AU2668999

申请日：1999-02-10

Applicant: DELSYS PHARMACEUTICAL CORP

Inventor： MCGINN JOSEPH T ,  CHRAI SUGGI S ,  BRYCKI BOGDAN ,  SINGH BAWA ,  COYLE PETER ,  SANTONASTASO GARY ,  SUN HOI CHEONG

IPC: A61M15/00 ,  A61M15/02

Abstract: An inhaler disc cartridge comprises a carrier disc with radially outwardly extending resilient fingers, each with a medicament powder dosage. A sealing disc and an indexing ring are bonded to the disc. A cam sequentially and manually deflects a selected finger causing it to snap against an anvil to release the dosage by momentum energy transfer. In other embodiments, a cassette includes a carrier substrate reel of deposited powder dosages with a dosage sealing tape. The substrate comprises a belt with a plurality of transversely extending triangular fingers, each finger tip with a dosage thereon. Each finger is snapped in sequence against an anvil while a clamp secures the belt as the fingers are deflected. The spring fingers are corrugated in one embodiment cooperating with an anvil having channels and a device for inducing agglomeration breakup air streams through the channels. Other embodiments are for impact deflection of a dosage carrying substrate in a cartridge or cassette against an anvil to release the dosages.

公开(公告)号：HU0103795A2

公开(公告)日：2002-03-28

申请号：HU0103795

申请日：1999-06-08

Applicant: DELSYS PHARMACEUTICAL CORP

Inventor： DESAI NITIN VITHALBHAI ,  POLINIAK EUGENE SAMUEL ,  ROSATI DOMINIC STEOHEN ,  SINGH BAWA ,  SUN HOI CHEONG

IPC: B01J19/00 ,  B01J19/08 ,  G01N35/00 ,  H02N13/00

Abstract: AC waveforms biasing of bead transporter chucks and their accumulated charge sensing circuits tailored for low resistivity substrates and beads where if traditional DC quasi-static biasing potentials were used, the bead attraction potentials of the chuck would undergo rapid RC decay and cause the bead transporter chuck to stop working. Methods for selecting AC waveforms are given, including those that maximize the time average of the bead attraction potential at the bead collection zone of the bead contact surface.

公开(公告)号：CA2322437A1

公开(公告)日：1999-09-10

申请号：CA2322437

申请日：1999-02-10

Applicant: DELSYS PHARMACEUTICAL CORP

Inventor： SUN HOI CHEONG ,  SANTONASTASO GARY ,  CHRAI SUGGI S ,  MCGINN JOSEPH T ,  BRYCKI BOGDAN ,  COYLE PETER ,  SINGH BAWA

IPC: A61M15/00 ,  A61M15/02

Abstract: An inhaler disc cartridge comprises a carrier disc with radially outwardly extending resilient fingers, each with a medicament powder dosage. A sealing disc and an indexing ring are bonded to the disc. A cam sequentially and manually deflects a selected finger causing it to snap against an anvil to release the dosage by momentum energy transfer. In other embodiments, a cassette includes a carrier substrate reel of deposited powder dosages with a dosage sealing tape. The substrate comprises a belt with a plurality of transversely extending triangular fingers, each finger tip with a dosage thereon. Each finger is snapped in sequence against an anvil while a clamp secures the belt as the fingers are deflected. The spring fingers are corrugated in one embodiment cooperating with an anvil having channels and a device for inducing agglomeration breakup air streams through the channels. Other embodiments are for impact deflection of a dosage carrying substrate in a cartridge or cassette against an anvil to release the dosages.