公开(公告)号：AU3507178A

公开(公告)日：1979-10-18

申请号：AU3507178

申请日：1978-04-13

Applicant: HOECHST AG

Inventor： DURCKHEIMER WALTER ,  EHLERS EBERHARD ,  SELIGER HUBERT ,  SCHRINNER ELMAR

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61K31/675 ,  A61K31/695 ,  A61P31/04 ,  B23K1/18 ,  B23Q5/033 ,  C07D20060101 ,  C07D277/20 ,  C07D277/40 ,  C07D501/00 ,  C07D501/20 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46 ,  C07D501/59 ,  C07D501/60 ,  C07D519/06

Abstract: What are disclosed are cephem compounds of the formula in which R1 denotes hydrogen, an optionally substituted alkyl, acyl, arylsulfonyl or alkylsulfonyl group or an amino-protective group which is known from peptide chemistry, R2 denotes hydrogen or an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aralkyl, acyl, aryl, arylsulfonyl, alkylsulfonyl or heterocyclic group, R3 denotes hydrogen, an ester group or a cation, R4 denotes hydrogen, a lower alkoxy group or a group which can be converted to this, X denotes a SO group in the R or S configuration or a SO2 group and A denotes hydrogen, an optionally substituted alkoxy or alkenyloxy group, halogen or a group -CH2Y, in which Y represents hydrogen, halogen or the radical of a nucleophilic compound, and in which the R2O group is in the syn-position, which compounds are valuable chemotherapeutic agents having a very powerful antimicrobial action against Gram-positive and Gram-negative bacteria and an unexpectedly good action against penicillinase-forming Staphilococci.

公开(公告)号：NO781322L

公开(公告)日：1978-10-17

申请号：NO781322

申请日：1978-04-14

Applicant: HOECHST AG

Inventor： DUERCKHEIMER WALTER ,  EHLERS EBERHARD ,  SELIGER HUBERT ,  SCHRINNER ELMAR

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61K31/675 ,  A61K31/695 ,  A61P31/04 ,  B23K1/18 ,  B23Q5/033 ,  C07D20060101 ,  C07D277/20 ,  C07D277/40 ,  C07D501/00 ,  C07D501/20 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46 ,  C07D501/59 ,  C07D501/60 ,  C07D519/06 ,  C07D

Abstract: What are disclosed are cephem compounds of the formula in which R1 denotes hydrogen, an optionally substituted alkyl, acyl, arylsulfonyl or alkylsulfonyl group or an amino-protective group which is known from peptide chemistry, R2 denotes hydrogen or an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aralkyl, acyl, aryl, arylsulfonyl, alkylsulfonyl or heterocyclic group, R3 denotes hydrogen, an ester group or a cation, R4 denotes hydrogen, a lower alkoxy group or a group which can be converted to this, X denotes a SO group in the R or S configuration or a SO2 group and A denotes hydrogen, an optionally substituted alkoxy or alkenyloxy group, halogen or a group -CH2Y, in which Y represents hydrogen, halogen or the radical of a nucleophilic compound, and in which the R2O group is in the syn-position, which compounds are valuable chemotherapeutic agents having a very powerful antimicrobial action against Gram-positive and Gram-negative bacteria and an unexpectedly good action against penicillinase-forming Staphilococci.

公开(公告)号：CA867766A

公开(公告)日：1971-04-06

申请号：CA867766D

Applicant: HOECHST AG

Inventor： TEICHMANN KARL H ,  SCHORR MANFRED ,  SCHRINNER ELMAR

公开(公告)号：HU212937B

公开(公告)日：1996-12-30

申请号：HU204891

申请日：1991-06-19

Applicant: HOECHST AG

Inventor： KLESEL NORBERT ,  LIMBERT MICHAEL ,  SCHRINNER ELMAR

IPC: A61K31/52 ,  A61K31/522 ,  A61K31/545 ,  A61K31/546 ,  A61P7/00 ,  A61P9/00 ,  A61P31/00 ,  A61P31/04

Abstract: Pharmaceutical combination products containing at least one cephalosporin derivative and at least one xanthine derivative are suitable for the prophylaxis and treatment of bacterial infectious diseases and for the prophylaxis and treatment of septic shock.

公开(公告)号：NO174834C

公开(公告)日：1994-07-20

申请号：NO883375

申请日：1988-07-29

Applicant: HOECHST AG

Inventor： SCHRINNER ELMAR ,  WINKLER IRVIN ,  MEICHSNER CHRISTOPH ,  HELSBERG MATTHIAS

IPC: C07D473/06 ,  A61K20060101 ,  A61K31/52 ,  A61K31/70 ,  A61K31/715 ,  A61P31/12 ,  C07D20060101 ,  C07D473/04 ,  C08B20060101 ,  C08B37/00 ,  A61K31/725

Abstract: The preparation contains or consists of… a) at least one sulphated polysaccharide and… b) at least one xanthine derivative. The preparation is suitable for the control and prophylaxis of viral diseases, especially those caused by retroviruses.

公开(公告)号：NZ238580A

公开(公告)日：1993-10-26

申请号：NZ23858091

申请日：1991-06-18

Applicant: HOECHST AG

Inventor： KLESEL NORBERT ,  LIMBERT MICHAEL ,  SCHRINNER ELMAR

IPC: A61K31/52 ,  A61K31/522 ,  A61K31/545 ,  A61K31/546 ,  A61P7/00 ,  A61P9/00 ,  A61P31/00 ,  A61P31/04

Abstract: Pharmaceutical combination products containing at least one cephalosporin derivative and at least one xanthine derivative are suitable for the prophylaxis and treatment of bacterial infectious diseases and for the prophylaxis and treatment of septic shock.

公开(公告)号：DK166759B1

公开(公告)日：1993-07-12

申请号：DK284787

申请日：1987-06-03

Applicant: HOECHST AG

Inventor： LIMBERT MICHAEL ,  SCHRINNER ELMAR ,  SEIBERT GERHARD

IPC: A61K31/545 ,  A61P31/04

Abstract: Pharmaceutical preparation having a synergistic, antibacterial activity and containing a) a cephalosporin derivative or physiologically acceptable salts or esters thereof, and b) a penem antibiotic of the basic structure (B) or physiologically acceptable salts or esters thereof, process for manufacturing such a preparation, and its use in the treatment of bacterial infections.

公开(公告)号：DK163244B

公开(公告)日：1992-02-10

申请号：DK162878

申请日：1978-04-14

Applicant: HOECHST AG

Inventor： DUERCKHEIMER WALTER ,  EHLERS EBERHARD ,  SELIGER HUBERT ,  SCHRINNER ELMAR

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61K31/675 ,  A61K31/695 ,  A61P31/04 ,  B23K1/18 ,  B23Q5/033 ,  C07D20060101 ,  C07D277/20 ,  C07D277/40 ,  C07D501/00 ,  C07D501/20 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46 ,  C07D501/59 ,  C07D501/60 ,  C07D519/06

Abstract: What are disclosed are cephem compounds of the formula in which R1 denotes hydrogen, an optionally substituted alkyl, acyl, arylsulfonyl or alkylsulfonyl group or an amino-protective group which is known from peptide chemistry, R2 denotes hydrogen or an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aralkyl, acyl, aryl, arylsulfonyl, alkylsulfonyl or heterocyclic group, R3 denotes hydrogen, an ester group or a cation, R4 denotes hydrogen, a lower alkoxy group or a group which can be converted to this, X denotes a SO group in the R or S configuration or a SO2 group and A denotes hydrogen, an optionally substituted alkoxy or alkenyloxy group, halogen or a group -CH2Y, in which Y represents hydrogen, halogen or the radical of a nucleophilic compound, and in which the R2O group is in the syn-position, which compounds are valuable chemotherapeutic agents having a very powerful antimicrobial action against Gram-positive and Gram-negative bacteria and an unexpectedly good action against penicillinase-forming Staphilococci.

公开(公告)号：AU617115B2

公开(公告)日：1991-11-21

申请号：AU2017988

申请日：1988-07-29

Applicant: HOECHST AG

Inventor： SCHRINNER ELMAR ,  WINKLER IRVIN ,  MEICHSNER CHRISTOPH ,  HELSBERG MATTHIAS

IPC: C07D473/06 ,  A61K20060101 ,  A61K31/52 ,  A61K31/70 ,  A61K31/715 ,  A61P31/12 ,  C07D20060101 ,  C07D473/04 ,  C08B20060101 ,  C08B37/00 ,  A61K31/735

Abstract: The preparation contains or consists of… a) at least one sulphated polysaccharide and… b) at least one xanthine derivative. The preparation is suitable for the control and prophylaxis of viral diseases, especially those caused by retroviruses.

公开(公告)号：NO912382D0

公开(公告)日：1991-06-19

申请号：NO912382

申请日：1991-06-19

Applicant: HOECHST AG

Inventor： KLESEL NORBERT ,  LIMBERT MICHAEL ,  SCHRINNER ELMAR

IPC: A61K31/52 ,  A61K31/522 ,  A61K31/545 ,  A61K31/546 ,  A61P7/00 ,  A61P9/00 ,  A61P31/00 ,  A61P31/04 ,  A61K

Abstract: Pharmaceutical combination products containing at least one cephalosporin derivative and at least one xanthine derivative are suitable for the prophylaxis and treatment of bacterial infectious diseases and for the prophylaxis and treatment of septic shock.