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    Stable NAD/NADH derivatives
    21.
    发明专利
    Stable NAD/NADH derivatives 未知

    公开(公告)号：AU2006274140B8

    公开(公告)日：2011-02-03

    申请号：AU2006274140

    申请日：2006-07-28

    Applicant: HOFFMANN LA ROCHE

    Inventor： HEINDL DIETER ,  HORN CARINA ,  GAESSLER-DIETSCHE CLAUDIA ,  HOENES JOACHIM

    IPC: C07H19/207 ,  C07H19/213 ,  C07H21/00 ,  C07H21/02 ,  C07H23/00 ,  C12Q1/32

    Abstract: Test element for the determination of an analyte, comprising a coenzyme dependent enzyme or a substrate of the enzyme, and a coenzyme compound (I) and its salt or optionally its reduced form, is new. Test element for the determination of an analyte, comprises a coenzyme dependent enzyme or a substrate of the enzyme, and a coenzyme of pyridine compound of formula (I) and its salt or optionally its reduced form. A : adenine or their analog; T : O or S; U 1> : OH, SH, BH 3 -> or BCNH 2 ->; V 1> : OH or phosphate group; W 1> : COOR, CON(R) 2, COR, CSN(R) 2; R : H or 1-2C-alkyl; X 1, X 2 : O, CH 2, CHCH 3, C(CH 3) 2, NH or NCH 3; Y 1> : NH, S, O or CH 2; Z : cyclic group with 5C atom optionally substituted with heteroatom of O, S or N and CR 4, where C(R 4) 2 is a cyclic group with X 2; and R 4 : H, F, Cl or CH 3. Where Z and pyridine are not connected by a glycosidic bond. Independent claims are included for: (1) a pyridine compound (I); (2) an enzyme-coenzyme-complex comprising (I) in combination with an enzyme; (3) a reagent kit comprising (I), optionally an enzyme or enzyme complex and optionally a reaction buffer; and (4) a method for the determination of analyte comprising contacting the sample with the test element or reagent kit comprising coenzyme, and detecting the analyte. [Image].

    STABLE NAD/NADH DERIVATIVES
    23.
    发明专利
    STABLE NAD/NADH DERIVATIVES 未知

    公开(公告)号：HK1123308A1

    公开(公告)日：2009-06-12

    申请号：HK09100651

    申请日：2009-01-21

    Applicant: HOFFMANN LA ROCHE

    Inventor： HOENES JOACHIM ,  HEINDL DIETER ,  HORN CARINA ,  GAESSLER-DIETSCHE CLAUDIA

    IPC: C07H20060101 ,  C12Q20060101

    Abstract: Test element for the determination of an analyte, comprising a coenzyme dependent enzyme or a substrate of the enzyme, and a coenzyme compound (I) and its salt or optionally its reduced form, is new. Test element for the determination of an analyte, comprises a coenzyme dependent enzyme or a substrate of the enzyme, and a coenzyme of pyridine compound of formula (I) and its salt or optionally its reduced form. A : adenine or their analog; T : O or S; U 1> : OH, SH, BH 3 -> or BCNH 2 ->; V 1> : OH or phosphate group; W 1> : COOR, CON(R) 2, COR, CSN(R) 2; R : H or 1-2C-alkyl; X 1, X 2 : O, CH 2, CHCH 3, C(CH 3) 2, NH or NCH 3; Y 1> : NH, S, O or CH 2; Z : cyclic group with 5C atom optionally substituted with heteroatom of O, S or N and CR 4, where C(R 4) 2 is a cyclic group with X 2; and R 4 : H, F, Cl or CH 3. Where Z and pyridine are not connected by a glycosidic bond. Independent claims are included for: (1) a pyridine compound (I); (2) an enzyme-coenzyme-complex comprising (I) in combination with an enzyme; (3) a reagent kit comprising (I), optionally an enzyme or enzyme complex and optionally a reaction buffer; and (4) a method for the determination of analyte comprising contacting the sample with the test element or reagent kit comprising coenzyme, and detecting the analyte. [Image].

    Estabilización de enzima en sensores electroquímicos
    28.
    发明专利
    Estabilización de enzima en sensores electroquímicos 未知

    公开(公告)号：ES2390404T3

    公开(公告)日：2012-11-12

    申请号：ES09160421

    申请日：2009-05-15

    Applicant: HOFFMANN LA ROCHE ,  ROCHE DIAGNOSTICS GMBH

    Inventor： OCVIRK GREGOR ,  GAESSLER-DIETSCHE CLAUDIA

    IPC: C12Q1/00

    Abstract: Composición para la formación de un electrodo, cuya composición comprende un componente eléctricamente conductor que tiene una enzima específica del analito unida de forma covalente al mismo, caracterizada porque la composición comprende, además, como mínimo, un componente eléctricamente no conductor o semiconductor, que estabiliza la enzima específica del analito al convertir sustancias químicas que provocan la descomposición de la enzima, de manera que dicho componente estabilizador de la enzima eléctricamente no conductor o semiconductor es seleccionado entre el grupo que consiste en un óxido de Mn, en particular, Mn02, Mn304 o Mn50e, CuO y ZnO.

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