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    Síntesis enzimática de carba-NAD
    22.
    发明专利
    Síntesis enzimática de carba-NAD 未知

    公开(公告)号：ES2425631T3

    公开(公告)日：2013-10-16

    申请号：ES10742423

    申请日：2010-07-23

    Applicant: HOFFMANN LA ROCHE

    Inventor： DUEFEL HARTMUT ,  HEINDL DIETER ,  HORN CARINA ,  MEIER THOMAS ,  SCHMUCK RAINER

    IPC: C12P19/32

    Abstract: Un método para la síntesis de carba-NAD o un análogo del mismo, comprendiendo el método los pasos dea) fosforilar el compuesto de Fórmula I con la ayuda de una enzima quinasa nicotinamida ribosa (NRK), Fórmula I en la que R1 es OH, NH2, O-metilo o N-dimetilo, metilo, Y-es un contraión y X es O o S, b) adenilar el producto fosforilado del paso (a) con un compuesto de Fórmula II con la ayuda de una enzima NMNAT. Fórmula II en el que R2 es NH2, OH, o NHalquilo, en el que R3 es H, OH, NH2, obteniendo de este modo carba-NAD o un análogo del mismo de fórmula III. Fórmula III en el que, R1, R2, R3, Y y X son como se han definido anteriormente.

    ANALYTICAL APPARATUS FOR DETECTING AT LEAST ONE ANALYTE IN A SAMPLE
    23.
    发明专利
    ANALYTICAL APPARATUS FOR DETECTING AT LEAST ONE ANALYTE IN A SAMPLE 未知

    公开(公告)号：CA2850693A1

    公开(公告)日：2013-05-23

    申请号：CA2850693

    申请日：2012-11-12

    Applicant: HOFFMANN LA ROCHE

    Inventor： PETRICH WOLFGANG ,  HORN CARINA ,  STEINKE NELLI ,  RINGEMANN CHRISTIAN ,  VON KETTELER ALEXA

    IPC: A61B5/145 ,  G01N21/64 ,  G01N35/00

    Abstract: An analytical apparatus (130) is proposed for detecting at least one analyte in a sample (126), in particular for detecting blood glucose, wherein the analytical apparatus (130) is designed to perform at least one analyte measurement, during which analyte measurement at least one changeable property of at least one test chemical (119) of a test element (110) is detected, in particular an electrical and/or optical property, and the analytical apparatus (130) is furthermore designed to conduct at least one quality measurement on the test chemical (119), at least one characteristic luminescence of the test chemical (119) being detected in the quality measurement, and a conclusion being drawn from the characteristic luminescence about the quality of the test chemical (119), especially a degradation.

    STABILIZATION OF DEHYDROGENASES USING STABLE CHEMICALLY MODIFIED COENZYMES
    26.
    发明专利
    STABILIZATION OF DEHYDROGENASES USING STABLE CHEMICALLY MODIFIED COENZYMES 未知

    公开(公告)号：NZ587397A

    公开(公告)日：2012-04-27

    申请号：NZ58739709

    申请日：2009-02-19

    Applicant: HOFFMANN LA ROCHE

    Inventor： HEINDL DIETER ,  HORN CARINA ,  GAESSLER-DIETSCHE CLAUDIA ,  HOENES JOACHIM

    IPC: C12N9/96 ,  C12N9/06 ,  C12Q1/32

    Abstract: Disclosed is a method for stabilizing a coenzyme dependent enzyme, characterized in that the enzyme is stored in the presence of the coenzyme, said coenzyme being a stable coenzyme chemically modified by comparison to, and having a higher stability than, the native coenzyme. Also disclosed is a coenzyme dependent enzyme which is stabilized with the coenzyme, said coenzyme being a stable coenzyme chemically modified by comparison to, and having a higher stability than, the native coenzyme, characterized in that it shows on storage for at least 2 weeks at a temperature of at least 20 degrees C, where appropriate with high humidity and without a drying reagent, a decline in the enzymatic activity of less than 50% compared with the initial level, wherein the enzyme is a mutated glucose dehydrogenase and the mutated glucose dehydrogenase has an increased thermal or hydrolytic stability compared with the corresponding wild-type glucose dehydrogenase.

    ELEMENTO DE PRUEBA PARA ANALIZAR UN FLUIDO CORPORAL Y METODO PARA SU MEDICION.
    27.
    发明专利
    ELEMENTO DE PRUEBA PARA ANALIZAR UN FLUIDO CORPORAL Y METODO PARA SU MEDICION. 未知

    公开(公告)号：MX2011009387A

    公开(公告)日：2011-09-28

    申请号：MX2011009387

    申请日：2010-03-19

    Applicant: HOFFMANN LA ROCHE

    Inventor： HAAR HANS-PETER ,  HORN CARINA

    IPC: C12Q1/54 ,  G01N21/63 ,  G01N33/52 ,  G01N33/66

    Abstract: La invención se refiere a un elemento de prueba para analizar un fluido corporal, en particular para determinar el nivel de glucosa en la sangre, que comprende un zona de evaluación que se carga con un reactivo, sensible al fluido corporal. De acuerdo con la invención se dispone un elemento funcional en y/o adyacente al zona de evaluación para detectar al menos un parámetro de estado para la zona de evaluación, siendo que este elemento funcional se puede evaluar mediante una medición de estado. La invención se refiere además a un método para medir el elemento de prueba.

    Stable NAD/NADH derivatives
    29.
    发明专利
    Stable NAD/NADH derivatives 未知

    公开(公告)号：AU2006274140B2

    公开(公告)日：2010-11-11

    申请号：AU2006274140

    申请日：2006-07-28

    Applicant: HOFFMANN LA ROCHE

    Inventor： HEINDL DIETER ,  HORN CARINA ,  GAESSLER-DIETSCHE CLAUDIA ,  HOENES JOACHIM

    IPC: C07H19/207 ,  C07H19/213 ,  C07H21/00 ,  C07H21/02 ,  C07H23/00 ,  C12Q1/32

    Abstract: Test element for the determination of an analyte, comprising a coenzyme dependent enzyme or a substrate of the enzyme, and a coenzyme compound (I) and its salt or optionally its reduced form, is new. Test element for the determination of an analyte, comprises a coenzyme dependent enzyme or a substrate of the enzyme, and a coenzyme of pyridine compound of formula (I) and its salt or optionally its reduced form. A : adenine or their analog; T : O or S; U 1> : OH, SH, BH 3 -> or BCNH 2 ->; V 1> : OH or phosphate group; W 1> : COOR, CON(R) 2, COR, CSN(R) 2; R : H or 1-2C-alkyl; X 1, X 2 : O, CH 2, CHCH 3, C(CH 3) 2, NH or NCH 3; Y 1> : NH, S, O or CH 2; Z : cyclic group with 5C atom optionally substituted with heteroatom of O, S or N and CR 4, where C(R 4) 2 is a cyclic group with X 2; and R 4 : H, F, Cl or CH 3. Where Z and pyridine are not connected by a glycosidic bond. Independent claims are included for: (1) a pyridine compound (I); (2) an enzyme-coenzyme-complex comprising (I) in combination with an enzyme; (3) a reagent kit comprising (I), optionally an enzyme or enzyme complex and optionally a reaction buffer; and (4) a method for the determination of analyte comprising contacting the sample with the test element or reagent kit comprising coenzyme, and detecting the analyte. [Image].

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