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公开(公告)号：JPH11292730A
公开(公告)日：1999-10-26
申请号：JP10107998
申请日：1998-04-13
Applicant: KAO CORP
Inventor： KOIKE KENZO , SHIMIZU MASANORI , OTA HIROSHI , FUKAZAWA JUNICHI , FUJIMURA TSUTOMU , TSUKAHARA KAZUE
IPC: A61K8/19 , A61K8/00 , A61K8/20 , A61K8/25 , A61K8/34 , A61K8/96 , A61K8/97 , A61K36/02 , A61P17/00 , A61Q19/00 , A61K7/00 , A61K7/48
Abstract: PROBLEM TO BE SOLVED: To obtain a cosmetic for improving skin slackening, having an excellent stiffening effect. SOLUTION: This cosmetic contains (A) an activated zeolite and (B) a solid salt. Zeolite A-3, zeolite A-4, zeolite A-5, etc., of the formula; Mx O.Al2 O3 .ySiO2 .zH2 O (M is an alkali metal or alkaline earth metal and (x), (y) and (z) are each an arbitrary number) are preferable as the activated zeolite. A zeolite subjected to specific treatment such as ion exchange, neutralization or the like can be used. Preferably the cosmetic can be formulated with (C) an extract of fucus and (D) a polyhydric alcohol besides the above-mentioned components. The cosmetic can be applied to a massaging agent for body, a cleansing agent, a dentifrice, a cream, a lotion, an ointment, etc.
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公开(公告)号：JPH08157436A
公开(公告)日：1996-06-18
申请号：JP30486994
申请日：1994-12-08
Applicant: KAO CORP
Inventor： FUJIMORI TAKETOSHI , AMANO SHINYA , SUZUKI YASUTO , OHASHI YUKIHIRO , FUJIMURA TSUTOMU , TAKEMA YOSHINORI
IPC: A61K31/165 , A61P17/00 , C07C235/46 , C07C235/48
Abstract: PURPOSE: To obtain the subject novel compound having a synthesis-accelerating activity to human cutis and an improving activity to wrinkle caused by aging or ultraviolet light, excellent percutaneous absorbency and chemical stability, etc. and useful as a cutaneous external application. CONSTITUTION: This compound is expressed by the formula I [R is an 8-24C hydroxyalkyl or 3,7,11-trimethyl-2,6,10-dodecatrienyl; R and R are each H or an (OH-substituted) 1-3C alkyl], e.g. 4-[(2E,6E)-3,7,11-trimethyl-2,6,10- dodecatrienyloxy] benzamide. The compound of the formula I is obtained by reacting 1 mole a compound of the formula II with 0.5-3 moles a compound of the formula R -Y (Y is a halogen or an eliminating group such as p- toluenesulfonyl) in the presence of a base such as sodium hydride in an inert solvent such as DMF at 0-150 deg.C, especially 20-100 deg.C.
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公开(公告)号：JP2004354159A
公开(公告)日：2004-12-16
申请号：JP2003150972
申请日：2003-05-28
Inventor： FUJIMURA TSUTOMU
Abstract: PROBLEM TO BE SOLVED: To provide a method for evaluating the degree of the skin aging on the basis of a biological change in the aging of the skin.
SOLUTION: A stimulator is added to a collagen gel in which the dermal fibroblast originating from a subject is embedded and a change in the force induced in the fibroblast is measured to evaluate the degree of the skin aging of the subject.
COPYRIGHT: (C)2005,JPO&NCIPI-
公开(公告)号：JP2003176208A
公开(公告)日：2003-06-24
申请号：JP2002372317
申请日：2002-12-24
Applicant: KAO CORP
Inventor： FUJIMURA TSUTOMU , TSUKAHARA KAZUE , ITO NORIKO , TAKEMA YOSHINORI
IPC: A61K8/96 , A61K8/00 , A61K8/97 , A61K36/00 , A61K36/02 , A61K36/07 , A61P17/16 , A61P43/00 , A61Q19/00 , A61K7/00 , A61K7/48 , A61K35/78 , A61K35/80 , A61K35/84
Abstract: PROBLEM TO BE SOLVED: To obtain a collagen gel shrinkage promoter having excellent percutaneous absorption, stability, safety and price, a composition for ameliorating flabbiness of the skin and a composition for tightening the skin. SOLUTION: This collagen gel shrinkage promoter comprises one or more kinds of plants selected from ginkgo, Ipomoea coccinea L., Fucales fucus, Matricaria chamomilla, Perilla frutescens crispa, Persica semen, Panax ginseng, Foeniculum vulgare, Morus alba, Gentiant lutea, Arctium lappa, Cortinellus shiitake, Allium sativum, Humulus lupulus, Paeonia suffruticosa, Lactuca sativa, Pachyma hoelen, Rosmarinus officiealis, Astragalus sinicus, Actinidia chinensis, Salvia officinalis and Filipendula multijuga or its extract as active ingredient. COPYRIGHT: (C)2003,JPO
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公开(公告)号：JP2001192315A
公开(公告)日：2001-07-17
申请号：JP2000001997
申请日：2000-01-07
Applicant: KAO CORP
Inventor： AMANO SHINYA , OHASHI YUKIHIRO , FUJIMURA TSUTOMU
Abstract: PROBLEM TO BE SOLVED: To obtain a dermal elasticity improving agent which exhibits a dermal elasticity improving effect and a skin straining effect, prevents or improves the change in the dermal state, e.g. dermal wrinkles caused by various causes, flabbiness, loss of tension and elasticity, somberness, stains, freckles or the like, effectively and is useful as a medicine or a cosmetic. SOLUTION: This dermal elasticity improving agent or skin straining agent is obtained by including a glyceryl ether derivative represented by the following general formula (I) wherein, R shows an 8-30C alkyl or alkenyl group; X1 and X2 show each H atom, -SO3M1 or -PO3M1M2 (here, M1 and M2 are each identical or different and show H atom, an alkali metal, an alkaline earth metal or an ammonia group; however, X1 and X2 are not simultaneously H atoms) as an active ingredient.
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Patent Agency Ranking
公开(公告)号：JPH06321766A
公开(公告)日：1994-11-22
申请号：JP2018494
申请日：1994-02-17
Applicant: KAO CORP
Inventor： OHASHI YUKIHIRO , FUJIMORI TAKETOSHI , KAWAMATA AKIRA , TAKEMA YOSHINORI , OSU HIROYUKI , YADA YUKIHIRO , HIGUCHI KAZUHIKO , IMOKAWA GENJI , KUSUOKU HIROSHI , FUJIMURA TSUTOMU
Abstract: PURPOSE:To obtain a medicine for external application for skin expressing antidandruff effect and improving effect after sunburn, excellent in preventing and improving effects on plication, capable of keeping the normal function of skin by containing an amine derivative as an effective component. CONSTITUTION:This medicine contains a compound of the formula (R is 1-3C hydrocarbon or 1-5C hydrocarbon containing a hetero atom; R -R are H, 1-20C hydrocarbon capable of being substituted with OH) or its acid adduct salt as an effective component. The compounding ratio is 0.0001-5wt.% for the external medicine for skin of emulsion type and 0.0001-10wt.% for an oily external medicine for skin using a liquid hydrocarbon such as squalane, etc., as a substrate. 1-(2-Hydroxyethylamino)-3-methoxy-2-propanol is an example of a compound of the formula. The external medicine for skin controls occurrence of plication, expresses marked effect on disappearing plication, further expresses marked controlling action on parakeratosis, acanthosis, abnormal lipids metabolism, etc., and contributes to recover the normal function of skin and maintain its homeostasis.
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公开(公告)号：JPH06271446A
公开(公告)日：1994-09-27
申请号：JP6059993
申请日：1993-03-19
Applicant: KAO CORP
Inventor： TAKEMA YOSHINORI , OGAWA AYUMI , FUJIMURA TSUTOMU , KUSUOKU HIROSHI , OHASHI YUKIHIRO , KAWAMATA AKIRA , IMOKAWA GENJI
IPC: A61K8/30 , A61K8/00 , A61K8/40 , A61K8/41 , A61K8/44 , A61K8/55 , A61K8/58 , A61K8/68 , A61P17/16 , A61Q19/00 , A61K7/48 , A61K7/00
Abstract: PURPOSE:To obtain a wrinkle improver having excellent action capable of suppressing occurrence of wrinkle and removing wrinkle. CONSTITUTION:The wrinkle improver contains a sphingosine analogue of the formula [R is 1-40C straight-chain, branched chain or cyclic hydrocarbon group which may have OH; X is CH2OH, CO2H, CH2OP(=0) (OH)2; Y is NH2, NHCH3, N(CH3)2 or N (CH3)3, e.g. D-erythrosphingosine as an active ingredient. Although the wrinkle improver can be administered by oral, external or other any method, the improver is preferably applied as a skin external preparation, e.g. ointment and the blend amount of the compound of the formula is preferably 0.0001-5wt.%, especially preferably 0.0001-1wt.% in an emulsion type skin external preparation and preferably 0.001-10wt.%, especially preferably 0.005-2wt.% in an oily skin external preparation.
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公开(公告)号：JP2010083857A
公开(公告)日：2010-04-15
申请号：JP2009030757
申请日：2009-02-13
Inventor： KAMEYAMA AKIYO , FUJIMURA TSUTOMU
CPC classification number: A61K36/77
Abstract: PROBLEM TO BE SOLVED: To provide a method for producing Hippocastanaceae plants seed extract suitable for preventing coloring and combining in medicines and cosmetics.
SOLUTION: The method is the production of Hippocastanaceae plants seed extract and carried out by removal of outer barks of seeds of Hippocastanaceae plants followed by extraction with a solvent.
COPYRIGHT: (C)2010,JPO&INPITAbstract translation: 待解决的问题：提供适于防止药物和化妆品着色和组合的海马科植物种子提取物的方法。 解决方案：该方法是生产海马科植物种子提取物，并通过除去海马科植物种子的外部树皮，然后用溶剂萃取进行。 版权所有（C）2010，JPO＆INPIT
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公开(公告)号：JP2005008571A
公开(公告)日：2005-01-13
申请号：JP2003175221
申请日：2003-06-19
Inventor： FUJIMURA TSUTOMU , TSUKAHARA KAZUE
Abstract: PROBLEM TO BE SOLVED: To provide a highly safe wrinkle-ameliorating agent having excellent effects of preventing the getting of the wrinkles and ameliorating the wrinkles.
SOLUTION: The wrinkle-ameliorating agent contains a horse chestnut or an extract thereof as an active ingredient. The wrinkle-ameliorating agent decreases the wrinkles or makes the appearance of the wrinkles inconspicuous.
COPYRIGHT: (C)2005,JPO&NCIPIAbstract translation: 要解决的问题：提供一种高度安全的皱纹改良剂，其具有优异的防止皱纹变形和改善皱纹的效果。 解决方案：皱纹改良剂含有栗子或其提取物作为活性成分。 皱纹改善剂减少皱纹或使皱纹的出现不显眼。 版权所有（C）2005，JPO＆NCIPI
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公开(公告)号：JP2004108794A
公开(公告)日：2004-04-08
申请号：JP2002268218
申请日：2002-09-13
Inventor： OSANAI TSUKASA , FUJIMURA TSUTOMU , TSUGITA TETSUYA , NAKAMURA YOSHIYUKI , YAMAZAKI TADAYUKI
Abstract: PROBLEM TO BE SOLVED: To provide a new method for evaluating surface characteristics such as elasticity in skin or the like, flexibility, and degree of slack, and the like without any contact with a part to be measured, and to provide an evaluating apparatus used for the method.
SOLUTION: A compression gas is jetted to the part S to be measured from an injection nozzle 1, surface displacement in the part S to be measured by the injection of the compression gas is measured by a displacement meter 2 or the like, and surface characteristics to the stress of the part S to be measured are evaluated based on the relationship between time from injection and the surface displacement.
COPYRIGHT: (C)2004,JPOAbstract translation: 要解决的问题：提供一种用于评价诸如皮肤等的弹性，柔软性和松弛度等表面特性的新方法，而不与待测部件接触，并且提供一种 用于该方法的评估装置。 解决方案：压缩气体从注射喷嘴1喷射到要测量的部分S，通过位移计2等测量待压缩气体测量的部分S中的表面位移， 并且基于从注射时间和表面位移之间的关系来评价要测量的部件S的应力的表面特性。 版权所有（C）2004，JPO
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