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公开(公告)号：WO2009107853A3
公开(公告)日：2009-11-19
申请号：PCT/JP2009054097
申请日：2009-02-26
Applicant: KAO CORP , KAMEYAMA AKIYO , FUJIMURA TSUTOMU
Inventor： KAMEYAMA AKIYO , FUJIMURA TSUTOMU
IPC: C07H15/256
CPC classification number: C07H15/256 , A61K8/63 , A61K8/97 , A61Q19/08
Abstract: An agent for preventing or ameliorating skin aging, which exhibits a more excellent effect on the suppression of formation, or the amelioration, of wrinkles on the skin or sagging skin. An agent for preventing or ameliorating skin aging, containing triterpenoid saponins represented by the following formula (1) as an active ingredient, wherein at least one of R1 and R2 is a tigloyl group and the other represents a tigloyl group or an angeloyl group; R3 represents a methyl group or a hydroxymethyl group; and R4 represents Glc, Xyl or Gal.
Abstract translation: 一种防止或改善皮肤老化的药剂，其在抑制皮肤或下垂的皮肤上形成皱纹或改善皱纹方面表现出更优异的效果。 一种含有下述式（1）所示的三萜皂苷作为有效成分的皮肤老化预防或改善剂，其中，R 1和R 2中的至少一个是三内酰脲基，另一个是邻苯二甲酰基或当归酰基; R3代表甲基或羟甲基; 和R4代表Glc，Xyl或Gal。
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公开(公告)号：EP0965327A4
公开(公告)日：2001-08-29
申请号：EP97943153
申请日：1997-10-08
Applicant: KAO CORP
Inventor： FUJIMURA TSUTOMU , ITO NORIKO , NAGAI MINORU , ONO TOSHIYA , YAMAMURO AKIRA , TAKEMA YOSHINORI
IPC: A01N43/00 , A01N43/36 , A01N43/40 , A01N43/58 , A01N43/64 , A61K6/00 , A61K8/49 , A61K31/395 , A61K31/397 , A61K31/40 , A61K31/41 , A61K31/435 , A61K31/445 , A61K31/495 , A61K31/50 , A61K31/535 , A61P17/00 , A61Q19/08 , A61K7/48 , A61K7/00
CPC classification number: A61Q19/08 , A61K8/49 , A61K8/4913 , A61K8/4926 , A61K8/494
Abstract: Wrinkling modifiers and anti-aging cosmetic preparations which contain guanidine derivatives of general formula (1) or salts thereof, wherein (a) is a group derived from a heterocyclic compound selected from among azetidine, pyrrolidine, piperidine, piperazine and morpholine; and R and R are each independently hydrogen, alkyl, hydroxyl, hydroxyalkyl, carboxyl, carboxyalkyl or amidino. The cosmetic preparations are excellent in the effect of suppressing wrinkling and the effect of making wrinkles disappear and exhibit an excellent feeling in use.
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公开(公告)号：EP1325737A4
公开(公告)日：2005-07-27
申请号：EP01943874
申请日：2001-06-29
Applicant: KAO CORP
Inventor： NISHIJIMA TAKAFUMI , AMANO SHINYA , FUJIMURA TSUTOMU
IPC: A61K8/46 , A61K8/55 , A61K8/60 , A61P17/16 , A61Q19/00 , A61Q19/08 , C07C279/14 , C07F9/09 , A61K7/48 , A61K7/00 , C07F9/10
CPC classification number: C07F9/091 , A61K8/463 , A61K8/55 , A61K8/602 , A61K8/604 , A61Q19/00 , A61Q19/08 , C07C279/14
Abstract: Skin pore minimizers containing as the active ingredient compounds of the following general formula: R1-OG or salts thereof [wherein R1 is C¿8-32? alkyl or alkenyl; and OG is a residue derived from a polyhydric alcohol, a monosaccharide, or an oligo- saccharide, at least one hydroxyl group of which is sulfated or phosphorylated, by removing a hydroxylic hydrogen atom]; and skin elasticity improvers containing as the active ingredient glyceryl ether derivatives of the following general formula: R?1O-CH¿2-CH(OX2)-CH2-OX1 or salts thereof [wherein R1 is as defined above; and X?1 and X2¿ are each hydrogen, -SO¿3?OH, or -PO(OH)2 with the proviso that the cases wherein both X?1 and X2¿ are hydrogen are excepted].
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公开(公告)号：EP0691327A4
公开(公告)日：1996-05-01
申请号：EP94910037
申请日：1994-03-17
Applicant: KAO CORP
Inventor： OHASHI YUKIHIRO , YADA YUKIHIRO , TAKEMA YOSHINORI , FUJIMORI TAKETOSHI , KAWAMATA AKIRA , OSU HIROYUKI , HIGUCHI KAZUHIKO , IMOKAWA GENJI , KUSUOKU HIROSHI , OGAWA AYUMI , FUJIMURA TSUTOMU
IPC: A61K8/41 , A61K8/46 , A61K8/49 , A61K8/68 , A61K31/13 , A61Q17/04 , A61Q19/00 , A61Q19/08 , C07C215/08 , C07C215/10 , C07C215/12 , C07C217/28 , C07C219/06 , C07C229/12 , C07C229/24 , C07C233/18 , C07C235/10 , C07C237/06 , C07C323/25 , C07D295/088 , C07D311/58 , C07D311/72 , C07D317/22 , C07F7/08 , C07F9/09 , C07H15/04 , A61K7/48
CPC classification number: C07C323/25 , A61K8/41 , A61K8/46 , A61K8/49 , A61K8/68 , A61Q17/04 , A61Q19/00 , A61Q19/08 , C07C215/08 , C07C215/10 , C07C215/12 , C07C217/28 , C07C219/06 , C07C229/12 , C07C229/24 , C07C233/18 , C07C235/10 , C07D295/088 , C07D311/58 , C07D311/72 , C07D317/22 , C07F7/0818 , C07F7/0847 , C07F7/0852 , C07F9/091 , C07H15/04 , Y10S514/844 , Y10S514/845 , Y10S514/873
Abstract: An amine derivative of following general formula (I) or (II) (wherein R1 represents a heteroatom-containing C¿1?-C40 hydrocarbon group which may have a ring structure, etc.; R?2 to R6¿ each represent a C¿1?-C10 hydrocarbon group, hydrogen, etc.; A?1¿ represents (i) or R?15-Z-R16(CH¿2)n-; B1 represents hydrogen, a C¿1?-C10 hydrocarbon group, nitrogen, etc.; and C?1¿ represents hydrogen, a C¿1?-C10 hydrocarbon group, nitrogen, alcohol residue, phosphoric acid residue, etc.); a dermatologic preparation containing the same; and a process for producing the amine derivative. The amine derivative has excellent effects of smoothing wrinkles and improving keratodermia.
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公开(公告)号：DE69732796T2
公开(公告)日：2006-05-04
申请号：DE69732796
申请日：1997-10-08
Applicant: KAO CORP
Inventor： FUJIMURA TSUTOMU , ITO NORIKO , NAGAI MINORU , ONO TOSHIYA , YAMAMURO AKIRA , TAKEMA YOSHINORI
IPC: A01N43/00 , A01N43/36 , A01N43/40 , A01N43/58 , A01N43/64 , A61K6/00 , A61K8/49 , A61K31/395 , A61K31/397 , A61K31/40 , A61K31/41 , A61K31/435 , A61K31/445 , A61K31/495 , A61K31/50 , A61K31/535 , A61P17/00 , A61Q19/08
Abstract: Wrinkling modifiers and anti-aging cosmetic preparations which contain guanidine derivatives of general formula (1) or salts thereof, wherein (a) is a group derived from a heterocyclic compound selected from among azetidine, pyrrolidine, piperidine, piperazine and morpholine; and R and R are each independently hydrogen, alkyl, hydroxyl, hydroxyalkyl, carboxyl, carboxyalkyl or amidino. The cosmetic preparations are excellent in the effect of suppressing wrinkling and the effect of making wrinkles disappear and exhibit an excellent feeling in use
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Patent Agency Ranking
公开(公告)号：DE69209513D1
公开(公告)日：1996-05-02
申请号：DE69209513
申请日：1992-09-22
Applicant: KAO CORP
Inventor： OHASHI YUKIHIRO , FUJIMORI TAKETOSHI , NAGAI MINORU , KAWAMATA AKIRA , YADA YUKIHIRO , HIGUCHI KAZUHIKO , IMOKAWA GENJI , TAKEMA YOSHINORI , SAKAINO YUKIKO , OGAWA AYUMI , FUJIMURA TSUTOMU
Abstract: PCT No. PCT/JP92/01210 Sec. 371 Date Mar. 23, 1994 Sec. 102(e) Date Mar. 23, 1994 PCT Filed Sep. 22, 1992 PCT Pub. No. WO93/05763 PCT Pub. Date Apr. 1, 1993A composition for external skin care comprising an amine derivative represented by the following formula (1), (1) wherein R1 is a linear, branched, or cyclic saturated or unsaturated hydrocarbon group having 4-40 carbon atoms, and R2, R3, R4, R5 and R6 are individually a hydrogen atom or a hydrocarbon group having 1-10 carbon atoms, which may be substituted or unsubstituted by 1 or more hydroxy groups; or an acid addition salt thereof, in an amount from 0.0001 to less than 0.1% by weight; and a method of curing wrinkles and keratinization of the skin characterized by applying said amine derivative or its salt to the skin.
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公开(公告)号：DE69732796D1
公开(公告)日：2005-04-21
申请号：DE69732796
申请日：1997-10-08
Applicant: KAO CORP
Inventor： FUJIMURA TSUTOMU , ITO NORIKO , NAGAI MINORU , ONO TOSHIYA , YAMAMURO AKIRA , TAKEMA YOSHINORI
IPC: A01N43/00 , A01N43/36 , A01N43/40 , A01N43/58 , A01N43/64 , A61K6/00 , A61K8/49 , A61K31/395 , A61K31/397 , A61K31/40 , A61K31/41 , A61K31/435 , A61K31/445 , A61K31/495 , A61K31/50 , A61K31/535 , A61P17/00 , A61Q19/08 , A61K7/48 , A61K7/00
Abstract: Wrinkling modifiers and anti-aging cosmetic preparations which contain guanidine derivatives of general formula (1) or salts thereof, wherein (a) is a group derived from a heterocyclic compound selected from among azetidine, pyrrolidine, piperidine, piperazine and morpholine; and R and R are each independently hydrogen, alkyl, hydroxyl, hydroxyalkyl, carboxyl, carboxyalkyl or amidino. The cosmetic preparations are excellent in the effect of suppressing wrinkling and the effect of making wrinkles disappear and exhibit an excellent feeling in use
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公开(公告)号：DE69419601T2
公开(公告)日：1999-12-02
申请号：DE69419601
申请日：1994-03-17
Applicant: KAO CORP
Inventor： OHASHI YUKIHIRO , YADA YUKIHIRO , TAKEMA YOSHINORI , FUJIMORI TAKETOSHI , KAWAMATA AKIRA , OHSU HIROYUKI , HIGUCHI KAZUHIKO , IMOKAWA GENJI , KUSUOKU HIROSHI , OGAWA AYUMI , FUJIMURA TSUTOMU
IPC: A61K8/41 , A61K8/46 , A61K8/49 , A61K8/68 , A61K31/13 , A61Q17/04 , A61Q19/00 , A61Q19/08 , C07C215/08 , C07C215/10 , C07C215/12 , C07C217/28 , C07C219/06 , C07C229/12 , C07C229/24 , C07C233/18 , C07C235/10 , C07C237/06 , C07C323/25 , C07D295/088 , C07D311/58 , C07D311/72 , C07D317/22 , C07F7/08 , C07F9/09 , C07H15/04 , A61K7/48
Abstract: An amine derivative of following general formula (I) or (II) (wherein R represents a heteroatom-containing C1-C40 hydrocarbon group which may have a ring structure, etc.; R to R each represent a C1-C10 hydrocarbon group, hydrogen, etc.; A represents (i) or R -Z-R (CH2)n-; B represents hydrogen, a C1-C10 hydrocarbon group, nitrogen, etc.; and C represents hydrogen, a C1-C10 hydrocarbon group, nitrogen, alcohol residue, phosphoric acid residue, etc.); a dermatologic preparation containing the same; and a process for producing the amine derivative. The amine derivative has excellent effects of smoothing wrinkles and improving keratodermia.
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公开(公告)号：DE69913233D1
公开(公告)日：2004-01-15
申请号：DE69913233
申请日：1999-04-13
Applicant: KAO CORP
Inventor： KOIKE KENZO , SHIMIZU MASAKI , FUKASAWA JUNICHI , OTA HIROSHI , FUJIMURA TSUTOMU , TSUKAHARA KAZUE , SUZUKI YUJI
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公开(公告)号：DE60140815D1
公开(公告)日：2010-01-28
申请号：DE60140815
申请日：2001-06-29
Applicant: KAO CORP
Inventor： NISHIJIMA TAKAFUMI , AMANO SHINYA , FUJIMURA TSUTOMU
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