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    3.
    发明专利
    未知

    公开(公告)号：DE69209513D1

    公开(公告)日：1996-05-02

    申请号：DE69209513

    申请日：1992-09-22

    Applicant: KAO CORP

    Inventor： OHASHI YUKIHIRO ,  FUJIMORI TAKETOSHI ,  NAGAI MINORU ,  KAWAMATA AKIRA ,  YADA YUKIHIRO ,  HIGUCHI KAZUHIKO ,  IMOKAWA GENJI ,  TAKEMA YOSHINORI ,  SAKAINO YUKIKO ,  OGAWA AYUMI ,  FUJIMURA TSUTOMU

    IPC: A61K8/41 ,  A61K31/13 ,  A61Q19/00 ,  A61Q19/08 ,  A61K7/48

    Abstract: PCT No. PCT/JP92/01210 Sec. 371 Date Mar. 23, 1994 Sec. 102(e) Date Mar. 23, 1994 PCT Filed Sep. 22, 1992 PCT Pub. No. WO93/05763 PCT Pub. Date Apr. 1, 1993A composition for external skin care comprising an amine derivative represented by the following formula (1), (1) wherein R1 is a linear, branched, or cyclic saturated or unsaturated hydrocarbon group having 4-40 carbon atoms, and R2, R3, R4, R5 and R6 are individually a hydrogen atom or a hydrocarbon group having 1-10 carbon atoms, which may be substituted or unsubstituted by 1 or more hydroxy groups; or an acid addition salt thereof, in an amount from 0.0001 to less than 0.1% by weight; and a method of curing wrinkles and keratinization of the skin characterized by applying said amine derivative or its salt to the skin.

    5.
    发明专利
    未知

    公开(公告)号：DE69209513T2

    公开(公告)日：1996-09-12

    申请号：DE69209513

    申请日：1992-09-22

    Applicant: KAO CORP

    Inventor： OHASHI YUKIHIRO ,  FUJIMORI TAKETOSHI ,  NAGAI MINORU ,  KAWAMATA AKIRA ,  YADA YUKIHIRO ,  HIGUCHI KAZUHIKO ,  IMOKAWA GENJI ,  TAKEMA YOSHINORI ,  SAKAINO YUKIKO ,  OGAWA AYUMI ,  FUJIMURA TSUTOMU

    IPC: A61K8/41 ,  A61K31/13 ,  A61Q19/00 ,  A61Q19/08 ,  A61K7/48

    Abstract: PCT No. PCT/JP92/01210 Sec. 371 Date Mar. 23, 1994 Sec. 102(e) Date Mar. 23, 1994 PCT Filed Sep. 22, 1992 PCT Pub. No. WO93/05763 PCT Pub. Date Apr. 1, 1993A composition for external skin care comprising an amine derivative represented by the following formula (1), (1) wherein R1 is a linear, branched, or cyclic saturated or unsaturated hydrocarbon group having 4-40 carbon atoms, and R2, R3, R4, R5 and R6 are individually a hydrogen atom or a hydrocarbon group having 1-10 carbon atoms, which may be substituted or unsubstituted by 1 or more hydroxy groups; or an acid addition salt thereof, in an amount from 0.0001 to less than 0.1% by weight; and a method of curing wrinkles and keratinization of the skin characterized by applying said amine derivative or its salt to the skin.

    SKIN COSMETIC
    6.
    发明专利
    SKIN COSMETIC 失效

    公开(公告)号：JPH08175959A

    公开(公告)日：1996-07-09

    申请号：JP32534094

    申请日：1994-12-27

    Applicant: KAO CORP

    Inventor： MURASE TAKATOSHI ,  HASE TADASHI ,  TAKEMA YOSHINORI ,  OGAWA AYUMI ,  OSU HIROYUKI ,  TOKIMITSU ICHIROU

    IPC: A61K8/30 ,  A61K8/00 ,  A61K8/02 ,  A61K8/42 ,  A61Q19/00 ,  A61Q19/02 ,  A61K7/48 ,  A61K7/00

    Abstract: PURPOSE: To provide a skin cosmetic containing a benzoic acid anilide compound and effective for suppressing the wrinkling and pigmentation of the skin. CONSTITUTION: This cosmetic contains a compound of formula (R is H or t-butyl; R is H, a 1-5C alkyl or an acyl) or its salt as an active component in an amount of 0.001-20wt.%, preferably 0.05-5wt.%. The suppression effect on the wrinkle and spots can be improved by incorporating the cosmetic with other conventional anti-inflammatory agent (e.g. allantoin), an antioxidant, etc. It can be prepared in the form of an O/W-type or W/O-type emulsified cosmetic, cream, cosmetic milky lotion, face lotion, oily cosmetic, pack, foundation, etc., by properly compounding with conventional cosmetic components. An example of the compound of formula is 4-hydroxy-N-(2-hydroxyphenyl) benzoic acid amide.

    WRINKLE IMPROVER
    7.
    发明专利
    WRINKLE IMPROVER 失效

    公开(公告)号：JPH0640885A

    公开(公告)日：1994-02-15

    申请号：JP11490293

    申请日：1993-05-17

    Applicant: KAO CORP

    Inventor： TAKEMA YOSHINORI ,  SAKAINO YUKIKO ,  OGAWA AYUMI ,  FUJIMURA TSUTOMU ,  YADA YUKIHIRO ,  OHASHI YUKIHIRO ,  FUJIMORI TAKETOSHI ,  IMOKAWA GENJI

    IPC: A61K8/30 ,  A61K8/00 ,  A61K8/41 ,  A61K31/13 ,  A61P17/00 ,  A61Q19/00 ,  A61Q19/08 ,  A61K7/48 ,  A61K7/00

    Abstract: PURPOSE:To provide a wrinkle improver capable of suppressing wrinkle development, also capable of giving aging-inhibitory cosmetics excellent in wrinkle vanishing effect, consisting of a specific amine derivative (a salt thereof). CONSTITUTION:The wrinkle improver consisting of an amine derivative of formula I [R is 4-40C straight chain, branched chain or cyclic (un) saturated hydrocarbon; R -R are each H or 1-10C hydrocarbon] or a salt thereof. The compound of the formula I is pref. a compound of formula II (m is 4-10; n is 5-11; (m+n) is 11-17) such as 1-(2-hydroxyethylamino)-3-methyl branched isostearyloxy-2-propanol and can be obtained, for example, by adding (A) an amine derivative of formula IV to a glycidyl ether derivative of formula III. Some of the compounds of the formula I have been known.

    WRINKLES IMPROVER
    8.
    发明专利
    WRINKLES IMPROVER 失效

    公开(公告)号：JPH09202710A

    公开(公告)日：1997-08-05

    申请号：JP27462896

    申请日：1996-10-17

    Applicant: KAO CORP

    Inventor： FUJIMURA TSUTOMU ,  OGAWA AYUMI ,  TSUKAHARA KAZUE ,  TAKEMA YOSHINORI ,  NAGAI MINORU ,  ONO TOSHIYA

    IPC: A61K8/30 ,  A61K8/00 ,  A61K8/36 ,  A61K8/362 ,  A61K8/37 ,  A61K8/43 ,  A61K8/46 ,  A61Q19/00 ,  A61Q19/08 ,  C07C279/08 ,  C07C279/14 ,  C07C309/15 ,  C07F9/09 ,  A61K7/00 ,  A61K7/48

    Abstract: PROBLEM TO BE SOLVED: To obtain a wrinkles improver containing a guanidine derivative having a specific structure or its acid addition salt as an active ingredient, capable of suppressing occurrence of wrinkles without impairing normal skin physiology and excellent in effect for eliminating wrinkles and having good feeling to users. SOLUTION: This wrinkles improver is obtained by using a guanidine derivative of formula I [A and B are each a 2-8C alkylene; D is a direct bond or a 1-6C alkylene; E is H, an alkyl, an aralkyl or an aryl; (m) is 1-6; (n) is 0-6; R is H, an alkyl or (AO)m (BO)n -D-E] or formula II [(k) is 1-10; G is H, OH, COOH, sulfonic acid or phosphoric acid] or its acid addition salt. The wrinkles improver is useful as a cosmetic for preventing aging. The content of the active ingredient is preferably 0.001-50wt.%. An organic acid or its ester in an amount of 0.001-30wt.% is preferably further added to the system. A dicarboxylic acid is preferably used as the organic acid. The compound of formula I is obtained by reacting, e.g. a compound of formula III with a guanidination reagent.

    WRINKLE-SUPPRESSING AGENT
    9.
    发明专利
    WRINKLE-SUPPRESSING AGENT 失效

    公开(公告)号：JPH08217655A

    公开(公告)日：1996-08-27

    申请号：JP2250695

    申请日：1995-02-10

    Applicant: KAO CORP

    Inventor： HASE TADASHI ,  MURASE TAKATOSHI ,  OKUDA MINEHIRO ,  TOKIMITSU ICHIROU ,  TAKEMA YOSHINORI ,  OSU HIROYUKI ,  OGAWA AYUMI ,  SHIBUYA YUSUKE ,  NISHIZAWA YOSHINORI

    IPC: A61K8/96 ,  A61K8/00 ,  A61K8/97 ,  A61Q1/00 ,  A61Q1/12 ,  A61Q19/00 ,  A61K7/48 ,  A61K7/00

    Abstract: PURPOSE: To obtain the subject agent containing an extract of Hamamelisvirginiana L. as an active component, excellent in suppressing activity against wrinkles of the skin formed by the irradiation of ultraviolet and useful as a skin external agent for preventing wrinkles. CONSTITUTION: This agent contains an extract of Hamamelisvirginiana L. as an active component preferably in a content of 0.001-5wt.% in terms of a dry solid material. The extract is preferably obtained by adding 100g of dry crashed material of Hamamelisvirginiana L. with 1000ml of 50v/v% ethanol aqueous solution, extracting it for 3 days at room temperature while it is stirred at intervals, subsequently filtering the extraction mixture, allowing the filtrate to stand at 5 deg.C for 3days and filtering this solution again to obtain a clear filtrate. Further, the above wrinkle-suppressing agent is preferably incorporated with a component selected from an anti-inflammatory agent such as glycyrrhizic acid, an extract of one of various kinds of plants other than Hamamelisvirginiana L., a singlet oxygen-removing agent and an antioxidant since this enhances the wrinkle-suppressing effect.

    WRINKLE-PREVENTING COSMETIC
    10.
    发明专利
    WRINKLE-PREVENTING COSMETIC 失效

    公开(公告)号：JPH08175960A

    公开(公告)日：1996-07-09

    申请号：JP32534194

    申请日：1994-12-27

    Applicant: KAO CORP

    Inventor： MURASE TAKATOSHI ,  HASE TADASHI ,  TAKEMA YOSHINORI ,  OGAWA AYUMI ,  OSU HIROYUKI ,  TOKIMITSU ICHIROU

    IPC: A61K8/30 ,  A61K8/00 ,  A61K8/33 ,  A61Q19/00 ,  A61K7/48 ,  A61K7/00

    Abstract: PURPOSE: To provide a wrinkle-preventing cosmetic containing a stilbene derivative and having an action to suppress the formation of wrinkles. CONSTITUTION: Thus cosmetic contains a compound expressed by formula (R , R and R are each H, a 1-6C alkyl or an acyl which may contain OH; (n) is 0-4; (m) is 0-5) or its salt as an active component in an amount of 0.001-20wt.%, preferably 0.05-5wt.%. The effect for suppressing the formation of wrinkle can be improved by adding conventional other anti-inflammatory agent (e.g. allantoin), antioxidant, etc. It can be prepared in the form of an O/W-type or W/O-type emulsified cosmetic, cream, cosmetic milky lotion, face lotion, oily cosmetic, pack, foundation, etc. An example of the compound of formula is 3,4,3',5'-tetrahydroxystilbene.

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