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    5ALPHA-REDUCTASE INHIBITOR
    22.
    发明专利
    5ALPHA-REDUCTASE INHIBITOR 失效

    公开(公告)号：JPH02193920A

    公开(公告)日：1990-07-31

    申请号：JP1348289

    申请日：1989-01-23

    Applicant: KAO CORP

    Inventor： JOKURA YOJI ,  ISHIKAWA SHINJI ,  NISHIZAWA YOSHINORI ,  YOSHIMURA KOICHI ,  KITAHARA TAKASHI ,  HATTORI MICHIHIRO

    IPC: C07D311/36 ,  A61K8/00 ,  A61K8/49 ,  A61K31/35 ,  A61K31/352 ,  A61P35/00 ,  A61P43/00 ,  A61Q5/00 ,  A61Q7/00 ,  A61Q15/00

    Abstract: PURPOSE:To provide the subject inhibitor having an excellent 5alpha-reductase- inhibiting activity and high safety and effective for the therapy of prostatic hypertroply, etc., caused by the action of androgenic hormone by containing an inflavone compound as an active ingredient. CONSTITUTION:A 5alpha-reductase inhibitor contains an isoflavone compound of the formula (R , R and R are H, chain or alicyclic hydrocarbon or 1-6C alkoxyl; A, B, C and D are H, hydroxyl or methoxyl, but R and C are simultaneously not H) as an active ingredient. The 5alpha-reductase inhibitor may be administered not only as such but also in the form of tablets, powder, etc. When the inhibitor is used e.g. in the form of a solid preparation, the solid preparation may contain an inert diluent such as lactose or mannitol, a lubricant such as magnesium stearate, a disintegrator such as cellulose or calcium gluconate, etc.

    Agent for ameliorating swelling, and slimming agent
    23.
    发明专利
    Agent for ameliorating swelling, and slimming agent 审中-公开
    用于改善破裂和滑动剂的代理

    公开(公告)号：JP2007130020A

    公开(公告)日：2007-05-31

    申请号：JP2006326526

    申请日：2006-12-04

    Applicant: Kao Corp ,  花王株式会社

    Inventor： CHIBA HIROE ,  FUKUDA YUKO ,  KITAHARA TAKASHI ,  HORI KIMIHIKO

    IPC: A23L1/30 ,  A61K31/7048 ,  A61P7/10

    Abstract: PROBLEM TO BE SOLVED: To provide a skin cosmetic, a quasi-drug for skin external use, a health food, a food for medical application, a food for a medicine and a food for improving a cosmetic, effective for reducing spontaneous swelling of legs or the like caused by a standing posture and a sitting posture for a long time, and slimming of the belly or the like. SOLUTION: The skin cosmetic, the quasi-drug for skin external use, the health food, the food for the medical application, the food for the medicine and the cosmetic for ameliorating the swelling contain α-glycosylated rutin as an active ingredient. A tablet (including a chewing tablet), a granule, a powder, a drinkable preparation, and a processed food such as a cookie, a biscuit, a cake and a bread are used as the oral dosage form. COPYRIGHT: (C)2007,JPO&INPIT

    Abstract translation: 要解决的问题：提供一种皮肤美容品，用于皮肤外用的准药物，保健食品，医疗应用食品，用于药物的食品和用于改善化妆品的食品，有效减少自发的 长时间站立姿势，坐姿引起的腿等肿胀，腹部等变瘦。

    解决方案：皮肤化妆品，皮肤外用准准药，保健食品，医疗用食品，药物食品和改善肿胀的化妆品含有α-糖基化芦丁作为活性成分 。 作为口服剂型，使用片剂（包括咀嚼片），颗粒剂，粉剂，饮料制剂，加工食品如饼干，饼干，蛋糕和面包。 版权所有（C）2007，JPO＆INPIT

    AGENT FOR INHIBITING HAIR GROWTH
    24.
    发明专利
    AGENT FOR INHIBITING HAIR GROWTH 审中-公开

    公开(公告)号：JP2003089626A

    公开(公告)日：2003-03-28

    申请号：JP2001286422

    申请日：2001-09-20

    Applicant: KAO CORP

    Inventor： WAKIZAKA ETSUJI ,  KITAHARA TAKASHI ,  TSUJI NAOKO ,  KUSUOKU HIROSHI

    IPC: A61K8/00 ,  A61K8/97 ,  A61Q9/04 ,  A61K7/155

    Abstract: PROBLEM TO BE SOLVED: To obtain an agent for inhibiting hair growth, effectively inhibiting the growth of the hair, enabling the number of the treatment for removing the hair to be decreased, making the hair thin especially to facilitate the removal of the hair of legs and arms. SOLUTION: This agent for inhibiting the hair growth comprises a crude medicine selected from Bupleurum root, beefsteak plant leaf, rhubarb and akebia stem, or an extract thereof.

    KERATOLYTIC AGENT
    26.
    发明专利
    KERATOLYTIC AGENT 失效

    公开(公告)号：JPH0881375A

    公开(公告)日：1996-03-26

    申请号：JP21502194

    申请日：1994-09-08

    Applicant: KAO CORP

    Inventor： SUZUKI ATSUSHI ,  WATANABE IKUO ,  KITAHARA TAKASHI ,  HORI KIMIHIKO

    IPC: A61K31/60 ,  A61P17/00

    Abstract: PURPOSE: To obtain a keratolytic agent containing, as active ingredient, a compound having excellent antiacned keratolytic ability and high safety to human health with few side effects, thus useful as a medicine for acne, dandruffy symptom, hyperkeratosis involved in keratinization promotion. CONSTITUTION: This keratolytic agent contains, as active ingredient, at least one kind of compound of formula I R is OH, OR [R is an alkali (alkaline earth) metal, ammonium, alkanolamine, etc.], or NHR ; R is OR (R is a 4-12C saturated or monounsaturated alkyl, etc.), or a group of formula II (X is 0 or NH; (n) is 1 or 2)}, e.g. 4-[(2E)-3,7-dimethylocta-2,6-dienyloxy]-2- hydroxybenzoic acid. The compound of formula I is obtained by reaction between e.g. an alkenyl halide and e.g. and alkoxyhydroxybenzoic ester followed by hydrolysis in the presence of a base. It is preferable that the active ingredient content of this agent be 0.001-20wt.%.

    SEBACEOUS GLAND SUPPRESSOR
    28.
    发明专利
    SEBACEOUS GLAND SUPPRESSOR 失效

    公开(公告)号：JPH02193919A

    公开(公告)日：1990-07-31

    申请号：JP1348189

    申请日：1989-01-23

    Applicant: KAO CORP

    Inventor： JOKURA YOJI ,  ISHIKAWA SHINJI ,  NISHIZAWA YOSHINORI ,  YOSHIMURA KOICHI ,  KITAHARA TAKASHI ,  HATTORI MICHIHIRO

    IPC: C07D311/36 ,  A61K31/35 ,  A61K31/352 ,  A61P3/06

    Abstract: PURPOSE:To provide a sebaceous gland-inhibiting agent capable of effectively suppressing excess sebum, causing no side effect even when used for long periods and being employed in the forms of an emulsified cosmetic, an oily cosmetic, etc., by containing an isoflavone compound as an active ingredient. CONSTITUTION:A sebaceous gland-inhibiting agent contains an isoflavone compound of the formula (R , R and R are H, chain or alicyclir hydrocarbon or 1-6C alkoxyl; A, B, C and D are H, hydroxy or methoxy, but R and C are not H simultaneously) as an active ingredient. The isoflavone compound of the formula can be used not only is the form of the especially isolated substance but only in the state of an extract separated from a plant belonging to e.g. the Rosaceae, Moraceae, Inidaceae, etc., as well as to two the subfamilies of the Leguminosae. When used an emulsified skin cosmetic or a hair cosmetic, the compound or extract is suitably compounded in the preparation in an amount of 0.005-5.0wt.% or 0.001-50%, respectively.

    MELANOGENESIS PROMOTER
    30.
    发明专利
    MELANOGENESIS PROMOTER 失效

    公开(公告)号：JP2002047130A

    公开(公告)日：2002-02-12

    申请号：JP2000225627

    申请日：2000-07-26

    Applicant: KAO CORP

    Inventor： KOBAYASHI AKIYOSHI ,  OUCHI ATSUSHI ,  KITAHARA TAKASHI ,  KUSUOKU HIROSHI ,  SHIBUYA YUSUKE

    IPC: A61K8/96 ,  A61K8/00 ,  A61K8/97 ,  A61K36/60 ,  A61P17/00 ,  A61P43/00 ,  A61Q5/00 ,  A61Q19/00 ,  A61K7/00 ,  A61K7/06 ,  A61K7/48 ,  A61K35/78

    Abstract: PROBLEM TO BE SOLVED: To provide a melanogenesis promoter comprising a specific plant or an extract therefrom which has a tyrosinase activity promotive effect thereby increases the melanin production in the skin and the hair, and capable of giving compositions each containing the above plant or the extract therefrom which therefore can prevent the damage of the skin through promoting the biophylactic ability inherent in melanin and have skin melanization or gray hair-prophylactic or ameliorating effect. SOLUTION: This melanogenesis promoter or tyrosinase activity promoter comprises Ficus carica or Morus alba or an extract therefrom. The other objective composition for skin melanization or gray hair protphylactic composition contains the above plant or the extract therefrom.

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