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公开(公告)号:JPH0672850A
公开(公告)日:1994-03-15
申请号:JP15734093
申请日:1993-06-28
Applicant: KAO CORP
Inventor: TAKANABE EISHIN , TOKIMITSU ICHIROU , MINEMATSU YOSHIHIRO
IPC: A61K8/00 , A61K8/89 , A61K8/891 , A61K9/06 , A61K9/107 , A61K31/352 , A61K31/405 , A61K38/00 , A61K45/00 , A61K47/34 , A61P17/00 , A61P29/00 , A61Q19/00 , C08L83/04 , C08L83/08 , A61K7/48
Abstract: PURPOSE:To provide external preparation for skin which has excellent skin persistence and transdermal absorption of the physiologically active substances and can sustain the efficacy for hours. CONSTITUTION:The preparation contains, as active ingredients, 0.01 to 40wt.% of organopolysiloxane of formula I and formula II (R , R are 1 to 4 C alkyl; R is 1 to 40C alkyl, alkenyl, fluoroalkyl; R is 7 to 40C alkyl, alkenyl, fluoroalkyl; l is 2 or more; m is 3 or more; l+m is 5 to 6,000) and physiologically active substances. As a physiologically active substance, are cited corticosteroids, non-steroids, antibiotics, bactericides, fungicides, vitamins, antihistamines, and local anesthesia. They can be prepared in the form of emulsion, dispersion, two-layered or solubilized preparations. When it is applied to the skin, the active substances can stay on the application sites without dissipation from the skin surface by sweat, skin lipid, washing or friction and develop the medicinal effect for many hours. Since it has high moisture retention, the preparation is particularly useful for xerotic skin diseases.
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公开(公告)号:JPH0672849A
公开(公告)日:1994-03-15
申请号:JP29450692
申请日:1992-11-02
Applicant: KAO CORP
Inventor: SHINPOU TSUNEO , MINEMATSU YOSHIHIRO , SHIBUE YUUKO , SUZUKI YUJI , MASUDA MITSUHARU , KIMURA MITSUTOSHI , IMOKAWA GENJI
Abstract: PURPOSE:To provide skin color-lightening cosmetics having extremely excellent effects of lightening skin color as well as preventing and curing blots and freckles caused by sun burning. CONSTITUTION:The objective skin color-lightening cosmetics contain (A) at least one member selected from the groups consisting of L-ascorbic acid and water-soluble derivatives thereof and (B) a tea extract.
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公开(公告)号:JPH0624954A
公开(公告)日:1994-02-01
申请号:JP18115992
申请日:1992-07-08
Applicant: KAO CORP
Inventor: SHINPOU TSUNEO , KIMURA MITSUTOSHI , MASUDA MITSUHARU , SUZUKI YUJI , MINEMATSU YOSHIHIRO
IPC: A61K8/30 , A61K8/00 , A61K8/06 , A61K8/40 , A61K8/96 , A61K8/97 , A61Q19/00 , A61Q90/00 , A61K7/48 , A61K7/00
Abstract: PURPOSE:To obtain a cosmetic, capable of maintaining actions such as water holding action in horny layers, keratolytic peeling, antimicrobial and skin absorption accelerating actions for a long period without producing side effects such as skin irritancy, etc. CONSTITUTION:This cosmetic comprises (A) urea and (B) one or two or more selected from respective extracts of Caryophyllus, Thea sinensis L., Puerariae Radix, Mori Cortex, Glycyrrhizae Radix, Scutellariae Radix, Aloe and Aurantii Pericarpium and (C) water.
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公开(公告)号:JPH05229931A
公开(公告)日:1993-09-07
申请号:JP29450592
申请日:1992-11-02
Applicant: KAO CORP
Inventor: SHINPOU TSUNEO , KIMURA MITSUTOSHI , MASUDA MITSUHARU , SUZUKI YUJI , MINEMATSU YOSHIHIRO
Abstract: PURPOSE:To provide a skin-whitening cosmetic wherein the action of L-ascorbic acid to suppress the melanin formation is increased synergetically, thus showing excellent skin-whitening effect and further prophylactic and curing effects for blots and freckles caused by sun burning. CONSTITUTION:(A) At least one compound selected from L-ascorbic acid and water-soluble L-ascorbic acid derivatives (for example, a monovalent to trivalent metal salt of L-ascorbic acid ester with phosphoric acid or sulfuric acid and (B) Puerariae Radix extract, for example, the extract of the roots with a solvent such as water, ethanol, methanol, 1,3-butylene glycol and/or propylene glycol, or the powder prepared by drying the extract or isoflavon derivatives isolated from the extract are combined in such amounts as A=0.001 to 30wt.%, preferably 0.1 to 5wt.%, B=0.001 to 10wt.%, preferably 0.01 to 5wt.% to give the objective skin-whitening cosmetic having the above-stated effects.
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公开(公告)号:JPH0445778B2
公开(公告)日:1992-07-27
申请号:JP28578087
申请日:1987-11-12
Applicant: KAO CORP
Inventor: HONMA YASUHIRO , MYAZAKI NOBUO , MISUMI HISASHI , SUDA TOSHASU , AKASAKI SHUICHI , MINEMATSU YOSHIHIRO , KAWAI MICHIO
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公开(公告)号:JPH0672854A
公开(公告)日:1994-03-15
申请号:JP15916093
申请日:1993-06-29
Applicant: KAO CORP
Inventor: TAKANABE EISHIN , TOKIMITSU ICHIROU , MINEMATSU YOSHIHIRO
IPC: A61K8/72 , A61K8/00 , A61K8/30 , A61K8/89 , A61K8/92 , A61P17/16 , A61Q19/00 , C08L83/04 , C08L83/08 , A61K7/48 , A61K7/00
Abstract: PURPOSE:To obtain the subject composition, comprising a specific oily substance and a specified organopolysiloxane in a specific proportion with hardly any stickiness, excellent in feeling of use and useful for kitchen work, etc. CONSTITUTION:The objective composition comprises (A) an oily substance having >=25 deg.C softening point and >=2 value of a ratio organicity/inorganicity such as vaseline and (B) an organopolysiloxane having units of formulas I and II (R and R are 1-4C alkyl; R is 1-40C alkyl, alkenyl or fluoroalkyl; R is 7-40C alkyl, alkenyl or fluoroalkyl; (l) is >=2; (m) is >=3; (l+m) is 5-6000] in the molecule in an amount of >=20wt.% in the total oily ingredient at (10/1) to (1/5) weight ratio of the ingredients (A)/(B).
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公开(公告)号:JPH0672853A
公开(公告)日:1994-03-15
申请号:JP15915993
申请日:1993-06-29
Applicant: KAO CORP
Inventor: TAKANABE EISHIN , TOKIMITSU ICHIROU , MINEMATSU YOSHIHIRO
IPC: A61K8/30 , A61K8/00 , A61K8/34 , A61K8/72 , A61K8/89 , A61P17/16 , A61Q19/00 , C08L83/04 , C08L83/08 , A61K7/48 , A61K7/00
Abstract: PURPOSE:To obtain a skin cosmetic, comprising a polyhydric alcohol and a specific organopolysiloxane as a humectant ingredient and capable of sustaining humectant effects without any irritation and stickiness and good in feeling of use. CONSTITUTION:The objective skin cosmetic is obtained by including 0.1-40wt.% polyhydric alcohol (e.g. glycerol) and 0.01-40wt.% organopolysiloxane of formulas I and II [R and R are 1-4C alkyl; R is 1-40C alkyl, alkenyl or fluoroalkyl; R is 7-40C alkyl, alkenyl or fluoroalkyl; (l) is >=2; (m) is >=3 and (l+m) is 5-6000]. Furthermore, an oiling agent, an emulsifying agent, powder, an ultraviolet ray scattering agent, a pH adjustor, a thickening agent, a coloring matter, a preservative, an antioxidant, an ultraviolet absorber, a perfume, a germicide, a chelating agent, an alcohol, etc., usually used in a cosmetic are suitably blended and this cosmetic can be prepared into a dosage form such as an emulsion type, a dispersion type, a two-layer type or a solubilized type. This cosmetic is not washed away even by kitchen work and washing with a soap, but resistant to perspiration and sustains the humectant effects for a long period.
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公开(公告)号:JPH0672852A
公开(公告)日:1994-03-15
申请号:JP15915893
申请日:1993-06-29
Applicant: KAO CORP
Inventor: TAKANABE EISHIN , TOKIMITSU ICHIROU , MINEMATSU YOSHIHIRO
IPC: A61K8/72 , A61K8/00 , A61K8/89 , A61K8/92 , A61P17/16 , A61Q19/00 , C08L83/04 , C08L83/08 , A61K7/48 , A61K7/00
Abstract: PURPOSE:To provide a skin-protecting composition which has high effect of protecting the skin from kitchen work and skin washing with good application feeling free from greasy touch by using a specific oil preparation and a specific organopoly-siloxane. CONSTITUTION:The objective composition contain an oil preparation which is liquid at 25 deg.C, for example, a polyether-modified silicone oil or squalane and an organopolysiloxane of formula I and formula II (R , R are 1 to 4C alkyl; R is 1 to 40C alkyl, alkenyl, fluoroalkyl; R is 7 to 40C alkyl, alkenyl, fluoroalkyl; l is 2 or more; m is 3 or more and l+m is 5 to 6,000) in a total amount of more than 20wt.% based on the whole oil components. The weight ratio of the oil preparation to the organopoly-siloxane is 10:1 to 1:5. In addition, aqueous components, emulsifier, preservative, antioxidant, perfume and powder are suitably added to produce solid, paste, water-in-oil or oil-in-water emulsion preparations.
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公开(公告)号:JPH05229928A
公开(公告)日:1993-09-07
申请号:JP3633492
申请日:1992-02-24
Applicant: KAO CORP
Inventor: MINEMATSU YOSHIHIRO , MATSUMOTO YASUNOBU , HOSOKAWA MASARU , TAKANABE EISHIN
IPC: A61K8/30 , A61K8/00 , A61K8/02 , A61K8/34 , A61K8/72 , A61K8/73 , A61K8/89 , A61K8/96 , A61Q19/00 , C08L83/12
Abstract: PURPOSE:To obtain toilet water having refreshing feeling of use while possessing excellent humectant properties without any skin irritation or odor due to a monohydric lower alcohol. CONSTITUTION:The objective toilet water is obtained by blending (A) a polyhydric alcohol, preferably a 2-4C polyhydric alcohol or combination of the alcohol with other alcohols with (B) a water-soluble polymer, especially pectin or kappa-carrageenan and (C) a polyether-modified silicone oil, preferably a water-soluble one, e.g. a compound expressed by the formula [R is 1-4C alkyl; (m) is a number of 5-50; (n) is a number of 2-10; (p) is number of 10-50; (q) is a number of 0-30] as essential ingredients therein. The concentrations of the ingredients are preferably 0.1-40wt.%, especially 2-20wt.% ingredient (A), preferably 0.01-1.0wt.%, especially 0.03-0.3wt.% ingredient (B) and preferably 0.1-1.0wt.%, especially 0.04-0.4wt.% ingredient (C). This toilet water is excellent in humectant properties, good in feeling of use with no irritancy or stickiness and useful as a nonalcohol and nonoil cosmetic.
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公开(公告)号:JPS6479195A
公开(公告)日:1989-03-24
申请号:JP13342688
申请日:1988-05-31
Applicant: KAO CORP
Inventor: KAWAMATA AKIRA , YAMADA SHINJI , MINEMATSU YOSHIHIRO , AKASAKI SHUICHI , ZAMA MITSUKO , IMOKAWA GENJI , TAKAISHI NAOTAKE
IPC: A61K8/60 , A61K8/00 , A61K8/68 , A61K31/70 , A61K31/7028 , A61P17/00 , A61P43/00 , A61Q19/00 , C07H15/04
Abstract: NEW MATERIAL:A compound expressed by formula I (R1 is 10-26C alkyl; R2 is 9-25C alkyl; X and Y are H or saccharide residue and both will not be H at the same time). EXAMPLE:N-( 3-Hexadecyloxy-2-hydroxypropyl)-N-(2-O-D-glucopyranosyl)ethyl )hexadecanamide. USE:A dermal agent for external use. PREPARATION:For example, a glycidyl ether expressed by formula II is reacted with ethanolamine and only the amino group of the resultant product is selective ly acylated to provide a compound expressed by formula III. Either of primary and secondary hydroxyl groups in the resultant compound expressed by formula III is then protected and the protected compound is subsequently reacted with O-(2,3,4,6-tetra-O-benzyl-alpha-D-glycopyranosyl)trichloroacet-imidate in the presence of boron trifluoride etherate. The protecting group is subsequently removed to afford the aimed compound expressed by formula I.
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