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公开(公告)号：WO2010144150A3
公开(公告)日：2011-07-14
申请号：PCT/US2010001690
申请日：2010-06-11
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , KORLACH JONAS , TURNER STEPHEN , FLUSBERG BENJAMIN , CHAISSON MARK , SCHADT ERIC , WEGENER JEFF
Inventor： KORLACH JONAS , TURNER STEPHEN , FLUSBERG BENJAMIN , SCHADT ERIC , WEGENER JEFF
CPC classification number: G01N33/68 , C12Q1/6825 , C12Q1/6827 , C12Q1/6869 , G01N33/542 , G01N33/54306 , G01N33/54373 , G01N33/582 , G01N33/6875 , G01N2333/705 , G01N2458/10 , C12Q2563/107 , C12Q2522/101 , C12Q2561/113 , C12Q2537/164 , C12Q2523/125
Abstract: The present invention is generally directed to compositions, methods, and systems for performing single-molecule, real-time analysis of a variety of different biological reactions, and for determining various characteristics of the different biological reactions. The ability to analyze such reactions provides an opportunity to study those reactions as well as to potentially identify factors and/or approaches for impacting such reactions, e.g., to stimulate, enhance, or inhibit such reactions.
Abstract translation: 本发明一般涉及用于进行各种不同生物反应的单分子实时分析以及用于确定不同生物反应的各种特征的组合物，方法和系统。 分析这些反应的能力提供研究这些反应的机会，并且潜在地鉴定影响这些反应的因素和/或方法，例如刺激，增强或抑制这些反应。
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公开(公告)号：WO2010129019A3
公开(公告)日：2011-03-31
申请号：PCT/US2010001236
申请日：2010-04-26
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , KORLACH JONAS , TURNER STEPHEN , SCHADT ERIC
Inventor： KORLACH JONAS , TURNER STEPHEN , SCHADT ERIC
CPC classification number: C12Q1/6869 , C12Q1/702 , C12Q2565/518 , C12Q2547/101
Abstract: The present invention is generally directed to compositions, methods, and systems for performing single-molecule, real-time analysis of a variety of different biological reactions. The ability to analyze such reactions provides an opportunity to study those reactions as well as to potentially identify factors and/or approaches for impacting such reactions, e.g., to either enhance or inhibit such reactions. In certain preferred embodiments, RNA templates are used in single-molecule real-time sequencing reactions.
Abstract translation: 本发明一般涉及用于进行各种不同生物反应的单分子实时分析的组合物，方法和系统。 分析这些反应的能力提供了研究这些反应以及潜在鉴定影响这些反应的因素和/或方法的机会，例如增强或抑制这种反应。 在某些优选实施方案中，RNA模板用于单分子实时测序反应。
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公开(公告)号：WO2010117470A3
公开(公告)日：2011-03-31
申请号：PCT/US2010001072
申请日：2010-04-09
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , TURNER STEPHEN , FLUSBERG BENJAMIN , FOQUET MATHIEU , CALLEBAUT HANS , SEBRA ROBERT , CHAUDHURI BIDHAN , SORENSON JON , BJORNSON KEITH , FEHR ADRIAN , KORLACH JONAS , EMIG ROBIN
Inventor： TURNER STEPHEN , FLUSBERG BENJAMIN , FOQUET MATHIEU , CALLEBAUT HANS , SEBRA ROBERT , CHAUDHURI BIDHAN , SORENSON JON , BJORNSON KEITH , FEHR ADRIAN , KORLACH JONAS , EMIG ROBIN
CPC classification number: G01N33/48721 , B82Y5/00 , B82Y15/00 , C12Q1/6869 , C12Q1/6874 , C12Q2565/631 , G01N27/447 , G01N27/44791 , C12Q2563/116 , C12Q2527/113
Abstract: The invention relates to devices and methods for nanopore sequencing. The invention includes arrays of nanopores having incorporated electronic circuits, for example, in CMOS. In some cases, the arrays of nanopores comprise resistive openings for isolating the electronic signals for improved sequencing. Methods for controlling translocation of through the nanopore are disclosed.
Abstract translation: 本发明涉及纳米孔测序的装置和方法。 本发明包括纳入电子电路的纳米孔阵列，例如在CMOS中。 在一些情况下，纳米孔阵列包括用于隔离电子信号的电阻开口以改善测序。 公开了通过纳米孔控制易位的方法。
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公开(公告)号：WO2009145828A2
公开(公告)日：2009-12-03
申请号：PCT/US2009002003
申请日：2009-03-30
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , BJORNSON KEITH , LEE HAROLD , KORLACH JONAS , TURNER STEPHEN , BIBILLO AREK , CHRISTIANS FRED , EMIG ROBIN , HE MOLLY , PARK INSIL , JIA LEI , FEDOROV ANDREI , LYLE JOHN
Inventor： BJORNSON KEITH , LEE HAROLD , KORLACH JONAS , TURNER STEPHEN , BIBILLO AREK , CHRISTIANS FRED , EMIG ROBIN , HE MOLLY , PARK INSIL , JIA LEI , FEDOROV ANDREI , LYLE JOHN
CPC classification number: C12Q1/6869 , C12Q1/6874 , C12Q2527/125 , C12Q2527/119 , C12Q2527/101 , C12Q2565/1015 , C12Q2527/137 , C12Q2521/101
Abstract: Compositions, kits, methods and systems for nucleotide sequencing comprising producing polymerase reactions that exhibit two kinetically observable steps within an observable phase of the polymerase reaction. Two slow step systems can be produced, for example, by selecting the appropriate polymerase enzyme, polymerase reaction conditions including cofactors, and polymerase reaction substrates including the primed template and nucleotides.
Abstract translation: 用于核苷酸测序的组合物，试剂盒，方法和系统，其包括产生聚合酶反应，其在聚合酶反应的可观察期内显示两个动力学可观察步骤。 可以通过例如选择合适的聚合酶，包括辅因子的聚合酶反应条件和包括引发的模板和核苷酸的聚合酶反应底物来产生两个缓慢的步骤系统。
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25.发明申请METHODS AND SYSTEMS FOR SIMULTANEOUS REAL-TIME MONITORING OF OPTICAL SIGNALS FROM MULTIPLE SOURCES 审中-公开用于同时实时监测来自多个光源的光信号的方法和系统
公开(公告)号：WO2007095119A3
公开(公告)日：2008-04-17
申请号：PCT/US2007003570
申请日：2007-02-09
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , LUNDQUIST PAUL , ZACCARIN DENIS , LACROIX YVES , MAXHAM MARK , FOQUET MATHIEU , TURNER STEPHEN
Inventor： LUNDQUIST PAUL , ZACCARIN DENIS , LACROIX YVES , MAXHAM MARK , FOQUET MATHIEU , TURNER STEPHEN
CPC classification number: G01N21/6452 , G01J3/02 , G01J3/0224 , G01J3/10 , G01J3/14 , G01J3/2803 , G01N21/6445 , G01N21/6456 , G01N21/648 , G01N2021/6417 , G01N2021/6441
Abstract: Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.
Abstract translation: 用于实时监测来自信号源阵列的光信号的方法和系统，特别是具有光谱不同的信号分量的光信号源。 系统包括与光学列车光学通信的信号源阵列，其将激发辐射引导到来自这种阵列的信号和从这些阵列发出的信号，并将信号映射到检测器阵列上，从而可以对这些信号进行额外的处理。
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Patent Agency Ranking
公开(公告)号：WO2007064905A2
公开(公告)日：2007-06-07
申请号：PCT/US2006046025
申请日：2006-12-01
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , EID JOHN , MURPHY DEVON , OTTO GEOFFREY , TURNER STEPHEN
Inventor： EID JOHN , MURPHY DEVON , OTTO GEOFFREY , TURNER STEPHEN
CPC classification number: A61K38/446 , A61K38/063 , A61K38/443 , G01N33/582
Abstract: Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.
Abstract translation: 用于通过一种或多种在反应混合物内掺入光损伤缓和剂和/或询问反应混合物的不同观察区域一段时间来减少和/或防止一种或多种反应物在照明分析反应中的光损伤的组合物，装置，系统和方法 这小于光损伤阈值期。
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公开(公告)号：CA2746632C
公开(公告)日：2020-06-30
申请号：CA2746632
申请日：2009-12-10
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： FLUSBERG BENJAMIN , TURNER STEPHEN , LEE JESSICA , JIA LEI , KORLACH JONAS , SORENSON JON , WEBSTER DALE , LYLE JOHN , TRAVERS KEVIN , HANES JEREMIAH , PUGLISI JOSEPH
IPC: C12Q1/68 , C12Q1/6809 , C12Q1/6869
Abstract: Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.
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公开(公告)号：CA2662521C
公开(公告)日：2016-08-09
申请号：CA2662521
申请日：2007-08-31
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： LUNDQUIST PAUL , TURNER STEPHEN
Abstract: Substrates, systems and methods for analyzing materials that include waveguide arrays disposed upon or within the substrate such that evanescent fields emanating from the waveguides illuminate materials disposed upon or proximal to the surface of the substrate, permitting analysis of such materials. The substrates, systems and methods are used in a variety of analytical operations, including, inter alia, nucleic acid analysis, including hybridization and sequencing analyses, cellular analyses and other molecular analyses.
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公开(公告)号：AU2008251861B2
公开(公告)日：2014-03-20
申请号：AU2008251861
申请日：2008-05-09
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： ZHONG CHENG-FRANK , ZHAO PEIQIAN , LUNDQUIST PAUL , TURNER STEPHEN , ZACCARIN DENIS
Abstract: Mitigative and remedial approaches to reduction of autofluorescence background noise are applied in analytical systems that rely upon sensitive measurement of fluorescent signals from arrays of fluorescent signal sources. Such systems are for particular use in fluorescence based sequencing by incorporation systems that rely upon small numbers or individual fluorescent molecules in detecting incorporation of nucleotides in primer extension reactions. Systems and methods for analyzing highly multiplexed sample arrays using highly multiplexed, high-density optical systems to illuminate high- density sample arrays and/or provide detection and preferably confocal detection off signals emanating from such high-density arrays. Systems and methods are applied in a variety of different analytical operations, including analysis of biological and biochemical reactions, including nucleic acid synthesis and derivation of sequence information from such synthesis.
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公开(公告)号：AU2008307617B2
公开(公告)日：2013-05-23
申请号：AU2008307617
申请日：2008-09-26
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： TRAVERS KEVIN , TURNER STEPHEN , HEINER CHERYL
Abstract: Methods of preparing nucleic acid templates and providing the nucleic acid templates to low copy number reaction volumes are provided. Related compositions of nucleic acid templates are also provided.
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