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公开(公告)号：AU2008304192A2
公开(公告)日：2010-04-08
申请号：AU2008304192
申请日：2008-09-26
Applicant: PORTOLA PHARM INC
Inventor： PHILLIPS DAVID R , ANDRE PATRICK , SINHA UMA , LU GENMIN
IPC: A61P7/02 , A61K31/4545 , A61K31/5377 , A61K31/715 , A61K31/727 , A61K38/36 , A61K38/48 , A61K39/00 , A61K39/395 , A61K47/48 , A61P7/04 , C07H21/00 , C07K14/00 , C07K16/00 , C12N5/10 , C12N9/64 , C12P21/00
Abstract: The present invention relates antidotes to anticoagulants targeting factor Xa.The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.
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公开(公告)号：AU2008304192A1
公开(公告)日：2009-04-02
申请号：AU2008304192
申请日：2008-09-26
Applicant: PORTOLA PHARM INC
Inventor： PHILLIPS DAVID R , ANDRE PATRICK , SINHA UMA , LU GENMIN
IPC: A61P7/02 , A61K31/4545 , A61K31/5377 , A61K31/715 , A61K31/727 , A61K38/36 , A61K38/48 , A61K39/00 , A61K39/395 , A61K47/48 , A61P7/04 , C07H21/00 , C07K14/00 , C07K16/00 , C12N5/10 , C12N9/64 , C12P21/00
Abstract: The present invention relates antidotes to anticoagulants targeting factor Xa.The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.
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公开(公告)号：AU2008247483A1
公开(公告)日：2008-11-13
申请号：AU2008247483
申请日：2008-05-02
Applicant: PORTOLA PHARM INC
Inventor： HUTCHALEELAHA ATHIWAT , WOLIN HUANG , PANDEY ANJALI , PHILLIPS DAVID R , GRETLER DANIEL D , CONLEY PAMELA B , ANDRE PATRICK , SCARBOROUGH ROBERT M
IPC: A61K31/216 , A61K31/517 , A61P7/02
Abstract: The invention provides methods and compositions for rapid and reversible inhibition of platelet aggregation in human subjects in need thereof by administering compounds of the formula: alone or in combination with a second agent which can be aspirin or a thrombolytic agent.
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公开(公告)号：AU2008247439A1
公开(公告)日：2008-11-13
申请号：AU2008247439
申请日：2008-05-02
Applicant: PORTOLA PHARM INC
Inventor： HOMCY CHARLES J , ANDRE PATRICK , PHILLIPS DAVID R
IPC: C12N9/02
Abstract: The present invention provides new methods of treating thrombosis and cardiovascular diseases using of antithrombotic agents, as well as methods of determining therapeutically effective amounts of antithrombotic agents and unit dose formulations thereof.
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公开(公告)号：HUE050063T2
公开(公告)日：2020-11-30
申请号：HUE16167534
申请日：2008-09-26
Applicant: PORTOLA PHARM INC
Inventor： LU GENMIN , PHILLIPS DAVID R , ANDRE PATRICK , SINHA UMA
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Patent Agency Ranking
公开(公告)号：LT3078743T
公开(公告)日：2020-09-25
申请号：LT16167534
申请日：2008-09-26
Applicant: PORTOLA PHARM INC
Inventor： LU GENMIN , PHILLIPS DAVID R , ANDRE PATRICK , SINHA UMA
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公开(公告)号：AU2019204123A1
公开(公告)日：2019-07-04
申请号：AU2019204123
申请日：2019-06-13
Applicant: PORTOLA PHARM INC
Inventor： LU GENMIN , PHILLIPS DAVID R , ANDRE PATRICK , SINHA UMA
IPC: A61P7/02 , A61K31/4545 , A61K31/5377 , A61K31/715 , A61K31/727 , A61K38/36 , A61K38/48 , A61K39/00 , A61K39/395 , A61P7/04 , C07H21/00 , C07K14/00 , C07K16/00 , C12N5/10 , C12N9/64 , C12P21/00
Abstract: The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or 5 have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.
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公开(公告)号：HUE031647T2
公开(公告)日：2017-07-28
申请号：HUE08834136
申请日：2008-09-26
Applicant: PORTOLA PHARM INC
Inventor： LU GENMIN , PHILLIPS DAVID R , ANDRE PATRICK , SINHA UMA
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公开(公告)号：CY1118482T1
公开(公告)日：2017-07-12
申请号：CY161101020
申请日：2016-10-12
Applicant: PORTOLA PHARM INC
Inventor： LU GENMIN , PHILLIPS DAVID R , ANDRE PATRICK , SINHA UMA
Abstract: Ηπαρούσαεφεύρεσησχετίζεταιμεαντίδοτααντιπηκτικήςαγωγήςπουστοχεύειστονπαράγοντα Xa. Τααντίδοταείναιπρωτεϊνικάπαράγωγατουπαράγοντα Xa πουπροσδένονταιστουςαναστολείςτουπαράγοντα Xa καιέτσιτουςεξουδετερώνουνουσιαστικάαλλάδενσυναθροίζονταισεσύμπλοκοπροθρομβινάσης. Ταπαράγωγαπουπεριγράφονταιεδώστερούνταιή έχουνμειωμένηεσωτερικήαντιπηκτικήδραστηριότητα. Στοπαρόναποκαλύπτονταιμέθοδοιγιατηδιακοπήή παρεμπόδισητηςαιμορραγίαςσεένανασθενήο οποίοςβρίσκεταιεπίτουπαρόντοςσεθεραπευτικήαντιπηκτικήαγωγήμεαναστολέατουπαράγοντα Xa.
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公开(公告)号：DK2193196T3
公开(公告)日：2016-11-07
申请号：DK08834136
申请日：2008-09-26
Applicant: PORTOLA PHARM INC
Inventor： LU GENMIN , PHILLIPS DAVID R , ANDRE PATRICK , SINHA UMA
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