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    24.
    发明专利
    未知

    公开(公告)号：NO315468B1

    公开(公告)日：2003-09-08

    申请号：NO971861

    申请日：1997-04-23

    Applicant: SERVIER LAB

    Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE-FRANCOISE ,  VERBEUREN TONY ,  VALLEZ MARIE-ODILE

    IPC: A61K31/35 ,  A61K31/352 ,  A61K31/36 ,  A61P9/00 ,  A61P43/00 ,  C07D311/30 ,  C07D407/12

    Abstract: Diosmetin acids and esters of formula (I), their enantiomers and salts are new. R2, R4, R6 = H, 1-5C alkyl, CH2CH=CH2, CH2C(CH3)=CH2, CH2CH=C(CH3)2, CH2CH2CH(CH3)2, 2,2-dimethyl-1,3-dioxolan-4-ylmethyl, CH2CH(OH)CH2OH or ACOOR8; A = 1-3C hydrocarbon chain (optionally substituted by methyl or OH); R8 = H or 1-5C alkyl; R3, R5 = H, CH2CH2CH3, CH2CH=CH2, CH2CH(CH3)2, C(CH3)2CH=CH2, C(CH3)2CH2CH3, CH2C(CH3)=CH2 or COCH3 R1, R7 = H, CH2CH2CH3, CH2CH=CH2, CH2CH=C(CH3)2, tert.-butyl, CH2CH2CH(CH3)CH3, CH2C(CH3)=CH2 or CH2CH(CH3)2 provided that if one or two of R2, R4, and R6 = ACOOR8, then at least one of the remaining R1-R7 is not H.

    27.
    发明专利
    未知

    公开(公告)号：BR0202279A

    公开(公告)日：2003-04-29

    申请号：BR0202279

    申请日：2002-06-13

    Applicant: SERVIER LAB

    Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE-FRACOISE ,  ROUSSEAU ANNE ,  ATASSI GHANAEM ,  HICKMAN JOHN ,  PIERRE ALAIN ,  LEONCE STEPHANE ,  GUILBAUD NICOLAS ,  KRAUS-BERTHIER LAURENCE

    IPC: C07D209/80 ,  A61K31/403 ,  A61K31/433 ,  A61K31/4439 ,  A61P35/00 ,  C07D209/94 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D491/04 ,  C07D491/056 ,  A61K31/15 ,  A61K31/407 ,  C07D209/56

    Abstract: Indenoindolone derivatives (I), their isomers and salts with acids and bases are new. Indenoindolone derivatives (I), their isomers and salts with acids and bases are new; R = H, alkyl (optionally substituted by carboxy, alkoxycarbonyl, or NR10R11), or alkenyl; R1-R8 = H, alkyl (optionally substituted by aryl, carboxy or alkoxycarbonyl), OH, acyloxy, NR12R13, carboxy, alkoxy (optionally substituted by aryl or NR14R15), alkenyloxy, or to adjacent groups R1-R8 = 1 or 2C alkylenedioxy; R9 = H, aryl, heteroaryl or alkyl (optionally containing one or more unsaturations and optionally substituted by one or more aryl, heteroaryl, 3-8C cycloalkyl, CN, or NR17R18 groups); X = O or NR16; R10, R11, R14, R15, R17, R18 = alkyl; NR10+R11, NR14+R15, NR17+R18 = nitrogen heterocycle; R12, R13 = H, alkyl, or NR14R15; R16 = H, alkyl, aryl, or aryl alkyl. Where alkyl, alkoxy, acyloxy, alkenyl and alkenyloxy groups have up to 6 C atoms, aryl is defined as phenyl, biphenyl, or naphthyl (optionally substituted by one or more halogen, alkyl, alkenyl, alkoxy, phenoxy, nitro, CN, amino, mono- and di-alkylamino or 1-2C alkylenedioxy groups) and heteroaryl groups may be mono- or bicyclic of 5-12 members with 1-3 heteroatoms (O, N, S) and optionally substituted by halogen, alkyl, OH, alkoxy, polyhaloalkyl, amino, mono- and di-alkylamino groups, and nitrogen heterocycles are monocyclic having 5-7 members including 1-3 heteroatoms, one of which is N and the others may be O, N, or S. An Independent claim is also included for the preparation of (I).

    Indenoidolone compounds, a process for their preparation and pharmaceutical compositions containing them.
    29.
    发明专利
    Indenoidolone compounds, a process for their preparation and pharmaceutical compositions containing them. 未知

    公开(公告)号：ZA200204757B

    公开(公告)日：2003-02-17

    申请号：ZA200204757

    申请日：2002-06-13

    Applicant: SERVIER LAB

    Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE-FRANCOISE ,  ROSSEAU ANNE ,  ATASSI GHANEM ,  HICKMAN JOHN ,  PIERRE ALAIN ,  LEONCE STEPHANE ,  GUILBAUD NICOLAS ,  KRAUS-BERTHIER LAURENCE

    IPC: C07D209/80 ,  A61K31/403 ,  A61K31/433 ,  A61K31/4439 ,  A61P35/00 ,  C07D209/94 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D491/04 ,  C07D491/056 ,  C07D ,  A61K

    Abstract: Indenoindolone derivatives (I), their isomers and salts with acids and bases are new. Indenoindolone derivatives (I), their isomers and salts with acids and bases are new; R = H, alkyl (optionally substituted by carboxy, alkoxycarbonyl, or NR10R11), or alkenyl; R1-R8 = H, alkyl (optionally substituted by aryl, carboxy or alkoxycarbonyl), OH, acyloxy, NR12R13, carboxy, alkoxy (optionally substituted by aryl or NR14R15), alkenyloxy, or to adjacent groups R1-R8 = 1 or 2C alkylenedioxy; R9 = H, aryl, heteroaryl or alkyl (optionally containing one or more unsaturations and optionally substituted by one or more aryl, heteroaryl, 3-8C cycloalkyl, CN, or NR17R18 groups); X = O or NR16; R10, R11, R14, R15, R17, R18 = alkyl; NR10+R11, NR14+R15, NR17+R18 = nitrogen heterocycle; R12, R13 = H, alkyl, or NR14R15; R16 = H, alkyl, aryl, or aryl alkyl. Where alkyl, alkoxy, acyloxy, alkenyl and alkenyloxy groups have up to 6 C atoms, aryl is defined as phenyl, biphenyl, or naphthyl (optionally substituted by one or more halogen, alkyl, alkenyl, alkoxy, phenoxy, nitro, CN, amino, mono- and di-alkylamino or 1-2C alkylenedioxy groups) and heteroaryl groups may be mono- or bicyclic of 5-12 members with 1-3 heteroatoms (O, N, S) and optionally substituted by halogen, alkyl, OH, alkoxy, polyhaloalkyl, amino, mono- and di-alkylamino groups, and nitrogen heterocycles are monocyclic having 5-7 members including 1-3 heteroatoms, one of which is N and the others may be O, N, or S. An Independent claim is also included for the preparation of (I).

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