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公开(公告)号：WO0071493A3
公开(公告)日：2002-01-17
申请号：PCT/US0014138
申请日：2000-05-24
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , SU TING , ZHAOZHANG JON JIA , SCARBOROUGH ROBERT M , SONG YONGHONG
IPC: A61P7/02 , A61K31/167 , A61K31/18 , A61K31/275 , A61K31/277 , A61K31/40 , A61K31/472 , A61K31/4725 , A61P9/00 , A61P9/04 , A61P9/10 , C07C311/16 , C07C311/18 , C07C311/40 , C07C311/44 , C07C311/46 , C07D207/16 , C07D217/22 , C07D401/06
CPC classification number: C07C311/40 , C07C311/16 , C07C311/18 , C07C311/44 , C07C311/46
Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 公开了与哺乳动物因子Xa具有活性的新型化合物，其盐和与其有关的组合物。 该化合物在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号：WO0071511A3
公开(公告)日：2001-08-09
申请号：PCT/US0014205
申请日：2000-05-24
Applicant: COR THERAPEUTICS INC
Inventor： SU TING , ZHU BING-YAN , KANE-MAGUIRE KIM , SCARBOROUGH ROBERT M , ZHANG PENGLIE
IPC: C07D213/74 , A61K31/18 , A61K31/198 , A61K31/341 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/4164 , A61K31/44 , A61K31/4406 , A61K31/4427 , A61K31/4453 , A61K31/472 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/5375 , A61K31/55 , A61P7/02 , A61P9/00 , A61P9/10 , A61P43/00 , C07C311/16 , C07C311/21 , C07C311/46 , C07D205/04 , C07D207/16 , C07D207/20 , C07D207/325 , C07D213/40 , C07D213/64 , C07D213/72 , C07D213/75 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/68 , C07D295/18 , C07D295/192 , C07D295/22 , C07D295/26 , C07D307/38 , C07D307/52 , C07D401/12 , A61K31/277 , A61K31/501
CPC classification number: C07D213/40 , C07C311/16 , C07C311/46 , C07D217/22 , C07D295/192 , C07D295/26 , C07D307/52 , C07D401/12
Abstract: Compounds of the formula A - Y - D - E - G - J - Z - L in which D is a direct link, a substituted or unsubstituted phenyl or naphtyl group or a heterocyclic ring system; Z is a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic ring system; and the other variables are as defined in the claims, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 式A-Y-D-E-G-J-Z-L的化合物，其中D是直链，取代或未取代的苯基或萘基或杂环系; Z是取代或未取代的苯基或萘基或杂环系; 并且其它变量如权利要求中所定义，公开了其与其相关的盐和组合物具有抗哺乳动物因子Xa的活性。 该化合物在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号：WO0100656A3
公开(公告)日：2001-05-25
申请号：PCT/US0017718
申请日：2000-06-28
Applicant: ORTHO MCNEIL PHARM INC , COR THERAPEUTICS INC
Inventor： ZHANG HAN-CHENG , MARYANOFF BRUCE E , PANDEY ANJALI , SCARBOROUGH ROBERT M
CPC classification number: C07K5/06078 , A61K31/416 , A61K38/00
Abstract: The invention is directed to novel indazole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indazole peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
Abstract translation: 本发明涉及新颖的吲唑拟肽化合物，其可用作治疗与血栓形成，再狭窄，高血压，心力衰竭，心律失常，炎症，心绞痛，中风，动脉粥样硬化，缺血性病症，血管发生相关疾病，癌症相关的疾病的凝血酶受体拮抗剂 ，和神经变性疾病。 还公开了包含本发明的取代的吲唑肽模拟物的药物组合物和治疗由凝血酶受体介导的病症的方法。
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公开(公告)号：WO0071516B1
公开(公告)日：2001-03-01
申请号：PCT/US0014209
申请日：2000-05-24
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , SCARBOROUGH ROBERT M , WANG LINGYAN
IPC: A61K31/155 , A61K31/18 , A61K31/275 , A61K31/401 , A61K31/402 , A61K31/451 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/10 , C07C311/46 , C07D207/16 , C07D211/60 , C07D241/04 , C07D243/08 , C07D401/04 , C07D403/04 , C07D413/04 , A61K31/40 , A61P7/00 , C07C311/39
CPC classification number: C07D401/04 , C07C311/46 , C07D207/16 , C07D211/60 , C07D241/04 , C07D243/08 , C07D403/04 , C07D413/04
Abstract: Compounds, e.g. described in claim 5, formula (I) and formula (II), where A-B is (1), their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 化合物，例如 如权利要求5，式（I）和式（II）所述，其中A-B是（1），公开了它们的盐和与其有关的组合物，其具有抗哺乳动物因子Xa的活性。 这些化合物可用于体外或体内用于预防或治疗凝血病症。
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公开(公告)号：WO0071516A2
公开(公告)日：2000-11-30
申请号：PCT/US0014209
申请日：2000-05-24
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , SCARBOROUGH ROBERT M , WANG LINGYAN
IPC: A61K31/155 , A61K31/18 , A61K31/275 , A61K31/401 , A61K31/402 , A61K31/451 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/10 , C07C311/46 , C07D207/16 , C07D211/60 , C07D241/04 , C07D243/08 , C07D401/04 , C07D403/04 , C07D413/04 , C07D207/00
CPC classification number: C07D401/04 , C07C311/46 , C07D207/16 , C07D211/60 , C07D241/04 , C07D243/08 , C07D403/04 , C07D413/04
Abstract: Compounds, e.g. described in claim 5, formula (I) and formula (II), where A-B is (1), their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 化合物，例如 在其中A-B为（1）的权利要求5所述的式（I）和式（II）中，其与其相关的盐和组合物具有抗哺乳动物因子Xa的活性。 该化合物可用于体内或体内用于预防或治疗凝血障碍。
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Patent Agency Ranking26.发明申请PHARMACEUTICAL PYRAZOLE COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES 审中-公开用作蛋白激酶抑制剂的药用吡唑组合物
公开(公告)号：WO9614843A3
公开(公告)日：1996-05-23
申请号：PCT/US9514723
申请日：1995-11-09
Applicant: COR THERAPEUTICS INC
Inventor： GIESE NEILL A , LOKKER NATHALIE , LAIBELMAN ALAN M , SCARBOROUGH ROBERT M
IPC: C07D231/38 , A61K31/415 , A61K31/4155 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/455 , A61P43/00 , C07D231/40 , C07D401/06 , C07D405/04 , C07D409/06
CPC classification number: A61K31/455 , A61K31/415 , A61K31/4155 , A61K31/4439
Abstract: A method for selectively inhibiting a kinase is disclosed, which comprises contacting a composition containing a kinase with a compound of formula (I), wherein: R1 is lower alkyl, lower hydrocarbyl, aryl lower alkyl, heteroaryl lower alkyl, 5- or 6-membered heterocyclic aromatic, polyaromatic, polyaromatic carbonyl, polyheteroaromatic or polyheteroaromatic carbonyl; R2 is lower alkyl, lower hydrocarbyl, aryl lower alkyl, heteroaryl lower alkyl, 5- or 6-membered heterocyclic aromatic, lower hydrocarboyl, 5- or 6-membered heterocyclic aromatic carbonyl, polyaromatic or polyheteroaromatic; R3 is H or lower alkyl; R5 is H, lower alkyl, lower hydrocarbyl, aryl lower alkyl, heteroaryl lower alkyl, 5- or 6-membered heterocyclic aromatic, halogen, or cyano; and R6 is H or lower hydrocarboyl. 00000
Abstract translation: 公开了选择性抑制激酶的方法，其包括将含有激酶的组合物与式（I）化合物接触，其中：R 1是低级烷基，低级烃基，芳基低级烷基，杂芳基低级烷基，5-或6- 多芳基，多芳基羰基，多杂芳基或多杂芳基羰基; R 2是低级烷基，低级烃基，芳基低级烷基，杂芳基低级烷基，5-或6-元杂环芳族，低级烃基，5-或6-元杂环芳族羰基，多芳族或多杂芳族; R3是H或低级烷基; R5是H，低级烷基，低级烃基，芳基低级烷基，杂芳基低级烷基，5-或6-元杂环芳族，卤素或氰基; R6为H或低级烃基。 00000
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27.发明申请PYRIDYL-CONTAINING SPIROCYCLIC COMPOUNDS AS INHIBITORS OF FIBRINOGEN-DEPENDENT PLATELET AGGREGATION 审中-公开含有吡啶基的螺环化合物作为依赖纤维蛋白原的血小板聚集的抑制剂
公开(公告)号：WO0130780A3
公开(公告)日：2001-11-29
申请号：PCT/US0029804
申请日：2000-10-27
Applicant: COR THERAPEUTICS INC , SCARBOROUGH ROBERT M , MEHROTA MUKUND , PANDEY ANJALI , SMYTH MARK
Inventor： SCARBOROUGH ROBERT M , MEHROTA MUKUND , PANDEY ANJALI , SMYTH MARK
IPC: A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/551 , A61P7/02 , A61P9/00 , A61P9/10 , C07D401/04 , C07D413/14 , C07D471/10 , A61K31/438
CPC classification number: C07D401/04 , C07D413/14 , C07D471/10
Abstract: This invention relates to certain substituted or unsubstituted pyridyl-containing spirocyclic compounds substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.
Abstract translation: 本发明涉及用碱性和酸性官能团取代的某些取代或未取代的含吡啶基螺环化合物，其可用于抑制血小板聚集。
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公开(公告)号：WO0047553A8
公开(公告)日：2001-09-20
申请号：PCT/US0003404
申请日：2000-02-11
Applicant: COR THERAPEUTICS INC
Inventor： SONG YOUNGHONG , SCARBOROUGH ROBERT M , ZHU BING-YAN
IPC: C07D295/14 , A61K31/18 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/341 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/4174 , A61K31/44 , A61K31/4409 , A61K31/472 , A61K31/4725 , A61K31/495 , A61K31/505 , A61K31/517 , A61P7/00 , A61P7/02 , A61P7/04 , A61P9/00 , A61P9/10 , A61P11/00 , A61P31/04 , A61P43/00 , C07C257/18 , C07C311/29 , C07C311/46 , C07C311/51 , C07D213/56 , C07D213/58 , C07D213/70 , C07D213/74 , C07D213/75 , C07D217/22 , C07D231/12 , C07D233/61 , C07D239/42 , C07D239/94 , C07D257/04 , C07D295/16 , C07D307/54 , C07D401/12 , C07D521/00
CPC classification number: C07D231/12 , C07C311/46 , C07C311/51 , C07C2601/10 , C07D217/22 , C07D233/56 , C07D239/94 , C07D249/08 , C07D307/54 , C07D401/12
Abstract: L'invention porte sur des composés alcényle and alkynyle s'avérant de puissants inhibiteurs du facteur Xa isolés ou rassemblés dans le complexe de prothrombinase et sur des compositions contenant lesdits composés qui montrent une sélectivité vis à vis du facteur Xa supérieure à celle des autres protéases de la coagulation (par exemple la thrombine, le fVIIa, le fIXa) ou des cascades fibrinolytiques (par exemple les activateurs du plasminogène, la plasmine). L'invention porte également sur des procédés d'utilisation desdits composés comme agents de diagnostic ou thérapeutiques en vue de la prévention ou du traitement chez les mammifères de troubles de la coagulation tels que les thromboses.
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公开(公告)号：WO9816523A2
公开(公告)日：1998-04-23
申请号：PCT/US9718291
申请日：1997-10-10
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , SCARBOROUGH ROBERT M
IPC: A61K38/00 , A61P7/02 , A61P9/10 , A61P43/00 , C07D417/00 , C07K5/02 , C07K5/06 , C07K5/078 , C07K5/08
CPC classification number: C07K5/06139 , A61K38/00 , C07K5/0202 , C07K5/06191
Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 公开了与哺乳动物因子Xa具有活性的新型化合物，其盐和与其相关的组合物。 该化合物在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号：WO9640743A3
公开(公告)日：1997-01-23
申请号：PCT/US9609285
申请日：1996-06-05
Applicant: COR THERAPEUTICS INC , MARLOWE CHARLES K , SCARBOROUGH ROBERT M , LAIBELMAN ALAN M , SINHA UMA , ZHU BING YAN
Inventor： MARLOWE CHARLES K , SCARBOROUGH ROBERT M , LAIBELMAN ALAN M , SINHA UMA , ZHU BING-YAN
IPC: A61K38/00 , A61P7/02 , C07C279/24 , C07C281/06 , C07C309/30 , C07C335/38 , C07K5/06 , C07K5/068 , C07K5/072 , C07K5/08 , A61K38/55
CPC classification number: C07K5/06095 , A61K38/00 , C07K5/06034 , C07K5/06086 , C07K5/06191
Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 公开了与哺乳动物因子Xa具有活性的新型化合物，其盐和与其相关的组合物。 该化合物在体外或体内可用于预防或治疗凝血障碍。
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