公开(公告)号：CA2829803A1

公开(公告)日：2012-09-20

申请号：CA2829803

申请日：2012-03-13

Applicant: VERTEX PHARMA

Inventor： HADIDA-RUAH SARA SABINA ,  BINCH HAYLEY MARIE ,  DENINNO MICHAEL PAUL ,  FANNING LEV TYLER DEWEY ,  FRIEMAN BRYAN A ,  GROOTENHUIS PETER DIEDERIK JAN ,  HILGRAF NICOLE ,  JOSHI PRAMOD ,  KALLEL EDWARD ADAM ,  PONTILLO JOSEPH ,  SILINA ALINA ,  SHETH URVI JAGDISHBHAI ,  HURLEY DENNIS JAMES ,  ARUMUGAM VIJAYALAKSMI ,  MILLER MARK THOMAS

IPC: C07D498/10 ,  A61K31/424 ,  A61P29/00

Abstract: The invention relates to morpholine spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.