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公开(公告)号:US20190250038A1
公开(公告)日:2019-08-15
申请号:US16279181
申请日:2019-02-19
Applicant: Massachusetts Institute of Technology
Inventor: Thomas H. Jeys , William D. Herzog , Brian G. Saar , Alexander M. Stolyarov , Ryan Sullenberger , David Crompton , Shawn Michael Redmond
CPC classification number: G01J3/433 , G01J3/108 , G01J3/2823 , G01J3/447 , G01N21/1717 , G01N21/636 , G01N2021/1725
Abstract: A device, and corresponding method, can include a pump light source configured to irradiate a target specimen. The device can also include a sensor configured to observe a probe speckle pattern based on light from a probe light source reflected from the target specimen. The device further may include a correlator configured to determine a material property of the target specimen by analyzing changes in images of the probe speckle pattern as a function of the irradiation with the pump light source. Advantages of the device and method can include much higher sensitivity than existing methods; the ability to use visible probe wavelengths for uncooled, low-cost visible detectors with high spatial resolution; and the ability to obtain target material properties without detecting infrared light.
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公开(公告)号:US20180328851A1
公开(公告)日:2018-11-15
申请号:US15705748
申请日:2017-09-15
Applicant: Electronics and Telecommunications Research Institute , Korea Advanced Institute of Science and Technology
Inventor: Won Kyoung LEE , Ki-Hun JEONG , Moonseong PARK
CPC classification number: G01N21/658 , G01J3/433 , G01J3/44 , G01J2001/4242 , G01J2003/4424 , G01N21/274 , G01N21/6428 , G01N2201/06113 , G01N2201/067 , G01N2201/121
Abstract: Disclosed is an apparatus and method for processing a bio optical signal based on a spread spectrum scheme including a demodulator configured to collect a bio optical signal generated in response to an incident beam modulated based on a spreading code being scattered from a target analyte, and remove a noise from the bio optical signal by demodulating the bio optical signal based on the spreading code, wherein the bio optical signal has a correlation with the modulated incident beam.
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343.
公开(公告)号:US20180283950A1
公开(公告)日:2018-10-04
申请号:US15941510
申请日:2018-03-30
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor: Nien-Hui Ge , Yuan Feng , Ilya Vinogradov
Abstract: A heterodyne optical spectroscopy system comprises a light source that acts as a local oscillator (LO); a beam splitting component that generates a reference beam from the LO; a signal component that generates a sample signal from a sample; a beam blocker that can turn off the sample signal to generate blank shots; a composite signal detection subsystem that detects a heterodyned signal that is a mix of the sample signal and a portion of the LO; a composite reference detection subsystem synchronized to the signal detection subsystem to detect a portion of the reference beam; and a processor that processes digital signals from the signal detection subsystem and the reference detection subsystem. A very versatile reference scheme is developed to treat different heterodyne spectroscopies in a unified way, which achieves optimal noise suppression.
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公开(公告)号:US20180209899A1
公开(公告)日:2018-07-26
申请号:US15874956
申请日:2018-01-19
Inventor: Jiaqi WANG , Chun ZHANG , Wei Mong TSANG
CPC classification number: G01N21/255 , G01J3/0286 , G01J3/12 , G01J3/433 , G01J2003/1265 , G01N21/359
Abstract: A derivative spectroscopy system for achieving a tunable resolution of 2 nm or less in resolving spectral components of an input optical signal is provided so as to estimate derivative spectra of the input optical signal based on the resolved spectral components. In the system, a first dispersive-element structure spectrally decomposes the input optical signal into subband signals. A second dispersive-element structure receives part or all of the subband signals and spectrally decomposes the received subband signals to plural spectral components. A material having a temperature-variant refractive index is used to build the second dispersive-element structure, enabling a shift of center wavelength of each spectral component as small as 2 nm of less upon changing a temperature of the second dispersive-element structure. By obtaining three spectral-component sets obtained at three different predetermined temperatures with the center-wavelength shift of 2 nm or less, first- and second-order derivative spectra are obtained with good accuracy.
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345.
公开(公告)号:US09903808B2
公开(公告)日:2018-02-27
申请号:US14590218
申请日:2015-01-06
Inventor: David F. Plusquellic , David A. Long , Kevin O. Douglass , Joseph T. Hodges , Adam J. Fleisher
CPC classification number: G01N21/255 , G01J3/433 , G01J3/453 , G01N21/39 , G01N2021/399 , G02F1/01 , G02F2203/56 , H01S3/0057
Abstract: A comb source includes a continuous wave frequency source to provide a continuous wave radiation; a first modulator in optical communication with the continuous wave frequency source; a second modulator in optical communication with continuous wave frequency source; and a waveform driver in electrical communication with the first modulator and the second modulator. A process for producing an analyte spectrum includes producing a first comb from a continuous wave frequency and a first waveform; producing a reference comb and a probe comb from the first comb; subjecting a sample to the probe comb; producing a sample comb in response to subjecting the sample to the probe comb; producing a composite comb from the reference comb and the sample comb; producing a second comb from the continuous wave frequency and a second waveform; and combining the second comb and the composite comb to produce the analyte spectrum.
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公开(公告)号:US20180003624A1
公开(公告)日:2018-01-04
申请号:US15537052
申请日:2015-12-02
Applicant: Siemens Aktiengesellschaft
Inventor: Franz STEINBACHER
IPC: G01N21/3504 , G01N21/39 , G01J3/10 , G01J3/433
CPC classification number: G01N21/3504 , G01J3/108 , G01J3/433 , G01J3/4338 , G01N21/39 , G01N2021/399 , G01N2201/0612 , G01N2201/068
Abstract: An absorption spectrometer which measures a gas component concentration in a measured gas and which operates via wavelength modulation spectroscopy, wherein the light wavelength of a wavelength-tunable light source is periodically varied over a gas component absorption line of interest and simultaneously sinusoidally modulated with a high frequency and a low amplitude signal, and wherein the measurement signal of a detector is demodulated in a phase-sensitive manner at the frequency and/or a harmonic of the frequency and further analyzed, where modulation starts in each period or each n-th period with the frequency in a time interval before the beginning of the time function and is performed with a higher amplitude than during the time function to demodulate the measurement signal in a phase-synchronous manner, where a device provided for the phase-sensitive demodulation is synchronized during the time interval such that a cable for transmitting synchronization signals is no longer necessary.
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公开(公告)号:US20170343477A1
公开(公告)日:2017-11-30
申请号:US15607457
申请日:2017-05-27
Applicant: Verily Life Sciences LLC
Inventor: Charles Santori , Supriyo Sinha , Cheng-Hsun Wu , James Higbie , Seung Ah Lee
CPC classification number: G01N21/6486 , A61B5/0071 , A61B5/0075 , G01J3/0224 , G01J3/0229 , G01J3/10 , G01J3/18 , G01J3/2823 , G01J3/32 , G01J3/433 , G01J3/4406 , G01J2003/1243 , G01N21/6408 , G01N21/6445 , G01N21/6458 , G01N2021/6471 , G01N2201/0675 , G02B21/004 , G02B21/0076 , G02B21/16
Abstract: Systems and methods for hyperspectral imaging are described. In one implementation, a hyperspectral imaging system includes a sample holder configured to hold a sample, an illumination system, and a detection system. The illumination system includes a light source configured to emit excitation light having one or more wavelengths, and a first set of optical elements that include a first spatial light modulator (SLM), at least one lens, and at least one dispersive element. The illumination system is configured to structure the excitation light into a predetermined two-dimensional pattern at a conjugate plane of a focal plane in the sample, spectrally disperse the structured excitation light in a first lateral direction, and illuminate the sample in an excitation pattern with the one or more wavelengths dispersed in the first lateral direction.
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公开(公告)号:US20170285030A1
公开(公告)日:2017-10-05
申请号:US15491305
申请日:2017-04-19
Applicant: UNIVERSITY OF CENTRAL LANCASHIRE
Inventor: Matthew James BAKER , Peter ABEL , Robert William LEA
IPC: G01N33/574
CPC classification number: G01N33/57407 , G01J3/433 , G01N21/35 , G01N21/552 , G01N21/63 , G01N33/49 , G01N33/574 , G01N2021/3196 , G01N2021/3595 , G01N2030/743 , G01N2201/129 , G01N2800/52 , G01N2800/7028
Abstract: The present invention relates to methods of diagnosing and/or prognosing proliferative disorders, especially brain cancers (e.g. gliomas). In particular, the present invention provides a means to conveniently detect malignant tumours merely by assaying or analysing blood (particularly blood serum). Cytokines and/or angiogenesis factors in blood serum have been found to be surprisingly powerful at indicating the presence of brain cancers in a subject. Moreover, spectroscopic analysis, especially ATR-FTIR analysis, of a blood sample has been demonstrated to be surprisingly effective at producing a signature that can be correlated with the presence, extent, severity, or aggressiveness of malignant tumours in a subject.
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公开(公告)号:US09719917B2
公开(公告)日:2017-08-01
申请号:US13130166
申请日:2009-11-23
Applicant: Hakan Frojdh , Mikael Hornqvist , Stig Tormod , Patrik Akerstrom
Inventor: Hakan Frojdh , Mikael Hornqvist , Stig Tormod , Patrik Akerstrom
CPC classification number: G01N21/33 , G01J3/0218 , G01J3/0291 , G01J3/42 , G01J3/433 , G01N21/05 , G01N21/51 , G01N2021/0346 , G01N2201/061 , G01N2201/0853 , G01N2201/086
Abstract: The present invention discloses a flow cell optical detection system comprising a light source, a flow cell and a light detector, wherein the light detector is arranged in a separate detector unit that is arranged to be releasably attached to a detector interface, the detector interface being in optical communication with the light source and comprises optical connectors for optically connecting the flow cell and the detector unit in the light path from the light source, and wherein the flow cell is an interchangeable unit arranged to be held in position by the detector unit when attached to the detector interface.
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公开(公告)号:US09628682B2
公开(公告)日:2017-04-18
申请号:US13548801
申请日:2012-07-13
Applicant: David B. Pollock , Patrick J. Reardon
Inventor: David B. Pollock , Patrick J. Reardon
IPC: H04N5/225 , G01J3/28 , G01J3/433 , G01J3/447 , G01J3/02 , G02B26/08 , G02B27/00 , H04N5/232 , H04N5/349
CPC classification number: H04N5/2254 , G01J3/0208 , G01J3/0262 , G01J3/2803 , G01J3/2823 , G01J3/433 , G01J3/447 , G02B26/0891 , G02B27/0018 , H04N5/23229 , H04N5/349
Abstract: A camera concurrently produces an orthographic map and map spectral content. Illumination from an image passes through a phase modulator and the resulting rotating photo-flux phase is converted to an electrical signal by multiple adjacent sensors of detectors of array of detectors. The amount of unwanted illumination reaching the sensors is reduced by a set of baffles that shield and protect the transducers from unwanted out-of-field light and other light sources.
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