Abstract:
본 발명은 기미 형성 예지방법 및 기미 형성 예지용 진단 키트에 관한 것으로서, 구체적으로는 기미 조직과 정상피부 조직 간에 다르게 발현되는 유전자들의 발현량을 확인하여 피부의 기미 형성 가능성을 진단하기 위하여, 상기 유전자 서열의 폴리뉴클레오티드와 혼성화하는 프로브로서 하나 이상의 폴리뉴클레오티드 또는 그의 상보적 폴리뉴클레오티드; 상기 유전자 서열의 폴리뉴클레오티드의 프라이머 쌍; 또는 상기 유전자에 의하여 코딩되는 아미노산 서열을 가변영역으로 가지는 하나 이상의 모노클로날 항체를 포함하는 기미 형성 예지방법 및 진단 키트에 관한 것이다. 본 발명에 따르면 기미 병변 부위에서 특이적으로 고발현되는 23종의 유전자 및 5종의 저발현 유전자를 기미 마커 유전자로 하여 피부에서의 기미 형성 가능성을 민감하고 빠르게 진단할 수 있다. 기미, 키트, 고발현, 저발현
Abstract:
The present invention relates to a method and a kit for predicting chloasma. More specifically, in order to diagnose possibility of forming the chloasma by checking expression amount of genes which are differently expressed between chloasma tissues and normal skin tissues, a method and a kit for predicting chloasma comprise: one or more polynucleotides or complementary polynucleotides as probes which hybridize with polynucleotides of the sequence of the genes; a pair of polynucleotide primers of the sequence of the genes; or one or more monoclonal antibodies having amino acid sequences coded by the genes as a variable region. According to the present invention, the possibility of forming the chloasma on skin can be sensitively and rapidly diagnosed by using 23 kinds of highly expressed genes and 5 kinds of down regulated genes, which are specific to chloasma lesion area, as chloasma marker genes. [Reference numerals] (AA) Relative mRNA expression amount in melasma regions compare to normal region; (BB) Normal region
Abstract:
The present invention relates to a method for predicting chloasma formation and a diagnostic kit for chloasma formation and, more specifically, to a method for predicting chloasma formation and a diagnostic kit for chloasma formation, capable of diagnosing the possibility of chloasma formation on the skin by confirming the expression levels of genes which are differently expressed between the chloasma tissue and the normal skin tissue, wherein the diagnostic kit comprises: at least one polynucleotide sequence or its complementary polynucleotide as a probe hybridizing with polynucleotide of the gene sequence; a primer pair of the polynucleotide of the gene sequence; or at least one monoclonal antibody having, as a variable region, an amino acid sequence coded by the gene. According to the present invention, 23 high-expression genes and five low-expression genes, which are specific to a chloasma lesion, are used as a chloasma marker gene, thereby precisely and promptly diagnosing the possibility of chloasma formation on the skin. [Reference numerals] (AA) Relative mRNA expression level of a chloasma region as compared with a normal region; (BBC) Normal region
Abstract:
PURPOSE: A composition for improving skin defensive power is provided to accelerate the antimicrobial peptide activity of skin, thereby obtaining excellent antibacterial and anti-inflammatory activity. CONSTITUTION: A composition for improving skin defensive power includes at least one selected from a protopanaxadiol compound and a torreya nucifera extract. The protopanaxadiol compound includes a compound K (20-O-(beta-D-glucopyranosyl)-20 (S)-protopanaxadiol). The torreya nucifera extract includes terreyae semen seed oil. The amount of the protopanaxadiol compound is 0.001-10 wt% based on the total weight of the composition. The amount of the torreya nucifera extract is 0.001-99 wt% based on the total weight of the composition. [Reference numerals] (AA) Untreated group; (BB) Compound K; (CC) Torreyae seed oil; (DD) Compound K + torreyae seed oil; (EE) Compound K + torreyae seed oil + EGCG; (FF) Tea tree oil
Abstract:
본 발명은 하기 화학식 1의 화합물, 그것의 이성질체 또는 약제학적으로 허용 가능한 염을 유효 성분으로 포함하는 피부 노화 방지용 조성물에 관한 것이다. (화학식 1)
본 발명에 따른 조성물에 포함되는 화학식 1의 화합물, 그것의 이성질체 또는 약제학적으로 허용 가능한 염은 피부 자극을 유발하지 않으면서, 신경 통증감각 수용체(TRPV1: Transient Receptor Potential family V 1) 길항제로 작용하여, 매트릭스 메탈로프로티아제(matrix metalloprotease) 활성 억제 효과를 발휘하는 바, 피부 노화 방지용 조성물의 유효 성분으로 적합하게 사용될 수 있다. 피부 노화 방지
Abstract:
PURPOSE: A composition for skin external application having antioxidant activity which contains lotus extracts and smoked dry plum extracts is provided to enhance skin erythema prevention, skin tone improvement, and anti-aging. CONSTITUTION: A composition for skin external application having antioxidant activity contains lotus extracts and smoked dry plum extracts as active ingredient. 0.001-10 weight% of the lotus extract is contained based on the total weight of the composition. 0.001-10 weight% of smoked dry plum extract is contained based on the total weight of the composition. The extract is obtained by dipping the raw material into an organic solvent and filtering, reducing pressure and concentrating thereof. The organic solvent is C1-C4 anhydrous or hydrous alcohol, acetone, ethyl acetate, chloroform, glycerine, propylene glycol or butylene glycol. The composition is used for skin erythema prevention or skin tone improvement. The composition is used for skin anti-aging. [Reference numerals] (AA) Prunus mume fructus (ppm); (BB) Prunus mume fructus (ppm) + Nulumbo nucifera 100ppm; (CC) Nulumbo nucifera (ppm)