Abstract:
PURPOSE: An antioxidant is provided to effectively enhance the expression of Rcan3 gene and to be used as an immunosuppressive agent for treating or preventing immune diseases because Rcan3 protein suppresses calcineurin pathway. CONSTITUTION: An antioxidant increases the expression of Rcan3 gene. The antioxidant is rebamipide or polyphenol compounds. The polyphenol compounds are proanthocyanidin. A method for increasing the expression of Rcan3 in vitro comprises the step of treating cells with the antioxidant. A composition for preventing or treating immune disease contains Rcan3 gene or protein as an active ingredient.
Abstract:
PURPOSE: Obesity preventing or treating composition comprising rebamipide is provided to reduce LDL cholesterol levels and to increase HDL cholesterol levels. CONSTITUTION: Obesity preventing or treating composition comprising rebamipide comprises rebamipide compounds or salt of the rebamipide compounds. Rebamipide is capable of reducing weight, fat cells, total cholesterol levels, glucose and LDL cholesterol levels. Rebamipide has anti-obesity activiation through an action of changing white fat into brown fat. Rebamipide increases the activation of amplification of a regulatory T cell.
Abstract:
본 발명은 유럽종 포도( Vitis vinifera )의 씨 추출물의 개선된 제조방법을 제공한다. 또한, 본 발명은 유럽종 포도( Vitis vinifera )의 씨 추출물 및 약제학적으로 허용가능한 담체를 포함하는 류마티스 관절염의 예방 또는 치료용 약학 조성물을 제공한다.
Abstract:
PURPOSE: A pharmaceutical composition containing Vitis vinifera seed extract is provided to prevent and treat gastrointestinal ulcer. CONSTITUTION: A pharmaceutical composition for preventing or treating gastrointestinal ulcer contains Vitis vinifera seed extract and pharmaceutically acceptable carrier. The extract of Vitis vinifera seeds contains 80-130 of procyanidolic value(PCV); 30% or less of (+)catechin and (-) epicatechin; and 95-105% of proanthocyanidin. A method for preparing the Vitis vinifera seed extract comprises: a step of extracting Vitis vinifera seed seeds in a mixture solvent of acetone and water and filtering; a step of distilling liquid and removing acetone; a step of saturating sodium chloride and filtering; a step of extracting the liquid with ethyl acetate and concentrating; and a step of adding chloroform and filtering to obtain precipitate.
Abstract:
PURPOSE: A pharmaceutical composition containing Vitis vinifera for preventing or treating osteoarthritis is provided. CONSTITUTION: A pharmaceutical composition for preventing or treating osteoarthritis contains Vitis vinifera extract and pharmaceutically acceptable carrier. Osteoarthritis is caused by aging, obesity or trauma. The Vitis vinifera extract contains 80-130 of procyanidolic value(PCV), 30% or less (+) catechin and (-) epicatechin, and 95-105% of proanthocyanidine. A method for producing Vitis vinifera extract comprises: a step of extracting Vitis vinifera and mixture of acetone and water at room temperature and filtering; a step of distilling remaining liquid and removing acetone; a step of saturating sodium chloride and filtering; a step of extracting with ethyl acetate and concentrating; and a step of adding chloroform and precipitating.
Abstract:
A method for preparing extracts from seeds of Vitis Vinifera is provided to reduce the quantity of acetone consumed for extraction by using a mixed solvent of water and acetone while securing a high yield. A method for preparing extracts from seeds of Vitis Vinifera comprises the following steps of: extracting an extract from a mixture of pulverized seeds of the Vitis Vinifera and a acetone/water mixed solvent in a mixing ratio of 1 to 1-2 at a room temperature and filtering the extract; removing the acetone by distilling the obtained extract and saturating the extract with sodium chloride; extracting the saturated extract by ethylacetate and concentrating the extract; and adding chloroform to the concentrated extract to obtain precipitate.