公开(公告)号：KR1020130116825A

公开(公告)日：2013-10-24

申请号：KR1020130041359

申请日：2013-04-16

Applicant: 가톨릭대학교 산학협력단

Inventor： 조미라 ,  민준기 ,  박진실 ,  전주연 ,  박민정 ,  정정희 ,  임미애 ,  이성희 ,  임예빈 ,  허양미

IPC: A61K31/4704 ,  A61K38/17 ,  C12N15/63 ,  C12N15/12

CPC classification number: A61K31/353 ,  A61K38/1709 ,  Y10S514/825

Abstract: PURPOSE: An antioxidant is provided to effectively enhance the expression of Rcan3 gene and to be used as an immunosuppressive agent for treating or preventing immune diseases because Rcan3 protein suppresses calcineurin pathway. CONSTITUTION: An antioxidant increases the expression of Rcan3 gene. The antioxidant is rebamipide or polyphenol compounds. The polyphenol compounds are proanthocyanidin. A method for increasing the expression of Rcan3 in vitro comprises the step of treating cells with the antioxidant. A composition for preventing or treating immune disease contains Rcan3 gene or protein as an active ingredient.

Abstract translation: 目的：提供抗氧化剂以有效增强Rcan3基因的表达，并用作免疫抑制剂，用于治疗或预防免疫疾病，因为Rcan3蛋白抑制钙调神经磷酸酶途径。 构成：抗氧化剂增加Rcan3基因的表达。 抗氧化剂是瑞巴派特或多酚化合物。 多酚化合物是原花色素。 在体外增加Rcan3表达的方法包括用抗氧化剂处理细胞的步骤。 用于预防或治疗免疫疾病的组合物含有Rcan3基因或蛋白质作为活性成分。

公开(公告)号：KR1020130044155A

公开(公告)日：2013-05-02

申请号：KR1020120114823

申请日：2012-10-16

Applicant: 가톨릭대학교 산학협력단

Inventor： 조미라 ,  민준기 ,  전주연 ,  변재경 ,  오혜좌

IPC: A61K31/4704 ,  A61P3/04 ,  A61P3/00

CPC classification number: A61K31/4704 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/0019 ,  A23V2200/332

Abstract: PURPOSE: Obesity preventing or treating composition comprising rebamipide is provided to reduce LDL cholesterol levels and to increase HDL cholesterol levels. CONSTITUTION: Obesity preventing or treating composition comprising rebamipide comprises rebamipide compounds or salt of the rebamipide compounds. Rebamipide is capable of reducing weight, fat cells, total cholesterol levels, glucose and LDL cholesterol levels. Rebamipide has anti-obesity activiation through an action of changing white fat into brown fat. Rebamipide increases the activation of amplification of a regulatory T cell.

Abstract translation: 目的：提供包含瑞巴派特的肥胖症预防或治疗组合物以降低LDL胆固醇水平和提高HDL胆固醇水平。 构成：包含瑞巴派特的肥胖症预防或治疗组合物包括雷巴米特化合物或雷巴米特化合物的盐。 瑞巴米特能够减轻体重，脂肪细胞，总胆固醇水平，葡萄糖和低密度脂蛋白胆固醇水平。 瑞巴米特通过将白脂肪变成棕色脂肪的作用，具有抗肥胖作用。 瑞巴米特可增加调节性T细胞扩增的活化。

公开(公告)号：KR101399925B1

公开(公告)日：2014-05-29

申请号：KR1020110020720

申请日：2011-03-09

Applicant: 가톨릭대학교 산학협력단 ,  에이치 엘 지노믹스(주)

Inventor： 민준기 ,  조미라 ,  박미경 ,  허유정 ,  박진실 ,  김호연 ,  류종현 ,  김현규 ,  이근혁

IPC: A61K36/87 ,  A61P19/02 ,  A61P19/00

CPC classification number: A61K36/87

Abstract: 본 발명은 유럽종 포도(
Vitis vinifera )의 씨 추출물의 개선된 제조방법을 제공한다. 또한, 본 발명은 유럽종 포도(
Vitis vinifera )의 씨 추출물 및 약제학적으로 허용가능한 담체를 포함하는 류마티스 관절염의 예방 또는 치료용 약학 조성물을 제공한다.

公开(公告)号：KR1020110049627A

公开(公告)日：2011-05-12

申请号：KR1020100025050

申请日：2010-03-22

Applicant: 에이치 엘 지노믹스(주) ,  가톨릭대학교 산학협력단

Inventor： 민준기 ,  김진일 ,  김태호 ,  정대영 ,  조미라 ,  류종현 ,  이근혁 ,  최병선 ,  박진하 ,  곽은영 ,  조경주

IPC: A61K36/87 ,  A61P1/04

Abstract: PURPOSE: A pharmaceutical composition containing Vitis vinifera seed extract is provided to prevent and treat gastrointestinal ulcer. CONSTITUTION: A pharmaceutical composition for preventing or treating gastrointestinal ulcer contains Vitis vinifera seed extract and pharmaceutically acceptable carrier. The extract of Vitis vinifera seeds contains 80-130 of procyanidolic value(PCV); 30% or less of (+)catechin and (-) epicatechin; and 95-105% of proanthocyanidin. A method for preparing the Vitis vinifera seed extract comprises: a step of extracting Vitis vinifera seed seeds in a mixture solvent of acetone and water and filtering; a step of distilling liquid and removing acetone; a step of saturating sodium chloride and filtering; a step of extracting the liquid with ethyl acetate and concentrating; and a step of adding chloroform and filtering to obtain precipitate.

Abstract translation: 目的：提供含有葡萄籽提取物的药物组合物，用于预防和治疗胃肠溃疡。 构成：用于预防或治疗胃肠溃疡的药物组合物含有葡萄种子提取物和药学上可接受的载体。 葡萄籽提取物含有原花青素含量（PCV）80-130; 30％以下（+）儿茶素和（ - ）表儿茶素; 和95-105％的原花色素。 一种葡萄种子提取物的制备方法，其特征在于：在丙酮和水的混合溶剂中提取葡萄种子种子并过滤; 蒸馏液并除去丙酮的步骤; 使氯化钠饱和并过滤的步骤; 用乙酸乙酯萃取液体并浓缩的步骤; 并加入氯仿和过滤以获得沉淀物的步骤。

公开(公告)号：KR1020100117184A

公开(公告)日：2010-11-03

申请号：KR1020090035796

申请日：2009-04-24

Applicant: 가톨릭대학교 산학협력단 ,  에이치 엘 지노믹스(주)

Inventor： 민준기 ,  조미라 ,  박미경 ,  허유정 ,  박진실 ,  김호연 ,  오혜좌 ,  우윤주 ,  류종현 ,  김현규 ,  이근혁 ,  박진하 ,  곽은영 ,  전주연

IPC: A61K36/87 ,  A61P19/02

CPC classification number: A61K36/87

Abstract: PURPOSE: A pharmaceutical composition containing Vitis vinifera for preventing or treating osteoarthritis is provided. CONSTITUTION: A pharmaceutical composition for preventing or treating osteoarthritis contains Vitis vinifera extract and pharmaceutically acceptable carrier. Osteoarthritis is caused by aging, obesity or trauma. The Vitis vinifera extract contains 80-130 of procyanidolic value(PCV), 30% or less (+) catechin and (-) epicatechin, and 95-105% of proanthocyanidine. A method for producing Vitis vinifera extract comprises: a step of extracting Vitis vinifera and mixture of acetone and water at room temperature and filtering; a step of distilling remaining liquid and removing acetone; a step of saturating sodium chloride and filtering; a step of extracting with ethyl acetate and concentrating; and a step of adding chloroform and precipitating.

Abstract translation: 目的：提供一种含有葡萄酒的预防或治疗骨关节炎的药物组合物。 构成：用于预防或治疗骨关节炎的药物组合物含有葡萄葡萄提取物和药学上可接受的载体。 骨关节炎是由衰老，肥胖或创伤引起的。 葡萄籽提取物含有原花青素值（PCV）80-130，儿茶素和（ - ）表儿茶素30％以下，原花青素95-105％。 一种葡萄酒提取物的制备方法，其特征在于：在室温下提取葡萄酒和丙酮与水的混合物，过滤; 蒸馏剩余液体并除去丙酮的步骤; 使氯化钠饱和并过滤的步骤; 用乙酸乙酯提取并浓缩的步骤; 并加入氯仿和沉淀的步骤。

公开(公告)号：KR1020090024647A

公开(公告)日：2009-03-09

申请号：KR1020080087109

申请日：2008-09-04

Applicant: 가톨릭대학교 산학협력단 ,  에이치 엘 지노믹스(주)

Inventor： 민준기 ,  조미라 ,  박미경 ,  허유정 ,  박진실 ,  김호연 ,  류종현 ,  김현규 ,  이근혁

IPC: A61K36/87 ,  A61P19/02

CPC classification number: A61K36/87

Abstract: A method for preparing extracts from seeds of Vitis Vinifera is provided to reduce the quantity of acetone consumed for extraction by using a mixed solvent of water and acetone while securing a high yield. A method for preparing extracts from seeds of Vitis Vinifera comprises the following steps of: extracting an extract from a mixture of pulverized seeds of the Vitis Vinifera and a acetone/water mixed solvent in a mixing ratio of 1 to 1-2 at a room temperature and filtering the extract; removing the acetone by distilling the obtained extract and saturating the extract with sodium chloride; extracting the saturated extract by ethylacetate and concentrating the extract; and adding chloroform to the concentrated extract to obtain precipitate.

Abstract translation: 提供了一种用于从酿酒酵母的种子制备提取物的方法，以通过使用水和丙酮的混合溶剂来减少用于提取的丙酮消耗量，同时确保高产率。 从酿酒酵母种子提取提取物的方法包括以下步骤：将葡萄酒的粉碎种子和丙酮/水混合溶剂的混合物中的提取物以1至1-2的混合比在室温下萃取 并过滤提取物; 通过蒸馏所得提取物并用氯化钠饱和提取物除去丙酮; 用乙酸乙酯提取饱和提取物，浓缩提取物; 并向浓缩的萃取液中加入氯仿，得到沉淀。