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公开(公告)号：KR1020090028212A
公开(公告)日：2009-03-18
申请号：KR1020070093643
申请日：2007-09-14
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: A61K35/648
CPC classification number: A61K35/648
Abstract: A manufacturing method of Scolopendra subspinipes extract making immunogenicity of animal is provided to be useful as immunostimulator preventing and treating efficiently disease of the animal, an adjuvant improving effect of vaccine and an adjuvant treatment making therapeutic efficacy reinforced. A manufacturing method of Scolopendra subspinipes extract making immunogenicity of animal comprises steps of: put the Scolopendra subspinipes powder into distilled water; obtaining extract by heating obtained solution, filtering obtained extract using filter paper firstly, filtering filtered material using filter paper secondly and sterilizing filtered material.
Abstract translation: 提供了提供动物免疫原性的Scolopendra subspinipes提取物的制造方法，可用作有效预防和治疗动物疾病的免疫刺激剂，疫苗的辅助改善效果和辅助治疗，增强治疗功效。 Scolopendra subspinipes提取物制备动物免疫原性的方法包括以下步骤：将Scolopendra subspinipes粉末放入蒸馏水中; 通过加热获得的溶液获得提取物，首先使用滤纸过滤获得的提取物，然后用滤纸过滤过滤材料并对过滤材料进行灭菌。
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公开(公告)号：KR1020090013600A
公开(公告)日：2009-02-05
申请号：KR1020070077855
申请日：2007-08-02
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
CPC classification number: A61K36/06
Abstract: An immunostimulant containing the lystic extract of Candida sake is provided to increase activity of neutrophil and lymphocyte as major immune cells of animals, thereby protecting animals from diseases. The immunostimulant contains the lystic extract of Candida sake which is prepared by cultivating Candida sake in yeast malt extract agar broth at 30 deg. C for 72 hours, centrifuging the cultured fluid at 3000Xg for 30 minutes and collecting it, rinsing the collected pellet with phosphate buffered saline(PBS) of pH 7.2 and suspending the rinsed pellet in PBS, adding 5% of TNT solution containing 50mM of Tris-HCl, 0.15M of NaCl and 4% Triton x-114 as solubilizing agent into the Candida sake suspension, stirring the mixture at room temperature for 2-3 days to solubilize the Streptomyces albus, and regulating pH of the solution to 6.5-7.2, and drying the solution in the thermostatic chamber.
Abstract translation: 提供含有念珠菌精液提取物的免疫刺激剂，以增加嗜中性粒细胞和淋巴细胞作为动物主要免疫细胞的活性，从而保护动物免受疾病。 免疫刺激剂含有通过在30℃下在酵母麦芽提取物琼脂培养液中培育念珠菌精油而制备的念珠菌清酒。 培养72小时，将培养液以3000Xg离心30分钟并收集，用pH7.2的磷酸盐缓冲盐水（PBS）冲洗收集的沉淀物，并将漂洗的沉淀悬浮于PBS中，加入5％含有50mM Tris -HCl，0.15M NaCl和4％Triton x-114作为增溶剂加入到念珠菌悬浮液中，在室温下搅拌混合物2-3天以溶解链霉菌，并将溶液的pH调节至6.5-7.2 ，并干燥恒温室中的溶液。
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公开(公告)号：KR1020090012575A
公开(公告)日：2009-02-04
申请号：KR1020070076507
申请日：2007-07-30
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: A61K31/70 , A61K36/48 , A61K36/185 , A61P37/02
CPC classification number: A61K38/168 , Y10S514/885
Abstract: Glycine max (L.) Merrill lectin is provided to reinforce immunogenicity of animals, to improve effect of an immunoadjuvant and a vaccine preventing and treating disease of the animals efficiently and to increase defence ability aspecific to attack inoculation of pathogenic bacteria. An immunoadjuvant comprises Glycine max (L.) Merrill lectin as an active ingredient. Additionally, the Glycine max (L.) Merrill lectin is used for a vaccine throne and an adjuvant treatment as the active ingredient.
Abstract translation: 提供大豆（L.）美林凝集素以增强动物的免疫原性，提高免疫佐剂的效果和预防和治疗动物疾病的疫苗，并提高对病原菌接种的防御能力。 免疫佐剂包含甘氨酸（L.）美林凝集素作为活性成分。 另外，甘氨酸（L.）美林凝集素用作疫苗王位和辅助治疗作为活性成分。
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公开(公告)号：KR1020080095988A
公开(公告)日：2008-10-30
申请号：KR1020070040731
申请日：2007-04-26
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
Abstract: A feed additive using a coptic rhizome and forsythia fruit extract is provided to accelerate the growth of animal, to reinforce an immune function and to prevent diseases, by adding predetermined amount of extracts obtained from Forsythiae Fructus and Coptidis Rhizoma and supplying it to domestic animals, thereby substituting antibiotics. A feed additive using a coptic rhizome and forsythia fruit extract comprises Coptis japonica extract 50 weight%, forsythia extract 10 weight%, and dextrose 30 weight% and Glycyrrhiza extract 10 weight%.
Abstract translation: 提供使用科普特根和连翘果提取物的饲料添加剂，通过加入预定量的连翘和黄连提取物提取动物，增加免疫功能，增强免疫功能，预防疾病，并将其提供给家畜， 从而代替抗生素。 使用科普特根和连翘果提取物的饲料添加剂包括50重量％的黄连提取物，10重量％的连翘提取物和30重量％的葡萄糖和10重量％的甘草提取物。
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公开(公告)号：KR1020080032809A
公开(公告)日：2008-04-16
申请号：KR1020060098780
申请日：2006-10-11
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
CPC classification number: Y02A50/473 , A61K35/74 , A61K36/06 , C12N1/16 , C12N1/20
Abstract: A method for preparing a cell lysis composition of bacterial and yeast cell wall is provided to improve yield of cell wall, and selectively employ antigen substances and immune-enhancing substances in the cell wall by using biochemical and chemical treatment, so that the composition is useful as vaccine antigen, heterologous delivery system, immune enhancer, vaccine assistant and complex feed additive. A method for preparing a cell lysis composition of bacterial and yeast cell wall comprises the steps of: culturing gram positive bacteria, gram negative bacteria and yeast; treating the cultured gram positive bacteria, gram negative bacteria and yeast biochemically and chemically by using transparent outer membrane extraction, TNT(Tris-HCl, sodium chloride, Triton X-114) method, NaOH-EDTA(sodium hydroxide-(ethylene dinitrilo) tetraacetic acid), TMC(Tris-HCl, magnesium chloride, calcium chloride) method or TET(Tris-HCl, EDTA, Triton X-100) method; and extracting useful ingredients of cell wall from the treated gram positive bacteria, gram negative bacteria and yeast, wherein the gram negative bacteria include Escherichia coli 055 and Bordetella pertussis; the gram positive bacteria include Staphylococcus aureus Cowan 1 and Erysipelothrix rhusiopathiae T2; and the yeast is Saccharomyces cerevisiae or Candida albicans. Further, the useful ingredients of cell wall are selected from a group consisting of a transparent cell outer membrane, a cell wall and bacteriolysant.
Abstract translation: 提供细菌和酵母细胞壁细胞裂解组合物的制备方法，以提高细胞壁的产量，并通过生物化学和化学处理选择性地在细胞壁中使用抗原物质和免疫增强物质，使组合物有用 作为疫苗抗原，异源递送系统，免疫增强剂，疫苗助剂和复合饲料添加剂。 制备细菌和酵母细胞壁的细胞裂解组合物的方法包括以下步骤：培养革兰氏阳性菌，革兰氏阴性细菌和酵母; 通过使用透明的外膜提取，TNT（Tris-HCl，氯化钠，Triton X-114）方法，NaOH-EDTA（氢氧化钠 - （亚乙基二硝基）四乙酸）处理培养的革兰氏阳性细菌，革兰氏阴性细菌和酵母生物化学和化学 酸），TMC（Tris-HCl，氯化镁，氯化钙）法或TET（Tris-HCl，EDTA，Triton X-100）法; 并从经处理的革兰氏阳性细菌，革兰氏阴性细菌和酵母提取细胞壁的有用成分，其中革兰氏阴性细菌包括大肠杆菌055和百日咳博德特氏菌; 革兰氏阳性细菌包括金黄色葡萄球菌Cowan 1和Erysipelothrix rhusiopathiae T2; 酵母是酿酒酵母或白色念珠菌。 此外，细胞壁的有用成分选自透明细胞外膜，细胞壁和细菌悬液。
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Patent Agency Ranking
公开(公告)号：KR102241521B1
公开(公告)日：2021-04-20
申请号：KR1020190043782
申请日：2019-04-15
Applicant: 주식회사 바이오노트 , 대한민국(농림축산식품부 농림축산검역본부장)
IPC: C07K16/10 , G01N33/569
Abstract: 구제역바이러스구조단백질 VP1과특이적으로결합하는구제역바이러스 O형에면역반응성을나타내는항체또는이의항원-결합단편, 이를포함하는구제역바이러스 O형검출용조성물, 및이를포함하는구제역바이러스 O형항체검출용조성물에관한것이다.
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公开(公告)号：KR101462986B1
公开(公告)日：2014-11-19
申请号：KR1020120068128
申请日：2012-06-25
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: C12Q1/68 , G01N33/569 , C12Q1/04
Abstract: 본 발명은 분변 중 요네균 신속분리를 위한 자석 나노입자를 이용한 검출방법에 관한 것으로, 구체적으로 요네균 특이적 항체가 결합된 자성 나노입자를 이용하여 가축 등의 분변 시료에 존재할 수 있는 요네균을 높은 감도로 분리해 내고, 요네균의 DNA에 특이적으로 결합하는 프라이머를 사용하여 중합효소 연쇄반응을 수행함으로써 요네균의 감염여부를 신속하고 간편하게 확인하기 위한 요네균 검출 방법에 관한 것이다.
본 발명에 따르면 분변 등의 생물학적 시료에 요네균이 매우 작은 수로 존재하더라도 용이하게 요네균을 검출할 수 있으며, 그 방법이 간단하고 매우 신속하게 이루어질 수 있어, 감염된 개체를 우군에서 격리함으로써 다른 개체로의 전염을 막을 수 있다.-
38.发明公开Ｌａｃｔｏｃｏｃｃｕｓ ｌａｃｔｉｓ ＮＫ34 ＫＦＣＣ 11458Ｐ의 배지 최적화를 통한 젖소 유방염 원인균에 효과가 있는 ｌａｃｔｉｃｉｎ ＮＫ34의 생산방법 无效新型LACTICIN NK34及其生产方法，通过优化培养液对乳腺发炎引起的微生物有效
公开(公告)号：KR1020110017241A
公开(公告)日：2011-02-21
申请号：KR1020090074809
申请日：2009-08-13
Applicant: 건국대학교 산학협력단 , 대한민국(농림축산식품부 농림축산검역본부장) , 서울대학교산학협력단
Abstract: PURPOSE: A Lactococcus lactis NK34 for producing bacteriocin lacticin NK34 having antibacterial effect to bovine mastitis bacteria is provided to replace antibiotics and to produce a large amount of lacticin NK34. CONSTITUTION: A Lactococcus lactis NK34 strain is purely cultured in MRS medium and produces bacteriocin lacticin NK34 having an effect of suppressing bovine mastitis causing bacteria. The Lactococcus lactis NK34 KFCC 11458P is cultured in a medium containing sucrose, tryptone, yeast extract, tween 80, sodium acetate, and NaCl. A medium composition for culturing Lactococcus lactis NK34 KFCC 11458P or performing biosynthesis of bacteriocin lactinic NK34 contains sucrose, tryptone, yeast extract, tween 80, sodium acetate, and NaCl.
Abstract translation: 目的：提供乳酸乳球菌NK34，用于产生对牛乳杆菌细菌具有抗菌作用的细菌素乳酸菌NK34，以代替抗生素并产生大量乳酸菌NK34。 构成：乳酸乳球菌NK34菌株纯化在MRS培养基中培养，产生具有抑制牛乳腺炎引起细菌的作用的细菌素乳酸菌NK34。 乳酸乳球菌NK34 KFCC 11458P在含有蔗糖，胰蛋白胨，酵母提取物，吐温80，乙酸钠和NaCl的培养基中培养。 用于培养乳酸乳球菌NK34KFCC11458P或进行细菌素乳内酯NK34的生物合成的培养基组合物含有蔗糖，胰蛋白胨，酵母提取物，吐温80，乙酸钠和NaCl。
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公开(公告)号：KR1020110009626A
公开(公告)日：2011-01-28
申请号：KR1020100070014
申请日：2010-07-20
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
CPC classification number: A23K10/18 , A23K20/195 , C12N1/20 , C12R1/225
Abstract: PURPOSE: A feed additive composition including lactobacillus reuteri is provided to improve the intestinal regulation effect and the enteropathogenic bacteria inhibition effect of animals. CONSTITUTION: A feed additive composition contains lactobacillus reuteri with the 16s rDNA including a base sequence of the sequence number 1. The lactobacillus reuteri has the acid resistance, the bile tolerance, and the intestine adhesion capacity. The feed additive is capable of inhibiting the intestinal proliferation of pathogenic bacteria.
Abstract translation: 目的：提供包括乳酸杆菌的饲料添加剂组合物，以改善肠道调节作用和动物肠道致病菌的抑菌作用。 构成：饲料添加剂组合物含有含有16s rDNA的乳酸杆菌，其含有序列号1的碱基序列。罗伊酸乳酸杆菌具有耐酸性，胆汁耐受性和肠粘连能力。 饲料添加剂能够抑制病原菌的肠道增殖。
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公开(公告)号：KR1020100114606A
公开(公告)日：2010-10-26
申请号：KR1020090033058
申请日：2009-04-16
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
Abstract: PURPOSE: A composition for preventing or treating Staphylococcus aureus-derived diseases is provided to suppress growth methicilin-resistant Staphylococcus aureus. CONSTITUTION: A composition for preventing or treating Staphylococcus aureus-derived diseases contains Celosia cristata extract as an active ingredient. The composition is veterinary composition, animal feed additive, feed having animal feed additive, and disinfection composition. The Celosia cristata extract is isolated using water, low alcohol of C1-C4 or mixture solvent thereof. The Staphylococcus aureus-derived disease is bovine mastitis.
Abstract translation: 目的：提供一种用于预防或治疗金黄色葡萄球菌来源疾病的组合物，以抑制耐甲氧西林金黄色葡萄球菌的生长。 构成：用于预防或治疗金黄色葡萄球菌来源的疾病的组合物含有作为活性成分的山楂提取物。 组合物是兽药组合物，动物饲料添加剂，具有动物饲料添加剂的饲料和消毒组合物。 使用水，C1-C4的低级醇或其混合溶剂来分离茜草提取物。 金黄色葡萄球菌来源的疾病是牛乳腺炎。
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